nach oben

Breast Cancer Research

Erschienen in:

01.10.2013 | Viewpoint

Par-4 prevents breast cancer recurrence

verfasst von: Nikhil Hebbar, Tripti Shrestha-Bhattarai, Vivek M Rangnekar

Erschienen in: Breast Cancer Research | Ausgabe 5/2013

Einloggen, um Zugang zu erhalten

Abstract

Therapy resistance and disease recurrence are two of the most challenging aspects in breast cancer treatment. A recent article in Cancer Cell makes a significant contribution toward a better understanding of this therapeutic problem by establishing downregulation of the tumor suppressor Par-4 as the primary determinant of breast cancer recurrence. This viewpoint brings forth the importance of their findings and its implications on future research and therapy.

Guarneri V, Dieci MV, Conte P: Relapsed triple-negative breast cancer: challenges and treatment strategies. Drugs. 2013, 73: 1257-1265. 10.1007/s40265-013-0091-6.CrossRefPubMed

Theriault RL, Carlson RW, Allred C, Anderson BO, Burstein HJ, Edge SB, Farrar WB, Forero A, Giordano SH, Goldstein LJ, Gradishar WJ, Hayes DF, Hudis CA, Isakoff SJ, Ljung BM, Mankoff DA, Marcom PK, Mayer IA, McCormick B, Pierce LJ, Reed EC, Schwartzberg LS, Smith ML, Soliman H, Somlo G, Ward JH, Wolff AC, Zellars R, Shead DA, Kumar R: Breast cancer, version 3.2013. J Natl Compr Canc Netw. 2013, 11: 753-761.PubMedPubMedCentral

Siegel R, Naishadham D, Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 2013, 63: 11-30. 10.3322/caac.21166.CrossRefPubMed

Rea D, Tomlins A, Francis A: Time to stop operating on breast cancer patients with pathological complete response?. Eur J Surg Oncol. 2013, 39: 924-930. 10.1016/j.ejso.2013.06.005.CrossRefPubMed

Pritchard KI: Endocrine therapy: is the first generation of targeted drugs the last?. J Intern Med. 2013, 274: 144-152. 10.1111/joim.12065.CrossRefPubMed

Alvarez JV, Pan TC, Ruth J, Feng Y, Zhou A, Pant D, Grimley JS, Wandless TJ, Demichele A: I-SPY 1 TRIAL Investigators, Chodosh LA: Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy. Cancer Cell. 2013, 24: 30-44. 10.1016/j.ccr.2013.05.007.CrossRefPubMed

Hebbar N, Wang C, Rangnekar VM: Mechanisms of apoptosis by the tumor suppressor Par-4. J Cell Physiol. 2012, 227: 3715-3721. 10.1002/jcp.24098.CrossRefPubMedPubMedCentral

Méndez-López LF, Zapata-Benavides P, Zavala-Pompa A, Aguado-Barrera ME, Pacheco-Calleros J, Rodríguez-Padilla C, Cerda-Flores RM, Cortés-Gutiérrez EI, Dávila-Rodríguez MI: Immunohistochemical analysis of prostate apoptosis response-4 (Par-4) in Mexican women with breast cancer: a preliminary study. Arch Med Res. 2010, 41: 261-268. 10.1016/j.arcmed.2010.05.005.CrossRefPubMed

Nagai MA, Gerhard R, Salaorni S, Fregnani JH, Nonogaki S, Netto MM, Soares FA: Down-regulation of the candidate tumor suppressor gene PAR-4 is associated with poor prognosis in breast cancer. Int J Oncol. 2010, 37: 41-49.CrossRefPubMed

10.

Shrestha-Bhattarai T, Rangnekar VM: Cancer-selective apoptotic effects of extracellular and intracellular Par-4. Oncogene. 2010, 29: 3873-3880. 10.1038/onc.2010.141.CrossRefPubMed

11.

Pruitt K, Ulku AS, Frantz K, Rojas RJ, Muniz-Medina VM, Rangnekar VM, Der CJ, Shields JM: Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells. J Biol Chem. 2005, 280: 23363-23370. 10.1074/jbc.M503083200.CrossRefPubMed

12.

Ahmed MM, Sheldon D, Fruitwala MA, Venkatasubbarao K, Lee EY, Gupta S, Wood C, Mohiuddin M, Strodel WE: Downregulation of PAR-4, a pro-apoptotic gene, in pancreatic tumors harboring K-ras mutation. Int J Cancer. 2008, 122: 63-70. 10.1002/ijc.23019.CrossRefPubMed

13.

Lostumbo L, Carbine NE, Wallace J: Prophylactic mastectomy for the prevention of breast cancer. Cochrane Database Syst Rev. 2010, 11: CD002748

Titel: Par-4 prevents breast cancer recurrence
verfasst von: Nikhil Hebbar
Tripti Shrestha-Bhattarai
Vivek M Rangnekar
Publikationsdatum: 01.10.2013
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 5/2013
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr3562

Neu im Fachgebiet Onkologie

25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Par-4 prevents breast cancer recurrence

Abstract

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2013

Assessing tumor contrast in radiographically dense breast tissue using Diffuse Optical Spectroscopic Imaging (DOSI)

Decision aids for breast cancer chemoprevention

Mammary Carcinoma Cell Derived Cyclooxygenase 2 Suppresses Tumor Immune Surveillanceby Enhancing Intratumoral Immune Checkpoint Activity

Breast cancer receptor status and stage at diagnosis in over 1,200 consecutive public hospital patients in Soweto, South Africa: a case series

Phase I trial of the oral PARP inhibitor olaparib in combination with paclitaxel for first- or second-line treatment of patients with metastatic triple-negative breast cancer

Cancer stem cell markers are enriched in normal tissue adjacent to triple negative breast cancer and inversely correlated with DNA repair deficiency

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie