Ausgabe 1/2023
Inhalt (347 Artikel)
Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development
Lixia Gao, Fan Yang, Dianyong Tang, Zhigang Xu, Yan Tang, Donglin Yang, Deping Sun, Zhongzhu Chen, Yong Teng
PCSK9 facilitates melanoma pathogenesis via a network regulating tumor immunity
Yan Gu, Xiaozeng Lin, Ying Dong, Geoffrey Wood, Nabil G. Seidah, Geoff Werstuck, Pierre Major, Michael Bonert, Anil Kapoor, Damu Tang
S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma
Xingtong Wang, Wei Guo, Xiaoju Shi, Yujia Chen, Youxi Yu, Beibei Du, Min Tan, Li Tong, Anna Wang, Xianying Yin, Jing Guo, Robert C. Martin, Ou Bai, Yan Li
Patterns of toxicity burden for FDA-approved immune checkpoint inhibitors in the United States
Fan Yang, Chloe Shay, Marin Abousaud, Chris Tang, Yamin Li, Zhaohui Qin, Nabil F. Saba, Yong Teng
KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element-binding protein 2
Hui Zhou, Junru Chen, Mingjie Fan, Huajian Cai, Yufei Dong, Yue Qiu, Qianqian Zhuang, Zhaoying Lei, Mengyao Li, Xue Ding, Peng Yan, Aifu Lin, Shusen Zheng, Qingfeng Yan
Targeting fatty acid synthase modulates sensitivity of hepatocellular carcinoma to sorafenib via ferroptosis
Yan Li, Wenjuan Yang, Yuanyuan Zheng, Weiqi Dai, Jie Ji, Liwei Wu, Ziqi Cheng, Jie Zhang, Jingjing Li, Xuanfu Xu, Jianye Wu, Mingwei Yang, Jiao Feng, Chuanyong Guo
BETi enhance ATGL expression and its lipase activity to exert their antitumoral effects in triple-negative breast cancer (TNBC) cells
Teresa Rossi, Raffaella Zamponi, Mattea Chirico, Maria Elena Pisanu, Egidio Iorio, Federica Torricelli, Mila Gugnoni, Alessia Ciarrocchi, Mariaelena Pistoni
“Proteotranscriptomic analysis of advanced colorectal cancer patient derived organoids for drug sensitivity prediction”
Federica Papaccio, Blanca García-Mico, Francisco Gimeno-Valiente, Manuel Cabeza-Segura, Valentina Gambardella, María Fernanda Gutiérrez-Bravo, Clara Alfaro-Cervelló, Carolina Martinez-Ciarpaglini, Pilar Rentero-Garrido, Sheila Zúñiga-Trejos, Juan Antonio Carbonell-Asins, Tania Fleitas, Susana Roselló, Marisol Huerta, Manuel M. Sánchez del Pino, Luís Sabater, Desamparados Roda, Noelia Tarazona, Andrés Cervantes, Josefa Castillo
Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression
Min Deng, Long Zhang, Wenying Zheng, Jiale Chen, Nan Du, Meiqi Li, Weiqing Chen, Yonghong Huang, Ning Zeng, Yuanbin Song, Yongming Chen
The N6-methyladenosine METTL3 regulates tumorigenesis and glycolysis by mediating m6A methylation of the tumor suppressor LATS1 in breast cancer
Youqin Xu, Mu Song, Ziyang Hong, Wancheng Chen, Qianbing Zhang, Jianlong Zhou, Chao Yang, Zilong He, Juanjuan Yu, Xiaolin Peng, Qiuhong Zhu, Shaotian Li, Kaiyuan Ji, Minfeng Liu, Qiang Zuo
Dose fractionation of CAR-T cells. A systematic review of clinical outcomes
Matthew Frigault, Anand Rotte, Ayub Ansari, Bradford Gliner, Christopher Heery, Bijal Shah
Downregulation of Linc00173 increases BCL2 mRNA stability via the miR-1275/PROCA1/ZFP36L2 axis and induces acquired cisplatin resistance of lung adenocarcinoma
Xingyu Tao, Yang Li, Songqing Fan, Liyang Wu, Jianyang Xin, Yun Su, Xiaoyang Xian, Yingying Huang, Rongquan Huang, Weiyi Fang, Zhen Liu
Parvimonas micra activates the Ras/ERK/c-Fos pathway by upregulating miR-218-5p to promote colorectal cancer progression
Yuxiao Chang, Ziran Huang, Fengyi Hou, Yuejiao Liu, Likun Wang, Zhen Wang, Yifan Sun, Zhiyuan Pan, Yafang Tan, Lei Ding, Hong Gao, Ruifu Yang, Yujing Bi
RETRACTED ARTICLE: LncRNA BCAR4 promotes migration, invasion, and chemo-resistance by inhibiting miR-644a in breast cancer
Tangwei Wu, Xiaoyi Li, Ge Yan, Zheqiong Tan, Dan Zhao, Shuiyi Liu, Hui Wang, Yuan Xiang, Weiqun Chen, Hongda Lu, Xinghua Liao, Yong Li, Zhongxin Lu
Correction: Identification of novel COX-2 / CYP19A1 axis involved in the mesothelioma pathogenesis opens new therapeutic opportunities
Barbara Nuvoli, Barbara Antoniani, Roberta Libener, Antonio Maconi, Andrea Sacconi, Mariantonia Carosi, Rossella Galati
Retraction Note: SP1-induced lncRNA AGAP2-AS1 expression promotes chemoresistance of breast cancer by epigenetic regulation of MyD88
Huaying Dong, Wei Wang, Shaowei Mo, Ru Chen, Kejian Zou, Jing Han, Fan Zhang, Jianguo Hu
Retraction Note: Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression
Qi Wu, Juanjuan Li, Zhiyu Li, Si Sun, Shan Zhu, Lijun Wang, Juan Wu, Jingping Yuan, Yimin Zhang, Shengrong Sun, Changhua Wang
Retraction Note: Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis
Li Huang, Bin Hu, Jianbo Ni, Jianghong Wu, Weiliang Jiang, Congying Chen, Lijuan Yang, Yue Zeng, Rong Wan, Guoyong Hu, Xingpeng Wang
STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent
Xilin Zhang, Qiuqiang Chen, Ying He, Qian Shi, Chengyi Yin, Yanping Xie, Huanming Yu, Ying Bao, Xiang Wang, Chengwu Tang, Zhaohui Dong
Stroma-derived miR-214 coordinates tumor dissemination
Francesca Orso, Federico Virga, Daniela Dettori, Alberto Dalmasso, Mladen Paradzik, Aurora Savino, Margherita A. C. Pomatto, Lorena Quirico, Stefania Cucinelli, Martina Coco, Katia Mareschi, Franca Fagioli, Leonardo Salmena, Giovanni Camussi, Paolo Provero, Valeria Poli, Massimiliano Mazzone, Pier Paolo Pandolfi, Daniela Taverna
Chemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study group
Stefanie V. Junk, Elke Schaeffeler, Martin Zimmermann, Anja Möricke, Rita Beier, Peter Schütte, Birthe Fedders, Julia Alten, Laura Hinze, Norman Klein, Andreas Kulozik, Martina U. Muckenthaler, Rolf Koehler, Arndt Borkhardt, Jayaram Vijayakrishnan, David Ellinghaus, Michael Forster, Andre Franke, Astrid Wintering, Christian P. Kratz, Martin Schrappe, Matthias Schwab, Richard S. Houlston, Gunnar Cario, Martin Stanulla
Repurposing nitric oxide donating drugs in cancer therapy through immune modulation
Chung-Yen Li, Gangga Anuraga, Chih-Peng Chang, Tzu-Yang Weng, Hui-Ping Hsu, Hoang Dang Khoa Ta, Pei-Fang Su, Pin-Hsuan Chiu, Shiang-Jie Yang, Feng-Wei Chen, Pei-Hsuan Ye, Chih-Yang Wang, Ming-Derg Lai
Correction: Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/ Akt signaling pathway in gastric cancer
Jiahui Xu, Deying Liu, Huilin Niu, Guifang Zhu, Yangwei Xu, Danli Ye, Jian Li, Qingling Zhang
Retraction Note: IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way
Xiang Zhang, Dawei Wang, Boke Liu, Xingwei Jin, Xianjin Wang, Junwei Pan, Weichao Tu, Yuan Shao
Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth
Magdalena Keller, Katharina Rohlf, Annika Glotzbach, Gregor Leonhardt, Simon Lüke, Katharina Derksen, Özlem Demirci, Defne Göçener, Mohammad AlWahsh, Jörg Lambert, Cecilia Lindskog, Marcus Schmidt, Walburgis Brenner, Matthias Baumann, Eldar Zent, Mia-Lisa Zischinsky, Birte Hellwig, Katrin Madjar, Jörg Rahnenführer, Nina Overbeck, Jörg Reinders, Cristina Cadenas, Jan G. Hengstler, Karolina Edlund, Rosemarie Marchan
Long-term exposure to house dust mites accelerates lung cancer development in mice
Dongjie Wang, Wen Li, Natalie Albasha, Lindsey Griffin, Han Chang, Lauren Amaya, Sneha Ganguly, Liping Zeng, Bora Keum, José M. González-Navajas, Matt Levin, Zohreh AkhavanAghdam, Helen Snyder, David Schwartz, Ailin Tao, Laela M. Boosherhri, Hal M. Hoffman, Michael Rose, Monica Valeria Estrada, Nissi Varki, Scott Herdman, Maripat Corr, Nicholas J. G. Webster, Eyal Raz, Samuel Bertin
Mesothelioma-associated fibroblasts enhance proliferation and migration of pleural mesothelioma cells via c-Met/PI3K and WNT signaling but do not protect against cisplatin
Alexander Ries, Daniela Flehberger, Astrid Slany, Christine Pirker, Johanna C. Mader, Thomas Mohr, Karin Schelch, Katharina Sinn, Berta Mosleh, Mir Alireza Hoda, Balazs Dome, Helmut Dolznig, Georg Krupitza, Leonhard Müllauer, Christopher Gerner, Walter Berger, Michael Grusch
Single-nucleus RNA sequencing and deep tissue proteomics reveal distinct tumour microenvironment in stage-I and II cervical cancer
Xiaosong Liu, Guoying Ni, Pingping Zhang, Hejie Li, Junjie Li, Bernardo Cavallazzi Sebold, Xiaolian Wu, Guoqiang Chen, Songhua Yuan, Tianfang Wang
A flexible liposomal polymer complex as a platform of specific and regulable immune regulation for individual cancer immunotherapy
Chia-Hung Chen, Tzu-Han Weng, Hsiao-Hsuan Huang, Ling-Ya Huang, Kai-Yao Huang, Pin-Rong Chen, Kuang-Yu Yeh, Chi-Ting Huang, Yu-Tzu Chien, Po-Ya Chuang, Yu-Ling Lin, Nu-Man Tsai, Shih-Jen Liu, Yu-Cheng Su, Shun-Long Weng, Kuang-Wen Liao
Retraction Note: Genistein inhibits stemness of SKOV3 cells induced by macrophages co-cultured with ovarian cancer stem-like cells through IL-8/STAT3 axis
Yingxia Ning, Weifeng Feng, Xiaocheng Cao, Kaiqun Ren, Meifang Quan, A. Chen, Chang Xu, Yebei Qiu, Jianguo Cao, Xiang Li, Xin Luo
Retraction Note: M2 macrophage-derived extracellular vesicles promote gastric cancer progression via a microRNA-130b-3p/MLL3/GRHL2 signaling cascade
Yu Zhang, Wenbo Meng, Ping Yue, Xun Li
Retraction Note: Hsa_circ_0001944 promotes the growth and metastasis in bladder cancer cells by acting as a competitive endogenous RNA for miR-548
Mingming Jin, Shengjie Lu, Yue Wu, Chen Yang, Chunzi Shi, Yanqiu Wang, Gang Huang
LARP6 suppresses colorectal cancer progression through ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis
Xiaoli Long, Xunhua Liu, Ting Deng, Jianxiong Chen, Jiawen Lan, Sijing Zhang, Miao Zhou, Dan Guo, Jun Zhou
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability
Xintian Chen, Hongmei Yong, Miaolei Chen, Chuyin Deng, Pengfei Wang, Sufang Chu, Minle Li, Pingfu Hou, Junnian Zheng, Zhongwei Li, Jin Bai
Cancer-educated mammary adipose tissue-derived stromal/stem cells in obesity and breast cancer: spatial regulation and function
Andreas Ritter, Nina-Naomi Kreis, Susanne Roth, Alexandra Friemel, Babek Kahn Safdar, Samira Catharina Hoock, Julia Maria Wildner, Roman Allert, Frank Louwen, Christine Solbach, Juping Yuan
Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer
Yuqi Chen, Wenying Yan, Kexi Yang, Yiting Qian, Yanjun Chen, Ruoqin Wang, Jinghan Zhu, Yuxin He, Hongya Wu, Guangbo Zhang, Tongguo Shi, Weichang Chen
Patient-derived cell-based pharmacogenomic assessment to unveil underlying resistance mechanisms and novel therapeutics for advanced lung cancer
Namhee Yu, Mihwa Hwang, Youngjoo Lee, Bo Ram Song, Eun Hye Kang, Hanna Sim, Beung-Chul Ahn, Kum Hui Hwang, Jihyun Kim, Sehwa Hong, Sunshin Kim, Charny Park, Ji-Youn Han
HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway
Yunzhi Liu, Qishan Xu, Fan Deng, Zhuojun Zheng, Jialiang Luo, Ping Wang, Jia Zhou, Xiao Lu, Liyun Zhang, Zhengliang Chen, Qifan Zhang, Qingyun Chen, Daming Zuo
Sunitinib efficacy with minimal toxicity in patient-derived retinoblastoma organoids
Atthapol Srimongkol, Natanan Laosillapacharoen, Duangporn Saengwimol, Vijender Chaitankar, Duangnate Rojanaporn, Thanastha Thanomchard, Suparerk Borwornpinyo, Suradej Hongeng, Rossukon Kaewkhaw
MiR-455-5p suppresses PDZK1IP1 to promote the motility of oral squamous cell carcinoma and accelerate clinical cancer invasion by regulating partial epithelial-to-mesenchymal transition
Sheng-Yen Hsiao, Shang-Mei Weng, Jenn-Ren Hsiao, Yi-Ying Wu, Jia-En Wu, Chia-Hao Tung, Wan-Lin Shen, Shu-Fang Sun, Wen-Tsung Huang, Cheng-Yao Lin, Shang-Hung Chen, Tse-Ming Hong, Yuh-Ling Chen, Jang-Yang Chang
HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway
Jiancheng Lv, Kai Li, Hao Yu, Jie Han, Juntao Zhuang, Ruixi Yu, Yidong Cheng, Qiang Song, Kexin Bai, Qiang Cao, Haiwei Yang, Xiao Yang, Qiang Lu
GPX8 regulates clear cell renal cell carcinoma tumorigenesis through promoting lipogenesis by NNMT
Tin Tin Manh Nguyen, Thi Ha Nguyen, Han Sun Kim, Thien T. P. Dao, Yechan Moon, Munjun Seo, Sunmi Kang, Van-Hieu Mai, Yong Jin An, Cho-Rok Jung, Jin-Mo Kim, Sunghyouk Park
Retraction Note: HnRNP A1 - mediated alternative splicing of CCDC50 contributes to cancer progression of clear cell renal cell carcinoma via ZNF395
Guoliang Sun, Hui Zhou, Ke Chen, Jin Zeng, Yangjun Zhang, Libin Yan, Weimin Yao, Junhui Hu, Tao Wang, Jinchun Xing, Kefeng Xiao, Lily Wu, Zhangqun Ye, Hua Xu
The BRD4 inhibitor JQ1 augments the antitumor efficacy of abemaciclib in preclinical models of gastric carcinoma
Mei Feng, Hao Xu, Wenyuan Zhou, Yisheng Pan
Procoxacin bidirectionally inhibits osteoblastic and osteoclastic activity in bone and suppresses bone metastasis of prostate cancer
Depei Kong, Chen Ye, Chenxi Zhang, Xiaochen Sun, Fubo Wang, Rui Chen, Guangan Xiao, Shipeng He, Jianrong Xu, Xiwu Rao, Jianzhong Ai, Xu Gao, Hong Li, Li Su
Exosomal circTUBGCP4 promotes vascular endothelial cell tipping and colorectal cancer metastasis by activating Akt signaling pathway
Chen Chen, Yang Liu, Lin Liu, Chaohua Si, Yanxin Xu, Xiaoke Wu, Chengzeng Wang, Zhenqiang Sun, Qiaozhen Kang
