Background
Methods
Inclusion and exclusion criteria
Literature review and study selection
Data collection
Quality assessment
Outcome measures
Statistical analysis
Results
First Author | Year | Single vs. Multi Center | Type of Study | Clinical Setting | N | Years of Follow Up | Age Range | Percent Male | Length of Hospital Stay in Daysa | AKI definition severity | Duration of AKI | Study Quality | Different covariates adjusted for | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | Max | Short, medium or long | Transient or Persistent | ||||||||||||
Brown | 2010 | Single | R | Cardiac surgery | 4987 | 2.6 | 5 | 64–72 | 29–33 | 6–24. | AKIN | √ | Fair | age, sex, prior CABG, COPD, emergency surgery, ejection fraction and baseline eGFR | |
Coca [7] | 2010 | Multi | R | Non cardiac | 35,302 | 3.8 | 9 | 66–88 | 96–98 | 6 | AKIN | √ | Good | age, sex, race, chronic insulin use, operative time, ASA class 4/5, emergency surgery, baseline GFR, smoking status,weight loss > 10% last 6 months, chronic alcohol intake, COPD, pre-op albumin, hematocrit,WBC, and hemoglobin A1C | |
Choi [11] | 2010 | Multi | R | General Hospital | 17,325 | 5.7 | 20 | 44–47 | 98 | NM | AKIN | √ | Fair | Age, sex, race, baseline GFR, albuminuria, viral load, cd4, htn, dm, lung ds, smoking, cancer, ICU admission | |
Goldberg [19] | 2009 | Single | R | Post MI | 1957 | 1.5 | 5 | 59–70 | 76 | NM | AKIN | √ | Fair | age, gender, estimated GFR (MDRD), previous diuretic therapy, HTN,DM, smoking, previou MI, heart rate and blood pressure on admission, use of reperfusion therapy ACE/ARB and beta-blockers), and left ventricular EF., | |
Han [12] | 2013 | Single | R | ICU | 2143 | 0.4 | 0.5 | 68 | 52–68 | 13–29 | KDIGO | √ | Fair | Age, sex, Apache, primary diagnosis, underlying CKD, history of malignancy, the need for mechanical ventilation, the use of vasoactive drugs, and AKI stages | |
Loef [26] | 2004 | Single | R | Cardiac surgery | 843 | 8.3 | 62–64 | 73 | 1–5 | AKI/ No AKI | Fair | Age, PVD,Operation time, pre op renal function by cockroft-gault formula,post op renal function deterioration | |||
TRIBE-AKI [21] | 2016 | Multi | P | Cardiac surgery | 1199 | 3 | 71–73 | 66–76 | 7–32 | AKIN | √ | Good | Age, sex, race, elective surgery, preop GFR, DM, HTN, CHF, MI,surgery type and center | ||
Wu [14] | 2015 | Single | R | Intensive | 318 | 8 | 65.6 | 71 | 31 | KDIGO | √ | Good | age, gender, need for a ventilator, emergent operation and baseline renal function; severity of sepsis, the use of vasoactive drugs and diuretics, surgery category; APACHE II, MODS, SOFA scores and peak KDIGO stage. | ||
Yoo [13] | 2014 | Single | P | General Hospital | 123 | 0.65 | 3.4 | 64.8 | 61 | 39 | AKIN | √ | Good | Age, sex, charlson comorbity index, recovery | |
Pannu [20] | 2013 | Multi | R | General Hospital | 190,714 | 2.8 | 6 | 63–66 | 47–53 | NM | KDIGO | √ | Good | age, sex, MI, PVD,CVA,CHF,DM, nondermatologic malignancy, baseline estimatedGFR,requirement for acute dialysis, primary diagnostic code for hospitalization, CIHI resource intensity weight. | |
Liano [19] | 2006 | Single | R | General Hospital | 413 | 7.2 | 22 | 57.8 | 66 | 54 | ATN/ No ATN | √ | Poor | Age, sex, type of admission, ATN etiology, need for RRT, ARF functional severity, ICU admission,incidence of comorbity factors | |
Uchino [27] | 2010 | Single | R | General Hospital | 20,126 | 2 | 65–78 | 49–56 | NM | RIFLE | √ | Fair | Age, sex, emergency admission, ICU admission,mech ventilation,baseline Cr in mg/dl,operation time | ||
Wamock [28] | 2015 | Single | R | General Hospital | 50,580 | 28 | 55 | 55–63 | 4–8 | AKI/ No AKI | √ | Fair | Age, race, sex, charlson comorbid index, admission source, egfr < 60 | ||
Gammelager [10] | 2014 | Multi | R | ICU | 21,550 | 2.7 | 3 | 57–68 | 53–61 | 8–23 | KDIGO | √ | Fair | age, gender, other ischemic heart diseases, CVA,HTN, PVD, CKD cancer, surgical status, primary diagnosis during current hospitalization, and preadmission use of drugs | |
Welton [29] | 2007 | Single | R | Cardiac surgery | 1324 | 6 | 10 | 66 | 80 | NM | AKI/ No AKI | √ | Good | Age, sex, HTN, DM, smoking,Hl, COPD, BMI,Prior MI and coronary revascularization,angina, CHF, baseline Cr Clearance, medications, and short term complications. | |
Heung [9] | 2015 | Single | R | General Hospital | 104,764 | 13 | 61.8 | 95 | 7 | KDIGO | √ | Good | Age, race, sex, preadmission,DM, HTN,Dx of sepsis, need for mechanical ventilation during index hospitalization, length of stay,charlson comorbity score and baseline GFR. | ||
Sood [30] | 2014 | multi | R | ICU | 5443 | 0 | 0 | 55–70 | 57 | NM | RIFLE | √ | Good | Demographics, illness severity, co-morbidity,and treatment | |
Perinel [31] | 2015 | multi | R | ICU | 447 | 0 | 0 | 45–75 | 63.3 | NM | AKIN | √ | Good | Age, type of AKI, use of vasopressors, illness severity |