Correction: Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
verfasst von:
Yulin Peng, Yan Wang, Ning Tang, Dongdong Sun, Yulong Lan, Zhenlong Yu, Xinyu Zhao, Lei Feng, Baojing Zhang, Lingling Jin, Fabiao Yu, Xiaochi Ma, Chuanzhu Lv
Following publication of the original article [1], errors were found in Figs. 6 and 8. The band of β-actin in Fig. 6B (Basal) and the band of CD31 in Fig. 8F were mistakenly uploaded.
The corrected figures are provided below:
Fig. 6
Effect of Andro on VEGF-induced angiogenesis. a HUVECs were exposed to Andro at the indicated doses, and viability was measured by CCK-8 assay. Data were represented as percentage of vehicle-treated control. b The expression level of COX-2 protein was analyzed by Western blot HUVECs treated with the indicated doses of Andro for 48 h, with or without VEGF induction. c-d Effects of Andro on tube formation on Matrigel c at 6 h (Original magnifcation, 50 ×), and sprouting from modifed human endothelial cell spheroids d at 24 h (Original magnifcation, 200 ×). Experiments were performed with or without VEGF and indicated Andro doses. (##p < 0.01, VEGF-treated group vs. Solvent; *P < 0.05, **P < 0.01, Andro treatment vs vehicle control groups)
Fig. 8
Effect of Andro on tumor growth and tumor angiogenesis in a breast cancer mouse model. An orthotopic mouse model of human breast cancer MDA-MB-231 cells was used to evaluate the anti-tumor effect of Andro. The tumor pictures (a), tumor volumes (b) and total weights (c) were measured. d The expressions of COX-2 and CD31 in tumor samples were analyzed by immunohistochemistry and cofocol immunofluorescence, respectively. e The quantitative analysis of relative COX-2 expression and microvessel number were also performed. f The expression of COX-2 and CD31 proteins in tumor tissues was analyzed by Western blot. Data were represented as the mean ± S.D. (*P < 0.05, **P < 0.01, Andro treatment vs vehicle control groups, N = 5 mice/group. Magnification, 200 ×)
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The corrections do not affect the overall result, discussion, or conclusion of the article.
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Correction: Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
verfasst von
Yulin Peng Yan Wang Ning Tang Dongdong Sun Yulong Lan Zhenlong Yu Xinyu Zhao Lei Feng Baojing Zhang Lingling Jin Fabiao Yu Xiaochi Ma Chuanzhu Lv
Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.
Das Risiko für Rezidiv oder Tod von Patienten und Patientinnen mit reseziertem ALK-positivem NSCLC ist unter einer adjuvanten Therapie mit dem Tyrosinkinase-Inhibitor Alectinib signifikant geringer als unter platinbasierter Chemotherapie.
Patienten, die zur Behandlung ihres Prostatakarzinoms eine Androgendeprivationstherapie erhalten, entwickeln nicht selten eine Anämie. Wer ältere Patienten internistisch mitbetreut, sollte auf diese Nebenwirkung achten.
Müssen sich Schwangere einer Krebstherapie unterziehen, rufen Immuncheckpointinhibitoren offenbar nicht mehr unerwünschte Wirkungen hervor als andere Mittel gegen Krebs.
Update Onkologie
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