Background
Historically, patients with unresectable Stage III or Stage IV (advanced) melanoma had limited treatment options and poor survival outcomes, with older patients having a particularly dismal prognosis [
1,
2]. In 2010, there were an estimated 13.6 melanoma-related deaths per 100 000 US inhabitants aged > 65 years compared with 1.2 per 100 000 US inhabitants aged ≤ 65 years [
3]. Current epidemiological data suggest the incidence of melanoma continues to rise in the elderly population despite indications that it has plateaued in younger people [
3,
4]. Combined with a rapid increase in the proportion of elderly people, this has resulted in melanoma becoming an increasingly important health concern in the developed world [
5].
A number of explanations for the poor prognosis of elderly patients with melanoma have been proposed. Older melanoma patients may be more predisposed to distant metastasis arising from the haematological distribution of tumour cells than younger patients due to changes in lymphatic drainage with ageing [
6]. In addition, elderly patients present with thicker melanomas, a higher mitotic rate and increased incidence of ulceration [
7], all of which are associated with a worse prognosis [
1]. It is likely, however, that the high mortality rates among elderly patients result from a number of age-related variables preventing optimal management of this disease [
8].
One confounding factor that may contribute to the poor prognosis of elderly patients with metastatic melanoma is a weakening of the immune system with age, a process referred to as immunosenescence. Therefore, the possibility of using immune-based therapies to promote immune function is an attractive therapeutic option [
8,
9]. In 2011, the novel immunotherapy agent ipilimumab was the first agent approved for the treatment of patients with advanced melanoma in over three decades [
10]. Ipilimumab is a fully human monoclonal antibody directed against cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), a negative regulator of T-cell-mediated immune responses. By blocking CTLA-4, ipilimumab enables prolonged T-cell activation, proliferation and tumour infiltration, thereby potentiating endogenous antitumour responses [
11].
Ipilimumab 3 mg/kg is now approved in over 40 countries for the treatment of adult patients with advanced melanoma. In Phase III trials, ipilimumab treatment significantly extended overall survival (OS) compared with control in both pretreated and treatment-naϊve patients [
12,
13], and follow-up data from clinical trials suggest ipilimumab can provide durable clinical benefit and long-term survival [
13‐
15]. Furthermore, retrospective analyses of clinical trial data suggest the survival benefit conferred by ipilimumab is independent of age, performance status and stage of metastasis, despite the identification of these variables as significant prognostic indicators [
1,
16,
17].
Expanded access programmes (EAPs) provide an opportunity to assess the efficacy and safety of ipilimumab at its approved dose of 3 mg/kg in elderly patients outside of a clinical trial, in a setting more representative of daily practice. Efficacy and safety results from the Spanish and US EAPs suggest ipilimumab 3 mg/kg is a feasible treatment option in elderly patients with metastatic melanoma [
18‐
20]. Here, we describe the efficacy and safety of ipilimumab 3 mg/kg in elderly (> 70 years old) patients with metastatic melanoma treated at Italian centres participating in the European EAP. Data from other patient subgroups treated in the Italian EAP have been published previously [
21,
22].
Discussion
Elderly patients with metastatic melanoma have higher rates of overall and disease-specific mortality than younger patients [
7]. Furthermore, older patients are more likely to have existing comorbidities, which often result in their exclusion from clinical trials of investigative new therapies [
25]. The EAP in Italy provided the opportunity to assess the efficacy and safety of ipilimumab 3 mg/kg in elderly patients with advanced melanoma outside of a clinical trial setting.
Most other subgroup analyses have used a cut-off age of 65 years when reporting the use of ipilimumab in elderly patients [
12,
19,
20,
26]. Our results suggest ipilimumab treatment is equally effective and safe in patients with advanced melanoma who are aged over or under 70 years. This higher cut-off age may be more relevant to the challenges associated with cancer treatment in an aging society. Indeed, the cut-off for many clinical cancer studies is now 70 years and this is expected to be revised upwards so that 75 years may soon be the standard upper age limit for inclusion in a clinical trial [
27,
28]. Among the 855 patients who participated in the EAP in Italy, almost one quarter were aged > 70 years and were eligible for treatment. This figure is consistent with the proportion of patients > 70 years diagnosed with melanoma in Italy as recorded in the Italian cancer registry, demonstrating that the elderly patients treated as part of the EAP can be considered as representative of the general population of patients > 70 years with melanoma.
Elderly patients had long-lasting clinical responses and prolonged survival with ipilimumab 3 mg/kg. The irBORR and irDCR in patients aged > 70 years were similar to those observed in the wider population of the Italian EAP [
24] and in 30 elderly patients (≥ 70 years old) treated at Spanish centres through the EAP [
20]. One- and 2-year survival rates of 38% and 22% are also comparable with those reported for the total population and consistent with results from the US EAP, in which 1-year survival rates for patients < 65 years or ≥ 65 years were 38% and 37%, respectively [
18]. In the Italian EAP, PFS and OS survival curves were comparable between older and younger patients. Although there was a tendency for survival to be better in the elderly patient cohort, the differences in median PFS and median OS between older and younger patients were not statistically significant and were most likely to chance since the inclusion and exclusion criteria were the same for all patients, as was the follow-up duration, This finding is also consistent with prespecified subgroup analyses of data from the Phase III trial of ipilimumab in pretreated patients, in which the survival benefit with ipilimumab monotherapy compared with gp100 monotherapy was slightly but not significantly greater in patients aged ≥65 years than in younger patients (<65 years) [
12,
16]. Similarly, in the registrational trial of vemurafenib, an inhibitor of mutated BRAF, no differences in survival or response were reported between older (≥ 65 years) and younger patients (< 65 years) with metastatic melanoma [
29].
