Introduction
Materials and methods
Clinical specimen
Patient number | Age (years) | Grade | Estrogen receptor | Progesterone receptor | Her-2 | Size | Nodal status | Tumor type |
---|---|---|---|---|---|---|---|---|
44 | 28 | III | Positive | Positive | Negative | 1 | Negative | Ductal |
45 | 36 | I | Positive | Positive | Negative | N/A | Negative | Ductal |
79 | 54 | I | Positive | Positive | Negative | 2.1 | Positive | Ductal |
96 | 31 | III | Negative | Negative | Negative | 3.7 | Negative | Ductal |
102 | 55 | I | Positive | Negative | Negative | 5.2 | Positive | Ductal |
121 | 45 | II | Positive | Positive | Positive | 1.5 | Positive | Ductal |
131 | 37 | II | Positive | Positive | Positive | 1.5 | Positive | Ductal |
133 | 44 | III | Negative | Negative | Positive | 1.5 | Positive | Ductal |
148 | 42 | II | Positive | Positive | Negative | 1.9 | Positive | Ductal |
153 | 46 | I | Positive | Positive | ND | N/A | Positive | Ductal |
169 | 34 | II | Positive | Positive | Negative | 2.6 | Positive | Ductal |
178 | 43 | III | Positive | Positive | Positive | 2.8 | Positive | Ductal |
179 | 37 | III | Negative | Negative | Positive | 1.5 | Positive | Ductal |
180 | 46 | I | Positive | Positive | Negative | 1.9 | Positive | Ductal |
Laser capture microdissection, RNA extraction and microarray analysis
Data analysis
Quantitative real-time PCR and immunohistochemistry
Results
Experimental design
Tumor | Stroma | |||||
---|---|---|---|---|---|---|
Patient | Normal |
In situ
| Invasive | Normal |
In situ
| Invasive |
44 | x | x | x | x | x | x |
45 | x | x | x | x | x | |
79 | x | x | x | x | x | |
96 | x | x | x | x | x | x |
102 | x | x | x | x | x | x |
121 | x | x | x | x | x | x |
131 | x | x | x | x | ||
133 | x | x | x | x | ||
148 | x | x | x | x | ||
153 | x | x | x | x | ||
169 | x | x | x | x | ||
178 | x | x | x | x | ||
179 | x | x | x | x | ||
180 | x | x | x | x |
Gene expression changes in the stromal and epithelial compartments during breast cancer progression
Name | Size (number of genes) | Normalized enrichment score | False discovery rate q value |
---|---|---|---|
Epithelium | |||
SPINDLE | 39 | 2.33 | 0 |
CHROMOSOME_SEGREGATION | 28 | 2.15 | 0 |
CELL_CYCLE_PROCESS | 180 | 2.12 | 0 |
MICROTUBULE_CYTOSKELETON_ORGANIZATION_AND_BIOGENESIS | 34 | 2.11 | 0 |
CHROMOSOME__PERICENTRIC_REGION | 27 | 2.11 | 0 |
MICROTUBULE_CYTOSKELETON | 142 | 2.11 | 0 |
PROTEASOME_COMPLEX | 22 | 2.09 | 1.40 × 10-4 |
CONDENSED_CHROMOSOME | 30 | 2.06 | 2.48 × 10-4 |
M_PHASE | 105 | 2.06 | 2.20 × 10-4 |
NUCLEAR_ENVELOPE | 71 | 2.05 | 1.98 × 10-4 |
CELL_CYCLE_PHASE | 157 | 2.05 | 1.80 × 10-4 |
M_PHASE_OF_MITOTIC_CELL_CYCLE | 78 | 2.04 | 2.49 × 10-4 |
CHROMOSOME | 115 | 2.03 | 2.30 × 10-4 |
CYTOSKELETAL_PART | 221 | 2.03 | 2.14 × 10-4 |
MITOSIS | 75 | 2.02 | 2.66 × 10-4 |
MICROTUBULE | 32 | 1.99 | 2.49 × 10-4 |
