Previous reports about laparoscopic total pelvic exenteration (LTPE) are still limited. In the present study, we described our single-center experience of the initial 11 cases.
Methods
Between April 2011 and September 2015, eight males and three females diagnosed as pelvic malignancies underwent LTPE by the same operation team. We retrospectively collected all cases’ parameters about surgical technique. Thirty-seven patients who received open surgery were also retrospectively collected. A comparison between LTPE and open surgery was performed to evaluate the feasibility and safety of LTPE.
Results
Eleven cases successfully underwent the LTPE without any intraoperative complication. No open conversion was required. Eight patients underwent Bricker’s procedure. Three patients were performed with the cutaneous ureterostomy. Anus preservation operation was performed in three patients. Compared with open surgery, LTPE had longer mean operative time (565.2 vs 468.2 min, p = 0.004) but less mean blood loss (547.3 vs 1033.0 ml, p < 0.001) and shorter postoperative hospitalization time (15.3 vs 22.4 days, p = 0.004). One patient died of pulmonary embolism in the 7th month of follow-up time. One patient died of recurrence in the 12th month of follow-up time. Nine patients are still alive without recurrence and metastasis. The mean follow-up time was 11.1 months.
Conclusions
The technique of LTPE seems to be feasible and safe in the treatment of carefully selected patients of pelvic malignancies. LTPE can also decrease the blood loss, the recovery time, and the hospital stay. But the oncological safety and long-term outcome of LTPE still need to be explored.
Hinweise
Kunlin Yang and Lin Cai contributed equally to this work.
Competing interests
All authors declare that they have no competing interests.
Authors’ contributions
KY and LC collected surgical data, reviewed related literatures, and drafted the article. KY processed the data and the images. JT and XL are corresponding authors who designed the study and revised the article. LY, ZZ, CZ, XW, JT, XL, ZH and LZ were a surgical team. All authors read and approved the final manuscript.
Abkürzungen
LTPE
laparoscopic total pelvic exenteration
TPE
total pelvic exenteration
UD
urinary diversion
IC
ileal conduit
DBWC
double-barreled wet colostomy
CU
cutaneous ureterostomy
UTI
urinary tract infection
DVT
deep vein thrombosis
Background
Total pelvic exenteration (TPE) is a surgical procedure that refers to a radical resection of the rectum, bladder, and reproductive organs. In 1948, it was first described by Brunschwig [1] as a palliative way for the terminal stages of the advanced pelvic malignancies. Classical open TPE has a high rate of postoperative morbidity but a relatively low mortality [2]. The open procedure is nowadays mainly used in the treatment of pelvic malignancies, such as locally advanced, recurrent cervical and colorectal cancer. It improves the long-term survival of patients with primary advanced rectal cancer [2].
In 2003, Pomel reported the first case of the laparoscopic total pelvic exenteration (LTPE) to treat the cervical cancer relapse [3]. From then, the LTPE was successively performed by some experienced laparoscopic centers. A cohort study has proved that the laparoscopic procedure is feasible and curative to selected patients [4]. From 2011, we began to carry out LTPE in our hospital by multidisciplinary cooperation.
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We have searched for almost all literature about LTPE in the past decade. The articles about this procedure are still limited. In this study, we introduced our experience of LTPE with the initial eleven cases’ results.
Methods
Eight males and three females were diagnosed as pelvic malignancies by biopsy and were selected to receive LTPE from April 2011 to September 2015. The selected criteria included the following: preoperative pathological diagnosis of pelvic malignancies (e.g., colorectal cancer, cervical cancer, or prostate cancer.), no evidence of distant metastasis, the possibility of complete resection, no surgical contraindication, and sufficient understanding about this procedure’s risk by the patient. The surgery was performed by the same surgical team. All cases’ demographic data, preoperative parameters (see Table 1), surgical parameters, and follow-up information about LTPE were retrospectively collected. The study was approved by the institutional review board from Peking University First Hospital.
Table 1
Patient demographics and preoperative parameters
Patient no.
