Background
Methods
Study design
Patient recruitment
Ethics
Interview methods
Qualitative analysis
Results
Patient Demographic and Clinical Characteristics
Characteristic | |
---|---|
Age in years, mean [range] | 71.1 [53 - 86] |
Mean years since prostate cancer diagnosis | 7.0 |
Mean years since onset of bone metastases | 1.7 |
Cancer stage* | |
Well differentiated (Gleason score 2-4) | 2 (12%) |
Moderately differentiated (Gleason score 5-7) | 5 (29%) |
Poorly differentiated or undifferentiated (Gleason score 8-10) | 5 (29%) |
Patient-rated overall bone pain** | |
Very mild | 3 (18%) |
Mild | 3 (18%) |
Moderate | 8 (47%) |
Severe | 2 (12%) |
Very severe | 0 |
Pain relief medication *** | |
Ibuprofen | 3 (18%) |
Percocet® (acetaminophen; oxycodone hydrochloride) | 8 (47%) |
Lortab® (acetaminophen, hydrocodone bitartrate) | 1 (6%) |
Oxycontin® (oxycodone hydrochloride) | 5 (29%) |
Tylenol® (acetaminophen) | 4 (24%) |
Zometa® (Zoledronic acid) | 2 (12%) |
Vicodin® (acetominophen, hydrocodone bitartrate) | 1 (6%) |
Darvocet® (acetominiphen; propoxyphen hydrocholoride) | 1 (6%) |
Concept Elicitation Phase: Patients' experiences of CRPC and bone metastases
Concept | Round I | Round II | Concept Frequency (%) | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PT 01
|
PT 02
|
PT 03
|
PT 04
|
PT 05
|
PT 06
|
PT 07
|
PT 08
|
PT 09
|
PT 10
|
PT 11
|
PT 12
|
PT 13
|
PT 14
|
PT 15
|
PT 16
|
PT 17
| ||
Bone Pain
|
X
| X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | 16 (94) | |
BTcP (incident) |
X
| X | X | X | X | 5 (29) | ||||||||||||
BTcP (idiopathic) |
X
| X | X | X | 4 (24) | |||||||||||||
BTcP ("end-of-dose failure") |
X
| X | X | X | X | X | X | 7 (41) | ||||||||||
Skeletal-related events (fractures)
|
X
| X | 2 (12) | |||||||||||||||
Fatigue
|
X
| X | X | X | X | X | X | X | 8 (47) | |||||||||
Low energy
|
X
| X | X | X | X | X | X | 7 (41) | ||||||||||
Loss of strength
|
X
| X | X | 3 (18) | ||||||||||||||
Urinary dysfunction
|
X
| X | X | X | X | X | X | X | X | X | X | X | 12 (71) | |||||
Blood in urine |
X
| X | X | 3 (18) | ||||||||||||||
Can't empty bladder |
X
| X | 2 (12) | |||||||||||||||
Increased urinary frequency during the day |
X
| X | X | X | 4 (24) | |||||||||||||
Difficulty starting urination |
X
| X | X | 3 (18) | ||||||||||||||
Urinary incontinence |
X
| X | X | X | 4 (24) | |||||||||||||
Weak or interrupted flow of urine |
X
| X | X | X | 4 (24) | |||||||||||||
Increased urinary frequency during the night |
X
| X | X | 3 (18) | ||||||||||||||
Painful or burning urination |
X
| X | 2 (12) | |||||||||||||||
Poor stream |
X
| X | 2 (12) | |||||||||||||||
Erectile dysfunction
|
X
| X | 2 (12) | |||||||||||||||
Fever/sweats/chills
|
X
| X | X | X | X | X | 6 (35) | |||||||||||
Numbness/loss of sensation
|
X
| X | X | X | 4 (24) | |||||||||||||
Altered taste perception
|
X
| X | 2 (12) | |||||||||||||||
Loss of appetite
|
X
| X | X | 3 (18) | ||||||||||||||
Weight loss
|
X
| X | X | 3 (18) | ||||||||||||||
Weight gain
|
X
| X | 2 (12) | |||||||||||||||
Gastrointestinal disturbance
|
X
| X | X | X | X | X | X | 7 (41) | ||||||||||
Bloating |
X
| X | 2 (12) | |||||||||||||||
Constipation |
X
| X | X | X | 4 (24) | |||||||||||||
Diarrhea |
X
| X | 2 (12) | |||||||||||||||
Nausea/vomiting |
X
| X | X | X | X | 5 (29) | ||||||||||||
Anxiety
|
X
| X | 2 (12) | |||||||||||||||
Depression
|
X
| X | X | X | 4 (24) |