Skip to main content
Erschienen in: Drugs & Aging 6/2010

01.06.2010 | Review Article

Management of Chronic Arthritis Pain in the Elderly

verfasst von: Dr Mary-Ann Fitzcharles, David Lussier, Yoram Shir

Erschienen in: Drugs & Aging | Ausgabe 6/2010

Einloggen, um Zugang zu erhalten

Abstract

Musculoskeletal pain in the elderly is common and disabling. As the conditions causing rheumatic pain, including osteoarthritis, inflammatory arthritis and soft-tissue conditions such as tendonitis and bursitis, are, for the most part, not curable, pain control is paramount in order to maintain quality of life. Pain management should be multimodal and tailored to the individual patient, and will likely include a combination of both nonpharmacological and pharmacological interventions.
Nonpharmacological treatments begin with education of the patient, encouragement to practise self-management strategies and attention to healthy life habits such as weight control and regular physical activity and exercise. Advice in this regard may be effectively given by healthcare professionals other than physicians. Although herbal products and nutritional supplements are commonly used by patients, studies of their efficacy and safety, especially in the elderly, are limited. In contrast, topical applications, and in particular those containing NSAIDs, are being used more frequently, are associated with fewer adverse effects than oral preparations and offer a new and safer treatment alternative. Similarly, intra-articular and soft-tissue injections of corticosteroids provide an easy and cost-effective option for symptom relief with minimal risk.
The use of any pharmacological agent in the elderly should be tempered with caution regarding increased sensitivity to medications, drug-drug interactions and associated co-morbidities. Therefore, the elderly will often require down-adjustment of dosage and careful attention to the risk/benefit ratio of the treatment. There is, however, no single ideal pain medication for management of rheumatic pain. The four broad categories of treatments, namely simple analgesics (i.e. paracetamol [acetaminophen]), NSAIDs, stronger analgesics (i.e. opioids) and adjuvant drugs, each have unique and particular concerns regarding their adverse effect profiles. The continued use of any medication should also be repeatedly assessed to ensure that efficacy is maintained. Throughout the treatment period, physicians must remain vigilant for emergent adverse effects.
Patients and physicians should have realistic outcome goals for effective rheumatic pain management. Although complete pain relief is seldom achieved, modulation of pain and the associated components of sleep disturbance, fatigue and mood disorder will improve overall quality of life in the elderly. However, barriers to effective pain management from both the patient and the healthcare professional perspectives still exist, and will be overcome only by educational efforts.
Successful rheumatic pain management in the elderly should begin with an accurate diagnosis by the physician, and patients must be realistic in their expectations. Treatments should be multimodal, with attention given to the co-morbidities of pain as well as the global health status of the patient. Whether or not an outcome is favourable should be determined not only by the treatment’s impact on pain but also by its capacity to improve function and enhance quality of life. The wider range of treatment options now available is both useful and encouraging for the physician managing musculoskeletal aches and pain in the elderly.
Literatur
1.
Zurück zum Zitat Barkin RL, Barkin SJ, Barkin DS. Pharmacotherapeutic management of pain with a focus directed at the geriatric patient. Rheum Dis Clin North Am 2007; 33: 1–31PubMedCrossRef Barkin RL, Barkin SJ, Barkin DS. Pharmacotherapeutic management of pain with a focus directed at the geriatric patient. Rheum Dis Clin North Am 2007; 33: 1–31PubMedCrossRef
2.
Zurück zum Zitat McCarberg BH. Rheumatic diseases in the elderly: dealing with rheumatic pain in extended care facilities. Rheum Dis Clin North Am 2007; 33: 87–108PubMedCrossRef McCarberg BH. Rheumatic diseases in the elderly: dealing with rheumatic pain in extended care facilities. Rheum Dis Clin North Am 2007; 33: 87–108PubMedCrossRef
3.
Zurück zum Zitat Hootman JM, Helmick CG. Projections of US prevalence of arthritis and associated activity limitations. Arthritis Rheum 2006; 54: 226–9PubMedCrossRef Hootman JM, Helmick CG. Projections of US prevalence of arthritis and associated activity limitations. Arthritis Rheum 2006; 54: 226–9PubMedCrossRef
4.
5.
Zurück zum Zitat Lawrence RC, Felson DT, Helmick CG, et al., for the National Arthritis Data Workgroup. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States part II. Arthritis Rheum 2008; 58: 26–35PubMedCrossRef Lawrence RC, Felson DT, Helmick CG, et al., for the National Arthritis Data Workgroup. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States part II. Arthritis Rheum 2008; 58: 26–35PubMedCrossRef
6.
Zurück zum Zitat Helmick CG, Felson DT, Lawrence RC, et al., for the National Arthritis Data Workgroup. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States part I. Arthritis Rheum 2008; 58: 15–25PubMedCrossRef Helmick CG, Felson DT, Lawrence RC, et al., for the National Arthritis Data Workgroup. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States part I. Arthritis Rheum 2008; 58: 15–25PubMedCrossRef
7.
Zurück zum Zitat Centers for Disease Control and Prevention (CDC). Prevalence of disabilities and associated health conditions among adults — United States, 1999. MMWR Morb Mortal Wkly Rep 2001; 50: 120–5 Centers for Disease Control and Prevention (CDC). Prevalence of disabilities and associated health conditions among adults — United States, 1999. MMWR Morb Mortal Wkly Rep 2001; 50: 120–5
8.
Zurück zum Zitat Harkness EF, Macfarlane GJ, Silman AJ, et al. Is musculoskeletal pain more common now than 40 years ago? Two population-based cross-sectional studies. Rheumatology 2005; 44: 890–5PubMedCrossRef Harkness EF, Macfarlane GJ, Silman AJ, et al. Is musculoskeletal pain more common now than 40 years ago? Two population-based cross-sectional studies. Rheumatology 2005; 44: 890–5PubMedCrossRef
9.
Zurück zum Zitat Caudill-Slosberg MA, Schwartz LM, Woloshin S. Office visits and analgesic prescriptions for musculoskeletal pain in US: 1980 vs. 2000. Pain 2004; 109: 514–9PubMedCrossRef Caudill-Slosberg MA, Schwartz LM, Woloshin S. Office visits and analgesic prescriptions for musculoskeletal pain in US: 1980 vs. 2000. Pain 2004; 109: 514–9PubMedCrossRef
10.
Zurück zum Zitat Skevington SM. Investigating the relationship between pain and discomfort and quality of life, using the WHOQOL. Pain 1998; 76: 395–406PubMedCrossRef Skevington SM. Investigating the relationship between pain and discomfort and quality of life, using the WHOQOL. Pain 1998; 76: 395–406PubMedCrossRef
11.
Zurück zum Zitat AGS Panel on Pharmacological Management of Persistent Pain in Older Persons. Pharmacological management of persistent pain in older persons. J Am Geriatr Soc 2009; 57: 1331–46CrossRef AGS Panel on Pharmacological Management of Persistent Pain in Older Persons. Pharmacological management of persistent pain in older persons. J Am Geriatr Soc 2009; 57: 1331–46CrossRef
