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Arthritis Research & Therapy

Erschienen in:

01.02.2002 | Review

Adult mesenchymal stem cells and cell-based tissue engineering

verfasst von: Rocky S Tuan, Genevieve Boland, Richard Tuli

Erschienen in: Arthritis Research & Therapy | Ausgabe 1/2002

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Abstract

The identification of multipotential mesenchymal stem cells (MSCs) derived from adult human tissues, including bone marrow stroma and a number of connective tissues, has provided exciting prospects for cell-based tissue engineering and regeneration. This review focuses on the biology of MSCs, including their differentiation potentials in vitro and in vivo, and the application of MSCs in tissue engineering. Our current understanding of MSCs lags behind that of other stem cell types, such as hematopoietic stem cells. Future research should aim to define the cellular and molecular fingerprints of MSCs and elucidate their endogenous role(s) in normal and abnormal tissue functions.

Lin H: The tao of stem cells in the germline. Annu Rev Genet. 1997, 31: 455-491. 10.1146/annurev.genet.31.1.455.PubMed

de Wynter EA, Emmerson AJ, Testa NG: Properties of peripheral blood and cord blood stem cells. Baillière's Best Pract Res Clin Haematol. 1999, 12: 1-17. 10.1053/beha.1999.0003.

Dua HS, Azuara-Blanco A: Limbal stem cells of the corneal epithelium. Surv Ophthalmol. 2000, 44: 415-425. 10.1016/S0039-6257(00)00109-0.PubMed

Rao MS: Multipotent and restricted precursors in the central nervous system. Anat Rec. 1999, 257: 137-148. 10.1002/(SICI)1097-0185(19990815)257:4<137::AID-AR7>3.3.CO;2-H.PubMed

Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, Wang X, Finegold M, Weissman IL, Grompe M: Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nature Med. 2000, 6: 1229-1234. 10.1038/81326.PubMed

Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, Boggs SS, Greenberger JS, Goff JP: Bone marrow as a potential source of hepatic oval cells. Science. 1999, 284: 1168-1170. 10.1126/science.284.5417.1168.PubMed

Alison MR, Poulsom R, Jeffery R, Dhillon AP, Quaglia A, Jacob J, Novelli M, Prentice G, Williamson J, Wright NA: Hepatocytes from non-hepatic adult stem cells. Nature. 2000, 406: 257-10.1038/35018642.PubMed

Jackson KA, Mi T, Goodell MA: Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proc Natl Acad Sci U S A. 1999, 96: 14482-14486. 10.1073/pnas.96.25.14482.PubMedCentralPubMed

Bjornson CR, Rietze RL, Reynolds BA, Magli MC, Vescovi AL: Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science. 1999, 283: 534-537. 10.1126/science.283.5401.534.PubMed

10.

Ferrari G, Cusella-De Angelis G, Coletta M, Paolucci E, Stornaiuolo A, Cossu G, Mavilio F: Muscle regeneration by bone marrow-derived myogenic progenitors. Science. 1998, 279: 1528-1530. 10.1126/science.279.5356.1528.PubMed

11.

Azizi SA, Stokes D, Augelli BJ, DiGirolamo C, Prockop DJ: Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats – similarities to astrocyte grafts. Proc Natl Acad Sci U S A. 1998, 95: 3908-3913. 10.1073/pnas.95.7.3908.PubMedCentralPubMed

12.

Kopen GC, Prockop DJ, Phinney DG: Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci U S A. 1999, 96: 10711-10716. 10.1073/pnas.96.19.10711.PubMedCentralPubMed

13.

Ito T, Suzuki A, Okabe M, Imai E, Hori M: Application of bone marrow-derived stem cells in experimental nephrology. Exp Nephrol. 2001, 9: 444-450. 10.1159/000052644.PubMed

14.

Fukuda K: Molecular characterization of regenerated cardiomyocytes derived from adult mesenchymal stem cells. Congenit Anom Kyoto. 2002, 42: 1-9.PubMed

15.

Makino S, Fukuda K, Miyoshi S, Konishi F, Kodama H, Pan J, Sano M, Takahashi T, Hori S, Abe H, Hata J, Umezawa A, Ogawa S: Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest. 1999, 103: 697-705.PubMedCentralPubMed

16.

Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, Benhaim P, Lorenz HP, Hedrick MH: Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001, 7: 211-228. 10.1089/107632701300062859.PubMed

17.

Nakahara H, Goldberg VM, Caplan AI: Culture-expanded human periosteal-derived cells exhibit osteochondral potential in vivo. J Orthop Res. 1991, 9: 465-476. 10.1002/jor.1100090402.PubMed

18.

De Bari C, Dell'Accio F, Luyten FP: Human periosteum-derived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor age. Arthritis Rheum. 2001, 44: 85-95. 10.1002/1529-0131(200101)44:1<85::AID-ANR12>3.0.CO;2-6.PubMed

19.