MITOTIC_CELL_CYCLE | 139 | 1.99 | 2.35 × 10-4 |
CELL_CYCLE_CHECKPOINT_GO_0000075 | 45 | 1.98 | 2.21 × 10-4 |
SPINDLE_MICROTUBULE | 16 | 1.97 | 2.63 × 10-4 |
DNA_REPAIR | 120 | 1.94 | 6.01 × 10-4 |
STRUCTURAL_CONSTITUENT_OF_RIBOSOME |
74
|
-3.09
|
0
|
Stroma | |||
EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT | 25 | 2.12 | 0 |
COLLAGEN | 23 | 2.07 | 0.001566 |
METALLOENDOPEPTIDASE_ACTIVITY | 26 | 2.06 | 0.001044 |
EXTRACELLULAR_MATRIX | 94 | 1.99 | 0.001568 |
PROTEINACEOUS_EXTRACELLULAR_MATRIX | 93 | 1.97 | 0.002923 |
EXTRACELLULAR_MATRIX_PART | 54 | 1.91 | 0.007826 |
SPINDLE | 39 | 1.89 | 0.008346 |
METALLOPEPTIDASE_ACTIVITY | 45 | 1.82 | 0.027006 |
SKELETAL_DEVELOPMENT | 99 | 1.80 | 0.032482 |
STRUCTURAL_CONSTITUENT_OF_RIBOSOME |
74
|
-3.04
|
0
|
Probe set | DICS | IDC | Gene description |
---|---|---|---|
g5174662_3p_at | 5.3 | 4.0 | S100P – S100 calcium binding protein P |
g11993936_3p_s_at | 4.5 | 3.4 | CYB561 – cytochrome b-561 |
g7415720_3p_a_at | 4.0 | 3.0 | SCD – stearoyl-CoA desaturase (delta-9-desaturase) |
Hs.75319.0.S3_3p_at | 3.0 | 3.8 | RRM2 – ribonucleotide reductase M2 polypeptide |
Hs.106552.0.S3_3p_s_at | 4.2 | 2.3 | CNTNAP2 – contactin associated protein-like 2 |
g12803628_3p_at | 3.7 | 2.6 | HIST1H1C – histone cluster 1, H1c |
g5031780_3p_at | 4.0 | 2.3 | IFI27 – interferon, alpha-inducible protein 27 |
Hs.180779.1.S1_3p_at | 3.1 | 3.0 | HIST1H2BD – histone cluster 1, H2bd |
Hs.184572.0.S2_3p_at | 2.7 | 3.3 | CDC2 – cell division cycle 2, G1 to S and G2 to M |
Hs.223025.0.S2_3p_a_at | 2.6 | 3.4 | RAB31 – RAB31, member RAS oncogene family |
g12804874_3p_a_at | 2.8 | 3.1 | RRM2 – ribonucleotide reductase M2 polypeptide |
Hs.239884.0.S1_3p_x_at | 3.5 | 2.4 | HIST1H2BC – histone cluster 1, H2bc |
g7661973_3p_at | 2.7 | 3.1 | MELK – maternal embryonic leucine zipper kinase |
g13259549_3p_at | 3.2 | 2.4 | IFI6 – interferon, alpha-inducible protein 6 |
g4504584_3p_at | 3.5 | 2.0 | IFIT1 – interferon-induced protein with tetratricopeptide repeats 1 |
Hs.155956.0.S1_3p_at | 2.6 | 2.8 | NAT1 – N-acetyltransferase 1 (arylamine N-acetyltransferase) |
Hs.152677.0.S1_3p_at | 3.1 | 2.3 | DHRS2 – dehydrogenase/reductase (SDR family) member 2 |
Hs.239884.0.S1_3p_at | 3.3 | 2.1 | HIST1H2BC – histone cluster 1, H2bc |
g5803130_3p_a_at | 2.2 | 3.2 | RAB31 – RAB31, member RAS oncogene family |
g13699814_3p_s_at | 2.7 | 2.7 | CYP2B6 – cytochrome P450, family 2, subfamily B, polypeptide 6 |
g9963780_3p_a_at | 2.2 | 3.2 | RAB31 – RAB31, member RAS oncogene family |
Hs.72472.0.A1_3p_at | 2.3 | 2.9 | - |
g13477106_3p_s_at | 3.3 | 1.8 | CEACAM6 – carcinoembryonic antigen-related cell adhesion molecule 6 (nonspecific cross-reacting antigen) |
Hs.133342.0.S1_3p_x_at | 2.9 | 2.2 | GPC1 – glypican 1 |
Hs.325335.1.S1_3p_at | 2.6 | 2.5 | CAPN13 – calpain 13 |
Hs.34853.0.S2_3p_at | -3.5 | -4.0 | ID4 – inhibitor of DNA binding 4, dominant negative helix-loop-helix protein |