Gender
Age
BMI
Preoperative diagnosis
Preoperative complications
nCRT
ASA
1
Male
57
25.3
Bladder transitional cell carcinoma (grade 3) and rectal adenocarcinoma
Lower gastrointestinal bleeding
No
2
2
Male
62
23.5
Prostate sarcoma (recurrent)
Difficult defecation
No
2
3
Male
58
19.9
Sigmoid adenocarcinoma (bladder invasion)
Rectovesical fistula Colonic obstruction
No
2
4
Male
62
23.3
Rectal adenocarcinoma (bladder invasion)
Rectovesical fistula
No
2
5
Male
75
25.9
Bladder transitional cell carcinoma (grade 2) and rectal adenocarcinoma
Acute renal insufficiency Hypertension
No
2
6
Female
69
21.7
Sigmoid adenocarcinoma (bladder and uterus invasion)
Hypertension
No
2
7
Female
55
23.4
Sigmoid adenocarcinoma (bladder invasion)
Rectovesical fistula
No
2
8
Male
44
24.7
Rectal adenocarcinoma (bladder invasion)
Renal calculi
No
2
9
Female
65
22.3
Sigmoid adenocarcinoma (bladder invasion)
Diabetes mellitus
No
2
10
Male
71
25.1
Sigmoid adenocarcinoma (bladder invasion)
Benign prostatic hyperplasia colonic obstruction
No
2
11
Male
30
20.2
Rectal adenocarcinoma (bladder invasion)
Rectal obstruction
No
2
Mean
58.9 (median, 62)
23.2
nCRT neoadjuvant chemoradiotherapy, ASA American Standards Association, BMI body mass index
The following criteria for preoperative preparation were listed:
1.
All patients had confirmed diagnosis with a preoperative biopsy.
2.
Ultrasonography, enhanced computerized tomography scan or magnetic resonance imaging of the abdomen and pelvis, should be done to stage the disease and determine the extent of the tumor (see Fig. 2a–d, the bladder was invaded by tumor).
3.
Preoperative standard bowel preparation in no ileus patient.
4.
Evaluation of the physical condition to exclude any preoperative contraindication.
5.
Informed contents were accepted and signed off by all patients and their family members.
To evaluate the efficiency and safety of LTPE, we also retrospectively collected the surgical parameters of 37 patients who received classical TPE from 2011 to 2015 to perform a comparison between LTPE and open surgery. The classical TPE needed a longitudinal incision (at least 15 cm) on the abdominal midline.
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Surgical technique
Epidural anesthesia was applied in combination with general anesthesia. All patients were equipped with patient-controlled analgesia after surgery.
After anesthesia, patient was placed in Lloyd-Davis position. Pneumoperitoneum was established by open technique from the umbilicus. The positions of ports were modified from the Puntambekar’s way [5] (see Fig. 1a). A Trendelenburg (30°) position and right lateral tilt (30°) were maintained during the dissection of the sigmoid and rectum.
Fig. 1
Trocar distribution and the situation of the stoma. a Trocar distribution; b the ileal bladder stoma and the sigmoid stoma of case 3; c the ileal bladder stoma of case 4 (the surgical scar is relatively small)
×
The procedure began with the dissection of posterior wall and lateral walls of the rectum. The right lateral peritoneum of the rectosigmoid was incised with the Harmonic Ace (Ethicon Endo-Surgery, Inc., Cincinnati, OH) by the middle enter approach. After entering to the posterior space of the rectosigmoid, the dissection was continued until to the root of inferior mesenteric artery. The inferior mesenteric vessels were ligated and cut. The left lateral peritoneum was also incised to meet with right lateral peritoneum. The retrorectal space was dissected to the level of levator ani muscle, and the lateral walls of the rectum were freed.