De Bari C, Dell'Accio F, Tylzanowski P, Luyten FP: Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum. 2001, 44: 1928-1942. 10.1002/1529-0131(200108)44:8<1928::AID-ART331>3.0.CO;2-P.PubMed

20.

Bosch P, Musgrave DS, Lee JY, Cummins J, Shuler T, Ghivizzani TC, Evans T, Robbins TD, Huard J: Osteoprogenitor cells within skeletal muscle. J Orthop Res. 2000, 18: 933-944. 10.1002/jor.1100180613.PubMed

21.

Young HE, Steele TA, Bray RA, Hudson J, Floyd JA, Hawkins K, Thomas K, Austin T, Edwards C, Cuzzourt J, Duenzl M, Lucas PA, Black AC: Human reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult, and geriatric donors. Anat Rec. 2001, 264: 51-62. 10.1002/ar.1128.PubMed

22.

Diefenderfer DL, Brighton CT: Microvascular pericytes express aggrecan message which is regulated by BMP-2. Biochem Biophys Res Commun. 2000, 269: 172-178. 10.1006/bbrc.2000.2148.PubMed

23.

Brighton CT, Lorich DG, Kupcha R, Reilly TM, Jones AR, Woodbury RA: The pericyte as a possible osteoblast progenitor cell. Clin Orthop. 1992, 275: 287-299.PubMed

24.

Reilly TM, Seldes R, Luchetti W, Brighton CT: Similarities in the phenotypic expression of pericytes and bone cells. Clin Orthop. 1998, 346: 95-103.PubMed

25.

Zvaifler NJ, Marinova-Mutafchieva L, Adams G, Edwards CJ, Moss J, Burger JA, Maini RN: Mesenchymal precursor cells in the blood of normal individuals. Arthritis Res. 2000, 2: 477-488. 10.1186/ar130.PubMedCentralPubMed

26.

Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR: Multilineage potential of adult human mesenchymal stem cells. Science. 1999, 284: 143-147. 10.1126/science.284.5411.143.PubMed

27.

Noth U, Osyczka AM, Tuli R, Hickok NJ, Danielson KG, Tuan RS: Multilineage mesenchymal differentiation potential of human trabecular bone-derived cells. J Orthop Res. 2002, 20: 1060-1069. 10.1016/S0736-0266(02)00018-9.PubMed

28.

Osyczka AM, Noth U, Danielson KG, Tuan RS: Different osteochondral potential of clonal cell lines derived from adult human trabecular bone. Ann N Y Acad Sci. 2002, 961: 73-77.PubMed

29.

Tuli R, Seghatoleslami MR, Tuli S, Wang ML, Hozack WJ, Manner PA, Danielson KG, Tuan RS: A simple, high-yield method for obtaining multipotential mesenchymal progenitor cells from trabecular bone. Mol Biotechnol. 2002,

30.

Friedenstein AJ, Gorskaja JF, Kulagina NN: Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol. 1976, 4: 267-274.PubMed

31.

Dexter TM: Stromal cell associated haemopoiesis. J Cell Physiol. 1982, 1 (suppl): 87-94. 10.1002/jcp.1041130414.

32.

Rickard DJ, Kassem M, Hefferan TE, Sarkar G, Spelsberg TC, Riggs BL: Isolation and characterization of osteoblast precursor cells from human bone marrow. J Bone Miner Res. 1996, 11: 312-324.PubMed

33.

Friedenstein AJ, Chailakhyan RK, Gerasimov UV: Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet. 1987, 20: 263-272.PubMed

34.

Keating A, Horsfall W, Hawley RG, Toneguzzo F: Effect of different promoters on expression of genes introduced into hematopoietic and marrow stromal cells by electroporation. Exp Hematol. 1990, 18: 99-102.PubMed

35.

Wakitani S, Saito T, Caplan AI: Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve. 1995, 18: 1417-1426. 10.1002/mus.880181212.PubMed

36.

Kuznetsov SA, Friedenstein AJ, Robey PG: Factors required for bone marrow stromal fibroblast colony formation in vitro. Br J Haematol. 1997, 97: 561-570. 10.1046/j.1365-2141.1997.902904.x.PubMed

37.

Digirolamo CM, Stokes D, Colter D, Phinney DG, Class R, Prockop DJ: Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate. Br J Haematol. 1999, 107: 275-281. 10.1046/j.1365-2141.1999.01715.x.PubMed

38.

Hung SC, Chen NJ, Hsieh SL, Li H, Ma HL, Lo WH: Isolation and characterization of size-sieved stem cells from human bone marrow. Stem Cells. 2002, 20: 249-258. 10.1634/stemcells.20-3-249.PubMed

39.

Caterson EJ, Nesti LJ, Danielson KG, Tuan RS: Human marrow-derived mesenchymal progenitor cells: isolation, culture expansion, and analysis of differentiation. Mol Biotechnol. 2002, 20: 245-256. 10.1385/MB:20:3:245.PubMed

40.

