Background
Methods
Patients and samples
Immunohistochemistry
Quantification of PD-L1 expression in tumor cell membrane
Quantification of PD-L1 expression in tumor-infiltrating mononuclear cells
Statistical analysis
Results
Patients and tumor characteristics
Characteristic | Total (n = 47) No. of patients | % |
---|---|---|
Gender | ||
Male | 26 | 55.3 |
Female | 21 | 44.7 |
Stage | ||
I | 9 | 19.1 |
II | 18 | 38.3 |
III | 5 | 10.6 |
IV | 15 | 31.9 |
Histology | ||
adenoid cystic carcinoma | 25 | 40.4 |
mucoepidermoid carcinoma | 9 | 17.0 |
adenocarcinoma | 11 | 23.4 |
mucinous adenocarcinoma | 2 | 6.4 |
Recurrence or metastasis after surgery | ||
No | 31 | 66.0 |
Yes | 16 | 34.0 |
PD-L1 expression in tumor cells membrane | ||
< 5% (negative) | 23 | 48.9 |
≥ 5% (positive) | 24 | 51.1 |
PD-L1 expression in tumor-infiltrating mononuclear cells (TIMC) | ||
Score < 4 (negative) | 27 | 57.4 |
Score ≥ 4 (positive) | 20 | 42.6 |
Median | Min-max | |
Age (years) | 62.0 | 24–80 |
PD-L1 expression in tumor cells and clinico-pathological features
Characteristic | % Positive tumor cell membrane | p-value | ||
---|---|---|---|---|
< 5% (negative) (n = 23, 48.9%), n | 5% or more (positive) (n = 24, 51.1%), n | Total (n = 47)‚ n | ||
Gender | > 0.999 | |||
Male | 13 | 13 | 26 | |
Female | 10 | 21 | 21 | |
Age | > 0.999 | |||
65≥ | 13 | 12 | 25 | |
65< | 10 | 12 | 22 | |
Stage | 0.047 | |||
I + II | 17 | 10 | 27 | |
III + IV | 6 | 14 | 20 | |
Recurrence or metastasis after surgery | 0.028 | |||
No | 19 | 12 | 31 | |
Yes | 4 | 12 | 16 | |
Outcome | 0.002 | |||
Alive | 22 | 13 | 35 | |
Death | 1 | 11 | 12 |
PD-L1 expression in TIMCs and clinico-pathological features
Characteristic | % Positive tumor- infiltrating mononuclear cells | p-value | ||
---|---|---|---|---|
Score < 5 (low) (n = 27, 57.4%), n | Score ≥ 5 (high) (n = 20, 42.6%), n | Total (n = 47)‚ n | ||
Gender | > 0.999 | |||
Male | 15 | 11 | 26 | |
Female | 12 | 9 | 21 | |
Age | 0.769 | |||
65≥ | 14 | 11 | 25 | |
65< | 13 | 9 | 22 | |
Stage | 0.073 | |||
I + II | 19 | 8 | 27 | |
III + IV | 8 | 12 | 20 | |
Recurrence or metastasis after surgery | 0.011 | |||
No | 19 | 12 | 31 | |
Yes | 8 | 8 | 16 | |
Outcome | 0.049 | |||
Alive | 23 | 12 | 35 | |
Death | 4 | 8 | 12 |