The tissues around the bladder and the ureter were dissected. Then, the bladder and the ureter were exposed. Seminiferous duct and superior vesical artery were bound with Hem-o-lok and cut with Harmonic Ace (Ethicon Endo-Surgery, Inc., Cincinnati, OH), following the bladder, lateral ligaments were cut with a Ligasure (Ligasure Vessel Sealing System: Valleylab, a division of Tyco Healthcare Group LP, Boulder, CO). The dissection should not be stopped until reaching the level of levator ani muscle. The urachus was cut off and the cave of Retzius was entered. The puboprostatic ligament was cut. After the dorsal vein complex was ligated and cut, the urethra and the ureter were cut with Harmonic Ace (Ethicon Endo-Surgery, Inc., Cincinnati, OH). The sigmoid was cut with the Endo-GIA.
Anus was sutured, and a new fusiform incision around the anus was performed. Ischiorectal fossa was dissected to the level of levator ani muscle. The specimen was removed (see Fig. 2e–h), and the fusiform incision was sutured. Further surgery needed a 4-cm vertical umbilical incision to perform the urinary diversion (like Bricker’s operation, cutaneous ureterostomy) and sigmoidostomy (see Fig. 1c).
Fig. 2
The computerized tomography (CT) image before surgery and surgical specimens of case 3 and case 4. a, b CT image of case 3, c, d CT image of case 4; the red arrows show the bladders are invaded by tumor; the white arrows show the air bubbles in the bladder because of rectovesical fistula; e, f the specimen of case 3, g, h the specimen of case 4 (the black arrows show the same results to the radiographic results)
×
If the patient was suitable for anus preservation operation, the operation was performed till the urethra and the ureter were cut according to the above steps. Then, the anterior rectal wall was exposed. After mesorectum was dissected, the rectum was cut with the Endo-GIA at about 5 cm away to the inferior margin of the tumor. A 4-cm vertical umbilical incision was performed. The bladder and rectal tumor was brought out from the incision, and the sigmoid was cut at about 10 cm away to the superior margin of the tumor. A string suture was performed at the end of the colon, and the anvil of a circular stapler was placed into it. The Bricker’s operation or cutaneous ureterostomy could be completed from the vertical incision (see Fig. 1b, c). Pneumoperitoneum was rebuilt after the incision was closed. At last, the head of the stapler was introduced from the anus into the distal stump. A colorectal anastomosis was successfully performed.
All patients routinely received the pelvic lymphadenectomy.
Postoperative management
The drain was removed depending on the drainage volume. The stomas should be kept flowing well. The patients diagnosed with metastatic lymph nodes by the pathological examination all received the adjuvant chemotherapy.
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Results
Surgery was successfully performed in all patients. Eight patients underwent Bricker’s procedure after the bladder was resected. The cutaneous ureterostomy was performed in case 2, case 10, and case 11. Anus preservation operation was performed in case 4, case 7, and case 9. The details about operation parameters were shown in Table 2.
Table 2
Operative parameters and follow-up results
Patient no.
Radical
Construction type
Operative time/min
Blood loss/ml
Pathological stage
PRM
Postoperative hospitalization/day
Postoperative complication (<30 days after surgery)
Postoperative complication (>30 days after surgery)
Follow-up time/month
pCRT
Outcome
1
Yes
Bricker’s procedure and sigmoidostomy (Miles procedure)
620
500
Rectum pT2N0M0 and Bladder pT2bN0M0
Negative
23
No
DVT (7 months)
7
No
Died of non-oncological disease (PE)
2
Yes
Cutaneous ureterostomy and sigmoidostomy (Miles procedure)
415
600
Prostate pT4N0M0
Negative
10
No
UTI (6 months)
12
No
Died of oncological recurrence
3
Yes
Bricker’s procedure and sigmoidostomy (Hartmann procedure)
574
420
Sigmoid pT3 N1M0
Negative
15
No
No
24
XELOX
Alive
4
Yes
Bricker’s procedure and anus preservation operation
616
650
Rectum pT4b N1M0
Negative
11
No
No
22
XELOX
Alive
5
Yes