Correction: NCSTN promotes hepatocellular carcinoma cell growth and metastasis via β-catenin activation in a Notch1/AKT dependent manner
Hui Li, Tian Lan, Lin Xu, Hailing Liu, Jinju Wang, Jiaxin Li, Xiangzheng Chen, Jiwei Huang, Xuefeng Li, Kefei Yuan, Yong Zeng, Hong Wu
Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-??B-IL-6 axis of tumor-associated macrophages
Boxuan Zhou, Zhaohong Mo, Guie Lai, Xiaohong Chen, Ruixi Li, Runxin Wu, Jia Zhu, Fang Zheng
Water channel protein AQP1 in cytoplasm is a critical factor in breast cancer local invasion
Zhifang Guo, Huikun Zhang, Xiaoli Liu, Yawen Zhao, Yongzi Chen, Jiaqi Jin, Caixia Guo, Ming Zhang, Feng Gu, Yongjie Ma
Beyond lymphopenia, unraveling radiation-induced leucocyte subpopulation kinetics and mechanisms through modeling approaches
Thao-Nguyen Pham, Julie Coupey, Serge M. Candeias, Viktoriia Ivanova, Samuel Valable, Juliette Thariat
Integrative analysis of bulk and single-cell gene expression profiles to identify tumor-associated macrophage-derived CCL18 as a therapeutic target of esophageal squamous cell carcinoma
Xinghua Sui, Chunxia Chen, Xiuman Zhou, Xueyan Wen, Chao Shi, Guanyu Chen, Juan Liu, Zhuoying He, Yongjie Yao, Yin Li, Yanfeng Gao
L-kynurenine induces NK cell loss in gastric cancer microenvironment via promoting ferroptosis
Jian-Xin Cui, Xian-Hui Xu, Tao He, Jia-Jia Liu, Tian-Yu Xie, Wen Tian, Jun-Yan Liu
Aryl hydrocarbon receptor nuclear translocator limits the recruitment and function of regulatory neutrophils against colorectal cancer by regulating the gut microbiota
Yujing Bi, Qiuli Yang, Zhengchao Li, Yuexin Wang, Yufei Wang, Anna Jia, Zhiyuan Pan, Ruifu Yang, Guangwei Liu
Retraction Note: LNCAROD enhances hepatocellular carcinoma malignancy by activating glycolysis through induction of pyruvate kinase isoform PKM2
Guizhi Jia, Yan Wang, Chengjie Lin, Shihui Lai, Hongliang Dai, Zhiqian Wang, Luo Dai, Huizhao Su, Yanjie Song, Naiwen Zhang, Yukuan Feng, Bo Tang
NAD pool as an antitumor target against cancer stem cells in head and neck cancer
Lola E. Navas, Elena Blanco-Alcaina, Elisa Suarez-Martinez, Eva M. Verdugo-Sivianes, Asuncion Espinosa-Sanchez, Laura Sanchez-Diaz, Eduardo Dominguez-Medina, Ceres Fernandez-Rozadilla, Angel Carracedo, Lindsay E. Wu, Amancio Carnero
Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer
Joyce Y. Buikhuisen, Patricia M. Gomez Barila, Kate Cameron, Saskia J. E. Suijkerbuijk, Cor Lieftink, Simone di Franco, Ana Krotenberg Garcia, Rebeca Uceda Castro, Kristiaan J. Lenos, Lisanne E. Nijman, Arezo Torang, Ciro Longobardi, Joan H. de Jong, Daniëlle Dekker, Giorgio Stassi, Louis Vermeulen, Roderick L. Beijersbergen, Jacco van Rheenen, Stephan Huveneers, Jan Paul Medema
Current advances in understanding the molecular profile of hereditary diffuse gastric cancer and its clinical implications
Hui Jun Lim, Lizhe Zhuang, Rebecca C. Fitzgerald
Retraction Note: Long non-coding RNA SLC2A1-AS1 induced by GLI3 promotes aerobic glycolysis and progression in esophageal squamous cell carcinoma by sponging miR-378a-3p to enhance Glut1 expression
Hongtao Liu, Qing Zhang, Yinsen Song, Yibin Hao, Yunxia Cui, Xin Zhang, Xueying Zhang, Yue Qin, Guangzhao Zhu, Feng Wang, Jinghan Dang, Shanshan Ma, Yanting Zhang, Wenna Guo, Shenglei Li, Fangxia Guan, Tianli Fan
Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
Shiming Tan, Yiqing Yang, Wenjuan Yang, Yaqian Han, Lisheng Huang, Ruiqian Yang, Zifan Hu, Yi Tao, Lin Liu, Yun Li, Linda Oyang, Jinguan Lin, Qiu Peng, Xianjie Jiang, Xuemeng Xu, Longzheng Xia, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Deliang Cao, Qianjin Liao, Yujuan Zhou
Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recycling
Zixian Huang, Xi Rui, Chen Yi, Yongju Chen, Rui Chen, Yancan Liang, Yan Wang, Weicheng Yao, Xiaoding Xu, Zhiquan Huang
CD46 targeted 212Pb alpha particle radioimmunotherapy for prostate cancer treatment
Jun Li, Tao Huang, Jun Hua, Qiong Wang, Yang Su, Ping Chen, Scott Bidlingmaier, Allan Li, Zhongqiu Xie, Anil P. Bidkar, Sui Shen, Weibin Shi, Youngho Seo, Robert R. Flavell, Daniel Gioeli, Robert Dreicer, Hui Li, Bin Liu, Jiang He
Research progress on non-protein-targeted drugs for cancer therapy
Yiwen Zhang, Lu Lu, Feifeng Song, Xiaozhou Zou, Yujia Liu, Xiaowei Zheng, Jinjun Qian, Chunyan Gu, Ping Huang, Ye Yang
CircFOXK2 promotes hepatocellular carcinoma progression and leads to a poor clinical prognosis via regulating the Warburg effect
Jun Zheng, Xijing Yan, Tongyu Lu, Wen Song, Yang Li, Jinliang Liang, Jiebin Zhang, Jianye Cai, Xin Sui, Jiaqi Xiao, Haitian Chen, Guihua Chen, Qi Zhang, Yubin Liu, Yang Yang, Kanghong Zheng, Zihao Pan
circMMD reduction following tumor treating fields inhibits glioblastoma progression through FUBP1/FIR/DVL1 and miR-15b-5p/FZD6 signaling
Shengchao Xu, Chengke Luo, Dikang Chen, Lu Tang, Quan Cheng, Ling Chen, Zhixiong Liu
METTL3 promotes chemoresistance in small cell lung cancer by inducing mitophagy
Yueqin Sun, Weitao Shen, Shulu Hu, Qiong Lyu, Qiongyao Wang, Ting Wei, Weiliang Zhu, Jian Zhang
A diagnostic circulating miRNA signature as orchestrator of cell invasion via TKS4/TKS5/EFHD2 modulation in human gliomas
Ana Belén Díaz Méndez, Andrea Sacconi, Elisa Tremante, Valentina Lulli, Valentina Caprara, Laura Rosanò, Frauke Goeman, Mariantonia Carosi, Marta Di Giuliani, Giulia Vari, Antonio Silvani, Bianca Pollo, Carlo Garufi, Sara Ramponi, Giorgia Simonetti, Emilio Ciusani, Chiara Mandoj, Stefano Scalera, Veronica Villani, Agnese Po, Elisabetta Ferretti, Giulia Regazzo, Maria Giulia Rizzo
Guadecitabine increases response to combined anti-CTLA-4 and anti-PD-1 treatment in mouse melanoma in vivo by controlling T-cells, myeloid derived suppressor and NK cells
Adriana Amaro, Francesco Reggiani, Daniela Fenoglio, Rosaria Gangemi, Anna Tosi, Alessia Parodi, Barbara Banelli, Valentina Rigo, Luca Mastracci, Federica Grillo, Alessandra Cereghetti, Aizhan Tastanova, Adhideb Ghosh, Fabio Sallustio, Laura Emionite, Antonio Daga, Tiziana Altosole, Gilberto Filaci, Antonio Rosato, Mitchell Levesque, Michele Maio, Ulrich Pfeffer, Michela Croce
CLDN6 inhibits breast cancer metastasis through WIP-dependent actin cytoskeleton-mediated autophagy
Yuan Dong, Qiu Jin, Minghao Sun, Da Qi, Huinan Qu, Xinqi Wang, Chengshi Quan
ALDOC- and ENO2- driven glucose metabolism sustains 3D tumor spheroids growth regardless of nutrient environmental conditions: a multi-omics analysis
Claudia De Vitis, Anna Martina Battaglia, Matteo Pallocca, Gianluca Santamaria, Maria Chiara Mimmi, Alessandro Sacco, Francesca De Nicola, Marco Gaspari, Valentina Salvati, Francesca Ascenzi, Sara Bruschini, Antonella Esposito, Giulia Ricci, Eleonora Sperandio, Alice Massacci, Licia Elvira Prestagiacomo, Andrea Vecchione, Alberto Ricci, Salvatore Sciacchitano, Gerardo Salerno, Deborah French, Ilenia Aversa, Cristina Cereda, Maurizio Fanciulli, Ferdinando Chiaradonna, Egle Solito, Giovanni Cuda, Francesco Costanzo, Gennaro Ciliberto, Rita Mancini, Flavia Biamonte
Correction: Astragaloside IV inhibits lung cancer progression and metastasis by modulating macrophage polarization through AMPK signaling
Fei Xu, Wen-Qiang Cui, Ying Wei, Jie Cui, Jian Qiu, Ling-Li Hu, Wei-Yi Gong, Jing-Cheng Dong, Bao-Jun Liu
TERRA G-quadruplex stabilization as a new therapeutic strategy for multiple myeloma
Francesca Scionti, Giada Juli, Roberta Rocca, Nicoletta Polerà, Matteo Nadai, Katia Grillone, Daniele Caracciolo, Caterina Riillo, Emanuela Altomare, Serena Ascrizzi, Basilio Caparello, Maria Cerra, Mariamena Arbitrio, Sara N. Richter, Anna Artese, Stefano Alcaro, Pierosandro Tagliaferri, Pierfrancesco Tassone, Maria Teresa Di Martino
HES1-mediated down-regulation of miR-138 sustains NOTCH1 activation and promotes proliferation and invasion in renal cell carcinoma
Shuangjie Liu, Lei Dou, Miao Miao, Xiaojun Man, Baojun Wei, Zhaowei Jiang, Yongze Ouyang, Toshinori Ozaki, Meng Yu, Yuyan Zhu
Targeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous cell carcinoma under hypoxia
Kang Fang, Mingchuang Sun, Zhuyun Leng, Yuan Chu, Ziying Zhao, Zhaoxing Li, Yunwei Zhang, Aiping Xu, Zehua Zhang, Li Zhang, Tao Chen, Meidong Xu
Retraction Note: Tripartite motif-containing 14 (TRIM14) promotes epithelial-mesenchymal transition via ZEB2 in glioblastoma cells
Shuang Feng, Xiaomin Cai, Yangyang Li, Xiaoguang Jian, Linxin Zhang, Bin Li
FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation
Yunzhi Pan, Jing Liu, Yingyin Gao, Yuqing Guo, Changxing Wang, Zhipan Liang, Meiying Wu, Yulan Qian, Yinyan Li, Jingyi Shen, Chenchen Lu, Sai Ma
First-in-human phase 1 clinical trial of anti-core 1 O-glycans targeting monoclonal antibody NEO-201 in treatment-refractory solid tumors
Christopher B. Cole, Maria Pia Morelli, Massimo Fantini, Markku Miettinen, Patricia Fetsch, Cody Peer, William D. Figg, Tyler Yin, Nicole Houston, Ann McCoy, Stanley Lipkowitz, Alexandra Zimmer, Jung-min Lee, Miroslava Pavelova, Erin N. Villanueva, Kathryn Trewhitt, B. Brooke Solarz, Maria Fergusson, Sharon A. Mavroukakis, Anjum Zaki, Kwong Y. Tsang, Philip M. Arlen, Christina M. Annunziata
Protein disulfide-isomerase A4 confers glioblastoma angiogenesis promotion capacity and resistance to anti-angiogenic therapy
Zewei Tu, Chong Wang, Qing Hu, Chuming Tao, Zhansheng Fang, Li Lin, Kunjian Lei, Min Luo, Yilei Sheng, Xiaoyan Long, Jingying Li, Lei Wu, Kai Huang, Xingen Zhu
Methylglyoxal: a novel upstream regulator of DNA methylation
Gaurav Dube, Assia Tiamiou, Martin Bizet, Yasmine Boumahd, Imène Gasmi, Rebekah Crake, Justine Bellier, Marie-Julie Nokin, Emilie Calonne, Rachel Deplus, Tom Wissocq, Olivier Peulen, Vincent Castronovo, François Fuks, Akeila Bellahcène
Platform combining statistical modeling and patient-derived organoids to facilitate personalized treatment of colorectal carcinoma
George M. Ramzy, Maxim Norkin, Thibaud Koessler, Lionel Voirol, Mathieu Tihy, Dina Hany, Thomas McKee, Frédéric Ris, Nicolas Buchs, Mylène Docquier, Christian Toso, Laura Rubbia-Brandt, Gaetan Bakalli, Stéphane Guerrier, Joerg Huelsken, Patrycja Nowak-Sliwinska
FYN/TOPK/HSPB1 axis facilitates the proliferation and metastasis of gastric cancer
SanFei Peng, YuHan Yin, YiZheng Zhang, Feng Zhu, Ge Yang, Yang Fu
Newly developed 3D in vitro models to study tumor–immune interaction
Peiyuan Mu, Shujuan Zhou, Tao Lv, Fan Xia, Lijun Shen, Juefeng Wan, Yaqi Wang, Hui Zhang, Sanjun Cai, Junjie Peng, Guoqiang Hua, Zhen Zhang
Retraction Note: Exosome-mediated transfer of lncRNA PART1 induces gefitinib resistance in esophageal squamous cell carcinoma via functioning as a competing endogenous RNA
Min Kang, Meiping Ren, Yan Li, Yuqiong Fu, Minmin Deng, Changping Li
Biological and clinical impact of membrane EGFR expression in a subgroup of OC patients from the phase IV ovarian cancer MITO-16A/MANGO-OV2A trial
Luca Forlani, Loris De Cecco, Vittorio Simeon, Biagio Paolini, Marina Bagnoli, Sabrina Chiara Cecere, Anna Spina, Eleonora Citeroni, Eliana Bignotti, Domenica Lorusso, Laura Arenare, Daniela Russo, Carmine De Angelis, Laura Ardighieri, Giosuè Scognamiglio, Michele Del Sesto, Germana Tognon, Daniela Califano, Clorinda Schettino, Paolo Chiodini, Francesco Perrone, Delia Mezzanzanica, Sandro Pignata, Antonella Tomassetti
Retraction Note: LncRNA BCAR4 promotes migration, invasion, and chemo-resistance by inhibiting miR-644a in breast cancer
Tangwei Wu, Xiaoyi Li, Ge Yan, Zheqiong Tan, Dan Zhao, Shuiyi Liu, Hui Wang, Yuan Xiang, Weiqun Chen, Hongda Lu, Xinghua Liao, Yong Li, Zhongxin Lu
Targeting inhibition of prognosis-related lipid metabolism genes including CYP19A1 enhances immunotherapeutic response in colon cancer
Lilong Liu, Min Mo, Xuehan Chen, Dongchen Chao, Yufan Zhang, Xuewei Chen, Yang Wang, Nan Zhang, Nan He, Xi Yuan, Honglei Chen, Jing Yang
Understanding the roles and regulation patterns of circRNA on its host gene in tumorigenesis and tumor progression
Jianxia Wei, Mengna Li, Changning Xue, Shipeng Chen, Lemei Zheng, Hongyu Deng, Faqing Tang, Guiyuan Li, Wei Xiong, Zhaoyang Zeng, Ming Zhou
Correction: Peglated-H1/pHGFK1 nanoparticles enhance anti-tumor effects of sorafenib by inhibition of drug-induced autophagy and stemness in renal cell carcinoma
Xiaoge Gao, Pin Jiang, Qian Zhang, Qian Liu, Shuangshuang Jiang, Ling Liu, Maomao Guo, Qian Cheng, Junnian Zheng, Hong Yao
Correction: CD90 is regulated by notch1 and hallmarks a more aggressive intrahepatic cholangiocarcinoma phenotype
Serena Mancarella, Grazia Serino, Isabella Gigante, Antonio Cigliano, Silvia Ribback, Paola Sanese, Valentina Grossi, Cristiano Simone, Raffaele Armentano, Matthias Evert, Diego F. Calvisi, Gianluigi Giannelli
LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization
Nasha Zhang, Bowen Wang, Chi Ma, Jiajia Zeng, Teng Wang, Linyu Han, Ming Yang
COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis
Janelle L. Hancock, Murugan Kalimutho, Jasmin Straube, Malcolm Lim, Irma Gresshoff, Jodi M. Saunus, Jason S. Lee, Sunil R. Lakhani, Kaylene J. Simpson, Ashley I. Bush, Robin L. Anderson, Kum Kum Khanna
Correction: AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma
Chunyan Gu, Yajun Wang, Lulin Zhang, Li Qiao, Shanliang Sun, Miaomiao Shao, Xiaozhu Tang, Pinggang Ding, Chao Tang, Yuhao Cao, Yanyan Zhou, Mengjie Guo, Rongfang Wei, Nianguang Li, Yibei Xiao, Jinao Duan, Ye Yang
Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy
Ali Talebi, Vincent de Laat, Xander Spotbeen, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, Frank Vanderhoydonc, Lara Rizotto, Mélanie Planque, Ginevra Doglioni, Sahar Motamedi, David Nittner, Tania Roskams, Patrizia Agostinis, Oliver Bechter, Veerle Boecxstaens, Marjan Garmyn, Marie O’Farrell, Alan Wagman, George Kemble, Eleonora Leucci, Sarah-Maria Fendt, Jean-Christophe Marine, Johannes V. Swinnen
Regulation of ERα-dependent breast cancer metastasis by a miR-29a signaling
Jinhui Lü, Qian Zhao, Yuefan Guo, Danni Li, Heying Xie, Cuicui Liu, Xin Hu, Suling Liu, Zhaoyuan Hou, Xunbin wei, Deyou Zheng, Richard G. Pestell, Zuoren Yu
Retraction Note: Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway
Zizhuo Li, Yaodong Chen, Tingting An, Pengfei Liu, Jiyuan Zhu, Haichao Yang, Wei Zhang, Tianxiu Dong, Jian Jiang, Yu Zhang, Maitao Jiang, Xiuhua Yang
Phytogalactolipids activate humoral immunity against colorectal cancer
Han-Huei Lin, Yi-Shin Wu, Ting-Yan Jian, Jia-Yun Liao, Meng-Ting Chang, Lie-Fen Shyur, Yu-Ling Lin
FGFR4 and EZH2 inhibitors synergistically induce hepatocellular carcinoma apoptosis via repressing YAP signaling
Yiqi Yang, Yibo Zhang, Jieqiong Cao, Zijian Su, Fu Li, Peiguang Zhang, Bihui Zhang, Rongzhan Liu, Linhao Zhang, Junye Xie, Jingsheng Li, Jinting Zhang, Xiaojia Chen, An Hong
Toosendanin targeting eEF2 impedes Topoisomerase I & II protein translation to suppress esophageal squamous cell carcinoma growth
Xuechao Jia, Penglei Wang, Chuntian Huang, Dengyun Zhao, Qiong wu, Bingbing Lu, Wenna Nie, Limeng Huang, Xueli Tian, Pan li, Kyle Vaughn Laster, Yanan Jiang, Xiang Li, Honglin Li, Zigang Dong, Kangdong Liu
Correction: Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression
Min Deng, Long Zhang, Wenying Zheng, Jiale Chen, Nan Du, Meiqi Li, Weiqing Chen, Yonghong Huang, Ning Zeng, Yuanbin Song, Yongming Chen
High-throughput and targeted drug screens identify pharmacological candidates against MiT-translocation renal cell carcinoma
Martin Lang, Laura S. Schmidt, Kelli M. Wilson, Christopher J. Ricketts, Carole Sourbier, Cathy D. Vocke, Darmood Wei, Daniel R. Crooks, Youfeng Yang, Benjamin K. Gibbs, Xiaohu Zhang, Carleen Klumpp-Thomas, Lu Chen, Rajarshi Guha, Marc Ferrer, Crystal McKnight, Zina Itkin, Darawalee Wangsa, Danny Wangsa, Amy James, Simone Difilippantonio, Baktir Karim, Francisco Morís, Thomas Ried, Maria J. Merino, Ramaprasad Srinivasan, Craig J. Thomas, W. Marston Linehan
MYC drives platinum resistant SCLC that is overcome by the dual PI3K-HDAC inhibitor fimepinostat
Jasmine Chen, Aleks C. Guanizo, W. Samantha N. Jakasekara, Chaitanya Inampudi, Quinton Luong, Daniel J. Garama, Muhammad Alamgeer, Nishant Thakur, Michael DeVeer, Vinod Ganju, D. Neil Watkins, Jason E. Cain, Daniel J. Gough
Retraction Note: Circular RNA hsa_circ_0001829 promotes gastric cancer progression through miR155-5p/SMAD2 axis
Qiuling Niu, Zhijie Dong, Min Liang, Yuanwei Luo, Hai Lin, Mingzhen Lin, Xiu Zhong, Wenxia Yao, Jinsheng Weng, Xinke Zhou
Correction: First-in-human phase 1 clinical trial of anti-core 1 O-glycans targeting monoclonal antibody NEO-201 in treatment-refractory solid tumors
Christopher B. Cole, Maria Pia Morelli, Massimo Fantini, Markku Miettinen, Patricia Fetsch, Cody Peer, William D. Figg, Tyler Yin, Nicole Houston, Ann McCoy, Stanley Lipkowitz, Alexandra Zimmer, Jung-min Lee, Miroslava Pavelova, Erin N. Villanueva, Kathryn Trewhitt, B. Brooke Solarz, Maria Fergusson, Sharon A. Mavroukakis, Anjum Zaki, Kwong Y. Tsang, Philip M. Arlen, Christina M. Annunziata
Disulfidptosis: a new target for metabolic cancer therapy
Peijie Zheng, Chuntao Zhou, Yuemin Ding, Shiwei Duan
Correction: Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recycling
Zixian Huang, Xi Rui, Chen Yi, Yongju Chen, Rui Chen, Yancan Liang, Yan Wang, Weicheng Yao, Xiaoding Xu, Zhiquan Huang
The β-catenin-LINC00183-miR-371b-5p-Smad2/LEF1 axis promotes adult T-cell lymphoblastic lymphoma progression and chemoresistance
Wei-Juan Huang, Song-Bin Guo, Hui Shi, Xin-Ling Li, Yong Zhu, Mei Li, Li-Yan Song, Rong-Min Yu, Qing-Qing Cai, Xiao-Peng Tian
Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice
Nanna Skeltved, Mie A. Nordmaj, Nicolai T. Berendtsen, Robert Dagil, Emilie M. R. Stormer, Nader Al-Nakouzi, Ke Jiang, Alexandra Aicher, Christopher Heeschen, Tobias Gustavsson, Swati Choudhary, Ismail Gögenur, Jan P. Christensen, Thor G. Theander, Mads Daugaard, Ali Salanti, Morten A. Nielsen
TRAF3 suppression encourages B cell recruitment and prolongs survival of microbiome-intact mice with ovarian cancer
Jonathan Zorea, Yair Motro, Roei D. Mazor, Yifat Koren Carmi, Ziv Shulman, Jamal Mahajna, Jacob Moran-Gilad, Moshe Elkabets
Activation of ACLY by SEC63 deploys metabolic reprogramming to facilitate hepatocellular carcinoma metastasis upon endoplasmic reticulum stress
Chenyu Hu, Zechang Xin, Xiaoyan Sun, Yang Hu, Chunfeng Zhang, Rui Yan, Yuying Wang, Min Lu, Jing Huang, Xiaojuan Du, Baocai Xing, Xiaofeng Liu
miR-92a-1-5p enriched prostate cancer extracellular vesicles regulate osteoclast function via MAPK1 and FoxO1
Lijuan Yu, Bingdong Sui, Xin Zhang, Jiayun Liu, Xiaoke Hao, Lei Zheng
Loss of Ufl1/Ufbp1 in hepatocytes promotes liver pathological damage and carcinogenesis through activating mTOR signaling
Fanghui Chen, Le Sheng, Tianci Zhou, Li Yan, Reid Loveless, Honglin Li, Yong Teng, Yafei Cai
Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis
Tianxing Zhou, Yongjie Xie, Xupeng Hou, Weiwei Bai, Xueyang Li, Ziyun Liu, Quan Man, Jingyan Sun, Danqi Fu, Jingrui Yan, Zhaoyu Zhang, Yifei Wang, Hongwei Wang, Wenna Jiang, Song Gao, Tiansuo Zhao, Antao Chang, Xiuchao Wang, Hongxia Sun, Xiufeng Zhang, Shengyu Yang, Chongbiao Huang, Jihui Hao, Jing Liu
Targeting homologous recombination deficiency in uterine leiomyosarcoma
Genevieve Dall, Cassandra J. Vandenberg, Ksenija Nesic, Gayanie Ratnayake, Wenying Zhu, Joseph H. A. Vissers, Justin Bedő, Jocelyn Penington, Matthew J. Wakefield, Damien Kee, Amandine Carmagnac, Ratana Lim, Kristy Shield-Artin, Briony Milesi, Amanda Lobley, Elizabeth L. Kyran, Emily O’Grady, Joshua Tram, Warren Zhou, Devindee Nugawela, Kym Pham Stewart, Reece Caldwell, Lia Papadopoulos, Ashley P. Ng, Alexander Dobrovic, Stephen B. Fox, Orla McNally, Jeremy D. Power, Tarek Meniawy, Teng Han Tan, Ian M. Collins, Oliver Klein, Stephen Barnett, Inger Olesen, Anne Hamilton, Oliver Hofmann, Sean Grimmond, Anthony T. Papenfuss, Clare L. Scott, Holly E. Barker
Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer
Li Yang, Xiaomin Chen, Christy Lee, Jiejun Shi, Emily B. Lawrence, Lanjing Zhang, Yumei Li, Nan Gao, Sung Yun Jung, Chad J. Creighton, Jingyi Jessica Li, Ya Cui, Sumimasa Arimura, Yunping Lei, Wei Li, Lanlan Shen
Tumor microenvironmental modification by the current target therapy for head and neck squamous cell carcinoma
Kohei Okuyama, Tomofumi Naruse, Souichi Yanamoto
Precision medicine applied to metastatic colorectal cancer using tumor-derived organoids and in-vitro sensitivity testing: a phase 2, single-center, open-label, and non-comparative study
Lars Henrik Jensen, Silvia Regina Rogatto, Jan Lindebjerg, Birgitte Havelund, Cecilie Abildgaard, Luisa Matos do Canto, Chris Vagn-Hansen, Claus Dam, Søren Rafaelsen, Torben Frøstrup Hansen
Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression
Boting Ning, Andrew M. Tilston-Lunel, Justice Simonetti, Julia Hicks-Berthet, Adeline Matschulat, Roxana Pfefferkorn, Avrum Spira, Matthew Edwards, Sarah Mazzilli, Marc E. Lenburg, Jennifer E. Beane, Xaralabos Varelas
Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery
Li Long, Wei Xiong, Fenwang Lin, Jiazhen Hou, Guihua Chen, Taoxing Peng, Yihao He, Rui Wang, Qin Xu, Yongzhuo Huang
Piperlongumine conquers temozolomide chemoradiotherapy resistance to achieve immune cure in refractory glioblastoma via boosting oxidative stress-inflamation-CD8+-T cell immunity
Feng Liu, Qian Zhou, Hai-feng Jiang, Ting-ting Zhang, Cheng Miao, Xiao-hong Xu, Jia-xing Wu, Song-lin Yin, Shi-jie Xu, Jing-yi Peng, Pan-pan Gao, Xuan Cao, Feng Pan, Ximiao He, Xiao Qian Chen
Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition
Achinto Saha, Shengyuan Zhao, Austin Kindall, Carly Wilder, Chelsea A. Friedman, Rachel Clark, George Georgiou, Everett Stone, Dawit Kidane, John DiGiovanni
Exploring circular MET RNA as a potential biomarker in tumors exhibiting high MET activity
Francesca Bersani, Francesca Picca, Deborah Morena, Luisella Righi, Francesca Napoli, Mariangela Russo, Daniele Oddo, Giuseppe Rospo, Carola Negrino, Barbara Castella, Marco Volante, Angela Listì, Vanessa Zambelli, Federica Benso, Fabrizio Tabbò, Paolo Bironzo, Emanuele Monteleone, Valeria Poli, Filippo Pietrantonio, Federica Di Nicolantonio, Alberto Bardelli, Carola Ponzetto, Silvia Novello, Giorgio V. Scagliotti, Riccardo Taulli
CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis
Janardhan Keshav Karapurkar, Min-Seong Kim, Jencia Carminha Colaco, Bharathi Suresh, Neha Sarodaya, Dong-Ho Kim, Chang-Hwan Park, Seok-Ho Hong, Kye-Seong Kim, Suresh Ramakrishna
Pancreatic cancer stemness: dynamic status in malignant progression
Yutong Zhao, Cheng Qin, Bangbo Zhao, Yuanyang Wang, Zeru Li, Tianyu Li, Xiaoying Yang, Weibin Wang
Retraction Note: Long non-coding RNA TPTEP1 inhibits hepatocellular carcinoma progression by suppressing STAT3 phosphorylation
Hongda Ding, Junpeng Liu, Ruoyao Zou, Pengrui Cheng, Yang Su
Correction: The Hippo pathway efector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease
Antonio Cigliano, Shanshan Zhang, Silvia Ribback, Sara Steinmann, Marcella Sini, Cindy E. Ament, Kirsten Utpatel, Xinhua Song, Jingxiao Wang, Maria G. Pilo, Fabian Berger, Haichuan Wang, Junyan Tao, Xiaolei Li, Giovanni M. Pes, Serena Mancarella, Gianluigi Giannelli, Frank Dombrowski, Matthias Evert, Diego F. Calvisi, Xin Chen, Katja Evert
CircZNF215 promotes tumor growth and metastasis through inactivation of the PTEN/AKT pathway in intrahepatic cholangiocarcinoma
Wenwei Liao, Jinpeng Du, Lian Li, Xianquan Wu, Xing Chen, Qingbo Feng, Lin Xu, Xiangzheng Chen, Mingheng Liao, Jiwei Huang, Kefei Yuan, Yong Zeng
Dual inhibition of CDK12 and CDK13 uncovers actionable vulnerabilities in patient-derived ovarian cancer organoids
Eleonora Cesari, Alessandra Ciucci, Marco Pieraccioli, Cinzia Caggiano, Camilla Nero, Davide Bonvissuto, Francesca Sillano, Marianna Buttarelli, Alessia Piermattei, Matteo Loverro, Floriana Camarda, Viviana Greco, Maria De Bonis, Angelo Minucci, Daniela Gallo, Andrea Urbani, Giuseppe Vizzielli, Giovanni Scambia, Claudio Sette
Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m6A-dependent recognition of Nrf2 mRNA mediated by SND1
Jianglin Zheng, Qing Zhang, Zhen Zhao, Yue Qiu, Yujie Zhou, Zhipeng Wu, Cheng Jiang, Xuan Wang, Xiaobing Jiang
Targeting PHB1 to inhibit castration-resistant prostate cancer progression in vitro and in vivo
Junmei Liu, Ranran Zhang, Tong Su, Qianqian Zhou, Lin Gao, Zongyue He, Xin Wang, Jian Zhao, Yuanxin Xing, Feifei Sun, Wenjie Cai, Xinpei Wang, Jingying Han, Ruixi Qin, Laurent Désaubry, Bo Han, Weiwen Chen
Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling
Yifeng Zheng, Neng Wang, Shengqi Wang, Juping Zhang, Bowen Yang, Zhiyu Wang
New insights into the ambivalent role of YAP/TAZ in human cancers
Juan Luo, Liang Deng, Hailin Zou, Yibo Guo, Tongyu Tong, Mingli Huang, Gengqiang Ling, Peng Li
Harnessing cancer stem cell-derived exosomes to improve cancer therapy
Jianqiang Yang, Yong Teng
Metastatic lymph node targeted CTLA4 blockade: a potent intervention for local and distant metastases with minimal ICI-induced pneumonia
Radhika Mishra, Ariunbuyan Sukhbaatar, Shiro Mori, Tetsuya Kodama
Integrated proteogenomic characterization reveals an imbalanced hepatocellular carcinoma microenvironment after incomplete radiofrequency ablation
Zheng-Rong Shi, Yu-Xin Duan, Fang Cui, Zhong-Jun Wu, Mao-Ping Li, Pei-Pei Song, Qi-Ling Peng, Wen-Tao Ye, Kun-Li Yin, Mei-Qing Kang, Yan-Xi Yu, Jian Yang, Wei Tang, Rui Liao
Therapeutic targeting of P2X4 receptor and mitochondrial metabolism in clear cell renal carcinoma models