g3387766_3p_a_at | -3.9 | -3.6 | GPM6B – glycoprotein M6B |
Hs.10587.0.S1_3p_at | -3.2 | -4.3 | DMN – desmuslin |
Hs2.348883.1.S1_3p_s_at | -3.9 | -3.6 | FOXC1 – forkhead box C1 |
g4758521_3p_at | -4.9 | -2.7 | SPARCL1 – SPARC-like 1 (mast9, hevin) |
g11037715_3p_x_at | -3.9 | -3.7 | ROPN1 – ropporin, rhophilin associated protein 1 |
g4504914_3p_at | -3.9 | -3.8 | KRT15 – keratin 15 |
Hs.82101.0.S3_3p_at | -3.7 | -4.0 | PHLDA1 – pleckstrin homology-like domain, family A, member 1 |
Hs.149356.0.S1_3p_at | -3.8 | -3.9 | LOC728264 – hypothetical protein LOC728264 |
g4506856_3p_s_at | -3.3 | -4.6 | CX3CL1 – chemokine (C-X3-C motif) ligand 1 |
g4506516_3p_at | -3.9 | -4.1 | RGS2 – regulator of G-protein signaling 2, 24 kDa |
g7657105_3p_at | -4.2 | -4.0 | GABRP – gamma-aminobutyric acid (GABA) A receptor, pi |
Hs.25956.0.S1_3p_at | -4.1 | -4.4 | SOSTDC1 – sclerostin domain containing 1 |
Hs.153961.2.S2_3p_at | -4.6 | -3.9 | BOC – Boc homolog (mouse) |
g11991655_3p_at | -4.5 | -4.2 | C2orf40 – chromosome 2 open reading frame 40 |
Hs.288850.0.S1_3p_at | -4.1 | -4.7 | PHLDA1 – pleckstrin homology-like domain, family A, member 1 |
g7662650_3p_at | -5.1 | -3.7 | C13orf15 – chromosome 13 open reading frame 15 |
g4557694_3p_a_at | -4.5 | -4.5 | KIT – v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
Hs.127428.2.S2_3p_a_at | -4.3 | -4.9 | HOXA9 – homeobox A9 |
g6005949_3p_at | -4.4 | -4.8 | WIF1 – WNT inhibitory factor 1 |
Hs.34853.0.S3_3p_at | -4.8 | -4.5 | ID4 – inhibitor of DNA binding 4, dominant negative helix-loop-helix protein |
g4559274_3p_a_at | -4.1 | -5.3 | ELF5 – E74-like factor 5 (ets domain transcription factor) |
g8400731_3p_a_at | -4.4 | -5.2 | SFRP1 – secreted frizzled-related protein 1 |
g5032314_3p_a_at | -4.9 | -4.9 | DMD – dystrophin (muscular dystrophy, Duchenne and Becker types) |
g6005714_3p_at | -4.7 | -5.6 | SLC6A14 – solute carrier family 6 (amino acid transporter), member 14 |
Probe set | DCIS | IDC | Gene description |
---|---|---|---|
Hs.179729.0.S1_3p_a_at | 6.5 | 7.0 | COL10A1 – collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia) |
Hs.28792.0.S1_3p_at | 5.9 | 6.0 | NA |
4876385_3p_at | 4.9 | 6.3 | COL11A1 – collagen, type XI, alpha 1 |
g7019348_3p_at | 4.9 | 5.7 | GREM1 – gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) |
Hs.179729.1.S1_3p_a_at | 4.8 | 5.5 | COL10A1 – collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia) |
Hs.297939.3.S1_3p_at | 4.6 | 5.1 | FNDC1 – fibronectin type III domain containing 1 |
37892_3p_at | 4.1 | 5.6 | COL11A1 – collagen, type XI, alpha 1 |
Hs.41271.0.S1_3p_at | 4.7 | 4.9 | COL8A1 – collagen, type VIII, alpha 1 |
g4502938_3p_s_at | 3.8 | 5.4 | COL11A1 – collagen, type XI, alpha 1 |
g186414_3p_a_at | 4.5 | 4.4 | INHBA – inhibin, beta A |
g8393842_3p_at | 4.4 | 4.4 | NOX4 – NADPH oxidase 4 |