Prockop DJ: Marrow stromal cells as stem cells for non-hematopoietic tissues. Science. 1997, 276: 71-74. 10.1126/science.276.5309.71.PubMed

41.

Majumdar MK, Thiede MA, Mosca JD, Moorman M, Gerson SL: Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. J Cell Physiol. 1998, 176: 57-66. 10.1002/(SICI)1097-4652(199807)176:1<57::AID-JCP7>3.0.CO;2-7.PubMed

42.

Majors AK, Boehm CA, Nitto H, Midura RJ, Muschler GF: Characterization of human bone marrow stromal cells with respect to osteoblastic differentiation. J Orthop Res. 1997, 15: 546-557. 10.1002/jor.1100150410.PubMed

43.

Bruder SP, Jaiswal N, Haynesworth SE: Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J Cell Biochem. 1997, 64: 278-294. 10.1002/(SICI)1097-4644(199702)64:2<278::AID-JCB11>3.0.CO;2-F.PubMed

44.

Simonsen JL, Rosada C, Serakinci N, Justesen J, Stenderup K, Rattan SI, Jensen TG, Kassem M: Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nat Biotechnol. 2002, 20: 592-596. 10.1038/nbt0602-592.PubMed

45.

Shi S, Gronthos S, Chen S, Reddi A, Counter CM, Robey PG, Wang CY: Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression. Nature Biotechnol. 2002, 20: 587-591. 10.1038/nbt0602-587.

46.

Osyczka AM, Noth U, O'Connor J, Caterson EJ, Yoon K, Danielson KG, Tuan RS: Multilineage differentiation of adult human bone marrow progenitor cells transduced with human papilloma virus type 16 E6/E7 genes. Calcif Tissue Int. 2002,

47.

Okamoto T, Aoyama T, Nakayama T, Nakamata T, Hosaka T, Nishijo K, Nakamura T, Kiyono T, Toguchida J: Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells. Biochem Biophys Res Commun. 2002, 295: 354-361. 10.1016/S0006-291X(02)00661-7.PubMed

48.

Waller EK, Olweus J, Lund-Johansen F, Huang S, Nguyen M, Guo GR, Terstappen L: The "common stem cell" hypothesis reevaluated: human fetal bone marrow contains separate populations of hematopoietic and stromal progenitors. Blood. 1995, 85: 2422-2435.PubMed

49.

Simmons PJ, Gronthos S, Zannettino A, Ohta S, Graves S: Isolation, characterization and functional activity of human marrow stromal progenitors in hemopoiesis. Prog Clin Biol Res. 1994, 389: 271-280.PubMed

50.

Simmons PJ, Torok-Storb B: Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood. 1991, 78: 55-62.PubMed

51.

Dennis JE, Carbillet JP, Caplan AI, Charbord P: The STRO-1+ marrow cell population is multipotential. Cells Tissues Organs. 2002, 170: 73-82. 10.1159/000046182.PubMed

52.

Bruder SP, Ricalton NS, Boynton RE, Connolly TJ, Jaiswal N, Zaia J, Barry FP: Mesenchymal stem cell surface antigen SB-10 corresponds to activated leukocyte cell adhesion molecule and is involved in osteogenic differentiation. J Bone Miner Res. 1998, 13: 655-663.PubMed

53.

Haynesworth SE, Baber MA, Caplan AI: Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone. 1992, 13: 69-80. 10.1016/8756-3282(92)90363-2.PubMed

54.

Barry FP, Boynton RE, Haynesworth S, Murphy JM, Zaia J: The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105). Biochem Biophys Res Commun. 1999, 265: 134-139. 10.1006/bbrc.1999.1620.PubMed

55.

Barry F, Boynton R, Murphy M, Haynesworth S, Zaia J: The SH-3 and SH-4 antibodies recognize distinct epitopes on CD73 from human mesenchymal stem cells. Biochem Biophys Res Commun. 2001, 289: 519-524. 10.1006/bbrc.2001.6013.PubMed

56.

Walsh S, Jefferiss C, Stewart K, Jordan GR, Screen J, Beresford JN: Expression of the developmental markers STRO-1 and alkaline phosphatase in cultures of human marrow stromal cells: regulation by fibroblast growth factor (FGF)-2 and relationship to the expression of FGF receptors 1–4. Bone. 2000, 27: 185-195. 10.1016/S8756-3282(00)00319-7.PubMed

57.

Tsutsumi S, Shimazu A, Miyazaki K, Pan H, Koike C, Yoshida E, Takagishi K, Kato Y: Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF. Biochem Biophys Res Commun. 2001, 288: 413-419. 10.1006/bbrc.2001.5777.PubMed

58.