Christofer Rupert, Carmela Dell’ Aversana, Laura Mosca, Vittorino Montanaro, Davide Arcaniolo, Marco De Sio, Antonio Bilancio, Lucia Altucci, Wulf Palinski, Roberto Pili, Filomena de Nigris
Correction: Complement inhibitor CSMD1 modulates epidermal growth factor receptor oncogenic signaling and sensitizes breast cancer cells to chemotherapy
Chrysostomi Gialeli, Emre Can Tuysuz, Johan Staaf, Safa Guleed, Veronika Paciorek, Matthias Mörgelin, Konstantinos S. Papadakos, Anna M. Blom
Spatial analysis of stromal signatures identifies invasive front carcinoma-associated fibroblasts as suppressors of anti-tumor immune response in esophageal cancer
Jian-Zhong He, Yang Chen, Fa-Min Zeng, Qing-Feng Huang, Hai-Feng Zhang, Shao-Hong Wang, Shuai-Xia Yu, Xiao-Xiao Pang, Ye Liu, Xiu-E Xu, Jian-Yi Wu, Wen-Jun Shen, Zhan-Yu Li, En-Min Li, Li-Yan Xu
Disulfidptosis: a new form of programmed cell death
Tingjin Zheng, Qingbo Liu, Feiyue Xing, Chong Zeng, Weidong Wang
CREBZF mRNA nanoparticles suppress breast cancer progression through a positive feedback loop boosted by circPAPD4
Boxuan Zhou, Jinhua Xue, Runxin Wu, Hongyu Meng, Ruixi Li, Zhaohong Mo, Hang Zhai, Xianyu Chen, Rongqiang Liu, Guie Lai, Xiaohong Chen, Taiyuan Li, Shiyang Zheng
Retraction Note: TRIM11 overexpression promotes proliferation, migration and invasion of lung cancer cells
Xiaolin Wang, Weiping Shi, Hongcan Shi, Shichun Lu, Kang Wang, Chao Sun, Jiansheng He, Weiguo Jin, Xiaoxia Lv, Hui Zou, Yusheng Shu
Kremen2 drives the progression of non-small cell lung cancer by preventing SOCS3-mediated degradation of EGFR
Yuxiao Sun, Yu Gao, Mingxin Dong, Jiuzhen Li, Xin Li, Ningning He, Huijuan Song, Manman Zhang, Kaihua Ji, Jinhan Wang, Yeqing Gu, Yan Wang, Liqing Du, Yang Liu, Qin Wang, Hezheng Zhai, Daqiang Sun, Qiang Liu, Chang Xu
Correction: Tobacco smoke induced hepatic cancer stem cell-like properties through IL-33/p38 pathway
Chunfeng Xie, Jianyun Zhu, Xueqi Wang, Jiaqi Chen, Shanshan Geng, Jieshu Wu, Caiyun Zhong, Xiaoting Li
Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer
Weikai Wang, Kaizhong Lu, Xin Jiang, Qi Wei, Liyuan Zhu, Xian Wang, Hongchuan Jin, Lifeng Feng
Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer
E. C. de Heer, C. E. Zois, E. Bridges, B. van der Vegt, H. Sheldon, W. A. Veldman, M. C. Zwager, T. van der Sluis, S. Haider, T. Morita, O. Baba, C. P. Schröder, S. de Jong, A. L. Harris, M. Jalving
Retraction Note: Downregulation of lncRNA ZNF582-AS1 due to DNA hypermethylation promotes clear cell renal cell carcinoma growth and metastasis by regulating the N(6)- methyladenosine modification of MT-RNR1
Wuping Yang, Kenan Zhang, Lei Li, Yawei Xu, Kaifang Ma, Haibiao Xie, Jingcheng Zhou, Lin Cai, Yanqing Gong, Kan Gong
MiR-494 induces metabolic changes through G6pc targeting and modulates sorafenib response in hepatocellular carcinoma
Christian Bergamini, Ilaria Leoni, Nicola Rizzardi, Mattia Melli, Giuseppe Galvani, Camelia Alexandra Coada, Catia Giovannini, Elisa Monti, Irene Liparulo, Francesca Valenti, Manuela Ferracin, Matteo Ravaioli, Matteo Cescon, Francesco Vasuri, Fabio Piscaglia, Massimo Negrini, Claudio Stefanelli, Romana Fato, Laura Gramantieri, Francesca Fornari
B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma
Yanan Cui, Jun Li, Pengpeng Zhang, Dandan Yin, Ziyu Wang, Jiali Dai, Wei Wang, Erbao Zhang, Renhua Guo
The lncRNA HOTAIR: a pleiotropic regulator of epithelial cell plasticity
Laura Amicone, Alessandra Marchetti, Carla Cicchini
AXL in cancer: a modulator of drug resistance and therapeutic target
Yaoxiang Tang, Hongjing Zang, Qiuyuan Wen, Songqing Fan
Biological roles of A-to-I editing: implications in innate immunity, cell death, and cancer immunotherapy
Jing Yuan, Li Xu, Hai-Juan Bao, Jie-lin Wang, Yang Zhao, Shuo Chen
Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer
Fangyuan Zhou, Haiyang Gao, Luorui Shang, Jinxiao Li, Mengqi Zhang, Shuhan Wang, Runze Li, Lin Ye, Shenglan Yang
METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression
Wei Wei, Zhong-Yuan Zhang, Bin Shi, Yike Cai, Hou-Shun Zhang, Chun-Lei Sun, Yun-Fei Fei, Wen Zhong, Shuang Zhang, Chen Wang, Bing He, Guan-Min Jiang, Hao Wang
Single-cell analysis reveals HBV-specific PD-1+CD8+ TRM cells in tumor borders are associated with HBV-related hepatic damage and fibrosis in HCC patients
Lulu Liu, Junwei Liu, Pan Li, Jijun Luo, Rui Qin, Qiao Peng, Bin Li, Xuyong Wei, Tian Wang, Hongyu Shi, Ming-Da Wang, Chao Li, Weijia Fang, Wei Chen, Xiao Xu, Tian Yang, Weiwei Yin, Xun Zeng
Correction: Dehydrodiisoeugenol inhibits colorectal cancer growth by endoplasmic reticulum stress-induced autophagic pathways
Changhong Li, Kui Zhang, Guangzhao Pan, Haoyan Ji, Chongyang Li, Xiaowen Wang, Xin Hu, Ruochen Liu, Longfei Deng, Yi Wang, Liqun Yang, Hongjuan Cui
Rewiring innate and adaptive immunity with TLR9 agonist to treat osteosarcoma
Caterina Cascini, Chiara Ratti, Laura Botti, Beatrice Parma, Valeria Cancila, Adriana Salvaggio, Cristina Meazza, Claudio Tripodo, Mario P. Colombo, Claudia Chiodoni
Epigenetic reprogramming-induced guanidinoacetic acid synthesis promotes pancreatic cancer metastasis and transcription-activating histone modifications
Jinshou Yang, Bo Ren, Jie Ren, Gang Yang, Yuan Fang, Xing Wang, Feihan Zhou, Lei You, Yupei Zhao
Retraction Note: Forkhead box (FOX) G1 promotes hepatocellular carcinoma epithelial-Mesenchymal transition by activating Wnt signal through forming T-cell factor-4/Beta-catenin/FOXG1 complex
Xingrong Zheng, Jiaxin Lin, Hewei Wu, Zhishuo Mo, Yunwen Lian, Peipei Wang, Zhaoxia Hu, Zhiliang Gao, Liang Peng, Chan Xie
Correction: Long non-coding RNA DANCR promotes malignant phenotypes of bladder cancer cells by modulating the miR-149/MSI2 axis as a ceRNA
Yonghao Zhan, Zhicong Chen, Yifan Li, Anbang He, Shiming He, Yanqing Gong, Xuesong Li, Liqun Zhou
Correction: CREBZF mRNA nanoparticles suppress breast cancer progression through a positive feedback loop boosted by circPAPD4
Boxuan Zhou, Jinhua Xue, Runxin Wu, Hongyu Meng, Ruixi Li, Zhaohong Mo, Hang Zhai, Xianyu Chen, Rongqiang Liu, Guie Lai, Xiaohong Chen, Taiyuan Li, Shiyang Zheng
TRAF2 promotes M2-polarized tumor-associated macrophage infiltration, angiogenesis and cancer progression by inhibiting autophagy in clear cell renal cell carcinoma
Yawei Xu, Lei Li, Wuping Yang, Kenan Zhang, Zedan Zhang, Chaojian Yu, Jianhui Qiu, Lin Cai, Yanqing Gong, Zheng Zhang, Jingcheng Zhou, Kan Gong
Cancer-associated fibroblast-derived PAI-1 promotes lymphatic metastasis via the induction of EndoMT in lymphatic endothelial cells
Wen-Fei Wei, Hui-Ling Zhou, Pei-Yu Chen, Xiao-Lan Huang, Long Huang, Luo-Jiao Liang, Chu-Hong Guo, Chen-Fei Zhou, Lan Yu, Liang-Sheng Fan, Wei Wang
Chronic stress accelerates glioblastoma progression via DRD2/ERK/β-catenin axis and Dopamine/ERK/TH positive feedback loop
Yan Wang, Xiang Wang, Kai Wang, Ji Qi, Yu Zhang, Xu Wang, Long Zhang, Yi Zhou, Linbo Gu, Rutong Yu, Xiuping Zhou
Cellular hierarchy framework based on single-cell/multi-patient sample sequencing reveals metabolic biomarker PYGL as a therapeutic target for HNSCC
Jiezhong Guan, Xi Xu, Guo Qiu, Chong He, Xiaoyue Lu, Kang Wang, Xinyu Liu, Yuanyuan Li, Zihang Ling, Xuan Tang, Yujie Liang, Xiaoan Tao, Bin Cheng, Bo Yang
rWTC-MBTA: autologous vaccine prevents metastases via antitumor immune responses
Juan Ye, Herui Wang, Rogelio Medina, Samik Chakraborty, Mitchell Sun, Alex Valenzuela, Xueyu Sang, Yaping Zhang, Ondrej Uher, Jan Zenka, Karel Pacak, Zhengping Zhuang
The Ephrin tyrosine kinase a3 (EphA3) is a novel mediator of RAGE-prompted motility of breast cancer cells
Marianna Talia, Francesca Cirillo, Asia Spinelli, Azzurra Zicarelli, Domenica Scordamaglia, Lucia Muglia, Salvatore De Rosis, Damiano Cosimo Rigiracciolo, Gianfranco Filippelli, Ida Daniela Perrotta, Mariano Davoli, Rosanna De Rosa, Rachele Macirella, Elvira Brunelli, Anna Maria Miglietta, Bruno Nardo, Daniela Tosoni, Salvatore Pece, Ernestina Marianna De Francesco, Antonino Belfiore, Marcello Maggiolini, Rosamaria Lappano
Host obesity alters the ovarian tumor immune microenvironment and impacts response to standard of care chemotherapy
Yueying Liu, Jing Yang, Tyvette S. Hilliard, Zhikun Wang, Jeff Johnson, Wanrui Wang, Elizabeth I. Harper, Connor Ott, Caitlin O’Brien, Leigh Campbell, Brian Crowley, Stephen Grisoli, Nicholas M. Stavrou, Anna Juncker-Jensen, M. Sharon Stack
Pulmonary interleukin 1 beta/serum amyloid A3 axis promotes lung metastasis of hepatocellular carcinoma by facilitating the pre-metastatic niche formation
Chong Zhang, Qing Li, Qi Xu, Wei Dong, Chunmei Li, Bin Deng, Jiao Gong, Li-Zhen Zhang, Junfei Jin
CD271 activation prevents low to high-risk progression of cutaneous squamous cell carcinoma and improves therapy outcomes
Marika Quadri, Natascia Tiso, Francesco Musmeci, Maria I. Morasso, Stephen R. Brooks, Luca Reggiani Bonetti, Rossana Panini, Roberta Lotti, Alessandra Marconi, Carlo Pincelli, Elisabetta Palazzo
Retraction Note: SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4
Ziming Li, Jia Huang, Shengping Shen, Zhenping Ding, Qingquan Luo, Zhiwei Chen, Shun Lu
Energy stress-induced circZFR enhances oxidative phosphorylation in lung adenocarcinoma via regulating alternative splicing
Zhifei Ma, Hao Chen, Zhijun Xia, Jing You, Chencheng Han, Siwei Wang, Wenjia Xia, Yongkang Bai, Tongyan Liu, Lin Xu, Guoren Zhou, Youtao Xu, Rong Yin
Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids
Mario Cioce, Maria Rita Fumagalli, Sara Donzelli, Frauke Goeman, Valeria Canu, Daniela Rutigliano, Giulia Orlandi, Andrea Sacconi, Claudio Pulito, Alina Catalina Palcau, Maurizio Fanciulli, Aldo Morrone, Maria Grazia Diodoro, Marco Caricato, Anna Crescenzi, Martina Verri, Vito Michele Fazio, Stefano Zapperi, Massimo Levrero, Sabrina Strano, Gian Luca Grazi, Caterina La Porta, Giovanni Blandino
Novel cancer treatment paradigm targeting hypoxia-induced factor in conjunction with current therapies to overcome resistance
Ting-Wan Kao, Geng-Hao Bai, Tian-Li Wang, Ie-Ming Shih, Chi-Mu Chuang, Chun-Liang Lo, Meng-Chen Tsai, Li-Yun Chiu, Chu-Chien Lin, Yao-An Shen
Bifidobacterium adolescentis induces Decorin+ macrophages via TLR2 to suppress colorectal carcinogenesis
Yifeng Lin, Lina Fan, Yadong Qi, Chaochao Xu, Dingjiacheng Jia, Yao Jiang, Shujie Chen, Liangjing Wang
Involvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalk
Mohammad Ahmad, Louis-Bastien Weiswald, Laurent Poulain, Christophe Denoyelle, Matthieu Meryet-Figuiere
Retraction Note: Exosomal microRNA-32-5p induces multidrug resistance in hepatocellular carcinoma via the PI3K/Akt pathway
Xiao Fu, Mengjie Liu, Shengyang Qu, Jiequn Ma, Yamin Zhang, Tingting Shi, Hongqing Wen, Yujuan Yang, Shuhong Wang, Jing Wang, Kejun Nan, Yu Yao, Tao Tian
Inhibition of p90 ribosomal S6 kinases disrupts melanoma cell growth and immune evasion
Corinna Kosnopfel, Simone Wendlinger, Heike Niessner, Johannes Siewert, Tobias Sinnberg, Angelika Hofmann, Jonas Wohlfarth, David Schrama, Marion Berthold, Claudia Siedel, Birgit Sauer, Aarthi Jayanthan, Georg Lenz, Sandra E. Dunn, Bastian Schilling, Birgit Schittek
Retraction Note: Integrin-β5, a miR-185-targeted gene, promotes hepatocellular carcinoma tumorigenesis by regulating β-catenin stability
Zhikun Lin, Ruiping He, Haifeng Luo, Chang Lu, Zhen Ning, Yuanhang Wu, Chuanchun Han, Guang Tan, Zhongyu Wang
Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches
Yaxian Wang, Xinyang Zhong, Xuefeng He, Zijuan Hu, Huixia Huang, Jiayu Chen, Keji Chen, Senlin Zhao, Ping Wei, Dawei Li
Exploring association of melanoma-specific Bcl-xL with tumor immune microenvironment
Anna Maria Lucianò, Marta Di Martile, Ana B. Pérez-Oliva, Marica Di Caprio, Maria Laura Foddai, Simonetta Buglioni, Victoriano Mulero, Donatella Del Bufalo
Correction: M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way
Kai Li, Zi-Yang Peng, Shan Gao, Qing-Shi Wang, Rui Wang, Xiang Li, Guo-Dong Xiao, Jing Zhang, Hong Ren, Shou-Ching Tang, Xin Sun
Correction: Energy stress-induced circZFR enhances oxidative phosphorylation in lung adenocarcinoma via regulating alternative splicing
Zhifei Ma, Hao Chen, Zhijun Xia, Jing You, Chencheng Han, Siwei Wang, Wenjia Xia, Yongkang Bai, Tongyan Liu, Lin Xu, Guoren Zhou, Youtao Xu, Rong Yin
Retraction Note: Long non-coding RNA MACC1-AS1 promoted pancreatic carcinoma progression through activation of PAX8/ NOTCH1 signaling pathway
Chen Qi, Chen Xiaofeng, Li Dongen, Yang Liang, Xu Liping, Hu Yue, Jiang Jianshuai
ISG15 and ISGylation modulates cancer stem cell-like characteristics in promoting tumor growth of anaplastic thyroid carcinoma
Tong Xu, Chaozhuang Zhu, Jinming Chen, Feifeng Song, Xinxin Ren, Shanshan Wang, Xiaofen Yi, Yiwen Zhang, Wanli Zhang, Qing Hu, Hui Qin, Yujia Liu, Song Zhang, Zhuo Tan, Zongfu Pan, Ping Huang, Minghua Ge
