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Annals of Surgical Oncology
Erschienen in: Annals of Surgical Oncology 7/2013

01.07.2013 | Thoracic Oncology

Correlation of p53 Status with the Response to Chemotherapy-Based Treatment in Esophageal Cancer: A Meta-Analysis

verfasst von: Shui-Shen Zhang, MD, Qing-Yuan Huang, MD, Hong Yang, MD, Xuan Xie, MD, Kong-Jia Luo, MD, PhD, Jing Wen, MD, PhD, Xiao-Li Cai, MD, Fu Yang, MD, Yi Hu, MD, PhD, Jian-Hua Fu, MD, PhD

Erschienen in: Annals of Surgical Oncology | Ausgabe 7/2013

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Abstract

Background

The value of p53 status for predicting response to chemotherapy-based treatment in patients with esophageal cancer has been controversial. We conducted a meta-analysis to elucidate the correlation of p53 status with the response to chemotherapy-based treatment.

Methods

Studies were searched in PubMed, Embase, and Web of Science (up to September 2012). The p53 status and response to therapy were defined and standardized. Subgroup analyses based on the treatment and histopathology were performed to explore the usefulness of p53 status for predicting response to therapy in esophageal cancer. Sensitivity analyses were conducted by removing specific studies to assess the effects of study quality.

Results

We included 28 studies with 1497 cases in our meta-analysis. Wild-type form of p53 status (low expression of p53 protein and/or wild-type p53 gene) was associated with high response to chemotherapy-based treatment in esophageal cancer (total major response [MR]: risk ratio [RR] = 1.09, 95 % CI = 1.03–1.16, P = .003; pathological MR: RR = 1.15, 95 % CI = 1.06–1.25, P = .001; total complete response [CR]: RR = 1.08, 95 % CI = 1.00–1.17, P = .040). The similar correlation between the wild-type form p53 and response to therapy were also detected in subgroup analyses (total MR, pathological MR, and total CR in chemoradiotherapy subgroup; total MR in chemotherapy subgroup; total MR and pathological CR in esophageal squamous cell carcinoma [ESCC]). Additionally, patients with wild-type form p53 status had high pathological complete response rate to neoadjuvant chemoradiotherapy in ESCC.

Conclusions

The current meta-analysis suggested that p53 status might be a predictive biomarker for response to chemotherapy-based treatment in esophageal cancer.
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Metadaten
Titel
Correlation of p53 Status with the Response to Chemotherapy-Based Treatment in Esophageal Cancer: A Meta-Analysis
verfasst von
Shui-Shen Zhang, MD
Qing-Yuan Huang, MD
Hong Yang, MD
Xuan Xie, MD
Kong-Jia Luo, MD, PhD
Jing Wen, MD, PhD
Xiao-Li Cai, MD
Fu Yang, MD
Yi Hu, MD, PhD
Jian-Hua Fu, MD, PhD
Publikationsdatum
01.07.2013
Verlag
Springer-Verlag
Erschienen in
Annals of Surgical Oncology / Ausgabe 7/2013
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-012-2859-4

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