Background
Patients and methods
Patient characteristics
Patient | Gender | Age | Histology | Localization | Opticpathway glioma | CTV [ccm] | Beam count | Isodose level in scalp [%] | Previous therapy | Total dose (GyE) | Single dose (GyE) | Time interval between inital diagnosis and initiation of proton beam therapy [months] |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1
| male | 10 | pilocytic astrocytoma WHO °I | central | no | 11 | 2 | 10 | resection | 54 | 2 | 45 |
2
| male | 38 | pilocytic astrocytoma WHO °I | central | no | 35 | 2 | 30 | resection | 54 | 1,8 | 20 |
3
| female | 12 | pilomyxoid astrocytoma WHO °II | central | yes | 48 | 2 | 30 | chemotherapy | 54 | 1,8 | >116 |
4
| male | 37 | pilocytic astrocytoma WHO °I | central | no | 220 | 2 | 30 | resection | 54 | 2 | 44 |
5
| female | 17 | pilocytic astrocytoma WHO °I | central to peripheral | no | 99 | 2 | 70 | resection | 54 | 1,8 | 80 |
6
| male | 39 | astrocytoma WHO °II | central to peripheral | no | 266 | 2 | 70 | chemotherapy | 54 | 1,8 | 69 |
7
| female | 12 | fibrillary astrocytoma WHO °II | central to peripheral | no | 212 | 2 | 90 | resection | 48,6 | 1,8 | 48 |
8
| female | 48 | astrocytoma WHO °II | central to peripheral | no | 75 | 1 | 70 | biopsy only | 54 | 2 | 3 |
9
| female | 36 | fibrillary astrocytoma WHO °II | central to peripheral | no | 212 | 2 | 70 | resection | 54 | 1,8 | 85 |
10
| female | 38 | astrocytoma WHO °II | peripheral | no | 187 | 2 | 70 | biopsy only | 54 | 1,8 | 11 |
11
| female | 28 | astrocytoma WHO °II | central to peripheral | no | 371 | 2 | 70 | resection | 54 | 1,8 | 26 |
12
| male | 56 | astrocytoma WHO °II | central to peripheral | no | 463 | 1 | 70 | biopsy only | 50,4 | 1,8 | 15 |
13
| female | 36 | oligoastrozytoma WHO °II | central to peripheral | no | 298 | 2 | 70 | chemotherapy | 54 | 1,8 | 42 |
14
| male | 13 | pilocytic astrocytoma WHO °I | central | yes | 204 | 2 | 30 | chemotherapy | 54 | 1,8 | 132 |
15
| male | 16 | pilocytic astrocytoma WHO °I | central | no | 17 | 2 | 30 | biopsy only | 54 | 1,8 | 99 |
16
| male | 29 | pilocytic astrocytoma WHO °I | central | no | 15 | 2 | 10 | biopsy only | 54 | 2 | 4 |
17
| male | 4 | pilocytic astrocytoma WHO °I | central | no | 6 | 2 | 30 | resection | 54 | 1,8 | 8 |
18
| male | 7 | pilocytic astrocytoma WHO °I | central | yes | 19 | 2 | 10 | chemotherapy | 50,4 | 1,8 | 33 |
19
| female | 43 | astrocytoma WHO °II | central | no | 57 | 2 | 30 | biopsy only | 52,2 | 1,8 | 4 |
Treatment planning
Particle therapy
Follow-up and statistics
Results
Response to treatment
Side effects
Type of side effect | n |
---|---|
Alopecia CTC °II
| 13 |
Fatigue CTC °I-II
| 6 |
Deficits in concentration CTC °I-II
| 1 |
Deficits in speech CTC °I-II
| 1 |
Deficits in short term memory CTC °I-II
| 1 |