Super-enhancers complexes zoom in transcription in cancer
MengTing Wang, QingYang Chen, ShuJie Wang, Han Xie, Jun Liu, RuiXiang Huang, YuFei Xiang, YanYi Jiang, DaSheng Tian, ErBao Bian
Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells
Yanfen Cui, Hui Liu, Zhaosong Wang, He Zhang, Jianfei Tian, Zhiyong Wang, Weijie Song, Hui Guo, Liming Liu, Ruinan Tian, Xiaoyan Zuo, Sixin Ren, Fei Zhang, Ruifang Niu
Correction: Up-regulation of long non-coding RNA PANDAR is associated with poor prognosis and promotes tumorigenesis in bladder cancer
Yonghao Zhan, Junhao Lin, Yuchen Liu, Mingwei Chen, Xiaoying Chen, Chengle Zhuang, Li Liu, Wen Xu, Zhicong Chen, Anbang He, Qiaoxia Zhang, Xiaojuan Sun, Guoping Zhao, Weiren Huang
Novel covalent CDK7 inhibitor potently induces apoptosis in acute myeloid leukemia and synergizes with Venetoclax
Tarang Gaur, Ramulu Poddutoori, Leena Khare, Bhausaheb Bagal, Sonal Rashmi, Nikhil Patkar, Prashant Tembhare, Subramanian PG, Dhanlaxmi Shetty, Amit Dutt, Qi Zhang, Marina Konopleva, Uwe Platzbeckar, Sudeep Gupta, Susanta Samajdar, Murali Ramchandra, Navin Khattry, Syed K. Hasan
A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer
Ioanna Mourkioti, Aikaterini Polyzou, Dimitris Veroutis, George Theocharous, Nefeli Lagopati, Emanuela Gentile, Vasiliki Stravokefalou, Dimitris-Foivos Thanos, Sophia Havaki, Dimitris Kletsas, Theocharis Panaretakis, Christopher J. Logothetis, Dimitris Stellas, Russell Petty, Giovanni Blandino, Angelos Papaspyropoulos, Vassilis G. Gorgoulis
Sertaconazole-repurposed nanoplatform enhances lung cancer therapy via CD44-targeted drug delivery
Ruolan Liu, Qiong Li, Siyuan Qin, Ling Qiao, Mei Yang, Shanshan Liu, Edouard C. Nice, Wei Zhang, Canhua Huang, Shaojiang Zheng, Wei Gao
The new world of RNA diagnostics and therapeutics
Giovanni Blandino, Roberto Dinami, Marco Marcia, Eleni Anastasiadou, Brid M. Ryan, Alina Catalina Palcau, Luigi Fattore, Giulia Regazzo, Rosanna Sestito, Rossella Loria, Ana Belén Díaz Méndez, Maria Chiara Cappelletto, Claudio Pulito, Laura Monteonofrio, George A. Calin, Gabriella Sozzi, Jit Kong Cheong, Ranit Aharonov, Gennaro Ciliberto
TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling
Teng Xu, Yuemei Yang, Zhihong Chen, Jinsong Wang, Xiaolei Wang, Yang Zheng, Chao Wang, Yachen Wang, Zaiou Zhu, Xu Ding, Junbo Zhou, Gang Li, Hongchuang Zhang, Wei Zhang, Yunong Wu, Xiaomeng Song
ZEB1-mediated biogenesis of circNIPBL sustains the metastasis of bladder cancer via Wnt/β-catenin pathway
Yuanlong Li, Yao Kong, Mingjie An, Yuming Luo, Hanhao Zheng, Yan Lin, Jiancheng Chen, Jin Yang, Libo Liu, Baoming Luo, Jian Huang, Tianxin Lin, Changhao Chen
Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy
Jing Ma, Ruijuan Ma, Xueke Zeng, Liming Zhang, Jianing Liu, Wei Zhang, Tao Li, Hanjing Niu, Guochen Bao, Chaojie Wang, Peng George Wang, Jiajia Wang, Xia Li, Taotao Zou, Songqiang Xie
Network approach in liquidomics landscape
Daniele Santini, Andrea Botticelli, Antonio Galvano, Michele Iuliani, Lorena Incorvaia, Valerio Gristina, Chiara Taffon, Simone Foderaro, Elisa Paccagnella, Sonia Simonetti, Federico Fazio, Simone Scagnoli, Giulia Pomati, Francesco Pantano, Giuseppe Perrone, Elena De Falco, Antonio Russo, Gian Paolo Spinelli
RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization
Shuang Tao, Shu-Juan Xie, Li-Ting Diao, Guo Lv, Ya-Rui Hou, Yan-Xia Hu, Wan-Yi Xu, Bin Du, Zhen-Dong Xiao
TSPAN18 facilitates bone metastasis of prostate cancer by protecting STIM1 from TRIM32-mediated ubiquitination
Qianghua Zhou, Xu Chen, Kai Yao, Yangjie Zhang, Haixia He, Hao Huang, Hao Chen, Shengmeng Peng, Ming Huang, Liang Cheng, Qiang Zhang, Ruihui Xie, Kaiwen Li, Tianxin Lin, Hai Huang
Anti-VEGF therapy selects for clones resistant to glucose starvation in ovarian cancer xenografts
Daniele Boso, Martina Tognon, Matteo Curtarello, Sonia Minuzzo, Ilaria Piga, Valentina Brillo, Elisabetta Lazzarini, Jessica Carlet, Ludovica Marra, Chiara Trento, Andrea Rasola, Ionica Masgras, Leonardo Caporali, Fabio Del Ben, Giulia Brisotto, Matteo Turetta, Roberta Pastorelli, Laura Brunelli, Filippo Navaglia, Giovanni Esposito, Angela Grassi, Stefano Indraccolo
Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models
Matteo Centonze, Giusy Di Conza, Michael Lahn, Isabel Fabregat, Francesco Dituri, Isabella Gigante, Grazia Serino, Rosanna Scialpi, Livianna Carrieri, Roberto Negro, Elena Pizzuto, Gianluigi Giannelli
GATA2 co-opts TGFβ1/SMAD4 oncogenic signaling and inherited variants at 6q22 to modulate prostate cancer progression
Xiayun Yang, Qin Zhang, Shuxuan Li, Raman Devarajan, Binjie Luo, Zenglai Tan, Zixian Wang, Nikolaos Giannareas, Tomasz Wenta, Wenlong Ma, Yuqing Li, Yuehong Yang, Aki Manninen, Song Wu, Gong-Hong Wei
Macrophage-organoid co-culture model for identifying treatment strategies against macrophage-related gemcitabine resistance
Shengwei Jiang, Tingwei Deng, Huan Cheng, Weihan Liu, Dan Shi, Jiahui Yuan, Zhiwei He, Weiwei Wang, Boning Chen, Li Ma, Xianbin Zhang, Peng Gong
An amino acid transporter subunit as an antibody–drug conjugate target in colorectal cancer
Juan Carlos Montero, Sofía del Carmen, Mar Abad, José M. Sayagués, Antonio Barbáchano, Asunción Fernández-Barral, Alberto Muñoz, Atanasio Pandiella
Fibronectin fragments generated by pancreatic trypsin act as endogenous inhibitors of pancreatic tumor growth
Andrea Resovi, Perla Persichitti, Laura Brunelli, Lucia Minoli, Patrizia Borsotti, Giulia Garattini, Matteo Tironi, Erica Dugnani, Miriam Redegalli, Giulia De Simone, Roberta Pastorelli, Maria Rosa Bani, Lorenzo Piemonti, Deane F. Mosher, Raffaella Giavazzi, Giulia Taraboletti, Dorina Belotti
Correction: PTENP1/miR-20a/PTEN axis contributes to breast cancer progression by regulating PTEN via PI3K/AKT pathway
Xue Gao, Tao Qin, Jun Mao, Jun Zhang, Shujun Fan, Ying Lu, Zhigang Sun, Qingqing Zhang, Bo Song, Lianhong Li
Mutant p53-ENTPD5 control of the calnexin/calreticulin cycle: a druggable target for inhibiting integrin-α5-driven metastasis
Evangelos Pavlakis, Michelle Neumann, Nastasja Merle, Ronja Wieboldt, Michael Wanzel, Viviane Ponath, Elke Pogge von Strandmann, Sabrina Elmshäuser, Thorsten Stiewe
AR antagonists develop drug resistance through TOMM20 autophagic degradation-promoted transformation to neuroendocrine prostate cancer
Linglong Yin, Yubing Ye, Ling Zou, Jinli Lin, Yi Dai, Yongming Fu, Youhong Liu, Yuchong Peng, Yingxue Gao, Yuxin Fu, Xuli Qi, Tanggang Deng, Songwei Zhang, Xiong Li
CIS deletion by CRISPR/Cas9 enhances human primary natural killer cell functions against allogeneic glioblastoma
Tsutomu Nakazawa, Takayuki Morimoto, Ryosuke Maeoka, Ryosuke Matsuda, Mitsutoshi Nakamura, Fumihiko Nishimura, Noriko Ouji, Shuichi Yamada, Ichiro Nakagawa, Young Soo Park, Toshihiro Ito, Hiroyuki Nakase, Takahiro Tsujimura
Predicting response to immunotherapy in gastric cancer via assessing perineural invasion-mediated inflammation in tumor microenvironment
Xunjun Li, Yiyun Wang, ZhongYa Zhai, Qingyi Mao, Dianjie Chen, Luxi Xiao, Shuai Xu, Qilin Wu, Keming Chen, Qiantong Hou, Qinglie He, Yuyang Shen, Manchun Yang, Zishan Peng, Siqing He, Xuanhui Zhou, Haoyang Tan, Shengwei Luo, Chuanfa Fang, Guoxin Li, Tao Chen
Global serum profiling: an opportunity for earlier cancer detection
Alexandra Sala, James M. Cameron, Paul M. Brennan, Emma J. Crosbie, Tom Curran, Ewan Gray, Pierre Martin-Hirsch, David S. Palmer, Ihtesham U. Rehman, Nicholas J. W. Rattray, Matthew J. Baker
Correction: MiR-29b/Sp1/FUT4 axis modulates the malignancy of leukemia stem cells by regulating fucosylation via Wnt/β-catenin pathway in acute myeloid leukemia
Bing Liu, Hongye Ma, Qianqian Liu, Yang Xiao, Shimeng Pan, Huimin Zhou, Li Jia
LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a/RREB1 positive feedback loop and a ceRNA network
Qingzhuo Dong, Hui Qiu, Chiyuan Piao, Zhengxiu Li, Xiaolu Cui
Breast cancer patient-derived microtumors resemble tumor heterogeneity and enable protein-based stratification and functional validation of individualized drug treatment
Nicole Anderle, Felix Schäfer-Ruoff, Annette Staebler, Nicolas Kersten, André Koch, Cansu Önder, Anna-Lena Keller, Simone Liebscher, Andreas Hartkopf, Markus Hahn, Markus Templin, Sara Y. Brucker, Katja Schenke-Layland, Christian Schmees
Correction: Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models
Matteo Centonze, Giusy Di Conza, Michael Lahn, Isabel Fabregat, Francesco Dituri, Isabella Gigante, Grazia Serino, Rosanna Scialpi, Livianna Carrieri, Roberto Negro, Elena Pizzuto, Gianluigi Giannelli
Correction: Bifidobacterium adolescentis induces Decorin+ macrophages via TLR2 to suppress colorectal carcinogenesis
Yifeng Lin, Lina Fan, Yadong Qi, Chaochao Xu, Dingjiacheng Jia, Yao Jiang, Shujie Chen, Liangjing Wang
Role of the DEAD-box RNA helicase DDX5 (p68) in cancer DNA repair, immune suppression, cancer metabolic control, virus infection promotion, and human microbiome (microbiota) negative influence
Fengzhi Li, Xiang Ling, Sayan Chakraborty, Christos Fountzilas, Jianmin Wang, Anmbreen Jamroze, Xiaozhuo Liu, Pawel Kalinski, Dean G. Tang
MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma
Consuelo Pitolli, Alberto Marini, Marika Guerra, Marco Pieraccioli, Veronica Marabitti, Fernando Palluzzi, Luciano Giacò, Gianpiero Tamburrini, Francesco Cecconi, Francesca Nazio, Claudio Sette, Vittoria Pagliarini
P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC
Mingpeng Zhang, Duo Kan, Boya Zhang, Xueqiao Chen, Chun Wang, Songmao Chen, Wenlong Gao, Zhao Yang, Yang Li, Yutong Chen, Shimiao Zhu, Simeng Wen, Yuanjie Niu, Zhiqun Shang
Dose-related immunomodulatory effects of recombinant TRAIL in the tumor immune microenvironment
Xupu Wang, Lizheng Wang, Wenmo Liu, Xinyao Liu, Xinyuan Jia, Xinyao Feng, Fangshen Li, Rui Zhu, Jiahao Yu, Haihong Zhang, Hui Wu, Jiaxin Wu, Chu Wang, Bin Yu, Xianghui Yu
m6A eraser FTO impairs gemcitabine resistance in pancreatic cancer through influencing NEDD4 mRNA stability by regulating the PTEN/PI3K/AKT pathway
Kai Lin, Endi Zhou, Ting Shi, Siqing Zhang, Jinfan Zhang, Ziruo Zheng, Yuetian Pan, Wentao Gao, Yabin Yu
The circadian clock circuitry modulates leukemia initiating cell activity in T-cell acute lymphoblastic leukemia
Emanuele Murgo, Elisabetta De Santis, Francesca Sansico, Valentina Melocchi, Tommaso Colangelo, Costanzo Padovano, Mattia Colucci, Annalucia Carbone, Beatrice Totti, Alireza Basti, Lisa Gottschlich, Angela Relogio, Nazzareno Capitanio, Fabrizio Bianchi, Gianluigi Mazzoccoli, Vincenzo Giambra
MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation
Yi Zhang, Qin-shan Li, Hong-lin Liu, Hong-ting Tang, Han-lin Yang, Dao-qiu Wu, Yu-ying Huang, Li-cheng Li, Li-hong Liu, Meng-xing Li
Correction: Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer
E. C. de Heer, C. E. Zois, E. Bridges, B. van der Vegt, H. Sheldon, W. A. Veldman, M. C. Zwager, T. van der Sluis, S. Haider, T. Morita, O. Baba, C. P. Schröder, S. de Jong, A. L. Harris, M. Jalving
Exosome nanovesicles as potential biomarkers and immune checkpoint signaling modulators in lung cancer microenvironment: recent advances and emerging concepts
Naushad Ahmad Khan, Mohammad Asim, Kabir H. Biswas, Amani N Alansari, Harman Saman, Mohammad Zahid Sarwar, Kudaibergen Osmonaliev, Shahab Uddin
FAT4 overexpression promotes antitumor immunity by regulating the β-catenin/STT3/PD-L1 axis in cervical cancer
Dongying Wang, Shuying Wu, Jiaxing He, Luguo Sun, Hongming Zhu, Yuxuan Zhang, Shanshan Liu, Xuefeng Duan, Yanhong Wang, Tianmin Xu
Retinoic acid and proteotoxic stress induce AML cell death overcoming stromal cell protection
Francesca Liccardo, Martyna Śniegocka, Claudia Tito, Alessia Iaiza, Tiziana Ottone, Mariadomenica Divona, Serena Travaglini, Maurizio Mattei, Rosella Cicconi, Selenia Miglietta, Giuseppe Familiari, Stefania Annarita Nottola, Vincenzo Petrozza, Luca Tamagnone, Maria Teresa Voso, Silvia Masciarelli, Francesco Fazi
Retraction Note: NF-κB maintains the stemness of colon cancer cells by downregulating miR-195- 5p/497–5p and upregulating MCM2
Longgang Wang, Jinxiang Guo, Jin Zhou, Dongyang Wang, Xiuwen Kang, Lei Zhou
Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application
Hongli Gao, Jianqiao Yin, Ce Ji, Xiaopeng Yu, Jinqi Xue, Xin Guan, Shuang Zhang, Xun Liu, Fei Xing
FBXW7 in breast cancer: mechanism of action and therapeutic potential
Siyu Chen, Ping Leng, Jinlin Guo, Hao Zhou
ERCC6L facilitates the onset of mammary neoplasia and promotes the high malignance of breast cancer by accelerating the cell cycle
Hong Yang, Xiangjin Zhen, Yihui Yang, Yizhi Zhang, Sen Zhang, Yue Hao, Guanhua Du, Hongquan Wang, Bailin Zhang, Wan Li, Jinhua Wang
Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis
Zhitao Han, Qi Jia, Jing Zhang, Miaomiao Chen, Lining Wang, Kai Tong, Weiwei He, Yajie Zhang, Weina Zhu, Ju Qin, Tao Wang, Tielong Liu, Yong Ma, Yuanming Chen, Siluo Zha, Chunlei Zhang
Circadian gene ARNTL initiates circGUCY1A2 transcription to suppress non-small cell lung cancer progression via miR-200c-3p/PTEN signaling
Deze Zhao, Yeping Dong, Minghao Duan, Dan He, Qun Xie, Wei Peng, Weifang Cui, Junjie Jiang, Yuanda Cheng, Heng Zhang, Faqing Tang, Chunfang Zhang, Yang Gao, Chaojun Duan
A patient-derived organoid-based study identified an ASO targeting SNORD14E for endometrial cancer through reducing aberrant FOXM1 Expression and β-catenin nuclear accumulation
Xi Chen, Xin Liu, Qian-hui Li, Bing-feng Lu, Bu-min Xie, Yu-meng Ji, Yang Zhao
RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia
Gunjan Sharma, Tiffany M. Tran, Ishu Bansal, Mohammad Sabique Beg, Ruchi Bhardwaj, Jaspal Bassi, Yuande Tan, Amit Kumar Jaiswal, Christine Tso, Ayushi Jain, Jay Singh, Parthaprasad Chattopadhyay, Archna Singh, Anita Chopra, Sameer Bakhshi, David Casero, Dinesh S. Rao, Jayanth Kumar Palanichamy
SEC23A confers ER stress resistance in gastric cancer by forming the ER stress-SEC23A-autophagy negative feedback loop
Quan Cheng, Kanghui Liu, Jian Xiao, Kuan Shen, Yuanhang Wang, Xinyi Zhou, Jiawei Wang, Zekuan Xu, Li Yang
Correction: Over-expression of oncigenic pesudogene DUXAP10 promotes cell proliferation and invasion by regulating LATS1 and β-catenin in gastric cancer
Yongcan Xu, Xiang Yu, Chenchen Wei, Fengqi Nie, Mingde Huang, Ming Sun
SENP5 promotes homologous recombination-mediated DNA damage repair in colorectal cancer cells through H2AZ deSUMOylation
Tingting Liu, Hang Wang, Yuanyuan Chen, Zhijie Wan, Zhipeng Du, Hui Shen, Yue Yu, Shengzhe Ma, Ying Xu, Zhuqing Li, Nanxi Yu, Fangxiao Zhang, Kun Cao, Jianming Cai, Wei Zhang, Fu Gao, Yanyong Yang
Electrolyte imbalance causes suppression of NK and T cell effector function in malignant ascites
Antonio Hrvat, Mathias Schmidt, Bernd Wagner, Denise Zwanziger, Rainer Kimmig, Lothar Volbracht, Sven Brandau, Nina Mallmann-Gottschalk
Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression
Xuehua Kong, Yu Zhang, Linwei Xiang, Yan You, Yaqian Duan, Yuqing Zhao, Shue Li, Rui Wu, Jiangbo Zhang, Lan Zhou, Liang Duan
Impact of chemotherapeutic agents on liver microenvironment: oxaliplatin create a pro-metastatic landscape
Yuanyuan Ma, Chang Guo, Xijun Wang, Xundong Wei, Jie Ma
Combination of RUNX1 inhibitor and gemcitabine mitigates chemo‐resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress
Chunhua She, Chao Wu, Weihua Guo, Yongjie Xie, Shouyi Li, Weishuai Liu, Chao Xu, Hui Li, Pei Cao, Yanfang Yang, Xiuchao Wang, Antao Chang, Yukuan Feng, Jihui Hao
Circ-RAPGEF5 promotes intrahepatic cholangiocarcinoma progression by stabilizing SAE1 to facilitate SUMOylation
Junhao Zheng, Yali Wang, Liye Tao, Jingwei Cai, Zefeng Shen, Yang Liu, Haoyu Pan, Shihao Li, Yeling Ruan, Tianyi Chen, Zhengtao Ye, Kainan Lin, Yin Sun, Junjie Xu, Xiao Liang
Correction: MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation
Yi Zhang, Qinshan Li, Honglin Liu, Hongting Tang, Hanlin Yang, Daoqiu Wu, Yuying Huang, Licheng Li, Lihong Liu, Mengxing Li
Correction: Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
Yulin Peng, Yan Wang, Ning Tang, Dongdong Sun, Yulong Lan, Zhenlong Yu, Xinyu Zhao, Lei Feng, Baojing Zhang, Lingling Jin, Fabiao Yu, Xiaochi Ma, Chuanzhu Lv
CircRNF10 triggers a positive feedback loop to facilitate progression of glioblastoma via redeploying the ferroptosis defense in GSCs
Chengbin Wang, Minjie Zhang, Yingliang Liu, Daming Cui, Liang Gao, Yang Jiang
Correction: Long non-coding RNA NCK1-AS1 promotes the tumorigenesis of glioma through sponging microRNA-138-2-3p and activating the TRIM24/Wnt/β-catenin axis
Lifa Huang, Xu Li, Hui Ye, Yajun Liu, Xiaolong Liang, Chao Yang, Lin Hua, Zhaoxian Yan, Xin Zhang
Different states of stemness of glioblastoma stem cells sustain glioblastoma subtypes indicating novel clinical biomarkers and high-efficacy customized therapies
Alberto Visioli, Nadia Trivieri, Gandino Mencarelli, Fabrizio Giani, Massimiliano Copetti, Orazio Palumbo, Riccardo Pracella, Maria Grazia Cariglia, Chiara Barile, Luigi Mischitelli, Amata Amy Soriano, Pietro Palumbo, Federico Legnani, Francesco DiMeco, Leonardo Gorgoglione, Graziano Pesole, Angelo L. Vescovi, Elena Binda
Functional polarization of tumor-associated macrophages dictated by metabolic reprogramming
Wentao Zeng, Fei Li, Shikai Jin, Ping-Chih Ho, Pu-Ste Liu, Xin Xie
LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement
Cong Zhang, Huixia Wang, Qingwei Liu, Suli Dai, Guo Tian, Xintong Wei, Xiaoya Li, Lianmei Zhao, Baoen Shan
Phosphoflow cytometry to assess cytokine signaling pathways in peripheral immune cells: potential for inferring immune cell function and treatment response in patients with solid tumors
Nicole J. Toney, Jeffrey Schlom, Renee N. Donahue
CHSY1 promotes CD8+ T cell exhaustion through activation of succinate metabolism pathway leading to colorectal cancer liver metastasis based on CRISPR/Cas9 screening
Guangshun Sun, Siqi Zhao, Zhongguo Fan, Yuliang Wang, Hanyuan Liu, Hengsong Cao, Guoqiang Sun, Tian Huang, Hongzhou Cai, Hong Pan, Dawei Rong, Yun Gao, Weiwei Tang
Hypoxia-induced TMTC3 expression in esophageal squamous cell carcinoma potentiates tumor angiogenesis through Rho GTPase/STAT3/VEGFA pathway
Hongyu Yuan, Zitong Zhao, Jing Xu, Ruiping Zhang, Liying Ma, Jing Han, Weihong Zhao, Mingzhou Guo, Yongmei Song
CRISPR-Cas9 knockout screening identifies KIAA1429 as an essential gene in Ewing sarcoma
Kezhe Tan, Wenjie Lu, Feng Chen, Hao Shi, Yingxuan Ma, Zhou Chen, Wei Wu, Zhibao Lv, Jialin Mo
Circulating extracellular vesicles are monitoring biomarkers of anti-PD1 response and enhancer of tumor progression and immunosuppression in metastatic melanoma
Simona Serratì, Roberta Di Fonte, Letizia Porcelli, Simona De Summa, Ivana De Risi, Livia Fucci, Eustachio Ruggieri, Tommaso Maria Marvulli, Sabino Strippoli, Rossella Fasano, Tania Rafaschieri, Gabriella Guida, Michele Guida, Amalia Azzariti
LncRNA like NMRK2 mRNA functions as a key molecular scaffold to enhance mitochondrial respiration of NONO-TFE3 rearranged renal cell carcinoma in an NAD+ kinase-independent manner
Yi Chen, Yanwen Lu, Lei Yang, Wenliang Ma, Yuhan Dong, Shuoming Zhou, Ning Liu, Weidong Gan, Dongmei Li
Oxamate enhances the efficacy of CAR-T therapy against glioblastoma via suppressing ectonucleotidases and CCR8 lactylation
Ting Sun, Bin Liu, Yanyan Li, Jie Wu, Yufei Cao, Shuangyu Yang, Huiling Tan, Lize Cai, Shiqi Zhang, Xinyue Qi, Dingjia Yu, Wei Yang
Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune system function in breast cancer mouse models
Roberto Ruiu, Chiara Cossu, Antonella Iacoviello, Laura Conti, Elisabetta Bolli, Luca Ponzone, Jolanda Magri, Alekya Rumandla, Enzo Calautti, Federica Cavallo
Chronic stress induces pulmonary epithelial cells to produce acetylcholine that remodels lung pre-metastatic niche of breast cancer by enhancing NETosis
Jun Pan, Leyi Zhang, Xiaomei Wang, Lili Li, Chenghui Yang, Zhen Wang, Ke Su, Xiaoxiao Hu, Yi Zhang, Guohong Ren, Jiahuan Jiang, Peng Li, Jian Huang
ATR-binding lncRNA ScaRNA2 promotes cancer resistance through facilitating efficient DNA end resection during homologous recombination repair
Yuanyuan Chen, Hui Shen, Tingting Liu, Kun Cao, Zhijie Wan, Zhipeng Du, Hang Wang, Yue Yu, Shengzhe Ma, Edward Lu, Wei Zhang, Jianming Cai, Fu Gao, Yanyong Yang
Correction: LncRNA MYLK-AS1 facilitates tumor progression and angiogenesis by targeting miR-424-5p/E2F7 axis and activating VEGF R-2 signaling pathway in hepatocellular carcinoma
Fei Teng, Ju-Xiang Zhang, Qi-Meng Chang, Xu-Bo Wu, Wei-Guo Tang, Jian-Fa Wang, Jin-Feng Feng, Zi-Ping Zhang, Zhi-Qiu Hu
Gastric cancer-derived LBP promotes liver metastasis by driving intrahepatic fibrotic pre-metastatic niche formation
Li Xie, Shengkui Qiu, Chen Lu, Chao Gu, Jihuan Wang, Jialun Lv, Lang Fang, Zetian Chen, Ying Li, Tianlu Jiang, Yiwen Xia, Weizhi Wang, Bowen Li, Zekuan Xu
Acute myeloid leukemia: from NGS, through scRNA-seq, to CAR-T. dissect cancer heterogeneity and tailor the treatment
Edoardo Peroni, Maria Luigia Randi, Antonio Rosato, Stefano Cagnin
Comparative analysis of response to treatments and molecular features of tumor-derived organoids versus cell lines and PDX derived from the same ovarian clear cell carcinoma
Lucie Thorel, Pierre-Marie Morice, Hippolyte Paysant, Romane Florent, Guillaume Babin, Cécilia Thomine, Marion Perréard, Edwige Abeilard, Florence Giffard, Emilie Brotin, Christophe Denoyelle, Céline Villenet, Shéhérazade Sebda, Mélanie Briand, Florence Joly, Enora Dolivet, Didier Goux, Cécile Blanc-Fournier, Corinne Jeanne, Marie Villedieu, Matthieu Meryet-Figuiere, Martin Figeac, Laurent Poulain, Louis-Bastien Weiswald
Anoikis resistance and immune escape mediated by Epstein-Barr virus-encoded latent membrane protein 1-induced stabilization of PGC-1α promotes invasion and metastasis of nasopharyngeal carcinoma
Chaoliang Liao, Min Li, Xue Chen, Chenpeng Tang, Jing Quan, Ann M. Bode, Ya Cao, Xiangjian Luo
Regnase-1 downregulation promotes pancreatic cancer through myeloid-derived suppressor cell-mediated evasion of anticancer immunity
Junya Okabe, Takahiro Kodama, Yu Sato, Satoshi Shigeno, Takayuki Matsumae, Kazuma Daiku, Katsuhiko Sato, Teppei Yoshioka, Minoru Shigekawa, Masaya Higashiguchi, Shogo Kobayashi, Hayato Hikita, Tomohide Tatsumi, Toru Okamoto, Takashi Satoh, Hidetoshi Eguchi, Shizuo Akira, Tetsuo Takehara
The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression
Nianli Liu, Jinqiang Zhang, Weina Chen, Wenbo Ma, Tong Wu
Tumor removal limits prostate cancer cell dissemination in bone and osteoblasts induce cancer cell dormancy through focal adhesion kinase
Ruihua Liu, Shang Su, Jing Xing, Ke Liu, Yawei Zhao, Mary Stangis, Diego P. Jacho, Eda D. Yildirim-Ayan, Cara M. Gatto-Weis, Bin Chen, Xiaohong Li
Hypoxia-induced SKA3 promoted cholangiocarcinoma progression and chemoresistance by enhancing fatty acid synthesis via the regulation of PAR-dependent HIF-1a deubiquitylation
Yananlan Chen, Xiao Xu, Yirui Wang, Yaodong Zhang, Tao Zhou, Wangjie Jiang, Ziyi Wang, Jiang Chang, Shuochen Liu, Ruixiang Chen, Jijun Shan, Jifei Wang, Yuming Wang, Changxian Li, Xiangcheng Li
Correction: Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44 + cancer stem cells to 5 azacytidine in hepatocellular carcinoma
Xiaomei Gao, Yuanyuan Sheng, Jing Yang, Chaoqun Wang, Rui Zhang, Ying Zhu, Ze Zhang, Kaili Zhang, Shican Yan, Haoting Sun, Jinwang Wei, Xuan Wang, Xinxin Yu, Yu Zhang, Qin Luo, Yan Zheng, Peng Qiao, Yue Zhao, Qiongzhu Dong, Lunxiu Qin
LncRNA FTO-IT1 promotes glycolysis and progression of hepatocellular carcinoma through modulating FTO-mediated N6-methyladenosine modification on GLUT1 and PKM2
Fan Wang, Yuhang Hu, Hongda Wang, Ping Hu, Hewei Xiong, Zhu Zeng, Shengbo Han, Decai Wang, Jie Wang, Yong Zhao, Yan Huang, Wenfeng Zhuo, Guozheng Lv, Gang Zhao
Histone acetyltransferase CSRP2BP promotes the epithelial–mesenchymal transition and metastasis of cervical cancer cells by activating N-cadherin
Xiaohui Yang, Fei Sun, Yueying Gao, MengYongwei Li, Mian Liu, Yunjian Wei, Qiuling Jie, Yibing Wang, Jiaoqi Mei, Jingjing Mei, Linna Ma, Yuechuan Shi, Manling Chen, Yongsheng Li, Qi Li, Mingyao Liu, Yanlin Ma
Paracrine activin B-NF-κB signaling shapes an inflammatory tumor microenvironment in gastric cancer via fibroblast reprogramming
Yangbing Jin, Qu Cai, Lingquan Wang, Jun Ji, Ying Sun, Jinling Jiang, Chao Wang, Junwei Wu, Benyan Zhang, Liqin Zhao, Feng Qi, Beiqin Yu, Jun Zhang
UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer
Brittney S. Harrington, Rahul Kamdar, Franklin Ning, Soumya Korrapati, Michael W. Caminear, Lidia F. Hernandez, Donna Butcher, Elijah F. Edmondson, Nadia Traficante, Joy Hendley, Madeline Gough, Rebecca Rogers, Rohan Lourie, Jyoti Shetty, Bao Tran, Fathi Elloumi, Abdalla Abdelmaksoud, Madhu Lal Nag, Krystyna Mazan-Mamczarz, Carrie D. House, John D. Hooper, Christina M. Annunziata
Correction: Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signaling in breast cancer
Jie Shen, Beibei Cao, Yatao Wang, Chenshen Ma, Zhuo Zeng, Liang Liu, Xiaolan Li, Deding Tao, Jianping Gong, Daxing Xie
A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity
Dong-hee Lee, Hyejin Ahn, Hye-In Sim, Eunji Choi, Seunghyun Choi, Yunju Jo, Bohwan Yun, Hyun Kyu Song, Soo Jin Oh, Kaori Denda-Nagai, Chan-Sik Park, Tatsuro Irimura, Yoon Park, Hyung-seung Jin
IGF-1R targeting in cancer – does sub-cellular localization matter?
