Background
Methods
Recruitment and follow up
Baseline questionnaires
Statistical methods
Results
Unaffected | Affected | HR | 95% CI |
P
| |||
---|---|---|---|---|---|---|---|
Number | Percentage | Number | Percentage | ||||
Age at baseline, years | |||||||
18–29 | 2407 | 15.9 | 49 | 5.5 | 1.00 | (referent) | |
30–39 | 3087 | 20.4 | 182 | 20.3 | 1.34 | 0.81, 2.20 | 0.3 |
40–49 | 3189 | 21.1 | 231 | 25.8 | 1.18 | 0.65, 2.14 | 0.6 |
50–59 | 2869 | 19.0 | 232 | 25.9 | 1.20 | 0.60, 2.40 | 0.6 |
60–69 | 2179 | 14.4 | 166 | 18.5 | 0.98 | 0.46, 2.11 | 1.0 |
70–79 | 1408 | 9.3 | 36 | 4.0 | 0.53 | 0.20, 1.38 | 0.2 |
1-year BOADICEA, % | |||||||
Q1: 0–0.13 | 4010 | 26.5 | 84 | 9.4 | 1.00 | (referent) | |
Q2: 0.14–0.34 | 3167 | 23.9 | 188 | 21.0 | 2.14 | 1.51, 3.04 | < 0.001 |
Q3: 0.35–0.53 | 3672 | 24.3 | 241 | 26.9 | 3.41 | 2.38, 4.89 | < 0.001 |
Q4: 0.54–7.94 | 3840 | 25.4 | 383 | 42.8 | 5.20 | 3.65, 7.42 | < 0.001 |
Body mass index, kg/m2 | |||||||
Q1: 14.69–21.86 | 3811 | 25.2 | 194 | 21.7 | 1.00 | (referent) | |
Q2: 21.87–24.60 | 3766 | 24.9 | 227 | 25.3 | 1.07 | 0.89, 1.30 | 0.5 |
Q3: 24.61–28.56 | 3771 | 24.9 | 252 | 28.1 | 1.17 | 0.96, 1.41 | 0.1 |
Q4: 28.57–58.86 | 3791 | 25.0 | 223 | 24.9 | 1.05 | 0.87, 1.28 | 0.6 |
History of benign breast disease | |||||||
No | 10,953 | 72.4 | 551 | 61.5 | 1.00 | (referent) | |
Yes | 3878 | 25.6 | 323 | 36.1 | 1.33 | 1.15, 1.54 | < 0.001 |
Menopausal status | |||||||
Premenopausal | 8669 | 57.3 | 467 | 52.1 | 1.00 | (referent) | |
Postmenopausal | 6470 | 42.7 | 429 | 47.9 | 1.02 | 0.81, 1.29 | 0.8 |
Race/ethnicity | |||||||
Non-Hispanic white | 11,969 | 79.1 | 750 | 83.7 | 1.00 | (referent) | |
Black | 726 | 4.8 | 29 | 3.2 | 0.60 | 0.40, 0.89 | 0.01 |
Hispanic | 1310 | 8.7 | 52 | 5.8 | 0.74 | 0.53, 1.04 | 0.08 |
Asian | 574 | 3.8 | 39 | 4.4 | 0.87 | 0.60, 1.26 | 0.5 |
Other | 417 | 2.8 | 17 | 1.9 | 0.72 | 0.45, 1.15 | 0.2 |
Missing | 143 | 0.9 | 9 | 1.0 | |||
Education, highest completed | |||||||
High school or general education development | 5031 | 33.2 | 260 | 29.0 | 1.00 | (referent) | |
Vocational, technical, or some college or university | 5709 | 37.7 | 319 | 35.6 | 1.15 | 0.97, 1.37 | 0.1 |
Bachelor or graduate degree | 4341 | 28.7 | 313 | 34.9 | 1.42 | 1.18, 1.70 | < 0.001 |
Missing | 58 | 0.4 | 4 | 0.5 |
Model | HRb | 95% CI |
P
| ΔLLc | |
---|---|---|---|---|---|
I | Log body mass indexa (per 5 kg/m2) | 1.28 | 0.91, 1.81 | 0.2 | 2.38 |
Age at baseline, years | 0.98 | 0.96, 1.00 | 0.1 | ||
Menopause, no/yes | 1.12 | 0.88, 1.43 | 0.4 | ||
II | Log body mass indexa (per 5 kg/m2) | 0.13 | 0.03, 0.56 | 0.006 | 7.36 |
Age at baseline, years | 0.98 | 0.96, 1.00 | 0.1 | ||
Menopause, no/yes | 1.12 | 0.88, 1.44 | 0.4 | ||
Log body mass index (per 5 kg/m2) × Age at baseline, years | 1.05 | 1.02, 1.08 | 0.002 | ||
III | Log body mass indexa (per 5 kg/m2) | 0.68 | 0.41, 1.01 | 0.1 | 9.14 |
Age at baseline, years | 0.98 | 0.96, 1.00 | 0.1 | ||
Menopause, no/yes | 1.12 | 0.87, 1.44 | 0.4 | ||
Log body mass index (per 5 kg/m2) × Menopause, no/yes | 3.68 | 1.86, 7.28 | < 0.001 | ||
IV | Log body mass indexa (per 5 kg/m2) | 0.40 | 0.06, 2.89 | 0.4 | 9.32 |
