Background
Herpes Zoster (HZ; shingles) results from the reactivation of Varicella-Zoster Virus (VZV) that has been latent in the spinal and cranial sensory ganglia after primary infection with varicella (chickenpox), usually during childhood [
1]. A vesicular skin rash in the affected dermatome, commonly accompanied by acute pain, characterizes the acute phase of HZ disease.
Approximately 14% of all patients with shingles will develop complications [
2]. The most common and weakening is postherpetic neuralgia (PHN), defined by most investigators as pain being present at 90 days after the rash appears [
1,
2]. Both the acute pain associated with HZ and PHN have a negative impact on health-related quality of life, interfering significantly with physical, emotional, and social functioning [
3‐
6], and quantitatively similar to congestive heart failure, severe depression, acute myocardial infarction, or uncontrolled diabetes [
7].
The risk of HZ and its complications increases with advancing age, being more manifest in persons over 50-60 years of age [
1,
2,
8,
9]. Among individuals who reach age 85 years of age, approximately 50% will have experienced at least one episode of HZ [
10]. The incidence of acute HZ in the European general population ranges between 2.0-4.8 per 1000 persons-year (PY) for all ages, and increases after age 50 years to around 7-8/1000 PY [
11,
12]. Over the coming decades, Europe’s demographic patterns will change dramatically, and it is expected that our populations will become older than ever before [
13]. This suggests that the incidence of HZ could vary in relation to an older population, possibly as a result of immunosenescence [
14].
Several studies support the hypothesis that exposure to childhood varicella reduces the risk of developing HZ by boosting specific immunity to VZV [
15‐
19]. Based on this hypothesis, mathematical models suggest that a successful childhood vaccination program may decrease the circulation of wild-type VZV, and therefore the stimulation of cellular immunity that could prevent the occurrence of shingles in the adult population [
20‐
23]. This could have significant public health consequences, if a universal mass VZV vaccination program is implemented in childhood. Although this issue is still controversial and there is no firm evidence that this increase will occur [
24‐
26], monitoring of disease trends over time will help understand the impact of different factors upon the incidence of HZ. In the Valencian Community (Spain), varicella vaccination is recommended and funded at 12 years of age in those subjects who have not been in clear contact with the virus. This helps avoid severe cases in adults with no impact upon circulation of the virus. About 30% of toddlers also receive the vaccine after their pediatrician’s recommendation [
27]. With this low coverage figure, the virus is circulating within the population and no effect upon HZ is expected.
The efficacy of a live attenuated zoster vaccine, Zostavax®, in preventing HZ and PHN has been tested in adults ≥ 60 years of age, yielding efficacy rates of 51% and 67%, respectively [
28], and of 70% for incident HZ in subjects aged 50–59 years old [
29]. In a recent population-based study of 766,330 individuals aged ≥ 65 years, the effectiveness was seen to be 48% [
30]. This vaccine is generally well tolerated, has been licensed in the European Union in 2006 for people aged ≥50 years [
31], and is expected to be widely used in Spain over the next few years. Another adjuvanted vaccine is under development [
32‐
34].
In Spain, HZ is presently not a notifiable disease, and epidemiological data are scarce. A recent prospective study in the Valencian Community (Spain) showed an HZ incidence of 4.1 per 1000 persons > 14 years of age during 2007 [
35,
36]. Reliable epidemiological data are needed before any universal recommendation of HZ vaccines can be made, in order to assess the impact of HZ vaccination. The purpose of this study was to explore the epidemiology of HZ in the Valencian Community during a four-year period (January 2007 to December 2010), and to estimate the reliability of the regional electronic medical database for epidemiological studies, with a view to creating surveillance tools for future and efficient assessments of HZ incidence in the post-HZ vaccine era.
Discussion
In this study we used medical electronic databases from a region of Spain in order to reliably estimate HZ incidence. Our results showed an HZ incidence of 4.60/1000 PY, with a strong correlation to age, and with a drop in incidence in patients ≥ 80 years of age, which was not observed in hospitalizations. Incidence rates were higher among women in most age groups, with an overall figure of 3.86 in males and 5.32 PER 1000 PY in females.
Epidemiological studies on HZ in Spain are scarce and are needed for future estimations of disease burden [
35,
36,
42,
43]. Our study used health databases that cover almost the entire population living in the Valencian Community, including hospitalizations and ambulatory patients. To the best of our knowledge, there is only one study of similar characteristics in Spain, conducted in Navarra (a northern region of the country) before systematic varicella vaccination [
44].
One of the limitations of the study is that the Abucasis database was not developed for medical billing purposes, and this may imply the obtainment of less detailed information. Although ICD-9-CM codes are routinely used, general practitioners (GP) may be unaware of its importance. To overcome this, codification is performed in simple way – the system presenting a list of possible ICD-9-CM codes after the diagnosis is written. In the case of Zoster, which is a common diagnosis, with no synonyms, ICD-9 coding is relatively easy. On the other hand, trained personnel codify CMBD. In order to assess the reliability of HZ codification, a random review of medical records showed good matching between ICD-9-CM coding and a real episode of HZ. A total of 7.7% of the reviewed notes with the diagnosis of Herpes Zoster did not meet the full requirements for being considered a case. Most of these situations were due to a lack of description of the lesions. We considered that most of these cases could be HZ, but the GP did not provide sufficient written details, possibly because of the great care burden found in primary care, which prevents entering detailed information in medical notes. This consequently may have understated HZ case confirmation.
