Background
Methods
Study design and patient selection
Patient population
Patient and public involvement
Outcome and definition
Procedure
Data collection
Analysis
Results
Variable | Bloodstream infection (n = 25) | No bloodstream infection(n = 164) | P value* |
---|---|---|---|
Age, y (SD) [median] | 71.8 (15.8) [75.0] | 62.8 (20.0) [68.0] | 0.246 |
Male, n (%) | 12 (46) | 93 (57) | 0.582 |
CRP, mg/l [median, IQR] | 120.5 [93.8, 50.4–160.7] | 63.5 [40.4, 8.7–88.7] | 0.017 |
Total white cell count, cells/mm3 [median, IQR] | 11,360 [11,100, 8400-12,700] | 9901 [8900, 6700-12,000] | 0.009 |
Eosinophil count, cells/mm3 [median, IQR] | 32.0 [11.0, 0.00–38.4] | 115.1 [37.6, 0.00–100.3] | 0.741 |
Neutrophil count, cells/mm3 [median, IQR] | 10,141 [9601, 6969-11,842] | 7971 [7250, 4754-9964] | 0.075 |
qSOFA score 0–1 | 22 | 145 | 0.208 |
qSOFA score 2–3 | 3 | 19 | |
Chills, n (%) | 8 (32) | 34 (20) | 0.891 |
Variable | Cut-off value | AUROC (95% CI) | P value* |
---|---|---|---|
Eosinophil count | < 24.4 cells/mm3 | 0.648 (0.547–0.748)0.648 (0.557–0.743)** | 0.007 |
White cell count | > 10,950 cells/mm3 | 0.597 (0.472–0.723) | 0.185 |
Neutrophil count | > 9033 cells/mm3 | 0.638 (0.519–0.758) | 0.040 |
CRP, mg/l | > 4.89 mg/dl | 0.699 (0.597–0.802) | 0.001 |
qSOFA | 0.502 (0.433–0.572) | 0.952 | |
Chills | 0.556 (0.458–0.655) | 0.211 |
Model | AUROC (95% CI) | P value | IDI | P value | NRI | P value |
---|---|---|---|---|---|---|
Baseline variables* | 0.650 (0.551–0.749) | |||||
Baseline variables + CRP + neutrophil count | 0.729 (0.622–0.835) | 0.002** | 0.069** | 0.023** | 0.583** | 0.005** |
Baseline variables + CRP + neutrophil count + eosinopenia | 0.758 (0.664–0.853) 0.758 (0.667–0.845)**** | 0.048*** | 0.016*** | 0.284*** | 0.592*** | 0.003*** |