Background
Methods
The malmö preventive project
T3 analysis
Study cohort and follow-up
Tumour grading and staging
Receptor status
Statistical methods
Results
Factor | CIS n = 21 | Invasive n = 149 | Rest of cohort* n = 2015 | All n = 2185 |
---|---|---|---|---|
(column percent; mean (SD) in italics) | ||||
Age at baseline (years)
|
48.1(6.7)
|
49.9(6.5)
|
50.5(6.4)
|
50.4(6.4)
|
Age <50
| 57.1 | 43.6 | 39.2 | 39.7 |
Age >50
| 42.9 | 56.4 | 60.8 | 60.3 |
BMI (kg/m2)
|
25.1(5.8)
|
24.7(4.4)
|
24.2(4.1)
|
24.3(4.1)
|
BMI <20
| 9.5 | 7.4 | 10.3 | 10.1 |
BMI ≥20 < 25
| 52.4 | 51.7 | 55.0 | 54.7 |
BMI ≥25 < 30
| 23.8 | 29.5 | 25.2 | 25.5 |
BMI ≥30
| 14.3 | 11.4 | 9.5 | 9.7 |
Age at menarche
| ||||
<12 years
| 9.5 | 14.1 | 12.6 | 12.6 |
>12 years
| 90.5 | 84.6 | 86.7 | 86.6 |
Missing
| - | 1.3 | 0.7 | 0.7 |
Oral contraceptives
| ||||
Yes
| 9.5 | 6.0 | 7.7 | 7.6 |
No
| 90.5 | 93.3 | 91.9 | 92.0 |
Missing
| - | 0.7 | 0.3 | 0.4 |
Postmenopausal
| ||||
Yes
| 47.6 | 56.4 | 61.0 | 60.5 |
No
| 52.6 | 43.6 | 39.0 | 39.5 |
Children
| ||||
Yes
| 76.2 | 77.9 | 83.1 | 82.6 |
No
| 23.8 | 21.5 | 16.7 | 17.1 |
Missing
| - | 0.7 | 0.2 | 0.3 |
HRT in postmenopausal
| ||||
Yes
| 10 | 11.9 | 15.7 | 15.4 |
No
| 90 | 88.1 | 84.2 | 84.5 |
Missing
| - | - | 0.1 | 0.1 |
Smoking status
| ||||
Never
| 42.9 | 51.7 | 46.3 | 46.6 |
Ex
| 23.8 | 20.1 | 19.0 | 19.1 |
Current
| 33.3 | 27.5 | 34.5 | 34.0 |
Missing
| - | 0.7 | 0.3 | 0.3 |
Married
| ||||
Yes
| 42.9 | 60.4 | 52.4 | 52.9 |
No
| 47.6 | 31.5 | 42.0 | 41.3 |
Missing
| 9.5 | 8.1 | 5.6 | 5.8 |
Alcohol consumption
| ||||
None
| 9.5 | 20.8 | 14.7 | 15.1 |
Less than every week
| 57.1 | 53.7 | 60.2 | 59.7 |
Every week
| 33.3 | 24.8 | 24.6 | 24.7 |
Missing
| - | 0.7 | 0.5 | 0.5 |
Education
| ||||
≤12 years
| 76.2 | 79.1 | 81.6 | 81.4 |
>12 years
| 23.8 | 16.9 | 14.4 | 14.6 |
Missing
| - | 4.0 | 4.0 | 4.0 |
Factor | T3 quartile | |||
---|---|---|---|---|
1 | 2 | 3 | All | |
n = 682 | n = 765 | n = 738 | n = 2185 | |
Column percent (T3 levels in italics) | ||||
T3 (mIU/l) |
<1.70
|
1.70-1.90
|
>1.90
| |
Age | ||||
< 50 | 60.6 | 37.9 | 22.4 | 39.7 |
> 50 | 39.4 | 62.1 | 77.6 | 60.3 |
Education | ||||
<12 years | 55.1 | 55.9 | 62.5 | 57.9 |
12 years | 20.8 | 26.9 | 22.4 | 23.5 |
>12 years | 19.6 | 13.5 | 11.2 | 14.6 |
Missing | 4.4 | 3.7 | 3.9 | 4.0 |
Married | 56.7 | 51.8 | 50.4 | 52.9 |
Missing | 0.7 | 3.8 | 12.6 | 5.8 |
Smoking | ||||
Never | 44.0 | 48.5 | 47.0 | 46.6 |
Current | 35.3 | 33.3 | 33.3 | 34.0 |
Ex | 20.7 | 18.0 | 18.8 | 19.1 |
Missing | - | 0.1 | 0.8 | 0.3 |
Alcohol consumption | ||||
Nothing | 13.5 | 14.0 | 17.8 | 15.1 |
Less than every week | 56.9 | 60.9 | 61.0 | 59.7 |
