Erschienen in:
01.08.2003 | Letter
Lack of evidence for an association of Epstein–Barr virus infection with breast carcinoma – another point of view
verfasst von:
María Victoria Preciado
Erschienen in:
Breast Cancer Research
|
Ausgabe 4/2003
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Excerpt
Herrmann and Niedobitek have recently ruled out the involvement of Epstein–Barr virus (EBV) in the pathogenesis of breast carcinomas [
1]. They looked for EBNA-1 (EBV nuclear antigen 1) and EBER (EBV-encoded small RNA) in 59 breast carcinoma biopsies. They stated that because the available antibodies to detect EBNA-1 usually produce only weak staining, a lack of EBNA-1 expression could not be taken as proof that the virus was absent and, besides, that this antibody could also cross-react with other proteins. Interestingly, they failed to find either specific or nonspecific staining among the 59 cases studied, and concluded that EBV was absent [
1]. …