Bricker’s procedure and sigmoidostomy (Hartmann procedure)
690
800
Rectum pT3N0M0 Bladder pT1N0M0
Negative
26
No
No
14
No
Alive
6
Yes
Bricker’s procedure and sigmoidostomy (Hartmann procedure)
660
400
Sigmoid pT4b N1M0
Negative
14
No
No
14
XELOX
Alive
7
Yes
Bricker’s procedure and anus preservation operation
515
600
Sigmoid pT4b N0M0
Negative
9
No
No
10
XELOX
Alive
8
Yes
Bricker’s procedure and sigmoidostomy (Miles procedure)
520
850
Rectum pT4b N0M0
Negative
16
No
No
7
No
Alive
9
Yes
Bricker’s procedure and anus preservation operation
610
400
Sigmoid pT4b N0M0
Negative
13
No
No
5
No
Alive
10
Yes
Cutaneous ureterostomy and sigmoidostomy (Hartmann procedure)
450
200
Sigmoid pT4b N1M0
Negative
11
No
UTI
5
No
Alive
11
Yes
Cutaneous ureterostomy and sigmoidostomy (Miles procedure)
547
600
Rectum pT4b N1M0
Negative
20
Ileus
Ileus
2
XELOX
Alive
Mean
565.2
547.3
15.3
11.1
pCRT postdischarge chemoradiotherapy, XELOX capecitabine + oxaliplatin, PE pulmonary embolism, PRM pathological resection margin, DVT deep vein thrombosis
The comparison between LTPE and open surgery was shown in Table 3. We could find that there were no differences in gender and age between two groups. But it was quite clear that LTPE had longer mean operative time (565.2 vs 468.2 min, p = 0.004), less mean blood loss (547.3 vs 1033.0 min, p < 0.001), and shorter mean postoperative hospitalization time (15.3 vs 22.4 days, p = 0.004).
Table 3
Comparison between LTPE and open surgery
LTPE
Open surgery
p
Gender, (male/female)/n
8/3
20/17
0.60
Median age, range/year
62 (30–75)
55 (35–80)
0.53
Mean operative time ± SD, range/minute
565.2 ± 81.4 (415–690)
468.2 ± 51.8 (360–560)
0.004
Mean blood loss ± SD, range/ml
547.3 ± 180.1 (200–850)
1033.0 ± 284.6 (670–2000)
<0.001
Mean postoperative hospitalization ± SD, range/day
15.3 ± 5.3 (9–23)
22.4 ± 9.0 (10–45)
0.004
LTPE laparoscopic total pelvic exenteration, SD standard deviation
The mean follow-up time was 11.1 months. Case 1 died of pulmonary embolism in the 7th month of follow-up time. Case 2 died of oncological recurrence and metastasis in the 12th month of follow-up time. Case 3 to case 11 were still alive without indication of recurrence and metastasis when followed up. Case 11 suffered from ileus after surgery. After conservative treatment, the ileus was relieved without surgical intervention. Five patients received adjuvant chemotherapy of XELOX regiment (Oxaliplatin, 130 mg/m2, IV over 2 h, day 1 plus capecitabine, 850–1000 mg/m2, twice daily, PO, for 14 days; repeat every 3 weeks) 3 weeks after hospital discharge.
Discussion
TPE has become a major surgical technique widely used for curative resection of locally advanced or recurrent pelvic malignancies since the 1940s. The classical TPE is open surgery which has a high rate of postoperative complication but relatively low surgical mortality. With the improvement of surgical techniques, the overall major morbidity rate after TPE is still up to 75 % (13 to 75 %) in previous literature [6‐9], but the mortality has decreased from rates up to 33 % [10‐14] down to rates less than 10 % (0 to 10 %) [15‐17].
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The emergence of laparoscopic surgery is an important milestone of the modern surgery. This revolution means the arrival of the minimal invasive surgery. Compared with open procedure, less intraoperative blood loss, less postoperative pain, and shorter hospital stay are the outstanding advantages of the laparoscopic procedure. Previously, the oncological outcome of the laparoscopic surgery was not acceptable, and the resection of the tumors was considered incomplete due to its small operative space. But in a randomized trail of 209 cases of colonic adenocarcinoma, the results showed that laparoscopy-assisted colectomy was more effective than open colectomy for treatment of colon cancer in terms of morbidity, hospital stay, tumor recurrence, and cancer-related survival [18]. Many other published studies have also proved the oncological safety of laparoscopic procedure [19‐22]. With the advancement of technology and surgical skills, the laparoscopy is now widely used in the treatment of gynecological, colonic, and prostatic cancer.
