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Breast Cancer Research
Erschienen in: Breast Cancer Research 3/2003

01.06.2003 | Review

The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer

verfasst von: Elizabeth O Lillie, Leslie Bernstein, Giske Ursin

Erschienen in: Breast Cancer Research | Ausgabe 3/2003

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Abstract

Testosterone binds to the androgen receptor in target tissue to mediate its effects. Variations in testosterone levels and androgen receptor activity may play a role in the etiology of breast cancer. Here, we review the epidemiologic evidence linking endogenous testosterone to breast cancer risk. Paradoxically, results from observational studies that have examined polymorphisms in the androgen receptor suggest that the low-activity androgen receptor increases breast cancer risk. We review the quality of this evidence and conclude with a discussion of how the androgen receptor and testosterone results coincide.
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Metadaten
Titel
The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer
verfasst von
Elizabeth O Lillie
Leslie Bernstein
Giske Ursin
Publikationsdatum
01.06.2003
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 3/2003
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr593

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