Age at baseline, years | 0.98 | 0.96, 1.00 | 0.1 | ||
Menopause, no/yes | 1.12 | 0.88, 1.44 | 0.4 | ||
Log body mass index (per 5 kg/m2) × Age at baseline, years | 1.01 | 0.97, 1.06 | 0.6 | ||
Log body mass index (per 5 kg/m2) × Menopause, no/yes | 2.91 | 0.91, 9.31 | 0.07 |
Model | HRb | 95% CI |
P
| ΔLLc | |
---|---|---|---|---|---|
V | Log body mass indexa (per 5 kg/m2) | 0.75 | 0.46, 1.22 | 0.2 | 158.03 |
Log 1-year BOADICEAa (%) | 2.05 | 1.89, 2.23 | < 0.001 | ||
Age at baseline, years | 0.98 | 0.96, 1.00 | 0.1 | ||
Menopause, no/yes | 1.04 | 0.81, 1.32 | 0.8 | ||
Log body mass index (per 5 kg/m2) × Menopause, no/yes | 3.36 | 1.71, 6.62 | < 0.001 | ||
VI | Log body mass indexa (per 5 kg/m2) | 0.75 | 0.46, 1.22 | 0.2 | 158.03 |
Log 1-year BOADICEAa (%) | 2.05 | 1.86, 2.26 | < 0.001 | ||
Age at baseline, years | 0.98 | 0.96, 1.00 | 0.1 | ||
Menopause, no/yes | 1.03 | 0.80, 1.34 | 0.8 | ||
Log body mass index (per 5 kg/m2) × Menopause, no/yes | 3.36 | 1.71, 6.63 | < 0.001 | ||
Menopause, no/yes × Log 1-year BOADICEAa (%) | 1.00 | 0.85, 1.19 | 1.0 | ||
VII | Log body mass indexa (per 5 kg/m2) | 0.70 | 0.41, 1.18 | 0.2 | 158.24 |
Log 1-year BOADICEAa (%) | 2.06 | 0.89, 2.24 | < 0.001 | ||
Age at baseline, years | 0.98 | 0.96, 1.00 | 0.1 | ||
Menopause, no/yes | 1.04 | 0.81, 1.32 | 0.8 | ||
Log body mass index (per 5 kg/m2) × Menopause, no/yes | 3.46 | 1.75, 6.84 | < 0.001 | ||
Log body mass indexa (per 5 kg/m2) × log 1-year BOADICEAa (%) | 1.13 | 0.79, 1.62 | 0.5 | ||
VIII | Log body mass indexa (per 5 kg/m2) | 0.66 | 0.38, 1.14 | 0.1 | 158.54 |
Log 1-year BOADICEAa (%) | 2.07 | 1.90, 2.25 | < 0.001 | ||
Age at baseline, years | 0.98 | 0.96, 1.00 | 0.1 | ||
Menopause, no/yes | 1.04 | 0.82, 1.32 | 0.8 | ||
Log body mass index (per 5 kg/m2) × Menopause, no/yes | 3.92 | 1.86, 8.28 | < 0.001 | ||
Log body mass indexa (per 5 kg/m2) × Log 1-year BOADICEAa (%) | 1.27 | 0.81, 2.00 | 0.3 | ||
Menopause, no/yes × Log body mass indexa (per 5 kg/m2) × Log 1-year BOADICEAa (%) | 0.73 | 0.34, 1.57 | 0.4 |
Discussion
Conclusions
Acknowledgements
Funding
Availability of data and materials
Ethics approval and consent to participate
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Northern California – Cancer Prevention Institute of California, Institutional Review Board (2001–033)
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New York – Columbia University Medical Center, Institutional Review Board (AAA7794)
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Philadelphia – Fox Chase Cancer Center, Institutional Review Board (95–009)
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Utah – Huntsman Cancer Institute, University of Utah, Institutional Review Board (00004965)
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Ontario – Mount Sinai Hospital Research Ethics Board (#02–0076-U) and University Health Network Research Ethics Board (#96-U107-CE)
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Australia – University of Melbourne, Human Ethics Sub-Committee (1441420.1)
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kConFab – Peter MacCallum Cancer Centre, the Peter Mac Ethics Committee (97/27)