Skip to main content
Erschienen in: European Journal of Medical Research 7/2010

01.12.2010 | Research

TME quality in rectal cancer surgery

verfasst von: T Herzog, O Belyaev, AM Chromik, D Weyhe, CA Mueller, J Munding, A Tannapfel, W Uhl, MH Seelig

Erschienen in: European Journal of Medical Research | Ausgabe 7/2010

Einloggen, um Zugang zu erhalten

Abstract

Background

The concept of total mesorectal excision has revolutionised rectal cancer surgery. TME reduces the rate of local recurrence and tumour associated mortality. However, in clinical trials only 50% of the removed rectal tumours have an optimal TME quality. Patients: During a period of 36 months we performed 103 rectal resections. The majority of patients (76%; 78/103) received an anterior resection. The remaining patients underwent either abdominoperineal resection (16%; 17/103), Hartmann's procedure (6%; 6/103) or colectomy (2%; 2/103).

Results

In 90% (93/103) TME quality control could be performed. 99% (92/93) of resected tumours had optimal TME quality. In 1% (1/93) the mesorectum was nearly complete. None of the removed tumours had an incomplete mesorectum. In 98% (91/93) the circumferential resection margin was negative. Major surgical complications occurred in 17% (18/103). 5% (4/78) of patients with anterior resection had anastomotic leakage. 17% (17/103) developed wound infections. Mortality after elective surgery was 4% (4/95).

