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Arthritis Research & Therapy

Erschienen in:

01.04.2007 | Commentary

T cells and post menopausal osteoporosis in murine models

verfasst von: Roberto Pacifici

Erschienen in: Arthritis Research & Therapy | Ausgabe 2/2007

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Abstract

Estrogen deficiency is one of the most frequent causes of osteoporosis in women and a possible cause of bone loss in men. But the mechanism involved remains largely unknown. Estrogen deficiency leads to an increase in the immune function, which culminates in an increased production of tumor necrosis factor (TNF) by activated T cells. TNF increases osteoclast formation and bone resorption both directly and by augmenting the sensitivity of maturing osteoclasts to the essential osteoclastogenic factor RANKL (the RANK ligand). Increased T cell production of TNF is induced by estrogen deficiency via a complex mechanism mediated by antigen presenting cells and the cytokines IFNγ, IL-7 and transforming growth factor-β. The experimental evidence that suggests that estrogen prevents bone loss by regulating T cell function and the interactions between immune cells and bone is reviewed here.

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Titel: T cells and post menopausal osteoporosis in murine models
verfasst von: Roberto Pacifici
Publikationsdatum: 01.04.2007
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 2/2007
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2126

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