Haynesworth SE, Baber MA, Caplan AI: Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-1α. J Cell Physiol. 1996, 166: 585-592. 10.1002/(SICI)1097-4652(199603)166:3<585::AID-JCP13>3.3.CO;2-7.PubMed

59.

Bellows CG, Heersche JN, Aubin JE: Determination of the capacity for proliferation and differentiation of osteoprogenitor cells in the presence and absence of dexamethasone. Dev Biol. 1990, 140: 132-138. 10.1016/0012-1606(90)90060-V.PubMed

60.

Liu F, Aubin JE, Malaval L: Expression of leukemia inhibitory factor (LIF)/interleukin-6 family cytokines and receptors during in vitro osteogenesis: differential regulation by dexamethasone and LIF. Bone. 2002, 31: 212-219. 10.1016/S8756-3282(02)00806-2.PubMed

61.

Chung CH, Golub EE, Forbes E, Tokuoka T, Shapiro IM: Mechanism of action of beta-glycerophosphate on bone cell mineralization. Calcif Tissue Int. 1992, 51: 305-311. 10.1007/BF00334492.PubMed

62.

Tenenbaum HC, Limeback H, McCulloch CA, Mamujee H, Sukhu B, Torontali M: Osteogenic phase-specific co-regulation of collagen synthesis and mineralization by beta-glycerophosphate in chick periosteal cultures. Bone. 1992, 13: 129-138. 10.1016/8756-3282(92)90002-E.PubMed

63.

Beck GR, Zerler B, Moran E: Phosphate is a specific signal for induction of osteopontin gene expression. Proc Natl Acad Sci U S A. 2000, 97: 8352-8357. 10.1073/pnas.140021997.PubMedCentralPubMed

64.

Fujita T, Izumo N, Fukuyama R, Meguro T, Nakamuta H, Kohno T, Koida M: Phosphate provides an extracellular signal that drives nuclear export of Runx2/Cbfa1 in bone cells. Biochem Biophys Res Commun. 2001, 280: 348-352. 10.1006/bbrc.2000.4108.PubMed

65.

Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G: Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell. 1997, 89: 747-754. 10.1016/S0092-8674(00)80257-3.PubMed

66.

Liu P, Oyajobi BO, Russell RG, Scutt A: Regulation of osteogenic differentiation of human bone marrow stromal cells: interaction between transforming growth factor-beta and 1,25(OH)(2) vitamin D(3) in vitro. Calcif Tissue Int. 1999, 65: 173-180. 10.1007/s002239900678.PubMed

67.

Hanada K, Dennis JE, Caplan AI: Stimulatory effects of basic fibroblast growth factor and bone morphogenetic protein-2 on osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells. J Bone Miner Res. 1997, 12: 1606-1614.PubMed

68.

Little RD, Carulli JP, Del Mastro RG, Dupuis J, Osborne M, Folz C, Manning SP, Swain PM, Zhao SC, Eustace B, Lappe MM, Spitzer L, Zweier S, Braunschweiger K, Benchekroun Y, Hu X, Adair R, Chee L, FitzGerald MG, Tulig C, Caruso A, Tzellas N, Bawa A, Franklin B, McGuire S, Nogues X, Gong G, Allen KM, Anisowicz A, Morales AJ, Lomedico PT, Recker SM, Van Eerdewegh P, Recker RR, Johnson ML: A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet. 2002, 70: 11-19. 10.1086/338450.PubMedCentralPubMed

69.

Kato M, Patel MS, Levasseur R, Lobov I, Chang BH, Glass DA, Hartmann C, Li L, Hwang TH, Brayton CF, Lang RA, Karsenty G, Chan L: Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol. 2002, 157: 303-314. 10.1083/jcb.200201089.PubMedCentralPubMed

70.

Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D, Zacharin M, Oexle K, Marcelino J, Suwairi W, Heeger S, Sabatakos G, Apte S, Adkins WN, Allgrove J, Arslan-Kirchner M, Batch JA, Beighton P, Black GC, Boles RG, Boon LM, Borrone C, Brunner HG, Carle GF, Dallapiccola B, De Paepe A, Floege B, Halfhide ML, Hall B, Hennekam RC, Hirose T, Jans A, Juppner H, Kim CA, Keppler-Noreuil K, Kohlschuetter A, LaCombe D, Lambert M, Lemyre E, Letteboer T, Peltonen L, Ramesar RS, Romanengo M, Somer H, Steichen-Gersdorf E, Steinmann B, Sullivan B, Superti-Furga A, Swoboda W, van den Boogaard MJ, Van Hul W, Vikkula M, Votruba M, Zabel B, Garcia T, Baron R, Olsen BR, Warman ML: LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 2001, 107: 513-523. 10.1016/S0092-8674(01)00571-2.PubMed

71.

Rose FR, Oreffo RO: Bone tissue engineering: hope vs hype. Biochem Biophys Res Commun. 2002, 292: 1-7. 10.1006/bbrc.2002.6519.PubMed

72.