In 2003, Pomel et al. reported the first case of LTPE with a cervical cancer relapse and showed the feasibility and safety of the procedure [3]. Subsequently, Lin et al. reported a case of laparoscopy-assisted transvaginal TPE [23]. In 2009, a robotic-assisted TPE was first reported by Peter in USA [24]. In 2011, an entirely robotic total pelvic exenteration and extended lymphadenectomy for recurrent endometrial cancer was reported by Vasilescu et al. [25]. Among the published literature, we found that 22 cases of different kinds of pelvic malignancies underwent LTPE in several oncological institutions around the world in the last decade (see Table 4) [3, 5, 23‐31]. At present, there is still no large sample report about the long-term outcome of LTPE.
Table 4
Previous reports of laparoscopic total pelvic exenteration
UD urinary diversion, NS not stated, UTI urinary tract infection, SSI surgical site infection, US ureterosigmoidostomy, CRAF colorectal anastomosis fistula, nCRT neoadjuvant chemoradiotherapy, AMI acute myocardial infarction
Previous reports show that mean operative time of LTPE is ranging from 230 up to 831 min, and mean postoperative hospitalization stay varies from 3.5 to 29 days. In our series, mean operative time and mean hospital stay are similar to others, respectively 565.2 min and 15.3 days. But both parameters are much shorter in Indian study than other studies. It may be the result of different surgical techniques and different health policies. In addition, all the cases were female patients whose anatomy is relatively simple in Indian study. The hospital stay is also closely associated with the postoperative complications. The mean estimated blood loss of our study is obviously reduced when patients underwent laparoscopic approach, ranging from 200 to 850 ml, compared to classical open approach, ranging from 1000 to 7550 ml [6, 32].
TPE is one of the most spoiling surgeries, requiring en bloc resection of the pelvic organs. More than half of the patients underwent the TPE suffered from different kinds of major or minor complications associated with urinary diversion and bowel reconstruction [33], especially previous radiotherapy before surgery [34]. We hope that the laparoscopic approach can play an important role in reducing the morbidity rate. But dramatically, in a cohort study, it did not work when compared to open approach [4]. Few data were reported. More scientific studies are still needed.
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The most commonly used form of urinary diversion (UD) for pelvic exentenration is Bricker’s ileal conduit (IC) described first in 1950 [35]. IC has been the safest and easiest way for urinary diversion while decreasing the morbidity rate. The advantage of this form is to overcome the high complication rate caused by primary wet colostomy. Primary wet colostomy has been abandoned because of the 9 % high mortality rate of complications [36], like electrolyte abnormalities, ascending pyelonephritis, and malodorous watery diarrhea. In 1989, Carter et al. [37] first described a modified wet colostomy technique called double-barreled wet colostomy (DBWC). In 2010, Golda et al. [38] reported their single institution experience about DBWC drawing a conclusion that DBWC is an alternative option for patients after TPE when reconstruction of the fecal and urinary streams is not possible. Compared with traditional IC, DBWC provides a single stoma allowing for easier maintenance and not increasing the morbidity rates. Chokshi et al. [39] concluded the similar result with Golda’s study that DBWC is able to provide a safe and feasible technique for urinary and fecal diversion.
In 11 cases of our study, eight patients underwent Bricker’s IC and three patients received cutaneous ureterostomy (CU). Because three patients were terminal, CU was performed as a temporary diversion. We can find that the operative time of case 2 and case 10 was obviously much shorter than others. The procedure of CU is simple and no need for bowel resection and anastomosis. CU is just widely used for abdominal wall diversion in children but rarely done in adult. The procedure is only used for diversion in terminal stage or when bowel resection cannot be performed [40].