12.
Zurück zum Zitat Blumstein H, Gorevic PD. Rheumatologic illnesses: treatment strategies for older adults. Geriatrics 2005; 60(6): 28–35PubMed Blumstein H, Gorevic PD. Rheumatologic illnesses: treatment strategies for older adults. Geriatrics 2005; 60(6): 28–35PubMed
13.
Zurück zum Zitat Fitzcharles MA, Shir Y. New concepts in rheumatic pain. Rheum Dis Clin North Am 2008; 34: 267–83PubMedCrossRef Fitzcharles MA, Shir Y. New concepts in rheumatic pain. Rheum Dis Clin North Am 2008; 34: 267–83PubMedCrossRef
14.
Zurück zum Zitat McDougall JJ. Arthritis and pain: neurogenic origin of joint pain. Arthritis Res Ther 2006; 8: 220–30PubMedCrossRef McDougall JJ. Arthritis and pain: neurogenic origin of joint pain. Arthritis Res Ther 2006; 8: 220–30PubMedCrossRef
15.
Zurück zum Zitat Kidd BL, Urban LA. Mechanisms of inflammatory pain. Br J Anaesthesia 2001; 87: 3–11CrossRef Kidd BL, Urban LA. Mechanisms of inflammatory pain. Br J Anaesthesia 2001; 87: 3–11CrossRef
16.
Zurück zum Zitat Coderre TJ, Katz J, Vaccarino AL, et al. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 1993; 52: 259–85PubMedCrossRef Coderre TJ, Katz J, Vaccarino AL, et al. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 1993; 52: 259–85PubMedCrossRef
17.
Zurück zum Zitat Bolay H, Moskowitz MA. Mechanisms of pain modulation in chronic syndromes. Neurology 2002; 59: S2–7PubMedCrossRef Bolay H, Moskowitz MA. Mechanisms of pain modulation in chronic syndromes. Neurology 2002; 59: S2–7PubMedCrossRef
18.
Zurück zum Zitat Schaible HG, Del Rosso A, Matucci-Cerinic M. Neurogenic aspects of inflammation. Rheum Dis Clin North Am 2005; 3: 77–101CrossRef Schaible HG, Del Rosso A, Matucci-Cerinic M. Neurogenic aspects of inflammation. Rheum Dis Clin North Am 2005; 3: 77–101CrossRef
19.
Zurück zum Zitat Basbaum AI, Fields HL. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 1984; 7: 309–38PubMedCrossRef Basbaum AI, Fields HL. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 1984; 7: 309–38PubMedCrossRef
21.
22.
Zurück zum Zitat Krasnokutsky S, Samuels J, Abramson SB. Osteoarthritis in 2007. Bull Hosp Jt Dis 2007; 65: 222–8 Krasnokutsky S, Samuels J, Abramson SB. Osteoarthritis in 2007. Bull Hosp Jt Dis 2007; 65: 222–8
23.
Zurück zum Zitat Carrino JA, Blum J, Parellada JA, et al. MRI of bone marrow edema-like signal in the pathogenesis of subchondral cysts. Osteoarthritis Cartilage 2006; 14: 1081–5PubMedCrossRef Carrino JA, Blum J, Parellada JA, et al. MRI of bone marrow edema-like signal in the pathogenesis of subchondral cysts. Osteoarthritis Cartilage 2006; 14: 1081–5PubMedCrossRef
24.
25.
Zurück zum Zitat Chakour MC, Gibson SJ, Bradbeer M, et al. The effect of age on A delta- and C-fibre thermal pain perception. Pain 1996; 64: 143–52PubMedCrossRef Chakour MC, Gibson SJ, Bradbeer M, et al. The effect of age on A delta- and C-fibre thermal pain perception. Pain 1996; 64: 143–52PubMedCrossRef
26.
Zurück zum Zitat Gibson SJ, Gorman MM, Helme RD. The assessment of pain in the elderly using cerebral event related potentials. In: Bond MR, Charlton JE, Woolf CJ, editors. Proceedings of the Vth World Congress on Pain. Amsterdam: Elsevier, 1991: 527–35 Gibson SJ, Gorman MM, Helme RD. The assessment of pain in the elderly using cerebral event related potentials. In: Bond MR, Charlton JE, Woolf CJ, editors. Proceedings of the Vth World Congress on Pain. Amsterdam: Elsevier, 1991: 527–35
27.
Zurück zum Zitat Washington LL, Gibson SJ, Helme RD. Age-related differences in the endogenous analgesic response to repeated cold water immersion in human volunteers. Pain 2000; 89: 89–96PubMedCrossRef Washington LL, Gibson SJ, Helme RD. Age-related differences in the endogenous analgesic response to repeated cold water immersion in human volunteers. Pain 2000; 89: 89–96PubMedCrossRef
28.
Zurück zum Zitat Edwards RR, Fillingim RB, Ness TJ. Age-related differences in endogenous pain modulation: a comparison of diffuse noxious inhibitory controls in healthy older and younger adults. Pain 2003; 101: 155–65PubMedCrossRef Edwards RR, Fillingim RB, Ness TJ. Age-related differences in endogenous pain modulation: a comparison of diffuse noxious inhibitory controls in healthy older and younger adults. Pain 2003; 101: 155–65PubMedCrossRef
29.
Zurück zum Zitat Larivière M, Goffaux P, Marchand S, et al. Changes in pain perception and descending inhibitory controls start at middle age in healthy adults. Clin J Pain 2007; 23: 506–10PubMedCrossRef Larivière M, Goffaux P, Marchand S, et al. Changes in pain perception and descending inhibitory controls start at middle age in healthy adults. Clin J Pain 2007; 23: 506–10PubMedCrossRef
30.
Zurück zum Zitat Bellamy N, Sothern RB, Campbell J. Rhythmic variations in pain perception in osteoarthritis of the knee. J Rheumatol 1990; 17: 364–72PubMed Bellamy N, Sothern RB, Campbell J. Rhythmic variations in pain perception in osteoarthritis of the knee. J Rheumatol 1990; 17: 364–72PubMed
31.
Zurück zum Zitat Fitzcharles MA, Almahrezi A, Shir Y. Pain: understanding and challenges for the rheumatologist. Arthritis Rheum 2005; 52: 3685–92PubMedCrossRef Fitzcharles MA, Almahrezi A, Shir Y. Pain: understanding and challenges for the rheumatologist. Arthritis Rheum 2005; 52: 3685–92PubMedCrossRef
32.
Zurück zum Zitat Fitzcharles MA, DaCosta D, Ware MA, et al. Patient barriers to pain management may contribute to poor pain control in rheumatoid arthritis. J Pain 2009; 10: 300–5PubMed Fitzcharles MA, DaCosta D, Ware MA, et al. Patient barriers to pain management may contribute to poor pain control in rheumatoid arthritis. J Pain 2009; 10: 300–5PubMed
33.
Zurück zum Zitat Guedj D, Weinberger A. Effect of weather conditions on rheumatic patients. Ann Rheum Dis 1990; 49: 158–9PubMedCrossRef Guedj D, Weinberger A. Effect of weather conditions on rheumatic patients. Ann Rheum Dis 1990; 49: 158–9PubMedCrossRef
34.
Zurück zum Zitat McAlindon T, Formica M, Schmid CH, et al. Changes in barometric pressure and ambient temperature influence osteoarthritis pain. Am J Med 2007; 120: 429–34PubMedCrossRef McAlindon T, Formica M, Schmid CH, et al. Changes in barometric pressure and ambient temperature influence osteoarthritis pain. Am J Med 2007; 120: 429–34PubMedCrossRef
35.
Zurück zum Zitat Morin CM, Gibson D, Wade J. Self-reported sleep and mood disturbance in chronic pain patients. Clin J Pain 1998; 14: 311–4PubMedCrossRef Morin CM, Gibson D, Wade J. Self-reported sleep and mood disturbance in chronic pain patients. Clin J Pain 1998; 14: 311–4PubMedCrossRef
36.
Zurück zum Zitat Hamerman D. The biology of osteoarthritis. N Eng J Med 1989; 320: 1322–30CrossRef Hamerman D. The biology of osteoarthritis. N Eng J Med 1989; 320: 1322–30CrossRef
37.
38.
Zurück zum Zitat American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. Arthritis Rheum 2000; 43: 1905–15CrossRef American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. Arthritis Rheum 2000; 43: 1905–15CrossRef
39.
Zurück zum Zitat Ostor AJ. Beyond methotrexate: biologic therapy in rheumatoid arthritis. Clin Med 2005; 5: 222–6PubMed Ostor AJ. Beyond methotrexate: biologic therapy in rheumatoid arthritis. Clin Med 2005; 5: 222–6PubMed
40.
Zurück zum Zitat Garcia GM, McCord GC, Kumar R. Hydroxyapatite crystal deposition disease. Semin Musculoskelet Radiol 2003; 7: 187–93PubMedCrossRef Garcia GM, McCord GC, Kumar R. Hydroxyapatite crystal deposition disease. Semin Musculoskelet Radiol 2003; 7: 187–93PubMedCrossRef
41.
Zurück zum Zitat Gosens T, Hofstee DJ. Calcifying tendinitis of the shoulder: advances in imaging and management. Curr Rheumatol Rep 2009; 11: 129–34PubMedCrossRef Gosens T, Hofstee DJ. Calcifying tendinitis of the shoulder: advances in imaging and management. Curr Rheumatol Rep 2009; 11: 129–34PubMedCrossRef
42.
Zurück zum Zitat Monsivais D, McNeill J. Multicultural influences on pain medication attitudes and beliefs in patients with non-malignant chronic pain syndromes. Pain Manag Nurs 2007; 8: 64–71PubMedCrossRef Monsivais D, McNeill J. Multicultural influences on pain medication attitudes and beliefs in patients with non-malignant chronic pain syndromes. Pain Manag Nurs 2007; 8: 64–71PubMedCrossRef
43.
Zurück zum Zitat Zhang W, Doherty M, Arden N, et al., EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 2005; 64: 669–81PubMedCrossRef Zhang W, Doherty M, Arden N, et al., EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 2005; 64: 669–81PubMedCrossRef
44.
Zurück zum Zitat Zhang W, Nuki G, Moskowitz RW, et al. OARSI recommendations for the management of hip and knee osteoarthritis part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage. Epub 2010 Feb 11 Zhang W, Nuki G, Moskowitz RW, et al. OARSI recommendations for the management of hip and knee osteoarthritis part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage. Epub 2010 Feb 11
45.
Zurück zum Zitat National Collaborating Centre for Chronic Conditions. Osteoarthritis: the care and management of osteoarthritis in adults. London: National Institute for Health and Clinical Excellence (NICE), 2008 Feb 22: Clinical guideline no. 59 National Collaborating Centre for Chronic Conditions. Osteoarthritis: the care and management of osteoarthritis in adults. London: National Institute for Health and Clinical Excellence (NICE), 2008 Feb 22: Clinical guideline no. 59
46.
Zurück zum Zitat Otis JAD, McGeeney B. Managing pain in the elderly. Clin Geriatr 2001; 9: 82–8 Otis JAD, McGeeney B. Managing pain in the elderly. Clin Geriatr 2001; 9: 82–8
47.
Zurück zum Zitat Farrar JT, Portenoy RK, Berlin JA, et al. Defining the clinically important difference in pain outcome measures. Pain 2000; 88: 287–94PubMedCrossRef Farrar JT, Portenoy RK, Berlin JA, et al. Defining the clinically important difference in pain outcome measures. Pain 2000; 88: 287–94PubMedCrossRef
48.
Zurück zum Zitat Somers TJ, Keefe FJ, Godiwala N, et al. Psychosocial factors and the pain experience of osteoarthritis patients: new findings and new directions. Curr Opin Rheumatol 2009; 21: 501–6PubMedCrossRef Somers TJ, Keefe FJ, Godiwala N, et al. Psychosocial factors and the pain experience of osteoarthritis patients: new findings and new directions. Curr Opin Rheumatol 2009; 21: 501–6PubMedCrossRef
49.
Zurück zum Zitat Sullivan MJ, Martel MO, Tripp D, et al. The relation between catastrophizing and the communication of pain experience. Pain 2006; 122: 282–8PubMedCrossRef Sullivan MJ, Martel MO, Tripp D, et al. The relation between catastrophizing and the communication of pain experience. Pain 2006; 122: 282–8PubMedCrossRef
50.
Zurück zum Zitat Yocum DE, Castro WL, Cornett M. Exercise, education, and behavioral modification as alternative therapy for pain and stress in rheumatic disease. Rheum Dis Clin North Am 2000; 26: 145–59PubMedCrossRef Yocum DE, Castro WL, Cornett M. Exercise, education, and behavioral modification as alternative therapy for pain and stress in rheumatic disease. Rheum Dis Clin North Am 2000; 26: 145–59PubMedCrossRef
51.
Zurück zum Zitat Patel A, Buszewicz M, Beecham J, et al. Economic evaluation of arthritis self management in primary care. BMJ 2009 Sep 22; 339: b3532PubMedCrossRef Patel A, Buszewicz M, Beecham J, et al. Economic evaluation of arthritis self management in primary care. BMJ 2009 Sep 22; 339: b3532PubMedCrossRef
52.
Zurück zum Zitat Buszewicz M, Rait G, Griffin M, et al. Self management of arthritis in primary care: randomized controlled trial. BMJ 2006 Oct 28; 333: 879–82PubMedCrossRef Buszewicz M, Rait G, Griffin M, et al. Self management of arthritis in primary care: randomized controlled trial. BMJ 2006 Oct 28; 333: 879–82PubMedCrossRef
53.
54.
Zurück zum Zitat Reid MC, Papaleontiou M, Ong A, et al. Self-management strategies to reduce pain and improve function among older adults in community settings: a review of the evidence. Pain Med 2008; 9: 409–24PubMedCrossRef Reid MC, Papaleontiou M, Ong A, et al. Self-management strategies to reduce pain and improve function among older adults in community settings: a review of the evidence. Pain Med 2008; 9: 409–24PubMedCrossRef
55.
Zurück zum Zitat Dixon KE, Keefe FJ, Scipio CD, et al. Psychological interventions for arthritis pain management in adults: a meta-analysis. Health Psychol 2007; 26: 241–50PubMedCrossRef Dixon KE, Keefe FJ, Scipio CD, et al. Psychological interventions for arthritis pain management in adults: a meta-analysis. Health Psychol 2007; 26: 241–50PubMedCrossRef
56.
Zurück zum Zitat Zhang W, Robertson J, Jones AC, et al. The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials. Ann Rheum Dis 2008; 67: 1716–23PubMedCrossRef Zhang W, Robertson J, Jones AC, et al. The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials. Ann Rheum Dis 2008; 67: 1716–23PubMedCrossRef
57.
Zurück zum Zitat Gloth MJ, Matesi AM. Physical therapy and exercise in pain management. Clin Geriatr Med 2001; 17: 525–35PubMedCrossRef Gloth MJ, Matesi AM. Physical therapy and exercise in pain management. Clin Geriatr Med 2001; 17: 525–35PubMedCrossRef
58.
Zurück zum Zitat Jonsdottir IH, Hoffmann P, Thoren P. Physical exercise, endogenous opioids and immune function. Acta Physiol Scand Suppl 1997; 640: 47–50PubMed Jonsdottir IH, Hoffmann P, Thoren P. Physical exercise, endogenous opioids and immune function. Acta Physiol Scand Suppl 1997; 640: 47–50PubMed
59.
Zurück zum Zitat Roddy E, Zhang W, Doherty M, et al. Evidence-based recommendations for the role of exercise in the management of osteoarthritis of the hip or knee: the MOVE consensus. Rheumatology 2005; 44: 67–73PubMedCrossRef Roddy E, Zhang W, Doherty M, et al. Evidence-based recommendations for the role of exercise in the management of osteoarthritis of the hip or knee: the MOVE consensus. Rheumatology 2005; 44: 67–73PubMedCrossRef
60.
Zurück zum Zitat Bosomworth NJ. Exercise and knee osteoarthritis: benefit or hazard? Can Fam Physician 2009; 55: 871–8PubMed Bosomworth NJ. Exercise and knee osteoarthritis: benefit or hazard? Can Fam Physician 2009; 55: 871–8PubMed
61.
Zurück zum Zitat Walsh NE, Hurley MV. Evidence based guidelines and current practice for physiotherapy management of knee osteoarthritis. Musculoskeletal Care 2009; 7: 45–56PubMedCrossRef Walsh NE, Hurley MV. Evidence based guidelines and current practice for physiotherapy management of knee osteoarthritis. Musculoskeletal Care 2009; 7: 45–56PubMedCrossRef