Bruder SP, Kraus KH, Goldberg VM, Kadiyala S: The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects. J Bone Joint Surg Am. 1998, 80: 985-996.PubMed

73.

El-Amin SF, Attawia M, Lu HH, Shah AK, Chang R, Hickok NJ, Tuan RS, Laurencin CT: Integrin expression by human osteoblasts cultured on degradable polymeric materials applicable for tissue engineered bone. J Orthop Res. 2002, 20: 20-28. 10.1016/S0736-0266(01)00062-6.PubMed

74.

Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L: Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994, 331: 889-895. 10.1056/NEJM199410063311401.PubMed

75.

O'Driscoll SW: The healing and regeneration of articular cartilage. J Bone Joint Surg Am. 1998, 80: 1795-1812.PubMed

76.

Johnstone B, Hering TM, Caplan AI, Goldberg VM, Yoo JU: In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res. 1998, 238: 265-272. 10.1006/excr.1997.3858.PubMed

77.

Cassiede P, Dennis JE, Ma F, Caplan AI: Osteochondrogenic potential of marrow mesenchymal progenitor cells exposed to TGF-β1 or PDGF-BB as assayed in vivo and in vitro. J Bone Miner Res. 1996, 11: 1264-1273.PubMed

78.

Barry F, Boynton RE, Liu B, Murphy JM: Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components. Exp Cell Res. 2001, 268: 189-200. 10.1006/excr.2001.5278.PubMed

79.

Mackay AM, Beck SC, Murphy JM, Barry FP, Chichester CO, Pittenger MF: Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow. Tissue Eng. 1998, 4: 415-428.PubMed

80.

Sekiya I, Colter DC, Prockop DJ: BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells. Biochem Biophys Res Commun. 2001, 284: 411-418. 10.1006/bbrc.2001.4898.PubMed

81.

Majumdar MK, Wang E, Morris EA: BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1. J Cell Physiol. 2001, 189: 275-284. 10.1002/jcp.10025.PubMed

82.

Rudnicki JA, Brown AM: Inhibition of chondrogenesis by Wnt gene expression in vivo and in vitro. Dev Biol. 1997, 185: 104-118. 10.1006/dbio.1997.8536.PubMed

83.

Tufan AC, Tuan RS: Wnt regulation of limb mesenchymal chondrogenesis is accompanied by altered N-cadherin-related functions. FASEB J. 2001, 15: 1436-1438.PubMed

84.

Fischer L, Boland G, Tuan RS: Wnt-3A enhances bone morphogenetic protein-2-mediated chondrogenesis of murine C3H10T1/2 mesenchymal cells. J Biol Chem. 2002, 277: 30870-30878. 10.1074/jbc.M109330200.PubMed

85.

Hurvitz JR, Suwairi WM, Van Hul W, El-Shanti H, Superti-Furga A, Roudier J, Holderbaum D, Pauli RM, Herd JK, Van Hul EV, Rezai-Delui H, Legius E, Le Merrer M, Al-Alami J, Bahabri SA, Warman ML: Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia. Nature Genet. 1999, 23: 94-98. 10.1038/12699.PubMed

86.

Pennica D, Swanson TA, Welsh JW, Roy MA, Lawrence DA, Lee J, Brush J, Taneyhill LA, Deuel B, Lew M, Watanabe C, Cohen RL, Melhem MF, Finley GG, Quirke P, Goddard AD, Hillan KJ, Gurney AL, Botstein D, Levine AJ: WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc Natl Acad Sci U S A. 1998, 95: 14717-14722. 10.1073/pnas.95.25.14717.PubMedCentralPubMed

87.

Grotendorst GR: Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev. 1997, 8: 171-179. 10.1016/S1359-6101(97)00010-5.PubMed

88.

Lako M, Strachan T, Bullen P, Wilson DI, Robson SC, Lindsay S: Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung. Gene. 1998, 219: 101-110. 10.1016/S0378-1119(98)00393-X.PubMed

89.

Sekiya I, Vuoristo JT, Larson BL, Prockop DJ: In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis. Proc Natl Acad Sci U S A. 2002, 99: 4397-4402. 10.1073/pnas.052716199.PubMedCentralPubMed

90.

Sen M, Lauterbach K, El-Gabalawy H, Firestein GS, Corr M, Carson DA: Expression and function of wingless and frizzled homologs in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2000, 97: 2791-2796. 10.1073/pnas.050574297.PubMedCentralPubMed

91.

Sen M, Chamorro M, Reifert J, Corr M, Carson DA: Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation. Arthritis Rheum. 2001, 44: 772-781. 10.1002/1529-0131(200104)44:4<772::AID-ANR133>3.3.CO;2-C.PubMed

92.