Conclusion

Optimal TME quality results can be achieved in all stages of rectal cancer with a rate of morbidity and mortality comparable to the results from the literature. Future studies should evaluate outcome and local recurrence in accordance to the degree of TME quality.
Literatur
1.
Zurück zum Zitat Heald RJ, Ryall RD: Recurrence and survival after total mesorectal excision for rectal cancer. Lancet 1986, 1: 1479–1482.PubMedCrossRef Heald RJ, Ryall RD: Recurrence and survival after total mesorectal excision for rectal cancer. Lancet 1986, 1: 1479–1482.PubMedCrossRef
2.
Zurück zum Zitat Hill GL, Rafique M: Extrafascial excision of the rectum for rectal cancer. Br J Surg 1998, 85: 809–812. 10.1046/j.1365-2168.1998.00735.xPubMedCrossRef Hill GL, Rafique M: Extrafascial excision of the rectum for rectal cancer. Br J Surg 1998, 85: 809–812. 10.1046/j.1365-2168.1998.00735.xPubMedCrossRef
3.
Zurück zum Zitat Ross A, Rusnak C, Weinerman B, et al.: Recurrence and survival after surgical management of rectal cancer. Am J Surg 1999, 177: 392–395. 10.1016/S0002-9610(99)00080-XPubMedCrossRef Ross A, Rusnak C, Weinerman B, et al.: Recurrence and survival after surgical management of rectal cancer. Am J Surg 1999, 177: 392–395. 10.1016/S0002-9610(99)00080-XPubMedCrossRef
4.
Zurück zum Zitat Bjerkeset T, Edna TH: Rectal cancer: the influence of type of operation on local recurrence and survival. Eur J Surg 1996, 162: 643–648.PubMed Bjerkeset T, Edna TH: Rectal cancer: the influence of type of operation on local recurrence and survival. Eur J Surg 1996, 162: 643–648.PubMed
6.
Zurück zum Zitat Kapiteijn E, Marijnen CA, Nagtegaal ID, et al.: Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001, 345: 638–646. 10.1056/NEJMoa010580PubMedCrossRef Kapiteijn E, Marijnen CA, Nagtegaal ID, et al.: Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001, 345: 638–646. 10.1056/NEJMoa010580PubMedCrossRef
7.
Zurück zum Zitat Nagtegaal ID, van de Velde CJ, van der Worp E, et al.: Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control. J Clin Oncol 2002, 20: 1729–1734. 10.1200/JCO.2002.07.010PubMedCrossRef Nagtegaal ID, van de Velde CJ, van der Worp E, et al.: Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control. J Clin Oncol 2002, 20: 1729–1734. 10.1200/JCO.2002.07.010PubMedCrossRef
8.
Zurück zum Zitat Z'Graggen K, Maurer CA, Buchler MW: Transverse coloplasty pouch. A novel neorectal reservoir. Dig Surg 1999, 16: 363–366. 10.1159/000018747PubMedCrossRef Z'Graggen K, Maurer CA, Buchler MW: Transverse coloplasty pouch. A novel neorectal reservoir. Dig Surg 1999, 16: 363–366. 10.1159/000018747PubMedCrossRef
9.
Zurück zum Zitat Quirke P, Durdey P, Dixon MF, Williams NS: Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet 1986, 2: 996–999.PubMedCrossRef Quirke P, Durdey P, Dixon MF, Williams NS: Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet 1986, 2: 996–999.PubMedCrossRef
10.
Zurück zum Zitat Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Trial N Engl J Med 1997, 336: 980–987. Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Trial N Engl J Med 1997, 336: 980–987.
11.
Zurück zum Zitat Hermanek P, Wiebelt H, Staimmer D, Riedl S: Prognostic factors of rectum carcinoma--experience of the German Multicentre Study SGCRC. German Study Group ColoRectal Carcinoma. Tumori 1995, 81: 60–64.PubMed Hermanek P, Wiebelt H, Staimmer D, Riedl S: Prognostic factors of rectum carcinoma--experience of the German Multicentre Study SGCRC. German Study Group ColoRectal Carcinoma. Tumori 1995, 81: 60–64.PubMed
12.
Zurück zum Zitat Gerard A, Buyse M, Nordlinger B, et al.: Preoperative radiotherapy as adjuvant treatment in rectal cancer. Final results of a randomized study of the European Organization for Research and Treatment of Cancer (EORTC). Ann Surg 1988, 208: 606–614. 10.1097/00000658-198811000-00011PubMedCentralPubMedCrossRef Gerard A, Buyse M, Nordlinger B, et al.: Preoperative radiotherapy as adjuvant treatment in rectal cancer. Final results of a randomized study of the European Organization for Research and Treatment of Cancer (EORTC). Ann Surg 1988, 208: 606–614. 10.1097/00000658-198811000-00011PubMedCentralPubMedCrossRef