Every week | 29.5 | 25.0 | 20.1 | 24.7 |
Missing | 0.1 | 0.1 | 1.2 | 0.5 |
Menarche < 12 years | 14.4 | 12.7 | 11.0 | 12.6 |
Missing | 0.1 | 0.7 | 1.4 | 0.7 |
OC-use | 4.5 | 7.1 | 11.1 | 7.6 |
Missing | - | 0.1 | 0.9 | 0.4 |
Nulliparity | 17.4 | 15.4 | 18.6 | 17.1 |
Missing | - | 0.1 | 0.7 | 0.3 |
Peri/postmenopausal | 41.2 | 63.3 | 75.5 | 60.5 |
HRT in peri/postmenopausal | 13.9 | 13.8 | 17.6 | 15.4 |
Missing | - | - | 0.2 | 0.1 |
Height | ||||
≤160 | 24.6 | 30.6 | 33.3 | 29.7 |
>160 ≤ 165 | 32.7 | 32.3 | 31.0 | 32.0 |
>165 ≤ 170 | 27.0 | 22.9 | 24.3 | 24.6 |
>170 | 15.7 | 14.2 | 11.4 | 13.7 |
BMI | ||||
<20 | 13.8 | 8.5 | 8.3 | 10.1 |
≥20 < 25 | 62.2 | 55.0 | 47.6 | 54.7 |
≥25 < 30 | 18.3 | 27.7 | 29.8 | 25.5 |
≥30 | 5.7 | 8.8 | 14.4 | 9.7 |
All breast tumours
Tumour group | Tertile* | Cases | HR | HR** | HR*** |
---|---|---|---|---|---|
(n) | (95% CI) | (95% CI) | (95% CI) | ||
All
|
Tertile 1
| 38 | 1.0 | 1.0 | 1.0 |
n = 149
|
Tertile 2
| 54 | 1.25 (0.85-1.84) | 1.33 (0.90-1.97) | 1.38 (0.93-2.04) |
Tertile 3
| 57 | 1.34 (0.92-1.97) | 1.50 (1.01-2.23) | 1.61 (1.07-2.43) | |
Grade I
|
Tertile 1
| 12 | 1.00 | 1.00 | 1.00 |
n = 42
|
Tertile 2
| 20 | 1.51 (0.74-3.09) | 1.57 (0.76-3.26) | 1.68 (0.81-3.49) |
Tertile 3
| 10 | 0.79 (0.34-1.82) | 0.84 (0.35-2.01) | 0.97 (0.40-2.37) | |
Grade II
|
Tertile 1
| 14 | 1.00 | 1.00 | 1.00 |
n = 56
|
Tertile 2
| 14 | 0.91 (0.43-1.19) | 0.95 (0.45-2.01) | 0.98 (0.46-2.69) |
Tertile 3
| 28 | 1.89 (1.00-3.50) | 2.04 (1.04-4.00) | 2.13 (1.06-4.30) | |
Grade III
|
Tertile 1
| 7 | 1.00 | 1.00 | 1.00 |
n = 38
|
Tertile 2
| 17 | 2.21 (0.92-5.32) | 2.30 (0.94-5.61) | 2.34 (0.96-5.74) |
Tertile 3
| 14 | 1.90 (0.77-4.71) | 2.04 (0.80-5.23) | 2.14 (0.82-5.59) | |
Size ≤20 mm
|
Tertile 1
| 28 | 1.00 | 1.00 | 1.00 |
n = 93
|
Tertile 2
| 31 | 1.01 (0.60-1.68) | 1.04 (0.62-1.75) | 1.09 (0.65-1.84) |
Tertile 3
| 34 | 1.15 (0.70-1.89) | 1.21 (0.72-2.05) | 1.36 (0.79-2.33) | |
Size >20 mm
|
Tertile 1
| 6 | 1.00 | 1.00 | 1.00 |
n = 45
|
Tertile 2
| 20 | 3.02 (1.21-7.53) | 3.21 (1.28-8.07) | 3.19 (1.26-8.06) |
Tertile 3
| 19 | 3.01 (1.20-7.53) | 3.33 (1.30-8.58) | 3.17 (1.20-8.36) | |
Node positive
|
Tertile 1
| 5 | 1.00 | 1.00 | 1.00 |
n = 39
|
Tertile 2
| 16 | 2.90 (1.06-7.92) | 3.22 (1.17-8.87) | 3.36 (1.22-9.30) |
Tertile 3
| 18 | 3.40 (1.26-9.16) | 4.08 (1.47-11.32) | 4.53 (1.60-12.83) | |
Node negative
|
Tertile 1
| 27 | 1.00 | 1.00 | 1.00 |
n = 91
|
Tertile 2
| 33 | 1.11 (0.67-1.85) | 1.13 (0.67-1.89) | 1.18 (0.70-1.99) |
Tertile 3
| 31 | 1.08 (0.65-1.82) | 1.12 (0.65-1.92) | 1.20 (0.69-2.10) | |
ER positive
|
Tertile 1
| 28 | 1.00 | 1.00 | 1.00 |