Nakamura K, Shirai T, Morishita S, Uchida S, Saeki-Miura K, Makishima F: p38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth/differentiation factor-5 in ATDC5 cells. Exp Cell Res. 1999, 250: 351-363. 10.1006/excr.1999.4535.PubMed

93.

Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E, Matsumoto K: Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science. 1995, 270: 2008-2011.PubMed

94.

Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K: TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science. 1996, 272: 1179-1182.PubMed

95.

Shirakabe K, Yamaguchi K, Shibuya H, Irie K, Matsuda S, Moriguchi T, Gotoh Y, Matsumoto K, Nishida E: TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase. J Biol Chem. 1997, 272: 8141-8144. 10.1074/jbc.272.13.8141.PubMed

96.

Moriguchi T, Kuroyanagi N, Yamaguchi K, Gotoh Y, Irie K, Kano T, Shirakabe K, Muro Y, Shibuya H, Matsumoto K, Nishida E, Hagiwara M: A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J Biol Chem. 1996, 271: 13675-13679. 10.1074/jbc.271.23.13675.PubMed

97.

Mucsi I, Skorecki KL, Goldberg HJ: Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-β1 on gene expression. J Biol Chem. 1996, 271: 16567-16572. 10.1074/jbc.271.28.16567.PubMed

98.

Hartsough MT, Mulder KM: Transforming growth factor-β signaling in epithelial cells. Pharmacol Ther. 1997, 75: 21-41. 10.1016/S0163-7258(97)00020-X.PubMed

99.

Heldin CH, Miyazono K, ten Dijke P: TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature. 1997, 390: 465-471. 10.1038/37284.PubMed

100.

Massague J: TGF-β signal transduction. Annu Rev Biochem. 1998, 67: 753-791. 10.1146/annurev.biochem.67.1.753.PubMed

101.

Luo G, Hofmann C, Bronckers AL, Sohocki M, Bradley A, Karsenty G: BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev. 1995, 9: 2808-2820.PubMed

102.

Kingsley DM, Bland AE, Grubber JM, Marker PC, Russell LB, Copeland NG, Jenkins NA: The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. Cell. 1992, 71: 399-410. 10.1016/0092-8674(92)90510-J.PubMed

103.

Yang X, Chen L, Xu X, Li C, Huang C, Deng CX: TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol. 2001, 153: 35-46. 10.1083/jcb.153.1.35.PubMedCentralPubMed

104.

Kretzschmar M, Doody J, Massague J: Opposing BMP and EGF signaling pathways converge on the TGF-beta family mediator Smad1. Nature. 1997, 389: 618-622. 10.1038/39348.PubMed

105.

de Caestecker MP, Parks WT, Frank CJ, Castagnino P, Bottaro DP, Roberts AB, Lechleider RJ: Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases. Genes Dev. 1998, 12: 1587-1592.PubMedCentralPubMed

106.

Oberlender SA, Tuan RS: Expression and functional involvement of N-cadherin in embryonic limb chondrogenesis. Development. 1994, 120: 177-187.PubMed

107.

DeLise AM, Tuan RS: Alterations in the spatiotemporal expression pattern and function of N-cadherin inhibit cellular condensation and chondrogenesis of limb mesenchymal cells in vitro. J Cell Biochem. 2002, 87: 342-359. 10.1002/jcb.10308.PubMed

108.

DeLise AM, Tuan RS: Analysis of N-cadherin function in limb mesenchymal chondrogenesis in vitro. Develop Dyn. 2002, 225: 195-204. 10.1002/dvdy.10151.

109.

Stott NS, Jiang TX, Chuong CM: Successive formative stages of precartilaginous mesenchymal condensations in vitro: modulation of cell adhesion by Wnt-7A and BMP-2. J Cell Physiol. 1999, 180: 314-324. 10.1002/(SICI)1097-4652(199909)180:3<314::AID-JCP2>3.3.CO;2-P.PubMed

110.

Tuli R, Seghatoleslami MR, Tuli S, Howard MS, Danielson KG, Tuan RS: p38 MAP kinase regulation of AP-2 binding in TGF-beta1-stimulated chondrogenesis of human trabecular bone-derived cells. Ann N Y Acad Sci. 2002, 961: 172-177.PubMed

111.

Wakitani S, Goto T, Pineda SJ, Young RG, Mansour JM, Caplan AI, Goldberg VM: Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg Am. 1994, 76: 579-592.PubMed

112.

Adachi N, Sato K, Usas A, Fu FH, Ochi M, Han CW, Niyibizi C, Huard J: Muscle derived, cell based ex vivo gene therapy for treatment of full thickness articular cartilage defects. J Rheumatol. 2002, 29: 1920-1930.PubMed

113.

Caplan AI, Elyaderani M, Mochizuki Y, Wakitani S, Goldberg VM: Principles of cartilage repair and regeneration. Clin Orthop. 1997, 342: 254-269. 10.1097/00003086-199709000-00033.PubMed

114.

