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Arthritis Research & Therapy

Erschienen in:

01.01.2001 | Review

The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma

verfasst von: Rick Brouwer, Ger JM Pruijn, Walther J van Venrooij

Erschienen in: Arthritis Research & Therapy | Ausgabe 2/2001

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Abstract

The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75. These autoantigens have been reported to associate into a large complex consisting of 11 to 16 proteins and to play a role in ribosome synthesis. Recently, it was discovered that the PM/Scl complex is the human counterpart of the yeast (Saccharomyces cerevisiae) exosome, which is an RNA-processing complex consisting of 11 3' → 5' exoribonucleases. To date, 10 human exosome components have been identified, although only some of these were studied in more detail. In this review, we discuss some recent advances in the characterization of the PM/Scl complex.

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Titel: The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma
verfasst von: Rick Brouwer
Ger JM Pruijn
Walther J van Venrooij
Publikationsdatum: 01.01.2001
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 2/2001
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar147

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