Background
Patients and methods
Study design
Patients
Treatment
Monitoring and laboratory investigations
Statistical Analysis
Results
Characteristics | Placebo group (n = 31) | Lactobacillus acidophilus plus bifidobacterium bifidum (Infloran®) group (n = 32) | p-value |
---|---|---|---|
Median age (year) | 52 | 47 | 0.146§ |
Stage of cervical cancer | 0.80¶ | ||
IIB, n (%) | 18 (58.1) | 17 (53.1) | |
IIIB, n (%) | 13 (41.9) | 15 (46.9) | |
ECOG performance status | 0.08¶ | ||
0, n (%) | 29 (93.5) | 24 (75.0) | |
1, n (%) | 2 (6.5) | 8 (25.0) | |
Whole pelvis Radiotherapy technique | 0.60¶ | ||
AP-PA technique, n (%) | 22 (71.0) | 20 (62.5) | |
4-field box technique, n (%) | 9 (29.0) | 12 (37.5) |
Characteristics | Placebo group n = 31 no. (%) | Study group n = 32 no. (%) | p-value |
---|---|---|---|
Median overall treatment time (days) | 51 | 48 | 0.05§ |
Median weight change from the beginning to the last treatment (kg) | -2.5 | -2.4 | 0.66§ |
Diarrhea | 0.002Θ | ||
Grade I | 17 (55) | 29 (91) | |
Grade II, III | 14 (45) | 3 (9) | |
Anti diarrhea drug used | 0.03¶ | ||
No | 21(68) | 29(91) | |
Yes | 10(32) | 3(9) | |
Stool | <0.001Θ | ||
Soft, Form | 11(35) | 26 (81) | |
Loose | 20 (65) | 6 (19) | |
White blood cell in stool | 0.08¶ | ||
No | 24 (77) | 30 (94) | |
Yes | 7 (23) | 2 (6) | |
Red blood cell in stool | 0.11¶ | ||
No | 28 (90) | 32(100) | |
Yes | 3 (10) | 0(0) |