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01.07.2012 | Adis Drug Profile

Vismodegib

In Locally Advanced or Metastatic Basal Cell Carcinoma

verfasst von: Gillian M. Keating

Erschienen in: Drugs | Ausgabe 11/2012

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Abstract

Vismodegib is the first Hedgehog pathway inhibitor to be approved in the US, where it is indicated for the treatment of adults with metastatic basal cell carcinoma (BCC), or with locally advanced BCC that has recurred following surgery or who are not candidates for surgery, and who are not candidates for radiation. Vismodegib selectively and potently inhibits the Hedgehog signalling pathway by binding to Smoothened, thereby inhibiting the activation of Hedgehog target genes.

Oral vismodegib was effective in the treatment of patients with locally advanced (n = 63) or metastatic (n= 33) BCC, according to the results of an ongoing, noncomparative, multinational, pivotal, phase II trial (ERIVANCE BCC). In this trial (using a clinical cutoff date of 26 November 2010), the independent review facility overall response rate was 42.9% in patients with locally advanced BCC and 30.3% in patients with metastatic BCC. In both patients with locally advanced BCC and those with metastatic BCC, the median duration of response was 7.6 months and median progression-free survival was 9.5 months.

Oral vismodegib had an acceptable tolerability profile in patients with advanced BCC.

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Titel: Vismodegib
In Locally Advanced or Metastatic Basal Cell Carcinoma
verfasst von: Gillian M. Keating
Publikationsdatum: 01.07.2012
Verlag: Springer International Publishing
Erschienen in: Drugs / Ausgabe 11/2012
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI: https://doi.org/10.2165/11209590-000000000-00000

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Vismodegib

In Locally Advanced or Metastatic Basal Cell Carcinoma

Abstract

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

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