Upendra K. Soni, Liam Jenny, Rashmi S. Hegde
ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer
Pingping Su, Xiaodan Mao, Jincheng Ma, Lixiang Huang, Lirui Yu, Shuting Tang, Mingzhi Zhuang, Zhonglei Lu, Kelvin Stefan Osafo, Yuan Ren, Xinrui Wang, Xite Lin, Leyi Huang, Xiaoli Huang, Elena Ioana Braicu, Jalid Sehouli, Pengming Sun
E3 ligase TRIM28 promotes anti-PD-1 resistance in non-small cell lung cancer by enhancing the recruitment of myeloid-derived suppressor cells
Manman Liang, Zhengui Sun, Xingwu Chen, Lijing Wang, Hanli Wang, Lilong Qin, Wenying Zhao, Biao Geng
Autoimmune PaneLs as PrEdictors of Toxicity in Patients TReated with Immune Checkpoint InhibiTors (ALERT)
Sofia Genta, Katherine Lajkosz, Noelle R. Yee, Pavlina Spiliopoulou, Alya Heirali, Aaron R. Hansen, Lillian L. Siu, Sam Saibil, Lee-Anne Stayner, Maryia Yanekina, Maxwell B. Sauder, Sareh Keshavarzi, Abdulazeez Salawu, Olga Vornicova, Marcus O. Butler, Philippe L. Bedard, Albiruni R. Abdul Razak, Robert Rottapel, Andrzej Chruscinski, Bryan Coburn, Anna Spreafico
Tumor cell-induced platelet aggregation accelerates hematogenous metastasis of malignant melanoma by triggering macrophage recruitment
Yuyi Chen, Jie Zhou, Zishen Liu, Tongtong Wu, Shumeng Li, Yutong Zhang, Xiaohui Yin, Guowang Yang, Ganlin Zhang
Correction: Circulating cell free DNA and citrullinated histone H3 as useful biomarkers of NETosis in endometrial cancer
Livia Ronchetti, Irene Terrenato, Margherita Ferretti, Giacomo Corrado, Frauke Goeman, Sara Donzelli, Chiara Mandoj, Roberta Merola, Ashanti Zampa, Mariantonia Carosi, Giovanni Blandino, Laura Conti, Anna Maria Lobascio, Marcello Iacobelli, Enrico Vizza, Giulia Piaggio, Aymone Gurtner
Autocrine regulation of tumor cell repopulation by Hsp70-HMGB1 alarmin complex
Dmitry V. Sverchinsky, Bashar A. Alhasan, Marina A. Mikeladze, Vladimir F. Lazarev, Liubov S. Kuznetcova, Alisa V. Morshneva, Alina D. Nikotina, Amr Ziewanah, Lidia V. Koludarova, Tatiana Y. Starkova, Boris A. Margulis, Irina V. Guzhova
Antibody drug conjugates: hitting the mark in pancreatic cancer?
Nicole L. Wittwer, Michael P. Brown, Vasilios Liapis, Alexander H. Staudacher
Implementing patient derived organoids in functional precision medicine for patients with advanced colorectal cancer
Jérôme Cartry, Sabrina Bedja, Alice Boilève, Jacques R. R. Mathieu, Emilie Gontran, Maxime Annereau, Bastien Job, Ali Mouawia, Pierre Mathias, Thierry De Baère, Antoine Italiano, Benjamin Besse, Isabelle Sourrouille, Maximiliano Gelli, Mohamed-Amine Bani, Peggy Dartigues, Antoine Hollebecque, Cristina Smolenschi, Michel Ducreux, David Malka, Fanny Jaulin
Splicing alterations in pancreatic ductal adenocarcinoma: a new molecular landscape with translational potential
Emilia Alors-Pérez, Sergio Pedraza-Arevalo, Ricardo Blázquez-Encinas, María Trinidad Moreno-Montilla, Víctor García-Vioque, Inmaculada Berbel, Raúl M. Luque, Bruno Sainz Jr, Alejandro Ibáñez-Costa, Justo P. Castaño
Exosomal long noncoding RNA MLETA1 promotes tumor progression and metastasis by regulating the miR-186-5p/EGFR and miR-497-5p/IGF1R axes in non-small cell lung cancer
Xiu-Rui Hsu, Jia-En Wu, Yi-Ying Wu, Sheng-Yen Hsiao, Jui-Lin Liang, Ya-Ju Wu, Chia-Hao Tung, Meng-Fan Huang, Ming-Shiu Lin, Pan-Chyr Yang, Yuh-Ling Chen, Tse-Ming Hong
The potential of swine pseudorabies virus attenuated vaccine for oncolytic therapy against malignant tumors
Guosong Wang, Jiali Cao, Mengxuan Gui, Pengfei Huang, Liang Zhang, Ruoyao Qi, Ruiqi Chen, Lina Lin, Qiangyuan Han, Yanhua Lin, Tian Chen, Peiqing He, Jian Ma, Rao Fu, Junping Hong, Qian Wu, Hai Yu, Junyu Chen, Chenghao Huang, Tianying Zhang, Quan Yuan, Jun Zhang, Yixin Chen, Ningshao Xia
Albumin-bound paclitaxel augment temozolomide treatment sensitivity of glioblastoma cells by disrupting DNA damage repair and promoting ferroptosis
Shanqiang Qu, Songtao Qi, Huayang Zhang, Zhiyong Li, Kaicheng Wang, Taichen Zhu, Rongxu Ye, Wanghao Zhang, Guanglong Huang, Guo-zhong Yi
TMEM147 aggravates the progression of HCC by modulating cholesterol homeostasis, suppressing ferroptosis, and promoting the M2 polarization of tumor-associated macrophages
Jingjing Huang, Huayang Pan, Jing Sun, Jiaming Wu, Qiyue Xuan, Jinge Wang, Shanjia Ke, Shounan Lu, Zihao Li, Zhigang Feng, Yongliang Hua, Qingan Yu, Bing Yin, Baolin Qian, Menghua Zhou, Yanan Xu, Miaoyu Bai, Yingmei Zhang, Yaohua Wu, Yong Ma, Hongchi Jiang, Wenjie Dai
CD28/PD1 co-expression: dual impact on CD8+ T cells in peripheral blood and tumor tissue, and its significance in NSCLC patients' survival and ICB response
Belinda Palermo, Ornella Franzese, Giuseppe Frisullo, Lorenzo D’Ambrosio, Mariangela Panetta, Giulia Campo, Daniel D’Andrea, Isabella Sperduti, Francesca De Nicola, Frauke Goeman, Filippo Gallina, Paolo Visca, Francesco Facciolo, Paola Nisticò
Circulating small extracellular vesicle-derived splicing factor 3b subunit 4 as a non-invasive diagnostic biomarker of early hepatocellular carcinoma
Ju A Son, Ji Hyang Weon, Geum Ok Baek, Hye Ri Ahn, Ji Yi Choi, Moon Gyeong Yoon, Hyo Jung Cho, Jae Youn Cheong, Jung Woo Eun, Soon Sun Kim
Tumor-associated macrophage-derived exosomes LINC01592 induce the immune escape of esophageal cancer by decreasing MHC-I surface expression
Xinwei Qiao, Zaixing Cheng, Kaming Xue, Cui Xiong, Zhikun Zheng, Xin Jin, Jinsong Li
FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression
Wei-Min Hu, Ming Li, Jin-Zhuo Ning, Yu-Qi Tang, Tian-Bao Song, Lin-Zhi Li, Fan Zou, Fan Cheng, Wei-Min Yu
Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity
Yue Zheng, Yiran Yao, Tongxin Ge, Shengfang Ge, Renbing Jia, Xin Song, Ai Zhuang
Suppression of TNBC metastasis by doxazosin, a novel dual inhibitor of c-MET/EGFR
Seongjae Kim, Jung Min Park, Soeun Park, Eunsun Jung, Dongmi Ko, Minsu Park, Juyeon Seo, Kee Dal Nam, Yong Koo Kang, Kyoungmin Lee, Lee Farrand, Yoon-Jae Kim, Ji Young Kim, Jae Hong Seo
CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models
Andrea Timpanaro, Caroline Piccand, Dzhangar Dzhumashev, Stenija Anton-Joseph, Andrea Robbi, Janine Moser, Jochen Rössler, Michele Bernasconi
MYL9 expressed in cancer-associated fibroblasts regulate the immune microenvironment of colorectal cancer and promotes tumor progression in an autocrine manner
Shenghe Deng, Denglong Cheng, Jun Wang, Junnan Gu, Yifan Xue, Zhenxing Jiang, Le Qin, Fuwei Mao, Yinghao Cao, Kailin Cai
PINK1-PTEN axis promotes metastasis and chemoresistance in ovarian cancer via non-canonical pathway
Fang Zheng, Jiamin Zhong, Kelie Chen, Yu Shi, Fang Wang, Shengchao Wang, Song Tang, Xiaoyu Yuan, Zhangjin Shen, Sangsang Tang, Dajing Xia, Yihua Wu, Weiguo Lu
Lnc AC016727.1/BACH1/HIF-1 α signal loop promotes the progression of non-small cell lung cancer
Li Zhang, Jingtian Liang, Hao Qin, Yin Lv, Xiucheng Liu, Zhuoqun Li, Zhixiang Chao, Caili Jia, Xichun Qin, Hao Zhang
Regulation of the Hippo/YAP axis by CXCR7 in the tumorigenesis of gastric cancer
Tianshi Wang, Dehai Wang, Yanan Sun, Ting Zhuang, Xin Li, Huijie Yang, Yifeng Zang, Ziping Liu, Penghe Yang, Chenmiao Zhang, Jiayao Cui, Mingxi Fu, Shuqing Zhang, Peng Su, Zhongbo Li, Jian Zhu, Yinlu Ding
Anti-tumor activity of all-trans retinoic acid in gastric-cancer: gene-networks and molecular mechanisms
Luca Guarrera, Mami Kurosaki, Silvio-Ken Garattini, Maurizio Gianni’, Gianpiero Fasola, Luca Rossit, Michele Prisciandaro, Maria Di Bartolomeo, Marco Bolis, Paola Rizzo, Claudia Nastasi, Marika Foglia, Adriana Zanetti, Gabriela Paroni, Mineko Terao, Enrico Garattini
Correction: circPVT1 regulates medullary thyroid cancer growth and metastasis by targeting miR-455-5p to activate CXCL12/CXCR4 signaling
Xun Zheng, Shu Rui, Xiao-Fei Wang, Xiu-He Zou, Yan-Ping Gong, Zhi-Hui Li
Differential immunomodulatory effects of epirubicin/cyclophosphamide and docetaxel in breast cancer patients
Kerstin Wimmer, Monika Sachet, Cristiano Ramos, Sophie Frantal, Hanna Birnleitner, Christine Brostjan, Ruth Exner, Martin Filipits, Zsuzsanna Bago-Horvath, Margaretha Rudas, Rupert Bartsch, Michael Gnant, Christian F. Singer, Marija Balic, Daniel Egle, Rudolf Oehler, Florian Fitzal
MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density
Christophe Papin, Abdulkhaleg Ibrahim, Jamal S. M. Sabir, Stéphanie Le Gras, Isabelle Stoll, Raed S. Albiheyri, Ali T. Zari, Ahmed Bahieldin, Alfonso Bellacosa, Christian Bronner, Ali Hamiche
Invasive FoxM1 phosphorylated by PLK1 induces the polarization of tumor-associated macrophages to promote immune escape and metastasis, amplified by IFITM1
Rong Xu, Young-Joo Lee, Chang-Hyeon Kim, Ga-Hong Min, Yeo-Bin Kim, Jung-Won Park, Dae-Hoon Kim, Jung-Hyun Kim, Hyungshin Yim
Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma
Jialiang Wang, Xiaoyu Zhang, Xinyi Ma, Dongmei Chen, Meina Cai, Lexin Xiao, Jing Li, Zexuan Huang, Yuehua Huang, Yifan Lian
Targeting FAcilitates Chromatin Transcription complex inhibits pleural mesothelioma and enhances immunotherapy
Anand Singh, Nathanael Pruett, Shivani Dixit, Sudheer K. Gara, Haitao Wang, Roma Pahwa, David S. Schrump, Chuong D. Hoang
Correction: Helicobacter pylori CagA promotes epithelial mesenchymal transition in gastric carcinogenesis via triggering oncogenic YAP pathway
Nianshuang Li, Yan Feng, Yi Hu, Cong He, Chuan Xie, Yaobin Ouyang, Stephen C. Artim, Deqiang Huang, Yin Zhu, Zhijun Luo, Zhongming Ge, Nonghua Lu
m6A modified BACE1-AS contributes to liver metastasis and stemness-like properties in colorectal cancer through TUFT1 dependent activation of Wnt signaling
Xidi Wang, Yu Liu, Miao Zhou, Lei Yu, Zizhen Si
Correction: UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expression of PDK1 through PI3K/AKT signaling
Jian-Xian Lin, Xin-Sheng Xie, Xiong-Feng Weng, Sheng-Liang Qiu, Changhwan Yoon, Ning-Zi Lian, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ying-Hong Yang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li
CRISPR/Cas9: a powerful tool in colorectal cancer research
Yang Hu, Liang Liu, Qi Jiang, Weiping Fang, Yazhu Chen, Yuntian Hong, Xiang Zhai
Cancer organoid-based diagnosis reactivity prediction (CODRP) index-based anticancer drug sensitivity test in ALK-rearrangement positive non-small cell lung cancer (NSCLC)
Sang-Yun Lee, Hyeong Jun Cho, Jimin Choi, Bosung Ku, Seok Whan Moon, Mi Hyoung Moon, Kyung Soo Kim, Kwanyong Hyun, Tae-Jung Kim, Yeoun Eun Sung, Yongki Hwang, Eunyoung Lee, Dong Hyuck Ahn, Joon Young Choi, Jeong Uk Lim, Chan Kwon Park, Sung Won Kim, Seung Joon Kim, In-Seong Koo, Woo Seok Jung, Sang-Hyun Lee, Chang Dong Yeo, Dong Woo Lee
CSPG4 CAR-redirected Cytokine Induced Killer lymphocytes (CIK) as effective cellular immunotherapy for HLA class I defective melanoma