Ipilimumab is associated with irAEs, which may reflect the proposed mechanism of action [
11,
30]. Most irAEs are mild or moderate and, provided they are recognised early, can be resolved effectively with appropriate management [
31]. Among patients > 70 years treated in the Italian EAP, ipilimumab was generally well tolerated with only 6% of patients experiencing Grade III–IV treatment-related AEs. In addition, most elderly patients received all four doses or discontinued treatment for reasons other than toxicity. The AE profile of ipilimumab in patients aged > 70 years was again consistent with that observed in the overall EAP population, with a similar incidence of Grade III–IV treatment-related AEs and no unexpected toxicities. The results were also in line with subgroup analyses of safety data from patients treated with ipilimumab in clinical trials, EAPs or as standard of care [
12,
19,
24]. In the US EAP, 11% patients aged ≥ 65 years had a Grade III–IV irAE compared with 7% patients aged < 65 years [
19]. Similarly, only four elderly patients (13%) treated in the Spanish EAP had a Grade III–V AE and no patients discontinued treatment due to toxicity [
20]. Taken together, these results suggest that increased age does not compromise the tolerability of ipilimumab treatment. However, this requires further validation in very elderly patients, as recent data suggest that patients aged ≥ 75 years treated with vemurafenib are more likely to experience AEs than younger patients, including secondary skin lesions, decreased appetite and cardiac disorders [
32].
The results of this EAP are particularly relevant as they show that ipilimumab provides a consistent survival benefit in patients aged over or under 70 years, despite the fact that the immune system often becomes less active in elderly people. Indeed, immunosenescence is an important risk factor for melanoma and is thought to affect all components of the immune system [
8,
9]. With regard to adaptive immunity, an age-related reduction in the proportion of naïve T cells occurs due to impaired T-cell development in the thymus. Functional defects in T-cell activity are also observed, partly due to a loss in costimulatory molecules, including CD28 [
33]. However, ipilimumab may be particularly appropriate for the treatment of elderly patients because the expression of coinhibitory receptors such as CTLA-4 increases with age [
34]. There is therefore a strong rationale for using anti-CTLA-4 therapy to treat elderly patients with metastatic melanoma in order to enhance adaptive immunity against this disease.
Most data regarding the use of ipilimumab in older patients are provided by EAP analyses. The EAPs are a valuable source of information regarding the efficacy and safety of ipilimumab outside of clinical trials, but they are also subject to limitations due to their retrospective, nonrandomised nature and the specific data collected. For example, the effect of patient comorbidities on the efficacy and safety of ipilimumab in elderly patients treated in the Italian EAP could not be assessed, as only limited comorbidity data were collected as part of the programme. In addition, it was not possible to stratify patients by activities of daily living (ADL) and instrumental ADL scales, which would have better characterised the patient population. However, these preliminary results suggest that ipilimumab is a safe and effective treatment option for elderly patients with metastatic melanoma. Continued follow-up in this patient population will provide long-term efficacy and safety results.
Acknowledgements
The authors would like to thank the patients and investigators who participated in the European EAP.
Funding
This work was supported in part by the Associazione Italiana per la Ricerca sul Cancro, the Italian Ministry of Health, via the Ricerca Finalizzata 2010. The EAP was sponsored by Bristol-Myers Squibb (BMS). Editorial and writing assistance was provided by StemScientific, funded by BMS. Statistical support was provided by Clinical Research Services, funded by BMS.
Competing interests
Vanna Chiarion Sileni has received travel expenses for medical meetings and conferences and honoraria for advisory boards and consultancy from Bristol-Myers Squibb, GlaxoSmithKline, Merck Sharp & Dohme and Roche-Genentech. Paolo Ascierto has served in a consultancy/advisory role for Bristol-Myers Squibb, Merck Sharp & Dohme, Roche-Genentech, GlaxoSmithKline, Amgen and Celgene; he has also received research funding from Bristol-Myers Squibb, and honoraria from Bristol-Myers Squibb, Merck Sharp & Dohme, Roche-Genentech and GlaxoSmithKline. Michele Maio has had an advisory role and received funding for communication programs from Bristol-Myers Squibb, Roche-Genentech and Merck Sharp & Dohme and has received research funding from Bristol-Myers Squibb. Paolo Marchetti has had advisory roles for Bristol-Myers Squibb, GlaxoSmithKine and Novartis. Alessandro Testori has received honoraria and travel reimbursement for advisory boards from Bristol-Myers Squibb. Paola Queirolo has served in a consultant or advisory role for Bristol-Myers Squibb, GlaxoSmithKline and Roche-Genentech. All remaining authors have declared no conflicts of interest.
Authors’ contributions
All authors made substantial contributions to the acquisition and interpretation of data, were involved in drafting the article or revising it critically for important intellectual content and provided final approval of the version to be published.