Hs.288467.0.S1_3p_at | 3.8 | 4.8 | LRRC15 – leucine rich repeat containing 15 |
Hs.105700.0.S1_3p_a_at | 4.1 | 4.2 | SFRP4 – secreted frizzled-related protein 4 |
g4481752_3p_at | 3.6 | 4.4 | GJB2 – gap junction protein, beta 2, 26 kDa |
g8923132_3p_at | 3.6 | 4.3 | ASPN – asporin |
Hs.287820.2.A1_3p_s_at | 3.8 | 4.1 | FN1 – fibronectin 1 |
g8400733_3p_a_at | 3.5 | 3.9 | SFRP4 – secreted frizzled-related protein 4 |
g10863087_3p_a_at | 3.4 | 3.9 | GREM1 – gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) |
g5174662_3p_at | 3.4 | 3.4 | S100P – S100 calcium binding protein P |
Hs.283713.0.A1_3p_at | 3.2 | 3.5 | CTHRC1 – collagen triple helix repeat containing 1 |
g4502844_3p_at | 3.1 | 3.5 | CILP – cartilage intermediate layer protein, nucleotide pyrophosphohydrolase |
Hs.76722.2.S1_3p_at | 2.8 | 3.7 | - |
Hs.70823.0.S3_3p_at | 3.3 | 3.2 | SULF1 – sulfatase 1 |
g4505186_3p_at | 3.3 | 3.0 | CXCL9 – chemokine (C-X-C motif) ligand 9 |
Hs.101302.0.S2_3p_s_at | 2.2 | 3.9 | COL12A1 – collagen, type XII, alpha 1 |
g11415037_3p_at | -3.2 | -3.0 | SLC22A3 – solute carrier family 22 (extraneuronal monoamine transporter), member 3 |
Hs.325823.0.A1_3p_at | -2.7 | -3.5 | CD36 – CD36 molecule (thrombospondin receptor) |
g4557418_3p_at | -2.7 | -3.6 | CD36 – CD36 molecule (thrombospondin receptor) |
g4557544_3p_a_at | -2.9 | -3.5 | EDN3 – endothelin 3 |
Hs2.147313.1.S1_3p_s_at | -2.9 | -3.5 | CD300LG – CD300 molecule-like family member g |
Hs.106283.4.S1_3p_at | -3.0 | -3.4 | KLHL13 – kelch-like 13 (Drosophila) |
g8400731_3p_a_at | -2.6 | -4.0 | SFRP1 – secreted frizzled-related protein 1 |
Hs.250692.0.S4_3p_at | -3.0 | -3.7 | HLF – hepatic leukemia factor |
g4826977_3p_at | -3.3 | -3.5 | RELN – reelin |
Hs.76325.1.A1_3p_x_at | -3.0 | -3.9 | IGJ – immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides |
Hs.76325.1.A1_3p_at | -3.1 | -4.0 | IGJ – immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides |
g10835124_3p_a_at | -4.0 | -3.1 | DCX – doublecortex; lissencephaly, X-linked (doublecortin) |
g7657105_3p_at | -3.2 | -4.0 | GABRP – gamma-aminobutyric acid A receptor, pi |
g4506328_3p_at | -3.4 | -3.9 | PTPRZ1 – protein tyrosine phosphatase, receptor-type, Z polypeptide 1 |
g4758377_3p_at | -3.9 | -3.4 | FIGF – c-fos induced growth factor (vascular endothelial growth factor D) |
g12707575_3p_at | -3.3 | -4.1 | OXTR – oxytocin receptor |
g13518036_3p_a_at | -2.5 | -4.9 | MATN2 – matrilin 2 |
g4559274_3p_a_at | -3.9 | -3.6 | ELF5 – E74-like factor 5 (ets domain transcription factor) |
Hs.10587.0.S1_3p_at | -2.5 | -5.1 | DMN – desmuslin |
Hs.49696.0.A1_3p_at | -3.7 | -4.0 | SCARA5 – scavenger receptor class A, member 5 (putative) |
g4557578_3p_at | -3.4 | -4.4 | FABP4 – fatty acid binding protein 4, adipocyte |
g13186315_3p_a_at | -3.5 | -4.3 | CAPN6 – calpain 6 |
g11991655_3p_at | -3.2 | -5.3 | C2orf40 – chromosome 2 open reading frame 40 |
