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Drugs in R&D
Erschienen in: Drugs in R&D 2/2008

01.03.2008 | Adis R&D Profile

Mepolizumab

240563, Anti-IL-5 Monoclonal Antibody — GlaxoSmithKline, Anti-Interleukin-5 Monoclonal Antibody — GlaxoSmithKline, SB 240563

Erschienen in: Drugs in R&D | Ausgabe 2/2008

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Excerpt

Mepolizumab is an anti-interleukin-5 monoclonal antibody that is in clinical trials with GlaxoSmithKline (GSK) for the treatment of severe asthma, nasal polyposis and hypereosinophilic syndrome and eosinophilic oesophagitis (the latter two indications are classed as eosinophilia in the phase table). Interleukin-5 stimulates the production, activation and maturation of eosinophils. Since mepolizumab inhibits interleukin-5 and has a long terminal half-life, treatment with mepolizumab causes a sustained reduction in the numbers of circulating eosinophils. Thus, mepolizumab may be a useful therapeutic agent for the treatment of conditions characterized by increased levels of eosinophils. …
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Flood-Page P, Phipps S, Menzies-Gow A, et al. Effect of intravenous administration of an anti-IL-5 mAb (mepolizumab) on allergen-induced tissue eosinophilia, the late-phase allergic reaction and the expression of a marker of repair/remodeling in human atopic subjects. Journal of Allergy and Clinical Immunology 111 (Suppl.): 261 (plus poster), Feb 2003CrossRef
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Menzies-Gow A, Flood-Page P, Compton C, et al. A double blind, placebo-controlled, parallel group study to assess the effect of mepolizumab (humanised monoclonal anti-IL-5 antibody) on bone marrow and peripheral blood eosinophils and eosinophil progenitors in atopic asthmatics. American Journal of Respiratory and Critical Care Medicine 165: B50, Part 2, Apr 2002
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Metadaten
Titel
Mepolizumab
240563, Anti-IL-5 Monoclonal Antibody — GlaxoSmithKline, Anti-Interleukin-5 Monoclonal Antibody — GlaxoSmithKline, SB 240563
Publikationsdatum
01.03.2008
Verlag
Springer International Publishing
Erschienen in
Drugs in R&D / Ausgabe 2/2008
Print ISSN: 1174-5886
Elektronische ISSN: 1179-6901
DOI
https://doi.org/10.2165/00126839-200809020-00006

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