Lidia Giraudo, Giulia Cattaneo, Loretta Gammaitoni, Ilenia Iaia, Chiara Donini, Annamaria Massa, Maria Laura Centomo, Marco Basiricò, Elisa Vigna, Alberto Pisacane, Franco Picciotto, Enrico Berrino, Caterina Marchiò, Alessandra Merlini, Luca Paruzzo, Stefano Poletto, Daniela Caravelli, Andrea Michela Biolato, Valentina Bortolot, Elisa Landoni, Marco Ventin, Cristina R. Ferrone, Massimo Aglietta, Gianpietro Dotti, Valeria Leuci, Fabrizio Carnevale-Schianca, Dario Sangiolo
Liver cancer stem cell dissemination and metastasis: uncovering the role of NRCAM in hepatocellular carcinoma
Lingyun Zhou, Linye He, Chang-Hai Liu, Huandi Qiu, Li Zheng, Klarke Michael Sample, Qin Wu, Jiaxin Li, Kunlin Xie, Javier Ampuero, Zhihui Li, Duoduo Lv, Miao Liu, Manuel Romero-Gómez, Yiguo Hu, Hong Tang
Correction: The potential of swine pseudorabies virus attenuated vaccine for oncolytic therapy against malignant tumors
Guosong Wang, Jiali Cao, Mengxuan Gui, Pengfei Huang, Liang Zhang, Ruoyao Qi, Ruiqi Chen, Lina Lin, Qiangyuan Han, Yanhua Lin, Tian Chen, Peiqing He, Jian Ma, Rao Fu, Junping Hong, Qian Wu, Hai Yu, Junyu Chen, Chenghao Huang, Tianying Zhang, Quan Yuan, Jun Zhang, Yixin Chen, Ningshao Xia
circ-hnRNPU inhibits NONO-mediated c-Myc transactivation and mRNA stabilization essential for glycosylation and cancer progression
Hongjun Li, Wanju Jiao, Jiyu Song, Jianqun Wang, Guo Chen, Dan Li, Xiaojing Wang, Banghe Bao, Xinyi Du, Yang Cheng, Chunhui Yang, Qiangsong Tong, Liduan Zheng
Correction: albumin-bound paclitaxel augment temozolomide treatment sensitivity of glioblastoma cells by disrupting DNA damage repair and promoting ferroptosis
Shanqiang Qu, Songtao Qi, Huayang Zhang, Zhiyong Li, Kaicheng Wang, Taichen Zhu, Rongxu Ye, Wanghao Zhang, Guanglong Huang, Guo-zhong Yi
Transcriptomic landscape based on annotated clinical features reveals PLPP2 involvement in lipid raft-mediated proliferation signature of early-stage lung adenocarcinoma
Yibei Wang, Ziwei Miao, Xiaoxue Qin, Yi Yang, Si Wu, Qi Miao, Beibei Li, Mingyu Zhang, Pengfei Wu, Yun Han, Bo Li
Cancer-associated fibroblasts-derived CXCL12 enhances immune escape of bladder cancer through inhibiting P62-mediated autophagic degradation of PDL1
Zhao Zhang, Yongbo Yu, Zhilei Zhang, Dan Li, Zhijuan Liang, Liping Wang, Yuanbin Chen, Ye Liang, Haitao Niu
Upregulated expression of miR-4443 and miR-4488 in drug resistant melanomas promotes migratory and invasive phenotypes through downregulation of intermediate filament nestin
Vittorio Castaldo, Michele Minopoli, Francesca Di Modugno, Andrea Sacconi, Domenico Liguoro, Rachele Frigerio, Arianna Ortolano, Marta Di Martile, Luisa Gesualdi, Gabriele Madonna, Mariaelena Capone, Roberto Cirombella, Angiolina Catizone, Donatella Del Bufalo, Andrea Vecchione, Maria Vincenza Carriero, Paolo Antonio Ascierto, Rita Mancini, Luigi Fattore, Gennaro Ciliberto
RSK3 switches cell fate: from stress-induced senescence to malignant progression
Anda Huna, Jean-Michel Flaman, Catalina Lodillinsky, Kexin Zhu, Gabriela Makulyte, Victoria Pakulska, Yohann Coute, Clémence Ruisseaux, Pierre Saintigny, Hector Hernandez-Vargas, Pierre-Antoine Defossez, Mathieu Boissan, Nadine Martin, David Bernard
Hsa_circ_0009092/miR-665/NLK signaling axis suppresses colorectal cancer progression via recruiting TAMs in the tumor microenvironment
Jialin Song, Qing Liu, Lei Han, Tiantian Song, Sihao Huang, Xinyao Zhang, Qiuming He, Chenxi Liang, Shuai Zhu, Bin Xiong
EZH2-H3K27me3-mediated silencing of mir-139-5p inhibits cellular senescence in hepatocellular carcinoma by activating TOP2A
Ke Wang, Xunliang Jiang, Yu Jiang, Jun Liu, Yongtao Du, Zecheng Zhang, Yunlong Li, Xinhui Zhao, Jipeng Li, Rui Zhang
Correction: Synthetic tetracycline-controllable shRNA targeting long non-coding RNA HOXD-AS1 inhibits the progression of bladder cancer
Jianfa Li, Chengle Zhuang, Yuchen Liu, Mingwei Chen, Yincong Chen, Zhicong Chen, Anbang He, Junhao Lin, Yonghao Zhan, Li Liu, Wen Xu, Guoping Zhao, Yinglu Guo, Hanwei Wu, Zhiming Cai, Weiren Huang
Ginseng-derived nanoparticles reprogram macrophages to regulate arginase-1 release for ameliorating T cell exhaustion in tumor microenvironment
Yan Lv, Mengyuan Li, Ling Weng, Haoying Huang, Yujie Mao, Danchen Aaron Yang, Qingyun Wei, Mengmeng Zhao, Qin Wei, Ke Rui, Xuan Han, Weiwei Fan, Xueting Cai, Peng Cao, Meng Cao
Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity
Quan Zheng, Jiajia Tang, Alexandra Aicher, Tony Bou Kheir, Berina Sabanovic, Preeta Ananthanarayanan, Chiara Reina, Minchun Chen, Jian-Min Gu, Bin He, Sonia Alcala, Diana Behrens, Rita T. Lawlo, Aldo Scarpa, Manuel Hidalgo, Bruno Sainz Jr., Patricia Sancho, Christopher Heeschen
Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer
Shangyou Zheng, Qing Tian, Yuan Yuan, Shuxin Sun, Tingting Li, Renpeng Xia, Rihua He, Yuming Luo, Qing Lin, Zhiqiang Fu, Yu Zhou, Rufu Chen, Chonghui Hu
Targeting PEG10 as a novel therapeutic approach to overcome CDK4/6 inhibitor resistance in breast cancer
Nar Bahadur Katuwal, Min Sil Kang, Mithun Ghosh, Sa Deok Hong, Yeong Gyu Jeong, Seong Min Park, Seul-Gi Kim, Joohyuk Sohn, Tae Hoen Kim, Yong Wha Moon
RIT1 regulates mitosis and promotes proliferation by interacting with SMC3 and PDS5 in hepatocellular carcinoma
Yang Su, Hechun Lin, Junming Yu, Lin Mao, Wenjiao Jin, Tengfei Liu, Shuqing Jiang, Yunyu Wu, Saihua Zhang, Qin Geng, Chao Ge, Fangyu Zhao, Taoyang Chen, Ying Cui, Jinjun Li, Helei Hou, Xinli Zhou, Hong Li
Correction: Reciprocal regulation of integrin β4 and KLF4 promotes gliomagenesis through maintaining cancer stem cell traits
Binbin Ma, Li Zhang, Yujie Zou, Ruiping He, Qiong Wu, Chuanchun Han, Bo Zhang
Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling
Sara F.F. Almeida, Liliana Santos, Gabriela Sampaio-Ribeiro, Hugo R.S. Ferreira, Nuno Lima, Rui Caetano, Mónica Abreu, Mónica Zuzarte, Ana Sofia Ribeiro, Artur Paiva, Tânia Martins-Marques, Paulo Teixeira, Rui Almeida, José Manuel Casanova, Henrique Girão, Antero J. Abrunhosa, Célia M. Gomes
Hedgehog-Gli1-derived exosomal circ-0011536 mediates peripheral neural remodeling in pancreatic cancer by modulating the miR-451a/VGF axis
Weiqi Dai, Xiaoli Wu, Jingjing Li, Wenxi Tang, Ying Wang, Wenqiang Xu, Dengyu Han, Xiaorong Xu, Xuanfu Xu
Circular RNA circATP9A promotes non-small cell lung cancer progression by interacting with HuR and by promoting extracellular vesicles-mediated macrophage M2 polarization
Yuanshan Yao, Chunji Chen, Jing Wang, Haojie Xuan, Xiuxiu Chen, Zheng Li, Fuzhi Yang, Bin Wang, Siyun Lin, Saitian Li, Dongfang Tang, Libao Gong, Wen Gao
SNORA56-mediated pseudouridylation of 28 S rRNA inhibits ferroptosis and promotes colorectal cancer proliferation by enhancing GCLC translation
Chang Xu, Zhixuan Bian, Xinyue Wang, Na Niu, Li Liu, Yixuan Xiao, Jiabei Zhu, Nan Huang, Yue Zhang, Yan Chen, Qi Wu, Fenyong Sun, Xiaoli Zhu, Qiuhui Pan
Correction: Cancer organoid-based diagnosis reactivity prediction (CODRP) index-based anticancer drug sensitivity test in ALK-rearrangement positive non-small cell lung cancer (NSCLC)
Sang-Yun Lee, Hyeong Jun Cho, Jimin Choi, Bosung Ku, Seok Whan Moon, Mi Hyoung Moon, Kyung Soo Kim, Kwanyong Hyun, Tae-Jung Kim, Yeoun Eun Sung, Yongki Hwang, Eunyoung Lee, Dong Hyuck Ahn, Joon Young Choi, Jeong Uk Lim, Chan Kwon Park, Sung Won Kim, Seung Joon Kim, In-Seong Koo, Woo Seok Jung, Sang-Hyun Lee, Chang Dong Yeo, Dong Woo Lee
Immune checkpoints are predominantly co-expressed by clonally expanded CD4+FoxP3+ intratumoral T-cells in primary human cancers
Delphine Bredel, Edi Tihic, Séverine Mouraud, François-Xavier Danlos, Sandrine Susini, Marine Aglave, Alexia Alfaro, Chifaou Mohamed-Djalim, Mathieu Rouanne, Héloise Halse, Amélie Bigorgne, Lambros Tselikas, Stéphane Dalle, Dana M. Hartl, Eric Baudin, Catherine Guettier, Eric Vibert, Olivier Rosmorduc, Caroline Robert, Sophie Ferlicot, Bastien Parier, Laurence Albiges, Vincent Thomas de Montpreville, Benjamin Besse, Olaf Mercier, Caroline Even, Ingrid Breuskin, Marion Classe, Camélia Radulescu, Thierry Lebret, Patricia Pautier, Sébastien Gouy, Jean-Yves Scoazec, Laurence Zitvogel, Aurélien Marabelle, Mélodie Bonvalet
CircGPRC5A enhances colorectal cancer progress by stabilizing PPP1CA and inducing YAP dephosphorylation
Zhenzhou Chen, Yidan Li, Kuan He, Jianguo Yang, Qican Deng, Yajun Chen, Zhongxue Fu
ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK
Li Cui, Ye Lu, Jiarong Zheng, Bing Guo, Xinyuan Zhao
Interleukin-30 subverts prostate cancer-endothelium crosstalk by fostering angiogenesis and activating immunoregulatory and oncogenic signaling pathways
Stefania Livia Ciummo, Carlo Sorrentino, Cristiano Fieni, Emma Di Carlo
Targeting the myeloid microenvironment in neuroblastoma
Marjolein C. Stip, Loes Teeuwen, Miranda P. Dierselhuis, Jeanette H. W. Leusen, Daniëlle Krijgsman
Nutlin-3a induces KRAS mutant/p53 wild type lung cancer specific methuosis-like cell death that is dependent on GFPT2
Dasom Kim, Dongwha Min, Joohee Kim, Min Jung Kim, Yerim Seo, Byung Hwa Jung, Seung‑Hae Kwon, Hyunju Ro, Seoee Lee, Jason K. Sa, Ji-Yun Lee
SNHG17 alters anaerobic glycolysis by resetting phosphorylation modification of PGK1 to foster pro-tumor macrophage formation in pancreatic ductal adenocarcinoma
Jiayu Lin, Yihao Liu, Pengyi Liu, Wenxin Qi, Jia Liu, Xingfeng He, Qian Liu, Zehua Liu, Jingxin Yin, Jiewei Lin, Haili Bao, Jianhong Lin
AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth
Hye Jin Yun, Min Li, Dong Guo, So Mi Jeon, Su Hwan Park, Je Sun Lim, Su Bin Lee, Rui Liu, Linyong Du, Seok-Ho Kim, Tae Hwan Shin, Seong-il Eyun, Yun-Yong Park, Zhimin Lu, Jong-Ho Lee
Immunotheranostic target modules for imaging and navigation of UniCAR T-cells to strike FAP-expressing cells and the tumor microenvironment
Liliana R. Loureiro, Lydia Hoffmann, Christin Neuber, Luise Rupp, Claudia Arndt, Alexandra Kegler, Manja Kubeil, Christoph E. Hagemeyer, Holger Stephan, Marc Schmitz, Anja Feldmann, Michael Bachmann
RGCC-mediated PLK1 activity drives breast cancer lung metastasis by phosphorylating AMPKα2 to activate oxidative phosphorylation and fatty acid oxidation
Shaojie Cheng, Xueying Wan, Liping Yang, Yilu Qin, Shanchun Chen, Yongcan Liu, Yan Sun, Yuxiang Qiu, Luyi Huang, Qizhong Qin, Xiaojiang Cui, Mingjun Wu, Manran Liu
Exploring the interaction between extracellular matrix components in a 3D organoid disease model to replicate the pathophysiology of breast cancer
Anamitra Bhattacharya, Kamare Alam, Nakka Sharmila Roy, Kulwinder Kaur, Santanu Kaity, Velayutham Ravichandiran, Subhadeep Roy
GABA induced by sleep deprivation promotes the proliferation and migration of colon tumors through miR-223-3p endogenous pathway and exosome pathway
Haijun Bao, Zuojie Peng, Xukai Cheng, Chenxing Jian, Xianguo Li, Yongping Shi, Wenzhong Zhu, Yuan Hu, Mi Jiang, Jia Song, Feifei Fang, Jinhuang Chen, Xiaogang Shu
Correction: circular RNA circATP9A promotes non-small cell Lung cancer progression by interacting with HuR and by promoting extracellular vesicles-mediated macrophage M2 polarization
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