n = 105
|
Tertile 2
| 41 | 1.32 (0.82-2.15) | 1.37 (0.84-2.23) | 1.42 (0.87-2.32) |
Tertile 3
| 36 | 1.22 (0.74-1.99) | 1.28 (0.77-2.15) | 1.39 (0.82-2.36) | |
ER negative
|
Tertile 1
| 6 | 1.00 | 1.00 | 1.00 |
n = 36
|
Tertile 2
| 11 | 1.67 (0.62-4.52) | 1.75 (0.64-4.77) | 1.85 (0.68-5.09) |
Tertile 3
| 19 | 3.01 (1.20-7.53) | 3.24 (1.25-8.40) | 3.52 (1.32-9.41) | |
PGR positive
|
Tertile 1
| 27 | 1.00 | 1.00 | 1.00 |
n = 97
|
Tertile 2
| 36 | 1.21 (0.73-1.99) | 1.25 (0.75-2.08) | 1.27 (0.77-2.13) |
Tertile 3
| 34 | 1.19 (0.72-1.97) | 1.26 (0.74-2.14) | 1.32 (0.77-2.27) | |
PGR negative
|
Tertile 1
| 7 | 1.00 | 1.00 | 1.00 |
n = 44
|
Tertile 2
| 16 | 2.09 (0.86-5.07) | 2.15 (0.87-5.29) | 2.35 (0.96-5.80) |
Tertile 3
| 21 | 2.87 (1.22-6.75) | 3.03 (1.25-7.34) | 3.52 (1.42-8.75) |
Tumour group | HR (95% CI) | HR*(95% CI) | HR**(95% CI) |
---|---|---|---|
All
| 1.57 (1.06-2.32) | 1.75 (1.18-2.60) | 1.89 (1.27-2.82) |
Grade I
| 0.93 (0.40-2.13) | 1.00 (0.42-2.39) | 1.20 (0.50-2.89) |
Grade II
| 2.45 (1.32-4.55) | 2.61 (1.40-4.87) | 2.68 (1.42-5.06) |
Grade III
| 1.68 (0.75-3.80) | 1.78 (0.80-4.10) | 1.86 (0.80-4.36) |
Size ≤20 mm
| 1.53 (0.90-2.60) | 1.65 (0.96-2.84) | 1.88 (1.09-3.23) |
Size >20 mm
| 1.98 (0.96-4.09) | 2.11 (1.01-4.41) | 1.96 (0.90-4.26) |
Node positive
| 2.81 (1.39-5.67) | 3.13 (1.57-6.23) | 3.34 (1.70-6.56) |
Node negative
| 1.18 (0.68-2.05) | 1.22 (0.68-2.17) | 1.32 (0.73-2.38) |
ER positive
| 1.38 (0.83-2.28) | 1.46 (0.87-2.46) | 1.60 (0.95-2.71) |
ER negative
| 3.95 (1.97-7.90) | 4.15 (2.08-8.30) | 4.32 (2.16-8.61) |
PGR positive
| 1.38 (0.82-2.33) | 1.48 (0.86-2.53) | 1.57 (0.91-2.71) |
PGR negative
| 3.38 (1.74-6.56) | 3.53 (1.80-6.89) | 3.89 (2.02-7.50) |
Tumour group | RR (95% CI) | RR* (95% CI) | RR** (95% CI) |
---|---|---|---|
All
| 2.87 (1.86-4.43) | 2.85 (1.86–4.37) | 2.88 (1.90-4.37) |
Grade I
| 2.32 (0.85-6.36) | 2.35 (0.82-6.75) | 2.37 (0.83-6.77) |
Grade II
| 4.12 (2.19-7.77) | 3.99 (2.17-7.36) | 3.98 (2.19-7.23) |
Grade III
| 1.18 (0.39-3.55) | 1.24 (0.42-3.67) | 1.30 (0.45-3.81) |
Size ≤20 mm
| 3.28 (1.86-5.76) | 3.31 (1.86-5.89) | 3.33 (1.89-5.86) |
Size >20 mm
| 1.64 (0.63-4.26) | 1.76 (0.71-4.33) | 1.83 (0.76-4.42) |
Node positive
| 3.44 (1.54-7.66) | 3.35 (1.59-7.07) | 3.37 (1.63-6.96) |
Node negative
| 2.08 (1.05-4.10) | 2.08 (1.05-4.10) | 2.12 (1.08-4.15) |
ER positive
| 2.44 (1.38-4.32) | 2.44 (1.39-4.29) | 2.48 (1.43-4.31) |
ER negative
| 4.83 (2.18-10.69) | 4.72 (2.16-10.29) | 4.69 (2.19-10.06) |
PGR positive
| 2.59 (1.44-4.65) | 2.59 (1.45-4.63) | 2.62 (1.48-4.63) |
PGR negative
| 3.87 (1.79-8.33) | 3.79 (1.81-7.96) | 3.81 (1.85-7.84) |