Erschienen in:
01.02.2002 | Letter
Expression profiling predicts outcome in breast cancer
verfasst von:
Laura J van 't Veer, Hongyue Dai, Marc J van de Vijver, Yudong D He, Augustinus AM Hart, René Bernards, Stephen H Friend
Erschienen in:
Breast Cancer Research
|
Ausgabe 1/2002
Einloggen, um Zugang zu erhalten
Excerpt
Gruvberger
et al. postulate, in their commentary [
1] published in this issue of
Breast Cancer Research, that our "prognostic gene set may not be broadly applicable to other breast tumor cohorts", and they suggest that "it may be important to define prognostic expression profiles separately in estrogen receptor (ER) positive and negative tumors". This is based on two observations derived from our gene expression profiling data in breast cancer [
2]: the overlap between reporter genes for prognosis and ER status, and Gruvberger
et al.'s inability to confirm the prognosis prediction using a nonoptimal selection of 58 of our 231 prognosis reporter genes. …