13.
Zurück zum Zitat Roswit B, Higgins GA, Keehn RJ: Preoperative irradiation for carcinoma of the rectum and rectosigmoid colon: reportof a National Veterans Administration randomized study. Cancer 1975, 35: 1597–1602. 10.1002/1097-0142(197506)35:6<1597::AID-CNCR2820350618>3.0.CO;2-SPubMedCrossRef Roswit B, Higgins GA, Keehn RJ: Preoperative irradiation for carcinoma of the rectum and rectosigmoid colon: reportof a National Veterans Administration randomized study. Cancer 1975, 35: 1597–1602. 10.1002/1097-0142(197506)35:6<1597::AID-CNCR2820350618>3.0.CO;2-SPubMedCrossRef
14.
Zurück zum Zitat Hainsworth PJ, Egan MJ, Cunliffe WJ: Evaluation of a policy of total mesorectal excision for rectal and rectosigmoid cancers. Br J Surg 1997, 84: 652–656. 10.1002/bjs.1800840519PubMedCrossRef Hainsworth PJ, Egan MJ, Cunliffe WJ: Evaluation of a policy of total mesorectal excision for rectal and rectosigmoid cancers. Br J Surg 1997, 84: 652–656. 10.1002/bjs.1800840519PubMedCrossRef
15.
Zurück zum Zitat Maslekar S, Sharma A, Macdonald A, et al.: Mesorectal grades predict recurrences after curative resection for rectal cancer. Dis Colon Rectum 2007, 50: 168–175. 10.1007/s10350-006-0756-2PubMedCrossRef Maslekar S, Sharma A, Macdonald A, et al.: Mesorectal grades predict recurrences after curative resection for rectal cancer. Dis Colon Rectum 2007, 50: 168–175. 10.1007/s10350-006-0756-2PubMedCrossRef
16.
Zurück zum Zitat Hyuk Baik S, Kyu Kim N, Young Lee K, et al.: Factors Influencing Pathologic Results after Total Mesorectal Excision for Rectal Cancer: Analysis of Consecutive 100 Cases. Ann Surg Oncol 2007, 5: 5. Hyuk Baik S, Kyu Kim N, Young Lee K, et al.: Factors Influencing Pathologic Results after Total Mesorectal Excision for Rectal Cancer: Analysis of Consecutive 100 Cases. Ann Surg Oncol 2007, 5: 5.
17.
Zurück zum Zitat Nagtegaal ID, Marijnen CA, Kranenbarg EK, et al.: Circumferential margin involvement is still an important predictor of local recurrence in rectal carcinoma: not one millimeter but two millimeters is the limit. Am J Surg Pathol 2002, 26: 350–357. 10.1097/00000478-200203000-00009PubMedCrossRef Nagtegaal ID, Marijnen CA, Kranenbarg EK, et al.: Circumferential margin involvement is still an important predictor of local recurrence in rectal carcinoma: not one millimeter but two millimeters is the limit. Am J Surg Pathol 2002, 26: 350–357. 10.1097/00000478-200203000-00009PubMedCrossRef
18.
Zurück zum Zitat Hermanek P, Heald RJ: Pre- operative radiotherapy for rectal carcinoma? Has the case really been made for short-course pre- operative radiotherapy if surgical standards for rectal carcinoma are optimal? Colorectal Dis 2004, 6: 10–14. 10.1111/j.1463-1318.2004.00569.xPubMedCrossRef Hermanek P, Heald RJ: Pre- operative radiotherapy for rectal carcinoma? Has the case really been made for short-course pre- operative radiotherapy if surgical standards for rectal carcinoma are optimal? Colorectal Dis 2004, 6: 10–14. 10.1111/j.1463-1318.2004.00569.xPubMedCrossRef
19.
Zurück zum Zitat Hermanek P, Hohenberger W, Klimpfinger M, et al.: The pathological assessment of mesorectal excision: implications for further treatment and quality management. Int J Colorectal Dis 2003, 18: 335–341.PubMed Hermanek P, Hohenberger W, Klimpfinger M, et al.: The pathological assessment of mesorectal excision: implications for further treatment and quality management. Int J Colorectal Dis 2003, 18: 335–341.PubMed
20.
Zurück zum Zitat Martling AL, Holm T, Rutqvist LE, et al.: Effect of a surgical training programme on outcome of rectal cancer in the County of Stockholm. Stockholm Colorectal Cancer Study Group, Basingstoke Bowel Cancer Research Project. Lancet 2000, 356: 93–96. 10.1016/S0140-6736(00)02469-7PubMedCrossRef Martling AL, Holm T, Rutqvist LE, et al.: Effect of a surgical training programme on outcome of rectal cancer in the County of Stockholm. Stockholm Colorectal Cancer Study Group, Basingstoke Bowel Cancer Research Project. Lancet 2000, 356: 93–96. 10.1016/S0140-6736(00)02469-7PubMedCrossRef
21.
Zurück zum Zitat Carlsen E, Schlichting E, Guldvog I, et al.: Effect of the introduction of total mesorectal excision for the treatment of rectal cancer. Br J Surg 1998, 85: 526–529. 10.1046/j.1365-2168.1998.00601.xPubMedCrossRef Carlsen E, Schlichting E, Guldvog I, et al.: Effect of the introduction of total mesorectal excision for the treatment of rectal cancer. Br J Surg 1998, 85: 526–529. 10.1046/j.1365-2168.1998.00601.xPubMedCrossRef
22.
Zurück zum Zitat Karanjia ND, Corder AP, Bearn P, Heald RJ: Leakage from stapled low anastomosis after total mesorectal excision for carcinoma of the rectum. Br J Surg 1994, 81: 1224–1226. 10.1002/bjs.1800810850PubMedCrossRef Karanjia ND, Corder AP, Bearn P, Heald RJ: Leakage from stapled low anastomosis after total mesorectal excision for carcinoma of the rectum. Br J Surg 1994, 81: 1224–1226. 10.1002/bjs.1800810850PubMedCrossRef
23.
Zurück zum Zitat Alves A, Panis Y, Mathieu P, et al.: Mortality and morbidity after surgery of mid and low rectal cancer. Results of a French prospective multicentric study. Gastroenterol Clin Biol 2005, 29: 509–514. 10.1016/S0399-8320(05)82121-9PubMedCrossRef Alves A, Panis Y, Mathieu P, et al.: Mortality and morbidity after surgery of mid and low rectal cancer. Results of a French prospective multicentric study. Gastroenterol Clin Biol 2005, 29: 509–514. 10.1016/S0399-8320(05)82121-9PubMedCrossRef
24.
Zurück zum Zitat Karanjia ND, Corder AP, Holdsworth PJ, Heald RJ: Risk of peritonitis and fatal septicaemia and the need to defunction the low anastomosis. Br J Surg 1991, 78: 196–198. 10.1002/bjs.1800780221PubMedCrossRef Karanjia ND, Corder AP, Holdsworth PJ, Heald RJ: Risk of peritonitis and fatal septicaemia and the need to defunction the low anastomosis. Br J Surg 1991, 78: 196–198. 10.1002/bjs.1800780221PubMedCrossRef
25.
Zurück zum Zitat Edler D, Ohrling K, Hallstrom M, et al.: The number of analyzed lymph nodes - a prognostic factor in colorectal cancer. Acta Oncol 2007, 46: 975–981. 10.1080/02841860701203537PubMedCrossRef Edler D, Ohrling K, Hallstrom M, et al.: The number of analyzed lymph nodes - a prognostic factor in colorectal cancer. Acta Oncol 2007, 46: 975–981. 10.1080/02841860701203537PubMedCrossRef
26.
Zurück zum Zitat Adam IJ, Mohamdee MO, Martin IG, et al.: Role of circumferential margin involvement in the local recurrence of rectal cancer. Lancet 1994, 344: 707–711. 10.1016/S0140-6736(94)92206-3PubMedCrossRef Adam IJ, Mohamdee MO, Martin IG, et al.: Role of circumferential margin involvement in the local recurrence of rectal cancer. Lancet 1994, 344: 707–711. 10.1016/S0140-6736(94)92206-3PubMedCrossRef
27.
Zurück zum Zitat Peeters KC, van de Velde CJ, Leer JW, et al.: Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients--a Dutch colorectal cancer group study. J Clin Oncol 2005, 23: 6199–6206. 10.1200/JCO.2005.14.779PubMedCrossRef Peeters KC, van de Velde CJ, Leer JW, et al.: Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients--a Dutch colorectal cancer group study. J Clin Oncol 2005, 23: 6199–6206. 10.1200/JCO.2005.14.779PubMedCrossRef
28.
Zurück zum Zitat Marijnen CA, van de Velde CJ, Putter H, et al.: Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trial. J Clin Oncol 2005, 23: 1847–1858. 10.1200/JCO.2005.05.256PubMedCrossRef Marijnen CA, van de Velde CJ, Putter H, et al.: Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trial. J Clin Oncol 2005, 23: 1847–1858. 10.1200/JCO.2005.05.256PubMedCrossRef
Metadaten
Titel
TME quality in rectal cancer surgery
verfasst von
T Herzog
O Belyaev
AM Chromik
D Weyhe
CA Mueller
J Munding
A Tannapfel
W Uhl
MH Seelig
Publikationsdatum
01.12.2010
Verlag
BioMed Central
Erschienen in
European Journal of Medical Research / Ausgabe 7/2010
Elektronische ISSN: 2047-783X
DOI
https://doi.org/10.1186/2047-783X-15-7-292

Weitere Artikel der Ausgabe 7/2010

European Journal of Medical Research 7/2010 Zur Ausgabe