62.
Zurück zum Zitat Fransen M, McConnell S, Hernandez-Molina G, et al. Exercise for osteoarthritis of the hip. Cochrane Database Syst Rev 2009 Jul 8; (3): CD007912 Fransen M, McConnell S, Hernandez-Molina G, et al. Exercise for osteoarthritis of the hip. Cochrane Database Syst Rev 2009 Jul 8; (3): CD007912
63.
Zurück zum Zitat Focht BC, Rejeski WJ, Ambrosius WT, et al. Exercise, self-efficacy, and mobility performance in overweight and obese older adults with knee osteoarthritis. Arthritis Rheum 2005; 53: 659–65PubMedCrossRef Focht BC, Rejeski WJ, Ambrosius WT, et al. Exercise, self-efficacy, and mobility performance in overweight and obese older adults with knee osteoarthritis. Arthritis Rheum 2005; 53: 659–65PubMedCrossRef
64.
Zurück zum Zitat Felson DT, Zhang Y, Anthony JM, et al. Weight loss reduces the risk for symptomatic knee osteoarthritis in women: The Framingham Study. Ann Intern Med 1992; 116: 535–9PubMed Felson DT, Zhang Y, Anthony JM, et al. Weight loss reduces the risk for symptomatic knee osteoarthritis in women: The Framingham Study. Ann Intern Med 1992; 116: 535–9PubMed
65.
Zurück zum Zitat Christensen R, Bartels EM, Astrup A, et al. Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis. Ann Rheum Dis 2007; 66: 433–9PubMedCrossRef Christensen R, Bartels EM, Astrup A, et al. Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis. Ann Rheum Dis 2007; 66: 433–9PubMedCrossRef
66.
Zurück zum Zitat Beaudreuil J, Bendaya S, Faucher M, et al. Clinical practice guidelines for rest orthosis, knee sleeves, and unloading knee braces in knee osteoarthritis. Joint Bone Spine 2009; 76: 629–36PubMedCrossRef Beaudreuil J, Bendaya S, Faucher M, et al. Clinical practice guidelines for rest orthosis, knee sleeves, and unloading knee braces in knee osteoarthritis. Joint Bone Spine 2009; 76: 629–36PubMedCrossRef
67.
Zurück zum Zitat Brouwer RW, Jakma TS, Verhagen AP, et al. Braces and orthoses for treating osteoarthritis of the knee. Cochrane Database Syst Rev 2005 Jan 25; (1): CD004020 Brouwer RW, Jakma TS, Verhagen AP, et al. Braces and orthoses for treating osteoarthritis of the knee. Cochrane Database Syst Rev 2005 Jan 25; (1): CD004020
68.
Zurück zum Zitat Bono CM, Berberian WS. Orthotic devices: degenerative disorders of the foot and ankle. Foot Ankle Clin 2001; 6: 329–40PubMedCrossRef Bono CM, Berberian WS. Orthotic devices: degenerative disorders of the foot and ankle. Foot Ankle Clin 2001; 6: 329–40PubMedCrossRef
69.
Zurück zum Zitat Osiri M, Welch V, Brosseau L, et al. Transcutaneous electrical nerve stimulation for knee osteoarthritis. Cochrane Database Syst Rev 2000; (4): CD002823 Osiri M, Welch V, Brosseau L, et al. Transcutaneous electrical nerve stimulation for knee osteoarthritis. Cochrane Database Syst Rev 2000; (4): CD002823
70.
Zurück zum Zitat Sluka KA, Walsh D. Transcutaneous electrical nerve stimulation: basic science mechanisms and clinical effectiveness. J Pain 2003; 4: 109–21PubMedCrossRef Sluka KA, Walsh D. Transcutaneous electrical nerve stimulation: basic science mechanisms and clinical effectiveness. J Pain 2003; 4: 109–21PubMedCrossRef
71.
Zurück zum Zitat Fiechtner JJ, Brodeur RR. Manual and manipulation techniques for rheumatic disease. Med Clin North Am 2002; 86: 91–103PubMedCrossRef Fiechtner JJ, Brodeur RR. Manual and manipulation techniques for rheumatic disease. Med Clin North Am 2002; 86: 91–103PubMedCrossRef
72.
Zurück zum Zitat Boisset M, Fitzcharles MA. Alternative medicine use by rheumatology patients in a universal health care setting. J Rheumatol 1994; 21: 148–52PubMed Boisset M, Fitzcharles MA. Alternative medicine use by rheumatology patients in a universal health care setting. J Rheumatol 1994; 21: 148–52PubMed
73.
Zurück zum Zitat Ernst E. Complementary treatments in rheumatic diseases. Rheum Dis Clin North Am 2008; 34: 455–67PubMedCrossRef Ernst E. Complementary treatments in rheumatic diseases. Rheum Dis Clin North Am 2008; 34: 455–67PubMedCrossRef
74.
Zurück zum Zitat Kikuchi M, Matsuura K, Matsumoto Y, et al. Bibliographical investigation of complementary alternative medicines for osteoarthritis and rheumatoid arthritis. Geriatr Gerontol Int 2009; 9: 29–40PubMedCrossRef Kikuchi M, Matsuura K, Matsumoto Y, et al. Bibliographical investigation of complementary alternative medicines for osteoarthritis and rheumatoid arthritis. Geriatr Gerontol Int 2009; 9: 29–40PubMedCrossRef
75.
Zurück zum Zitat Ernst E. Musculoskeletal conditions and complementary/alternative medicine. Best Pract Res Clin Rheumatol 2004; 18: 539–56PubMedCrossRef Ernst E. Musculoskeletal conditions and complementary/alternative medicine. Best Pract Res Clin Rheumatol 2004; 18: 539–56PubMedCrossRef
76.
Zurück zum Zitat Long L, Soeken K, Ernst E. Herbal medicines for the treatment of osteoarthritis: a systematic review. Rheumatology 2001; 40: 779–93PubMedCrossRef Long L, Soeken K, Ernst E. Herbal medicines for the treatment of osteoarthritis: a systematic review. Rheumatology 2001; 40: 779–93PubMedCrossRef
77.
Zurück zum Zitat Goldberg RJ, Katz J. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain 2007; 129: 210–23PubMedCrossRef Goldberg RJ, Katz J. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain 2007; 129: 210–23PubMedCrossRef
78.
Zurück zum Zitat McAlindon TE. Nutraceuticals: do they work and when should we use them? Best Pract Res Clin Rheumatol 2006; 20: 99–115PubMedCrossRef McAlindon TE. Nutraceuticals: do they work and when should we use them? Best Pract Res Clin Rheumatol 2006; 20: 99–115PubMedCrossRef
79.
Zurück zum Zitat Black C, Clar C, Henderson R, et al. The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation. Health Technol Assess 2009; 13: 1–148PubMed Black C, Clar C, Henderson R, et al. The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation. Health Technol Assess 2009; 13: 1–148PubMed
81.
Zurück zum Zitat Brandt KD, Mazzuca SA, Buckwalter KA. Acetaminophen, like conventional NSAIDs, may reduce synovitis in osteoarthritic knees. Rheumatology 2006; 45: 1389–94PubMedCrossRef Brandt KD, Mazzuca SA, Buckwalter KA. Acetaminophen, like conventional NSAIDs, may reduce synovitis in osteoarthritic knees. Rheumatology 2006; 45: 1389–94PubMedCrossRef
82.
Zurück zum Zitat Chandrasekharan NV, Dai H, Roos KL, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Pro Natl Acad Sci U S A 2002; 99: 13926–31CrossRef Chandrasekharan NV, Dai H, Roos KL, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Pro Natl Acad Sci U S A 2002; 99: 13926–31CrossRef
83.
Zurück zum Zitat Bertolini A, Ferrari A, Ottani A, et al. Paracetamol: new vistas of an old drug. CNS Drug Rev 2006; 12: 250–75PubMedCrossRef Bertolini A, Ferrari A, Ottani A, et al. Paracetamol: new vistas of an old drug. CNS Drug Rev 2006; 12: 250–75PubMedCrossRef
84.
Zurück zum Zitat Sunshine A, Olsen NZ. Nonnarcotic analgesics. In: Wall PD, Melzack R, editors. Textbook of pain. 3rd ed. Edinburgh: Churchill Livingstone, 1994: 923–42 Sunshine A, Olsen NZ. Nonnarcotic analgesics. In: Wall PD, Melzack R, editors. Textbook of pain. 3rd ed. Edinburgh: Churchill Livingstone, 1994: 923–42
85.
Zurück zum Zitat Ellmers SE, Parker LRC, Notarianni LJ, et al. Excretion of paracetamol in fit and frail elderly people. J Am Geriatr Soc 1991; 31 (Suppl.): 596–7 Ellmers SE, Parker LRC, Notarianni LJ, et al. Excretion of paracetamol in fit and frail elderly people. J Am Geriatr Soc 1991; 31 (Suppl.): 596–7
86.
Zurück zum Zitat Fored CM, Ejerblad E, Lindblad P, et al. Acetaminophen, aspirin, and chronic renal failure. N Engl J Med 2001; 345: 1801–8PubMedCrossRef Fored CM, Ejerblad E, Lindblad P, et al. Acetaminophen, aspirin, and chronic renal failure. N Engl J Med 2001; 345: 1801–8PubMedCrossRef
87.
Zurück zum Zitat Gloth FM. Pain management in older adults: prevention and treatment. J Am Geriatr Soc 2001; 49: 188–99PubMedCrossRef Gloth FM. Pain management in older adults: prevention and treatment. J Am Geriatr Soc 2001; 49: 188–99PubMedCrossRef
88.
Zurück zum Zitat Bjordal JM, Ljunggren AE, Klovning A, et al. Non-steroidal anti-inflammatory drugs, including cyclo-oxygenase-2 inhibitors, in osteoarthritic knee pain: meta-analysis of randomised placebo controlled trials. BMJ 2004; 329: 1317–20PubMedCrossRef Bjordal JM, Ljunggren AE, Klovning A, et al. Non-steroidal anti-inflammatory drugs, including cyclo-oxygenase-2 inhibitors, in osteoarthritic knee pain: meta-analysis of randomised placebo controlled trials. BMJ 2004; 329: 1317–20PubMedCrossRef
89.
Zurück zum Zitat Tannenbaum H, Bombardier C, Davis P, et al., Third Canadian Consensus Conference Group. Evidence-based approach to prescribing nonsteroidal antiinflammatory drugs. Third Canadian Consensus Conference. J Rheumatol 2006; 33: 140–57PubMed Tannenbaum H, Bombardier C, Davis P, et al., Third Canadian Consensus Conference Group. Evidence-based approach to prescribing nonsteroidal antiinflammatory drugs. Third Canadian Consensus Conference. J Rheumatol 2006; 33: 140–57PubMed
90.
Zurück zum Zitat White WB, West CR, Borer JS, et al. Risk of cardiovascular events in patients receiving celecoxib: a metaanalysis of randomized clinical trials. Am J Cardiol 2007; 99: 91–8PubMedCrossRef White WB, West CR, Borer JS, et al. Risk of cardiovascular events in patients receiving celecoxib: a metaanalysis of randomized clinical trials. Am J Cardiol 2007; 99: 91–8PubMedCrossRef
91.
Zurück zum Zitat Soni P, Shell B, Cawkwell G, et al. The hepatic safety and tolerability of the cyclooxygenase-2 selective NSAID celecoxib: pooled analysis of 41 randomized controlled trials. Curr Med Res Opin 2009; 25: 1841–51PubMedCrossRef Soni P, Shell B, Cawkwell G, et al. The hepatic safety and tolerability of the cyclooxygenase-2 selective NSAID celecoxib: pooled analysis of 41 randomized controlled trials. Curr Med Res Opin 2009; 25: 1841–51PubMedCrossRef
92.
93.
Zurück zum Zitat Dominick KL, Bosworth HB, Dudley TK, et al. Patterns of opioid analgesic prescription among patients with osteoarthritis. J Pain Palliat Care Pharmacother 2004; 18: 31–46PubMedCrossRef Dominick KL, Bosworth HB, Dudley TK, et al. Patterns of opioid analgesic prescription among patients with osteoarthritis. J Pain Palliat Care Pharmacother 2004; 18: 31–46PubMedCrossRef
94.
Zurück zum Zitat Caldwell JR, Hale ME, Boyd RE, et al. Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial. J Rheumatol 1999; 26: 862–9PubMed Caldwell JR, Hale ME, Boyd RE, et al. Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial. J Rheumatol 1999; 26: 862–9PubMed
95.
Zurück zum Zitat Caldwell JR, Rapoport RJ, Davis JC, et al. Efficacy and safety of a once-daily morphine formulation in chronic, moderate-to-severe osteoarthritis pain: results from a randomized, placebo-controlled, double-blind trial and open label extension trial. J Pain Symptom Manage 2002; 23: 278–91PubMedCrossRef Caldwell JR, Rapoport RJ, Davis JC, et al. Efficacy and safety of a once-daily morphine formulation in chronic, moderate-to-severe osteoarthritis pain: results from a randomized, placebo-controlled, double-blind trial and open label extension trial. J Pain Symptom Manage 2002; 23: 278–91PubMedCrossRef
96.
Zurück zum Zitat Jovey RD, Ennis J, Gardner-Nix J, et al., Canadian Pain Society. Use of opioid analgesics for the treatment of chronic noncancer pain: a consensus statement and guidelines from the Canadian Pain Society, 2002. Pain Res Manag 2003; 8Suppl. A: 3A–28APubMed Jovey RD, Ennis J, Gardner-Nix J, et al., Canadian Pain Society. Use of opioid analgesics for the treatment of chronic noncancer pain: a consensus statement and guidelines from the Canadian Pain Society, 2002. Pain Res Manag 2003; 8Suppl. A: 3A–28APubMed
97.
Zurück zum Zitat Chou R, Fanciullo GJ, Fine PG, et al., American Pain Society — American Academy of Pain Medicine Opioids Guidelines Panel. Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain 2009; 10: 113–30PubMedCrossRef Chou R, Fanciullo GJ, Fine PG, et al., American Pain Society — American Academy of Pain Medicine Opioids Guidelines Panel. Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain 2009; 10: 113–30PubMedCrossRef
98.
Zurück zum Zitat Kalso E, Edwards JE, Moore RA, et al. Opioids in chronic non-cancer pain: systematic review of efficacy and safety. Pain 2004; 112: 372–80PubMedCrossRef Kalso E, Edwards JE, Moore RA, et al. Opioids in chronic non-cancer pain: systematic review of efficacy and safety. Pain 2004; 112: 372–80PubMedCrossRef
99.
Zurück zum Zitat Twycross RG. Opioids. In: Wall PD, Melzack R, editors. Textbook of pain. 4th ed. London: Churchill Livingstone, 1999: 1187–214 Twycross RG. Opioids. In: Wall PD, Melzack R, editors. Textbook of pain. 4th ed. London: Churchill Livingstone, 1999: 1187–214
100.
Zurück zum Zitat Chen ZR, Somogyi AA, Bochner F. Polymorphic Odemethylation of codeine. Lancet 1988; 2: 914–5PubMedCrossRef Chen ZR, Somogyi AA, Bochner F. Polymorphic Odemethylation of codeine. Lancet 1988; 2: 914–5PubMedCrossRef
101.
Zurück zum Zitat Pergolizzi J, Böger RH, Budd K, et al. Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone). Pain Pract 2008; 8: 287–313PubMedCrossRef Pergolizzi J, Böger RH, Budd K, et al. Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone). Pain Pract 2008; 8: 287–313PubMedCrossRef
102.
Zurück zum Zitat Pergolizzi JV, Raffa RB, Gould E. Considerations on the use of oxymorphone in geriatric patients. Expert Opin Drug Saf 2009; 8: 603–13PubMedCrossRef Pergolizzi JV, Raffa RB, Gould E. Considerations on the use of oxymorphone in geriatric patients. Expert Opin Drug Saf 2009; 8: 603–13PubMedCrossRef
103.
Zurück zum Zitat Lussier D, Pickering G. Pharmacological considerations in older patients. In: Beaulieu P, Lussier D, Porreca F, editors. Pharmacology of pain. Seattle (WA): IASP Press, 2010: 547–65 Lussier D, Pickering G. Pharmacological considerations in older patients. In: Beaulieu P, Lussier D, Porreca F, editors. Pharmacology of pain. Seattle (WA): IASP Press, 2010: 547–65
104.
105.
Zurück zum Zitat Fitzcharles MA, Shir Y. Pain management: opioid guidelines. Helpful for the rheumatologist? Nat Rev Rheumatol 2009; 5: 242–4PubMedCrossRef Fitzcharles MA, Shir Y. Pain management: opioid guidelines. Helpful for the rheumatologist? Nat Rev Rheumatol 2009; 5: 242–4PubMedCrossRef
106.
Zurück zum Zitat Weiner D, Hanlon JT, Studenski SA. Effects of central nervous system polypharmacy on falls liability in community-dwelling elderly. Gerontology 1998; 44: 217–21PubMedCrossRef Weiner D, Hanlon JT, Studenski SA. Effects of central nervous system polypharmacy on falls liability in community-dwelling elderly. Gerontology 1998; 44: 217–21PubMedCrossRef
107.
Zurück zum Zitat Schnitzer TJ, Gray WL, Paster RZ, et al. Efficacy of tramadol in treatment of chronic low back pain. J Rheumatol 2000; 27: 772–8PubMed Schnitzer TJ, Gray WL, Paster RZ, et al. Efficacy of tramadol in treatment of chronic low back pain. J Rheumatol 2000; 27: 772–8PubMed
108.
Zurück zum Zitat Wilder-Smith CH, Hill L, Spargo K, et al. Treatment of severe pain from osteoarthritis with slow-release tramadol or dihydrocodeine in combination with NSAIDs: a randomised study comparing analgesia, antinociception and gastrointestinal effects. Pain 2001; 91: 23–31PubMedCrossRef Wilder-Smith CH, Hill L, Spargo K, et al. Treatment of severe pain from osteoarthritis with slow-release tramadol or dihydrocodeine in combination with NSAIDs: a randomised study comparing analgesia, antinociception and gastrointestinal effects. Pain 2001; 91: 23–31PubMedCrossRef
109.
Zurück zum Zitat Ruoff GE, Rosenthal N, Jordan D, et al., Protocol CAPSS-112 Study Group. Tramadol/acetaminophen combination tablets for the treatment of chronic lower back pain: a multi-center, randomized, double blind, placebo-controlled outpatient study. Clin Ther 2003; 23: 1123–40CrossRef Ruoff GE, Rosenthal N, Jordan D, et al., Protocol CAPSS-112 Study Group. Tramadol/acetaminophen combination tablets for the treatment of chronic lower back pain: a multi-center, randomized, double blind, placebo-controlled outpatient study. Clin Ther 2003; 23: 1123–40CrossRef
110.
Zurück zum Zitat Babul N, Noveck R, Chipman H, et al. Efficacy and safety of extended-release, once-daily tramadol in chronic pain: a randomized 12-week clinical trial in osteoarthritis of the knee. J Pain Symptom Manag 2004; 28: 59–71CrossRef Babul N, Noveck R, Chipman H, et al. Efficacy and safety of extended-release, once-daily tramadol in chronic pain: a randomized 12-week clinical trial in osteoarthritis of the knee. J Pain Symptom Manag 2004; 28: 59–71CrossRef
111.
Zurück zum Zitat Beaulieu AD, Peloso PM, Haraoui B, et al. Once-daily, controlled-release tramadol and sustained-release diclofenac relieve chronic pain due to osteoarthritis: a randomized controlled trial. Pain Res Manag 2008; 13: 103–10PubMed Beaulieu AD, Peloso PM, Haraoui B, et al. Once-daily, controlled-release tramadol and sustained-release diclofenac relieve chronic pain due to osteoarthritis: a randomized controlled trial. Pain Res Manag 2008; 13: 103–10PubMed
112.
Zurück zum Zitat Barnung SK, Treschow M, Borgbjerg FM. Respiratory depression following oral tramadol in a patient with impaired renal function. Pain 1997; 71: 111–2PubMedCrossRef Barnung SK, Treschow M, Borgbjerg FM. Respiratory depression following oral tramadol in a patient with impaired renal function. Pain 1997; 71: 111–2PubMedCrossRef
113.
Zurück zum Zitat Likar R, Wittels M, Molnar M, et al. Pharmacokinetic and pharmacodynamic properties of tramadol IR and SR in elderly patients: a prospective, age-group-controlled study. Clin Ther 2006; 28: 2022–39PubMedCrossRef Likar R, Wittels M, Molnar M, et al. Pharmacokinetic and pharmacodynamic properties of tramadol IR and SR in elderly patients: a prospective, age-group-controlled study. Clin Ther 2006; 28: 2022–39PubMedCrossRef
114.
Zurück zum Zitat Wade WE, Spruill WJ. Tapentadol hydrochloride: a centrally acting oral analgesic. Clin Ther 2009; 31: 2804–18PubMedCrossRef Wade WE, Spruill WJ. Tapentadol hydrochloride: a centrally acting oral analgesic. Clin Ther 2009; 31: 2804–18PubMedCrossRef
115.
Zurück zum Zitat Lussier D, Portenoy RK. Adjuvant analgesics in pain management. In: Doyle D, Hanks G, Cherny N, et al., editors. Oxford textbook of palliative medicine. 3rd ed. Oxford: Oxford University Press, 2003: 349–77 Lussier D, Portenoy RK. Adjuvant analgesics in pain management. In: Doyle D, Hanks G, Cherny N, et al., editors. Oxford textbook of palliative medicine. 3rd ed. Oxford: Oxford University Press, 2003: 349–77
116.
Zurück zum Zitat Onghena P, Van Houdenhov B. Antidepressant-induced analgesia in chronic nonmalignant pain: a meta-analysis of 39 placebo controlled studies. Pain 1992; 49: 205–19PubMedCrossRef Onghena P, Van Houdenhov B. Antidepressant-induced analgesia in chronic nonmalignant pain: a meta-analysis of 39 placebo controlled studies. Pain 1992; 49: 205–19PubMedCrossRef
117.
Zurück zum Zitat Max MB. Antidepressants as analgesics. In: Fields HL, Liebeskin JC, editors. Progress in pain research management. Seattle (WA): IASP Press, 1994: 229–46 Max MB. Antidepressants as analgesics. In: Fields HL, Liebeskin JC, editors. Progress in pain research management. Seattle (WA): IASP Press, 1994: 229–46
118.
Zurück zum Zitat Lynch ME. Antidepressants as analgesics: a review of random controlled trials examining analgesic effects of antidepressant agents. J Psychiatry Neurosci 2001; 26: 30–6PubMed Lynch ME. Antidepressants as analgesics: a review of random controlled trials examining analgesic effects of antidepressant agents. J Psychiatry Neurosci 2001; 26: 30–6PubMed
119.
Zurück zum Zitat McQuay H, Carroll D, Jadad AR, et al. Anticonvulsant drugs for management of pain: a systemic review. BMJ 1995; 311: 1047–52PubMedCrossRef McQuay H, Carroll D, Jadad AR, et al. Anticonvulsant drugs for management of pain: a systemic review. BMJ 1995; 311: 1047–52PubMedCrossRef
120.
Zurück zum Zitat Rogawski MA, Loscher W. The neurobiology of anti-epileptic drugs for the treatment of nonepileptic conditions. Nat Med 2004; 10: 685–92PubMedCrossRef Rogawski MA, Loscher W. The neurobiology of anti-epileptic drugs for the treatment of nonepileptic conditions. Nat Med 2004; 10: 685–92PubMedCrossRef
121.
Zurück zum Zitat Chappell AS, Ossanna MJ, Liu-Seifert H, et al. Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13-week, randomized, placebo-controlled trial. Pain 2009; 146: 253–60PubMedCrossRef Chappell AS, Ossanna MJ, Liu-Seifert H, et al. Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13-week, randomized, placebo-controlled trial. Pain 2009; 146: 253–60PubMedCrossRef
122.
Zurück zum Zitat Preskorn SH, Irwin HA. Toxicity of tricyclic antidepressants — kinetics, mechanism, intervention: a review. J Clin Psychiatry 1982; 43: 151–6PubMed Preskorn SH, Irwin HA. Toxicity of tricyclic antidepressants — kinetics, mechanism, intervention: a review. J Clin Psychiatry 1982; 43: 151–6PubMed
123.
Zurück zum Zitat Glassman AH, Bigger Jr JT. Cardiovascular effects of therapeutic doses of tricyclic antidepressants: a review. Arch Gen Psychiatr 1981; 38: 815–20PubMedCrossRef Glassman AH, Bigger Jr JT. Cardiovascular effects of therapeutic doses of tricyclic antidepressants: a review. Arch Gen Psychiatr 1981; 38: 815–20PubMedCrossRef
124.
Zurück zum Zitat Jaffe M, Iacobelis D, Young JP, et al. Post-hoc results show beneficial effects of pregabalin in patients with osteoarthritis of the hip [abstract]. Arthritis Rheum 2000; 43 Suppl.: 1621 Jaffe M, Iacobelis D, Young JP, et al. Post-hoc results show beneficial effects of pregabalin in patients with osteoarthritis of the hip [abstract]. Arthritis Rheum 2000; 43 Suppl.: 1621