g562105_3p_a_at | -4.9 | -4.5 | DLK1 – delta-like 1 homolog (Drosophila) |
g6005949_3p_at | -5.0 | -4.8 | WIF1 – WNT inhibitory factor 1 |
Stromal gene expression signature associated with tumor invasion
Probe set | Log2 (fold change) | Adjusted P value | Gene description |
---|---|---|---|
Hs2.434299.1.S1_3p_at | 1.61 | 8.58 × 10-3 | - |
g13027795_3p_s_at | 1.45 | 1.74 × 10-2 | MMP11 – matrix metallopeptidase 11 (stromelysin 3) |
Hs.50081.1.S1_3p_a_at | 1.36 | 5.47 × 10-3 | KIAA1199 – KIAA1199 |
g11641276_3p_s_at | 1.24 | 3.71 × 10-2 | PDE4DIP – phosphodiesterase 4D interacting protein (myomegalin) |
Hs.169517.0.S1_3p_a_at | 1.16 | 5.72 × 10-3 | ALDH1B1 – aldehyde dehydrogenase 1 family, member B1 |
Hs.98523.0.A1_3p_at | 1.13 | 5.32 × 10-3 | FAT3 – FAT tumor suppressor homolog 3 (Drosophila) |
g10938018_3p_at | 1.04 | 1.74 × 10-2 | EPYC – epiphycan |
Hs2.350890.1.S1_3p_s_at | 1.03 | 3.72 × 10-2 | GABRB2 – gamma-aminobutyric acid (GABA) A receptor, beta 2 |
g4507922_3p_at | 0.98 | 1.70 × 10-2 | WISP2 – WNT1 inducible signaling pathway protein 2 |
g11342665_3p_at | 0.98 | 4.53 × 10-2 | MMP2 – matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72 kDa type IV collagenase) |
g13124890_3p_a_at | 0.93 | 3.28 × 10-2 | GALNT1 – UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) |
Hs.98523.0.A1_3p_x_at | 0.87 | 3.15 × 10-2 | FAT3 – FAT tumor suppressor homolog 3 (Drosophila) |
Hs.238532.0.A1_3p_at | 0.76 | 3.71 × 10-2 | GALNTL2 – UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2 |
Hs.42927.0.S1_3p_at | 0.75 | 3.39 × 10-2 | ANTXR1 – anthrax toxin receptor 1 |
Hs2.359399.1.S1_3p_at | 0.74 | 3.71 × 10-2 | LOC285758 – hypothetical protein LOC285758 |
Hs.235795.0.A1_3p_at | 0.74 | 1.38 × 10-2 | - |
Hs2.46679.2.S1_3p_s_at | 0.66 | 2.11 × 10-3 | - |
g469044_3p_a_at | 0.60 | 3.22 × 10-2 | CNTN1 – contactin 1 |
g4758607_3p_at | 0.53 | 1.20 × 10-2 | - |
Hs.288553.0.S1_3p_s_at | 0.52 | 2.82 × 10-2 | - |
200661_3p_at | 0.51 | 4.16 × 10-2 | CTSA – cathepsin A |
Hs.2399.1.S1_3p_s_at | 0.51 | 4.48 × 10-2 | MMP14 – matrix metallopeptidase 14 (membrane-inserted) |
Hs.98183.0.A1_3p_at | 0.48 | 8.58 × 10-3 | RSPO4 – R-spondin family, member 4 |
208756_3p_at | 0.48 | 2.28 × 10-2 | EIF3I – eukaryotic translation initiation factor 3, subunit I |
Hs.162647.0.S1_3p_at | 0.48 | 2.69 × 10-2 | DKFZP547L112 – hypothetical protein DKFZp547L112 |
Hs.22968.0.S1_3p_a_at | -2.00 | 8.37 × 10-6 | FLT1 – fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) |
g11545907_3p_at | -2.03 | 2.68 × 10-5 | ELTD1 – EGF, latrophilin and seven transmembrane domain containing 1 |
g5032094_3p_at | -2.03 | 3.64 × 10-7 | SLCO2A1 – solute carrier organic anion transporter family, member 2A1 |
Hs.8707.0.S1_3p_at | -2.07 | 1.29 × 10-5 | HECW2 – HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 |
Hs.134970.0.S1_3p_a_at | -2.07 | 6.66 × 10-3 | KIF26A – kinesin family member 26A |
