Introduction
Patients and methods
Results
Medical Center | Patients number (%) | Radiation dose (Gy) | Radiation delivery technique |
---|---|---|---|
Sourasky Medical Center, Israel | 8 (30) | 70.0 (2.5 X 28) | IMRT |
Lübeck University, Germany | 2 (7) | 72.0 (2.0 X 36) | 3DCRT |
Padova Medical Center, Italy | 9 (33) | 78.0 (2.0 X 39) | 3DCRT |
Massey Medical Center, USA | 1 (4) | 78.0 (2.0 X 39) | IMRT |
Montefiore Medical Center, USA | 2 (7) | 76.0 (1.8 X 42) | IMRT |
Virginia Urology, Richmond, USA | 5 (19) | 75.6 (1.8 X 42) | IMRT |
78.0 (2.0 X 39) |
Balloon implant procedure | Radiotherapy period | |
---|---|---|
Number of patients (%) | ||
Number of patients evaluated: | 26 | 23 |
Pain at the perineal skin (1 & 7 VAS score): | 7 (27) | — — — — — — — |
Acute pain in the anus (2 & 9 VAS score): | 4 (15) | — — — — — — — |
Acute urinary retention: | 3 (12) | 1 (4) |
Dysuria and Nocturia (grade 1–2): | 3(12) | 15 (65) |
Penile bleeding: | 1 (4) | — — — — — — — |
Proctitis (Grade 1): | — — — — — — — | 2 (8) |
Diarrhea (Grade 1): | — — — — — — — | 4 (17) |
Signs of blood in feces (Grade 1): | — — — — — — — | 1 (4) |
Constipation (Grade 1): | — — — — — — — | 1 (4) |
Erectile dysfunction: | — — — — — — — | 1 (4) |
Pruritus: | — — — — — — — | 1 (4) |
Fatigue | — — — — — — — | 1 (4) |
Decreased urine flow: | — — — — — — — | 1 (4) |
1 week after implantation | During radiotherapy | 3 months post implant | 6 months post implant | |
---|---|---|---|---|
Number of patients | ||||
Patients evaluated: |
26
|
23
|
23
|
23
|
Balloon in place: |
26
|
23
|
23
|
2
|
Balloon fully inflated: |
26
|
23
|
15
|
0
|
Balloon partly inflated: |
— — —
|
— — —
|
4
|
0
|
Balloon deflated: |
— — —
|
— — —
|
4
|
23
|
Pre implantation | Post implantation | End radiotherapy | P value | 3-month follow up | P value | |
---|---|---|---|---|---|---|
# of patients | 26 | 26 | 18 | 18 | ||
Prostate measurements (cm) | ||||||
Width | 4.37 ± 0.59 | 4.39 ± 0.64 | 4.44 ± 0.86 | 4.15 ± 0.75 | ||
Length | 3.74 ± 0.84 | 4.15 ± 1.08 | 4.29 ± 0.95 | 4.10 ± 1.27 | ||
Height | 3.42 ± 0.79 | 3.17 ± 0.61 | 3.19 ± 0.69 | 3.14 ± 0.73 | ||
Balloon measurements (cm) | ||||||
Width | 3.06 ± 0.27 | 2.96 ± 0.25 | NS | 2.62 ± 0.58 | ||
Length | 4.25 ± 0.49 | 3.81 ± 0.84 | 0.023 *1 | 2.97 ± 1.25 | 0.05 *3 | |
Height | 1.86 ± 0.24 | 1.67 ± 0.22 | 0.03 *2 | 1.28 ± 0.47 | 0.003*4 | |
Prostate-rectum distance (cm) | ||||||
0.22 ± 0.2 | 2.47 ± 0.47 | 2.41 ± 0.43 | NS *5 | 1.59 ± 0.60 | 0.005*6 |
Pre implant | Post implant | Reduction % | P-value | |
---|---|---|---|---|
Mean value (Standard deviation) | ||||
V50 | 40% ± 17.8 | 25% ± 17.7 | 43 ± 28.3 | P < 0.0001 |
V60 | 30% ± 17.4 | 15% ± 13.1 | 57 ± 28.4 | P < 0.0001 |
D50 | 63Gy ± 20.2 | 48Gy ± 25.1 | 25 ± 28.2 | P < 0.0001 |
D70 | 38Gy ± 16.1 | 22Gy ± 15.0 | 46 ± 26.2 | P < 0.0001 |
D80 | 31Gy ± 15.2 | 15Gy ± 11.8 | 57 ± 25.9 | P < 0.0001 |
D90 | 22Gy ± 14.3 | 8Gy ± 8.2 | 67 ± 25.6 | P < 0.0001 |
D100 | 8Gy ± 8.3 | 1Gy ± 1.6 | 82 ± 22.1 | P < 0.0001 |