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Annals of Surgical Oncology
Erschienen in: Annals of Surgical Oncology 8/2018

01.05.2018 | Colorectal Cancer

Management of Mucinous Appendiceal Tumors

verfasst von: Haroon A. Choudry, MD, Reetesh K. Pai, MD

Erschienen in: Annals of Surgical Oncology | Ausgabe 8/2018

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Excerpt

Mucinous appendix neoplasms (MAN) are rare epithelial malignancies of the appendix, with approximately 1000–2000 cases diagnosed each year in the USA.1,2 These tumors are characterized by neoplastic epithelial cells containing abundant cytoplasmic mucin that is secreted into the lumen of the appendix. They have a high tendency for peritoneal metastasis that occurs following rupture of the mucin-filled appendix or transmural invasion of mucin-secreting neoplastic epithelial cells from the primary neoplasm. Peritoneal metastasis from MAN is referred to as pseudomyxoma peritonei (PMP), a clinical entity that is characterized by peritoneal dissemination of mucinous ascites and mucinous tumor nodules3‐5 (Fig. 1a, b). Pathologically, the extracellular mucinous component is predominantly composed of mucin 2 (MUC2) protein and accounts for over 50% of the tumor volume in PMP.6 Since goblet cells are the primary source of mucin production within the normal intestinal epithelium, MAN/PMP is thought to arise from mucin-secreting neoplastic goblet-like cells.3,7‐9 …
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Metadaten
Titel
Management of Mucinous Appendiceal Tumors
verfasst von
Haroon A. Choudry, MD
Reetesh K. Pai, MD
Publikationsdatum
01.05.2018
Verlag
Springer International Publishing
Erschienen in
Annals of Surgical Oncology / Ausgabe 8/2018
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-018-6488-4

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