Erratum
The original article [1] contained an error whereby the formatting of Table 1 was not presented correctly; this error has now been corrected.
Table 1
Clinical and molecular characteristics of TCGA AML patients according to the mutation and/or copy number variation status of genes encoding m6A regulatory enzymes
Mutation and/or CNV | CNV onlya
| Mutation | |||||||
|---|---|---|---|---|---|---|---|---|---|
Yes (n = 23) | No (n = 168) |
P
| Yes (n = 18) | No (n = 168) |
P
| Yes (n = 5) | No (n = 186) |
P
| |
Age | 0.083 | 0.193 | 0.205 | ||||||
Median (range) | 65 (18–81) | 57 (21–88) | 62.5 (18–81) | 57 (21–88) | 65 (45–76) | 57.5 (18–88) | |||
Sex, no. (%) | 0.123 | 0.321 | 0.376 | ||||||
Male | 16 (8.4) | 87 (45.5) | 12 (6.5) | 87 (46.8) | 4 (2.1) | 99 (51.8) | |||
Female | 7 (3.7) | 81 (42.4) | 6 (3.2) | 81 (43.5) | 1 (0.5) | 87 (45.5) | |||
BM blast | 0.072 |
0.038
| 0.915 | ||||||
Median % (range) | 60 (30–97) | 73 (30–100) | 54 (30–97) | 73 (30–100) | 75 (33–90) | 72 (30–100) | |||
WBC, ×103/mm3
| 0.084 |
0.047
| 0.889 | ||||||
Median (range) | 5.4 (0.7–202.7) | 17.5 (0.4–298.4) | 5.2 (2.3–101.3) | 17.45 (0.4–298.4) | 14.5 (2.3–101.3) | 15.6 (0.4–298.4) | |||
Cytogenetic risk, no. (%) |
<0.0001
|
<0.0001
| 0.483 | ||||||
Favorable | 0 (0) | 37 (19.4) | 0 (0) | 37 (19.9) | 0 (0) | 37 (19.4) | |||
Intermediate | 4 (2.1) | 105 (55) | 1 (0.5) | 105 (56.5) | 3 (1.6) | 106 (55.5) | |||
Unfavorable | 19 (9.9) | 21 (11) | 17 (9.1) | 21 (11.3) | 2 (1) | 38 (19.9) | |||
Missing data | 0 (0) | 5 (2.6) | 0 (0) | 5 (2.6) | 0 (0) | 5 (2.6) | |||
Mutation, no./total no. (%) | |||||||||
FLT3
| 1/23 (4.3) | 53/168 (31.5) |
0.005
| 0/18 (0) | 53/168 (31.5) |
0.002
| 1/5 (20) | 53/186 (28.4) | 1.000 |
NPM1
| 1/23 (4.3) | 51/168 (30) |
0.006
| 0/18 (0) | 51/168 (30.3) |
0.004
| 1/5 (20) | 51/186 (27.4) | 1.000 |
DNMT3A
| 4/23 (17.4) | 43/168 (25.6) | 0.453 | 2/18 (11.1) | 43/168 (25.6) | 0.249 | 2/5 (40) | 45/186 (24.2) | 0.598 |
IDH1 or IDH2
| 1/23 (4.3) | 34/168 (20.2) | 0.084 | 0/18 (0) | 34/168 (20.2) |
0.048
| 1/5 (20) | 34/186 (18.3) | 1.000 |
NRAS or KRAS
| 3/23 (13) | 20/168 (11.9) | 0.744 | 3/18 (16.7) | 20/168 (11.9) | 0.471 | 0/5 (0) | 23/186 (12.4) | 1.000 |
RUNX1
| 2/23 (8.7) | 17/168 (10.1) | 1.000 | 0/18 (0) | 17/168 (10.1) | 0.380 | 2/5 (40) | 17/186 (9.1) | 0.078 |
TET2
| 1/23 (4.3) | 15/168 (8.9) | 0.698 | 1/18(5.6) | 15/168 (8.9) | 1.000 | 0/5 (0) | 16/186 (8.6) | 1.000 |
TP53
| 15/23 (65.2) | 1/168 (0.6) |
<0.0001
| 13/18 (72.2) | 1/168 (0.6) |
<0.0001
| 2/5 (40) | 14/186 (7.5) | 0.057 |
CEBPA
| 2/23 (8.7) | 10/168 (6.0) | 0.641 | 2/18 (11.1) | 10/168 (6.0) | 0.327 | 0/5 (0) | 12/186 (6.5) | 1.000 |
WT1
| 0/23 (0) | 12/168 (7.1) | 0.366 | 0/18 (0) | 12/168 (7.1) | 0.610 | 0/5 (0) | 12/186 (6.5) | 1.000 |
PTPN11
| 2/23 (8.7) | 6/168 (3.6) | 0.248 | 2/18 (11.1) | 6/168 (3.6) | 0.175 | 0/5 (0) | 8/186 (4.3) | 1.000 |
KIT
| 1/23 (4.3) | 6/168 (3.6) | 0.599 | 0/18 (20) | 6/168 (3.6) | 1.000 | 1/5 (20) | 6/186 (3.2) | 0.172 |
Furthermore, the error was mistakenly carried forward by the production team handling this article, and thus was not the fault of the authors.
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