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Erschienen in: Breast Cancer Research 5/2005

01.10.2005 | Commentary

Treating breast cancer through novel inhibitors of the phosphatidylinositol 3'-kinase pathway

verfasst von: Robert J Crowder, Matthew J Ellis

Erschienen in: Breast Cancer Research | Ausgabe 5/2005

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Abstract

Recent studies indicate that constitutive signaling through the phosphatidylinositol 3'-kinase (PI3K) pathway is a cause of treatment resistance in breast cancer patients. This implies that patients with tumors that exhibit aberrant PI3K signaling may benefit from targeted pathway inhibitors. The first agents to make it to the clinic are the rapamycin analogs. These compounds inhibit the downstream PI3K effector mTOR (mammalian target of rapamycin). A study presented in this issue of Breast Cancer Research suggests that recently developed inhibitors of phosphoinositide-dependent protein kinase 1, a more proximal target of the PI3K pathway, may provide an alternative route to effective PI3K pathway inhibition for breast cancer treatment.
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Metadaten
Titel
Treating breast cancer through novel inhibitors of the phosphatidylinositol 3'-kinase pathway
verfasst von
Robert J Crowder
Matthew J Ellis
Publikationsdatum
01.10.2005
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 5/2005
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1307

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