Hs2.420404.1.S1_3p_at | -2.08 | 7.70 × 10-6 | PELO – pelota homolog (Drosophila) |
g4504850_3p_a_at | -2.11 | 3.62 × 10-2 | KCNK5 – potassium channel, subfamily K, member 5 |
Hs.288681.0.S1_3p_at | -2.13 | 4.98 × 10-4 | THSD7A – thrombospondin, type I, domain containing 7A |
g4557546_3p_at | -2.15 | 1.58 × 10-3 | EDNRB – endothelin receptor type B |
g11321596_3p_at | -2.19 | 1.64 × 10-3 | KDR – kinase insert domain receptor (a type III receptor tyrosine kinase) |
Hs.124675.0.A1_3p_at | -2.21 | 2.21 × 10-4 | GIMAP7 – GTPase, IMAP family member 7 |
Hs.211388.0.S1_3p_at | -2.24 | 5.72 × 10-3 | RUNDC3B – RUN domain containing 3B |
g4885556_3p_at | -2.25 | 2.13 × 10-3 | PODXL – podocalyxin-like |
Hs.26530.0.S2_3p_at | -2.30 | 1.60 × 10-3 | SDPR – serum deprivation response (phosphatidylserine binding protein) |
g13518036_3p_a_at | -2.41 | 7.19 × 10-3 | MATN2 – matrilin 2 |
Hs.102415.0.S1_3p_at | -2.43 | 2.67 × 10-8 | EMCN – endomucin |
Hs.61935.0.S1_3p_at | -2.45 | 2.68 × 10-5 | PCDH17 – protocadherin 17 |
g8547214_3p_at | -2.46 | 3.74 × 10-5 | EMCN – endomucin |
g4520327_3p_at | -2.48 | 2.67 × 10-3 | IL33 – interleukin 33 |
Hs.10587.0.S1_3p_at | -2.66 | 2.29 × 10-3 | DMN – desmuslin |
g3644039_3p_a_at | -2.67 | 1.43 × 10-2 | TP63 – tumor protein p63 |
Hs.78344.1.S2_3p_a_at | -2.87 | 2.13 × 10-3 | MYH11 – myosin, heavy chain 11, smooth muscle |
g6580814_3p_s_at | -2.93 | 8.90 × 10-5 | INMT – indolethylamine N-methyltransferase |
Hs.173560.0.S1_3p_at | -2.94 | 3.58 × 10-2 | ODZ2 – odz, odd Oz/ten-m homolog 2 (Drosophila) |
g4506870_3p_at | -3.23 | 1.80 × 10-3 | SELE – selectin E (endothelial adhesion molecule 1) |
Stromal gene expression signature associated with tumor grade
Name | Size (number of genes) | Normalized enrichment score | False discovery rate q value |
---|---|---|---|
CELLULAR_DEFENSE_RESPONSE | 52 | 2.31 | 0 |
IMMUNE_RESPONSE | 220 | 2.17 | 0 |
IMMUNE_SYSTEM_PROCESS | 312 | 2.16 | 0 |
T_CELL_ACTIVATION | 42 | 2.14 | 0 |
LEUKOCYTE_ACTIVATION | 67 | 2.09 | 0 |
JAK_STAT_CASCADE | 28 | 2.05 | 6.82 × 10-4 |
LYMPHOCYTE_ACTIVATION | 59 | 2.05 | 5.85 × 10-4 |
CELL_ACTIVATION | 73 | 2.04 | 5.12 × 10-4 |
M_PHASE_OF_MITOTIC_CELL_CYCLE | 78 | 2.04 | 4.55 × 10-4 |
RESPONSE_TO_VIRUS | 48 | 2.04 | 5.12 × 10-4 |
SPINDLE | 39 | 2.03 | 5.60 × 10-4 |
MITOSIS | 75 | 2.02 | 5.99 × 10-4 |
INTERLEUKIN_RECEPTOR_ACTIVITY | 20 | 2.01 | 6.33 × 10-4 |
POSITIVE_REGULATION_OF_IMMUNE_RESPONSE | 28 | 2.00 | 7.35 × 10-4 |
REGULATION_OF_IMMUNE_SYSTEM_PROCESS | 66 | 1.99 | 7.54 × 10-4 |
POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS | 50 | 1.99 | 7.07 × 10-4 |
RESPONSE_TO_BIOTIC_STIMULUS | 112 | 1.99 | 6.65 × 10-4 |
REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_CASCADE | 89 | 1.99 | 6.85 × 10-4 |
MRNA_PROCESSING_GO_0006397 | 67 | 1.97 | 0.001135 |
RESPONSE_TO_OTHER_ORGANISM | 76 | 1.96 | 0.001282 |