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Arthritis Research & Therapy
Erschienen in: Arthritis Research & Therapy 4/2006

01.08.2006 | Review

Scar wars: is TGFβ the phantom menace in scleroderma?

verfasst von: Andrew Leask

Erschienen in: Arthritis Research & Therapy | Ausgabe 4/2006

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Abstract

The autoimmune disease scleroderma (systemic sclerosis (SSc)) is characterized by extensive tissue fibrosis, causing significant morbidity. There is no therapy for the fibrosis observed in SSc; indeed, the underlying cause of the scarring observed in this disease is unknown. Transforming growth factor-β (TGFβ) has long been hypothesized to be a major contributor to pathological fibrotic diseases, including SSc. Recently, the signaling pathways through which TGFβ activates a fibrotic program have been elucidated and, as a consequence, several possible points for anti-fibrotic drug intervention in SSc have emerged.
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Metadaten
Titel
Scar wars: is TGFβ the phantom menace in scleroderma?
verfasst von
Andrew Leask
Publikationsdatum
01.08.2006
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 4/2006
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1976

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