Quintavalla J, Uziel-Fusi S, Yin J, Boehnlein E, Pastor G, Blancuzzi V, Singh HN, Kraus KH, O'Byrne E, Pellas TC: Fluorescently labeled mesenchymal stem cells (MSCs) maintain multilineage potential and can be detected following implantation into articular cartilage defects. Biomaterials. 2002, 23: 109-119. 10.1016/S0142-9612(01)00086-2.PubMed

115.

Radice M, Brun P, Cortivo R, Scapinelli R, Battaliard C, Abatangelo G: Hyaluronan-based biopolymers as delivery vehicles for bone-marrow-derived mesenchymal progenitors. J Biomed Mater Res. 2000, 50: 101-109. 10.1002/(SICI)1097-4636(200005)50:2<101::AID-JBM2>3.3.CO;2-D.PubMed

116.

Caterson EJ, Nesti LJ, Li WJ, Danielson KG, Albert TJ, Vaccaro AR, Tuan RS: Three-dimensional cartilage formation by bone marrow-derived cells seeded in polylactide/alginate amalgam. J Biomed Mater Res. 2001, 57: 394-403. 10.1002/1097-4636(20011205)57:3<394::AID-JBM1182>3.0.CO;2-9.PubMed

117.

Noth U, Tuli R, Osyczka AM, Danielson KG, Tuan RS: In vitro engineered cartilage constructs produced by press-coating biodegradable polymer with human mesenchymal stem cells. Tissue Eng. 2002, 8: 131-144. 10.1089/107632702753503126.PubMed

118.

Li WJ, Laurencin CT, Caterson EJ, Tuan RS, Ko FK: Electrospun nanofibrous structure: A novel scaffold for tissue engineering. J Biomed Mater Res. 2002, 60: 613-621. 10.1002/jbm.10167.PubMed

119.

Wolfman NM, Hattersley G, Cox K, Celeste AJ, Nelson R, Yamaji N, Dube JL, DiBlasio-Smith E, Nove J, Song JJ, Wozney JM, Rosen V: Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. J Clin Invest. 1997, 100: 321-330.PubMedCentralPubMed

120.

Helm GA, Li JZ, Alden TD, Hudson SB, Beres EJ, Cunningham M, Mikkelsen MM, Pittman DD, Kerns KM, Kallmes DF: A light and electron microscopic study of ectopic tendon and ligament formation induced by bone morphogenetic protein-13 adenoviral gene therapy. J Neurosurg. 2001, 95: 298-307.PubMed

121.

Aspenberg P, Forslund C: Enhanced tendon healing with GDF 5 and 6. Acta Orthop Scand. 1999, 70: 51-54.PubMed

122.

Young RG, Butler DL, Weber W, Caplan AI, Gordon SL, Fink DJ: Use of mesenchymal stem cells in a collagen matrix for Achilles tendon repair. J Orthop Res. 1998, 16: 406-413. 10.1002/jor.1100160403.PubMed

123.

Awad HA, Butler DL, Boivin GP, Smith FN, Malaviya P, Huibregtse B, Caplan AI: Autologous mesenchymal stem cell-mediated repair of tendon. Tissue Eng. 1999, 5: 267-277.PubMed

124.

Awad HA, Butler DL, Harris MT, Ibrahim RE, Wu Y, Young RG, Kadiyala S, Boivin GP: In vitro characterization of mesenchymal stem cell-seeded collagen scaffolds for tendon repair: effects of initial seeding density on contraction kinetics. J Biomed Mater Res. 2000, 51: 233-240. 10.1002/(SICI)1097-4636(200008)51:2<233::AID-JBM12>3.0.CO;2-B.PubMed

125.

Hsieh AH, Tsai CM, Ma QJ, Lin T, Banes AJ, Villarreal FJ, Akeson WH, Sung KL: Time-dependent increases in type-III collagen gene expression in medical collateral ligament fibroblasts under cyclic strains. J Orthop Res. 2000, 18: 220-227. 10.1002/jor.1100180209.PubMed

126.

Lehmann JM, Lenhard JM, Oliver BB, Ringold GM, Kliewer SA: Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem. 1997, 272: 3406-3410. 10.1074/jbc.272.6.3406.PubMed

127.

Ross SE, Hemati N, Longo KA, Bennett CN, Lucas PC, Erickson RL, MacDougald OA: Inhibition of adipogenesis by Wnt signaling. Science. 2000, 289: 950-953. 10.1126/science.289.5481.950.PubMed

128.

Park SR, Oreffo RO, Triffitt JT: Interconversion potential of cloned human marrow adipocytes in vitro. Bone. 1999, 24: 549-554. 10.1016/S8756-3282(99)00084-8.PubMed

129.

Beresford JN, Bennett JH, Devlin C, Leboy PS, Owen ME: Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J Cell Sci. 1992, 102: 341-351.PubMed

130.