For recurrent cases our temporal filters were not wholly suitable, and therefore the system did not allow for analysis of recurrent cases.
Another limitation is that emergency room visits and private medical visits were not included in any of the databases. Since the medication usually prescribed for HZ is expensive and is not subsidized in these situations, we assumed that only a minority of patients would not seek public medical care in order to receive subsidized drugs. As a population database study, it is possible that some individuals did not seek medical care. Another limitation to be taken into account is that we only included clinical diagnoses of HZ, since laboratory confirmation of HZ is rarely used in normal clinical practice.
Due to bureaucratic problems, SIA data for the year 2010 were given until 20 December. We assume that the remaining 11 days would have no significant impact upon our estimations.
On comparing results corresponding to 2007 from the Abucasis database and a prospective study carried out in a similar population (>14 years) [
35,
36], the incidence figures were found to be similar, being slightly higher when using the electronic database (5.0/1000 PY versus 4.1/1000 PY). These differences mainly occurred in two age groups (15-49 and 60-69 years), and as the authors point out [
35], this may reflect their low precision. The study conducted in Navarra [
42] showed a mean HZ incidence of 4.25/1000 PY during 2005-2006.
The number of hospitalizations in our study was lower than in similar retrospective Spanish studies during the previous study period [
41,
42]. In one of these studies [
41], differences were found among the Spanish autonomous communities, with lower incidence rates in the Valencian Community. To confirm the reliability of our data, we compared them with the national data for the same study period (data not shown), and found both figures to be the same, with a decrease in the incidence of HZ hospitalization over time, possibly due to changes in admission criteria, to greater awareness among physicians of the need for early antiviral treatment, or to changes in coding practices. However, similar hospitalizations rates were found (2.69/100,000 PY) in another Spanish study using the CMBD database for the study period 1997-2004 [
45].
As in other epidemiological studies, the incidence of HZ is strongly sex- and age-related, with higher incidences in women over 50 years. Our incidence was slightly higher than in other European studies using electronic databases. In France, the yearly HZ incidence rate for all ages averaged 3.82/1000 PY in the study period 2005-2008 [
46], while in Italy a retrospective study showed an incidence of 4.31/1000 PY for population aged 15 years or older during the three-year study period (2003-2005) [
47]. Another study conducted in the Netherlands during 1994-1999, calculated an HZ incidence of 3.4/1000 PY [
48]. A similar German study performed in an older population (≥ 50 years) reported higher figures (9.60/1000 PY during 2007-2008) [
49]. We found similar rates in the United States: 4.4/1000 PY for all ages during 2006 [
50]. Apart from the fact that the results of different descriptive epidemiological studies are highly dependent upon the methodology used, some of these studies included emergency room visits, and some countries use ICD-9-CM for billing purposes, which would result in variable incidence rates.
Higher incidence rates were found in the placebo controls of clinical trials in the ≥ 60 years age group, specifically 13.00/1000 PY [
50,
51] or 11.12/1000 PY [
28], which indicates that an active search of HZ cases considerably increases their incidence.
Our incidence peaked at 70-79 years of age and decreased thereafter, especially in the ≥95 years age group (data not shown). This drop in incidence was not seen in hospitalizations (Table
3). There are several explanations for this. Firstly, there could be a gradually reduced risk of HZ, explained by the hypothesis that exposure to VZV provides the host with progressive immunity to VZV reactivation [
52,
53]. Secondly, large proportions of subjects in this age group have disabilities or walking difficulties, and consequently are usually visited by family physicians at home. These visits are commonly not recorded in the Abucasis database, and medical prescriptions are handwritten. On the other hand, many of these patients live with relatives and usually move to other provinces outside our study area during part of the year, without unsubscribing from the Abucasis database; a potential HZ case therefore could have been registered elsewhere and not be counted as an incident case.
HZ incidence is age-related. This correlation could be explained by the progressive decline in VZV cell-mediated immunity related to aging. The incidence should increase in a progressively aging population, which would imply a greater burden and cost of disease. Determinants of direct costs of an HZ episode are usually related to the prescription of antiviral drugs and repetitive primary care visits in the case of PHN. Direct outpatient costs in several European countries average between 72.05 € and 247 € [
36,
54‐
56].
Competing interests
JDD Is acting as national coordinator and principal investigators for clinical studies and receiving funding from non-commercial funding bodies as well as commercial sponsors (Novartis Vaccines, GlaxoSmithKline, Baxter, Sanofi Pasteur MSD, MedImmune, and Pfizer Vaccines) conducted on behalf of CSISP-FISABIO. He served as a as a board member for GSK, and received payment for lectures from SP-MSD, Novartis and Baxter that included support for travel and accommodation for meetings.
JPB Is acting as national coordinator and principal investigators for clinical studies and receiving funding from non-commercial funding bodies as well as commercial sponsors (Novartis Vaccines, GlaxoSmithKline and Sanofi-Pasteur) conducted on behalf of CSISP-FISABIO. He served as a as a board member for GSK, and received payment for lectures that included support for travel and accommodation for meetings.
Other authors declare no conflict of interest.
Authors’ contributions
NMT, JDD and JPB designed the study. SMU analyzed the data and performed the statistical analysis. NMT wrote the manuscript and reviewed clinical records. JDD coordinated the study. SAS, LPB, JDD and JPB provided valuable insight for revising the manuscript. All authors read and approved the final manuscript.