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Arthritis Research & Therapy

Erschienen in:

01.04.2000 | Review

Macrophages in rheumatoid arthritis

verfasst von: Raimund W Kinne, Rolf Bräuer, Bruno Stuhlmüller, Ernesta Palombo-Kinne, Gerd-R Burmester

Erschienen in: Arthritis Research & Therapy | Ausgabe 3/2000

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Abstract

The abundance and activation of macrophages in the inflamed synovial membrane/pannus significantly correlates with the severity of rheumatoid arthritis (RA). Although unlikely to be the 'initiators' of RA (if not as antigen-presenting cells in early disease), macrophages possess widespread pro-inflammatory, destructive, and remodeling capabilities that can critically contribute to acute and chronic disease. Also, activation of the monocytic lineage is not locally restricted, but extends to systemic parts of the mononuclear phagocyte system. Thus, selective counteraction of macrophage activation remains an efficacious approach to diminish local and systemic inflammation, as well as to prevent irreversible joint damage.

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Titel: Macrophages in rheumatoid arthritis
verfasst von: Raimund W Kinne
Rolf Bräuer
Bruno Stuhlmüller
Ernesta Palombo-Kinne
Gerd-R Burmester
Publikationsdatum: 01.04.2000
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 3/2000
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar86

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