125.
126.
Zurück zum Zitat Dominkus M, Nicolakis M, Kotz R, et al. Comparison of tissue and plasma levels of ibuprofen after oral and topical administration. Arzneimittelforschung 1996; 46: 1138–43PubMed Dominkus M, Nicolakis M, Kotz R, et al. Comparison of tissue and plasma levels of ibuprofen after oral and topical administration. Arzneimittelforschung 1996; 46: 1138–43PubMed
127.
Zurück zum Zitat Heyneman CA, Lawless-Liday C, Wall GC. Oral versus topical NSAIDs in rheumatic diseases. Drugs 2000; 2000: 555–74CrossRef Heyneman CA, Lawless-Liday C, Wall GC. Oral versus topical NSAIDs in rheumatic diseases. Drugs 2000; 2000: 555–74CrossRef
128.
Zurück zum Zitat Lynch ME, Clark AJ, Sawnyok J. Topical amitriptyline, ketamine and a combination of both in the treatment of neuropathic pain. Clin J Pain 2003; 19: 323–7PubMedCrossRef Lynch ME, Clark AJ, Sawnyok J. Topical amitriptyline, ketamine and a combination of both in the treatment of neuropathic pain. Clin J Pain 2003; 19: 323–7PubMedCrossRef
129.
Zurück zum Zitat Bookman AA, Williams KS, Stainhouse JZ. Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial. CMAJ 2004; 171: 333–8PubMedCrossRef Bookman AA, Williams KS, Stainhouse JZ. Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial. CMAJ 2004; 171: 333–8PubMedCrossRef
130.
Zurück zum Zitat Mason L, Moore RA, Derry S, et al. Systematic review of topical capsaicin for the treatment of chronic pain. BMJ 2004; 328: 991–4PubMedCrossRef Mason L, Moore RA, Derry S, et al. Systematic review of topical capsaicin for the treatment of chronic pain. BMJ 2004; 328: 991–4PubMedCrossRef
131.
Zurück zum Zitat Mason L, Moore RA, Edwards JE, et al. Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis. BMC Musculoskelet Disord 2004; 19: 5–28 Mason L, Moore RA, Edwards JE, et al. Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis. BMC Musculoskelet Disord 2004; 19: 5–28
132.
Zurück zum Zitat Mason L, Moore RA, Edwards JE, et al. Systematic review of efficacy of topical rubefacients containing salicylates for the treatment of acute and chronic pain. BMJ 2004; 328: 991–4PubMedCrossRef Mason L, Moore RA, Edwards JE, et al. Systematic review of efficacy of topical rubefacients containing salicylates for the treatment of acute and chronic pain. BMJ 2004; 328: 991–4PubMedCrossRef
133.
Zurück zum Zitat Harvey WF, Hunter DJ. The role of analgesics and intraarticular injections in disease management. Rheum Dis Clin N Am 2008; 34: 777–88CrossRef Harvey WF, Hunter DJ. The role of analgesics and intraarticular injections in disease management. Rheum Dis Clin N Am 2008; 34: 777–88CrossRef
134.
Zurück zum Zitat Tugwell PS, Wells GA, Shainhouse JZ. Equivalence study of a topical diclofenac solution (Pennsaid) compared with oral diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial. J Rheumatol 2004; 31: 2002–12PubMed Tugwell PS, Wells GA, Shainhouse JZ. Equivalence study of a topical diclofenac solution (Pennsaid) compared with oral diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial. J Rheumatol 2004; 31: 2002–12PubMed
135.
Zurück zum Zitat Barkin RL. Reducing cardiovascular risks of nonsteroidal anti-inflammatory drugs by using topical formulations [letter]. Am J Cardiol 2009 Nov 1; 104: 1315PubMedCrossRef Barkin RL. Reducing cardiovascular risks of nonsteroidal anti-inflammatory drugs by using topical formulations [letter]. Am J Cardiol 2009 Nov 1; 104: 1315PubMedCrossRef
136.
Zurück zum Zitat Moore RA, Tramer MR, Carroll D, et al. Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs. BMJ 1998; 316: 333–8PubMedCrossRef Moore RA, Tramer MR, Carroll D, et al. Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs. BMJ 1998; 316: 333–8PubMedCrossRef
137.
Zurück zum Zitat Lin J, Zhang W, Jones A, et al. Efficacy of topical nonsteroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomised controlled trials. BMJ 2004; 329(7461): 324–7PubMedCrossRef Lin J, Zhang W, Jones A, et al. Efficacy of topical nonsteroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomised controlled trials. BMJ 2004; 329(7461): 324–7PubMedCrossRef
138.
Zurück zum Zitat Towheed TE. Pennsaid therapy for osteoarthritis of the knee: a systematic review and metaanalysis of randomized controlled trials. J Rheumatol 2006; 33: 567–73PubMed Towheed TE. Pennsaid therapy for osteoarthritis of the knee: a systematic review and metaanalysis of randomized controlled trials. J Rheumatol 2006; 33: 567–73PubMed
139.
Zurück zum Zitat Altman R, Barkin RL. Topical therapy for osteoarthritis: clinical and pharmacologic perspectives. Postgrad Med 2009; 121: 139–47PubMedCrossRef Altman R, Barkin RL. Topical therapy for osteoarthritis: clinical and pharmacologic perspectives. Postgrad Med 2009; 121: 139–47PubMedCrossRef
140.
Zurück zum Zitat Creamer P. Intra-articular corticosteroid treatment in osteoarthritis. Curr Opin Rheumatol 1999; 11: 417–21PubMedCrossRef Creamer P. Intra-articular corticosteroid treatment in osteoarthritis. Curr Opin Rheumatol 1999; 11: 417–21PubMedCrossRef
141.
Zurück zum Zitat Meenagh GK, Patton J, Kynes C, et al. A randomized control trial of intra-articular corticosteroid injection of the carpometacarpal joint of the thumb in osteoarthritis. Ann Rheum Dis 2004; 63: 1260–3PubMedCrossRef Meenagh GK, Patton J, Kynes C, et al. A randomized control trial of intra-articular corticosteroid injection of the carpometacarpal joint of the thumb in osteoarthritis. Ann Rheum Dis 2004; 63: 1260–3PubMedCrossRef
142.
Zurück zum Zitat Gaujoux-Viala C, Dougados M, Gossec L. Efficacy and safety of steroid injections for shoulder and elbow tendonitis: a meta-analysis of randomized controlled trials. Ann Rheum Dis 2009; 68: 1843–9PubMedCrossRef Gaujoux-Viala C, Dougados M, Gossec L. Efficacy and safety of steroid injections for shoulder and elbow tendonitis: a meta-analysis of randomized controlled trials. Ann Rheum Dis 2009; 68: 1843–9PubMedCrossRef
143.
Zurück zum Zitat Bellamy N, Campbell J, Robinson V, et al. Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev 2005; 18: CD005321 Bellamy N, Campbell J, Robinson V, et al. Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev 2005; 18: CD005321
144.
Zurück zum Zitat Reichenbach S, Blank S, Rutjes AW, et al. Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis. Arthritis Rheum 2007; 57: 1410–18PubMedCrossRef Reichenbach S, Blank S, Rutjes AW, et al. Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis. Arthritis Rheum 2007; 57: 1410–18PubMedCrossRef
145.
Zurück zum Zitat Brzusek D, Petron D. Treating knee osteoarthritis with intrarticular hyaluronans. Curr Med Res Opin 2008; 24: 3307–22PubMedCrossRef Brzusek D, Petron D. Treating knee osteoarthritis with intrarticular hyaluronans. Curr Med Res Opin 2008; 24: 3307–22PubMedCrossRef
Metadaten
Titel
Management of Chronic Arthritis Pain in the Elderly
verfasst von
Dr Mary-Ann Fitzcharles
David Lussier
Yoram Shir
Publikationsdatum
01.06.2010
Verlag
Springer International Publishing
Erschienen in
Drugs & Aging / Ausgabe 6/2010
Print ISSN: 1170-229X
Elektronische ISSN: 1179-1969
DOI
https://doi.org/10.2165/11536530-000000000-00000