Goldring K, Partridge T, Watt D: Muscle stem cells. J Pathol. 2002, 197: 457-467. 10.1002/path.1157.PubMed

131.

Fukuda K: Development of regenerative cardiomyocytes from mesenchymal stem cells for cardiovascular tissue engineering. Artif Organs. 2001, 25: 187-193. 10.1046/j.1525-1594.2001.025003187.x.PubMed

132.

Shake JG, Gruber PJ, Baumgartner WA, Senechal G, Meyers J, Redmond JM, Pittenger MF, Martin BJ: Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. Ann Thorac Surg. 2002, 73: 1919-1926. 10.1016/S0003-4975(02)03517-8.PubMed

133.

Strauer BE, Brehm M, Zeus T, Kostering M, Hernandez A, Sorg RV, Kogler G, Wernet P: Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation. 2002, 106: 1913-1918. 10.1161/01.CIR.0000034046.87607.1C.PubMed

134.

Akins RE: Can tissue engineering mend broken hearts?. Circ Res. 2002, 90: 120-122.PubMed

135.

Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM: Embryonic stem cell lines derived from human blastocysts. Science. 1998, 282: 1145-1147. 10.1126/science.282.5391.1145.PubMed

136.

Nippert I: The pros and cons of human therapeutic cloning in the public debate. J Biotechnol. 2002, 98: 53-60. 10.1016/S0168-1656(02)00085-8.PubMed

137.

Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR: Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science. 2000, 290: 1779-1782. 10.1126/science.290.5497.1779.PubMed

138.

Wada MR, Inagawa-Ogashiwa M, Shimizu S, Yasumoto S, Hashimoto N: Generation of different fates from multipotent muscle stem cells. Development. 2002, 129: 2987-2995.PubMed

139.

Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, Verfaillie CM: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002, 418: 41-49. 10.1038/nature00870.PubMed

140.

Rosu-Myles M, Khandaker M, Wu DM, Keeney M, Foley SR, Howson-Jan K, Yee IC, Fellows F, Kelvin D, Bhatia M: Characterization of chemokine receptors expressed in primitive blood cells during human hematopoietic ontogeny. Stem Cells. 2000, 18: 374-381. 10.1634/stemcells.18-5-374.PubMed

141.

Hackney JA, Charbord P, Brunk BP, Stoeckert CJ, Lemischka IR, Moore KA: A molecular profile of a hematopoietic stem cell niche. Proc Natl Acad Sci U S A. 2002, 99: 13061-13066. 10.1073/pnas.192124499.PubMedCentralPubMed

142.

Ivanova NB, Dimos JT, Schaniel C, Hackney JA, Moore KA, Lemischka IR: A stem cell molecular signature. Science. 2002, 298: 601-604. 10.1126/science.1073823.PubMed

143.

Bianco P, Costantini M, Dearden LC, Bonucci E: Alkaline phosphatase positive precursors of adipocytes in the human bone marrow. Br J Haematol. 1988, 68: 401-403.PubMed

144.

Theise ND, Badve S, Saxena R, Henegariu O, Sell S, Crawford JM, Krause DS: Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology. 2000, 31: 235-240. 10.1002/hep.510310135.PubMed

145.

Owen M, Friedenstein AJ: Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found Symp. 1988, 136: 42-60.PubMed

146.

Haynesworth SE, Goshima J, Goldberg VM, Caplan AI: Characterization of cells with osteogenic potential from human marrow. Bone. 1992, 13: 81-88. 10.1016/8756-3282(92)90364-3.PubMed

147.

Jaiswal N, Haynesworth SE, Caplan AI, Bruder SP: Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem. 1997, 64: 295-312. 10.1002/(SICI)1097-4644(199702)64:2<295::AID-JCB12>3.3.CO;2-6.PubMed

148.

Majumdar MK, Thiede MA, Haynesworth SE, Bruder SP, Gerson SL: Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. J Hematother Stem Cell Res. 2000, 9: 841-848. 10.1089/152581600750062264.PubMed

149.

Qu-Petersen Z, Deasy B, Jankowski R, Ikezawa M, Cummins J, Pruchnic R, Mytinger J, Cao B, Gates C, Wernig A, Huard J: Identification of a novel population of muscle stem cells in mice: potential for muscle regeneration. J Cell Biol. 2002, 157: 851-864. 10.1083/jcb.200108150.PubMedCentralPubMed

150.

Gronthos S, Franklin DM, Leddy HA, Robey PG, Storms RW, Gimble JM: Surface protein characterization of human adipose tissue-derived stromal cells. J Cell Physiol. 2001, 189: 54-63. 10.1002/jcp.1138.PubMed

Titel: Adult mesenchymal stem cells and cell-based tissue engineering
verfasst von: Rocky S Tuan
Genevieve Boland
Richard Tuli
Publikationsdatum: 01.02.2002
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 1/2002
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar614

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