For fecal diversion, eight patients underwent the sigmoidostomy and three patients underwent anus preservation operation. In case 1, the distance of rectal tumor from the anus verge was 3 cm, so a sigmoidostomy (Miles procedure) was performed. But in case 4, patient received the anus preservation operation as the distance of tumor from the anus verge was 10 cm (>5 cm). This situation was similar to case 7 and case 9. For case 2, case 3, case 5, case 6, and case 10, Hartmann’s procedure was performed in consideration of the possible subsequent radiotherapy or chemotherapy and the high risk of bowel anastomosis’ leakage.
Traditionally, open TPE is associated with high complications rates of UD and fecal diversion. Complication rate directly related to UD after laparoscopic approach is reported more than 50 % [4]. According to both open approach and laparoscopic approach, the most common complication is infection, especially urinary tract infection (UTI, 21–36 %) [4], followed by ureteral stricture (5–22.1 %) [4], ureteral/anastomosis leaks (8–14 %) [4], urinary stomal stricture (4–25 %) [4], and stone formation (2–18 %) [4]. In our study, UTI occurred in two patients (2/7, 28.6 %) more than 30 days after operation. Deep vein thrombosis (DVT) occurred in one patient, and the patient died of pulmonary embolism; the others were well. The patient suffered increased stool frequency at 2 months after anus preservation operation. It was still unknown whether LTPE can really reduce the high morbidity rates or not. More contrast studies about morbidity rate of TPE between open approach and laparoscopic approach need to be done. It is proved, in this study, that the laparoscopic approach is advantageous in decreasing the recovery time, blood loss, and hospital stay.
In this study, all patients did not received the preoperative chemotherapy and radiotherapy. For case 3, case 4, case 6, and case 11, because the pathologic staging information showed positive regional lymph nodes, XELOX regimen as postoperative chemotherapy was recommended to patients. Case 10 refused to accept postoperative chemotherapy. No complications-related chemotherapy occurred. By now, no evidences of recurrence and metastasis have been found in these patients.
In reported literature, more than half of cases were females who underwent the LTPE because of cervical cancer. But in our study, only three cases were females. Because the physiology and pelvic anatomy of the male are different from those of the female, we do not know whether the gender is an influencing factor to the LTPE or not. Larger sample and gender-related analysis will be needed in further study.
Although the oncological safety of the laparoscopic approach has been accepted in treating many oncological diseases, the oncological safety of LTPE is still indeterminate as follow-up time was very limited; no series reach 5 years of follow-up time.
We believe that the selection of patients is crucial for a satisfactory oncological result. Patients’ compliance and patients’ education regarding the LTPE are also important. The patient should know this surgical approach means the obvious decrease of the quality of life. The multidisciplinary team is an important guaranty of the successful LTPE. Based on our experiences, at least the urologist, the colorectal specialist and special postoperative nursing group are needed.
Although in our study, the number of cases is maybe the largest compared with previous published articles, 11 was far from enough for a persuasive study. In addition, this was a retrospective study which was another limitation. A randomized control trial will be needed in our later work.
Conclusions
In conclusion, with the initial experience of 11 cases of LTPE, we think that the technique of LTPE seems to be a feasible and safe procedure in the treatment of carefully selected patients of pelvic malignancies. LTPE is also advantageous in decreasing blood loss, recovery time, and hospital stay. But the oncological safety and long-term outcome of LTPE still need to be explored in the future.
Consent
Written informed consent was obtained from the patient for the publication of this report and any accompanying images.
Acknowledgements
We are grateful to He Wang who helped us in the medical image management and to all the colleagues who helped in the preparation of this paper. This work was also supported by grants from the Natural Science Foundation of China (81272710).
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Competing interests
All authors declare that they have no competing interests.
Authors’ contributions
KY and LC collected surgical data, reviewed related literatures, and drafted the article. KY processed the data and the images. JT and XL are corresponding authors who designed the study and revised the article. LY, ZZ, CZ, XW, JT, XL, ZH and LZ were a surgical team. All authors read and approved the final manuscript.
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