Weitere Artikel der Ausgabe 6/2010

Drugs & Aging 6/2010 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Triglyzeridsenker schützt nicht nur Hochrisikopatienten

10.05.2024 Hypercholesterinämie Nachrichten

Patienten mit Arteriosklerose-bedingten kardiovaskulären Erkrankungen, die trotz Statineinnahme zu hohe Triglyzeridspiegel haben, profitieren von einer Behandlung mit Icosapent-Ethyl, und zwar unabhängig vom individuellen Risikoprofil.

Gibt es eine Wende bei den bioresorbierbaren Gefäßstützen?

In den USA ist erstmals eine bioresorbierbare Gefäßstütze – auch Scaffold genannt – zur Rekanalisation infrapoplitealer Arterien bei schwerer PAVK zugelassen worden. Das markiert einen Wendepunkt in der Geschichte dieser speziellen Gefäßstützen.

Vorsicht, erhöhte Blutungsgefahr nach PCI!

10.05.2024 Koronare Herzerkrankung Nachrichten

Nach PCI besteht ein erhöhtes Blutungsrisiko, wenn die Behandelten eine verminderte linksventrikuläre Ejektionsfraktion aufweisen. Das Risiko ist umso höher, je stärker die Pumpfunktion eingeschränkt ist.

Wie managen Sie die schmerzhafte diabetische Polyneuropathie?

10.05.2024 DDG-Jahrestagung 2024 Kongressbericht

Mit Capsaicin-Pflastern steht eine neue innovative Therapie bei schmerzhafter diabetischer Polyneuropathie zur Verfügung. Bei therapierefraktären Schmerzen stellt die Hochfrequenz-Rückenmarkstimulation eine adäquate Option dar.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.