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Erschienen in: CNS Drugs 10/2012

01.10.2012 | Therapy In Practice

Acute Treatment of Migraines

verfasst von: Dr Arnaldo N. Da Silva, Dr Stewart J. Tepper

Erschienen in: CNS Drugs | Ausgabe 10/2012

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Abstract

Migraine is a prevalent and disabling brain disorder that costs billions of dollars annually in direct healthcare costs, and school and work absenteeism and presenteeism. The objective of acute treatment is a cost-effective, rapid restoration of functional ability, with minimal recurrence and adverse effects.
The acute treatment of migraine includes specific drugs, which currently all have vasoconstrictive effects (dihydroergotamine and triptans), and nonspecific drugs that include paracetamol (acetaminophen), combination analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), dopamine antagonists, narcotics and corticosteroids.
NSAIDs have both peripheral and central effects on reversing migraine, and so may represent the best alternative for patients who cannot use triptans and ergots due to vascular contraindications. Narcotics and habituating medications should be avoided in the acute treatment of migraine, as the risk for transformation to chronic daily headache is excessively high at a relatively infrequent rate of exposure.
Literatur
1.
Zurück zum Zitat Leonardi M, Steiner TJ, Scher AT, et al. The global burden of migraine: measuring disability in headache disorders with WHO’ Classification of Functioning, Disability and Health (ICF). J Headache Pain 2005 Dec; 6(6): 429–40PubMedCrossRef Leonardi M, Steiner TJ, Scher AT, et al. The global burden of migraine: measuring disability in headache disorders with WHO’ Classification of Functioning, Disability and Health (ICF). J Headache Pain 2005 Dec; 6(6): 429–40PubMedCrossRef
2.
Zurück zum Zitat Lipton RB, Stewart WF, Diamond S, et al. Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 2001 Jul–Aug; 41(7): 646–57PubMedCrossRef Lipton RB, Stewart WF, Diamond S, et al. Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 2001 Jul–Aug; 41(7): 646–57PubMedCrossRef
3.
Zurück zum Zitat Stewart WF, Ricci JA, Chee E, et al. Lost productive work time costs from health conditions in the United States: results from the American Productivity Audit. J Occup Environ Med 2003 Dec; 45(12): 1234–46PubMedCrossRef Stewart WF, Ricci JA, Chee E, et al. Lost productive work time costs from health conditions in the United States: results from the American Productivity Audit. J Occup Environ Med 2003 Dec; 45(12): 1234–46PubMedCrossRef
4.
Zurück zum Zitat Andlin-Sobocki P, Jonsson B, Wittchen HU, et al. Cost of disorders of the brain in Europe. Eur J Neurol 2005 Jun; 12 Suppl. 1: 1–27PubMedCrossRef Andlin-Sobocki P, Jonsson B, Wittchen HU, et al. Cost of disorders of the brain in Europe. Eur J Neurol 2005 Jun; 12 Suppl. 1: 1–27PubMedCrossRef
5.
Zurück zum Zitat Tepper SJ, Dahlof CG, Dowson A, et al. Prevalence and diagnosis of migraine in patients consulting their physician with a complaint of headache: data from the Landmark Study. Headache 2004 Oct; 44(9): 856–64PubMedCrossRef Tepper SJ, Dahlof CG, Dowson A, et al. Prevalence and diagnosis of migraine in patients consulting their physician with a complaint of headache: data from the Landmark Study. Headache 2004 Oct; 44(9): 856–64PubMedCrossRef
6.
Zurück zum Zitat Akerman S, Holland PR, Goadsby PJ. Diencephalic and brainstem mechanisms in migraine. Nat Rev Neurosci 2011 Sep 20; 12(10): 570–84PubMedCrossRef Akerman S, Holland PR, Goadsby PJ. Diencephalic and brainstem mechanisms in migraine. Nat Rev Neurosci 2011 Sep 20; 12(10): 570–84PubMedCrossRef
7.
Zurück zum Zitat Charles A. Advances in the basic and clinical science of migraine. Ann Neurol 2009 May; 65(5): 491–8PubMedCrossRef Charles A. Advances in the basic and clinical science of migraine. Ann Neurol 2009 May; 65(5): 491–8PubMedCrossRef
8.
Zurück zum Zitat Pietrobon D, Striessnig J. Neurobiology of migraine. Nat Rev Neurosci 2003 May; 4(5): 386–98PubMedCrossRef Pietrobon D, Striessnig J. Neurobiology of migraine. Nat Rev Neurosci 2003 May; 4(5): 386–98PubMedCrossRef
9.
Zurück zum Zitat Lambert GA, Truong L, Zagami AS. Effect of cortical spreading depression on basal and evoked traffic in the trigeminovascular sensory system. Cephalalgia 2011 Oct; 31(14): 1439–51PubMedCrossRef Lambert GA, Truong L, Zagami AS. Effect of cortical spreading depression on basal and evoked traffic in the trigeminovascular sensory system. Cephalalgia 2011 Oct; 31(14): 1439–51PubMedCrossRef
10.
Zurück zum Zitat Silberstein SD. Practice parameter: evidence-based guidelines for migraine headache (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2000 Sep 26; 55(6): 754–62PubMedCrossRef Silberstein SD. Practice parameter: evidence-based guidelines for migraine headache (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2000 Sep 26; 55(6): 754–62PubMedCrossRef
11.
12.
Zurück zum Zitat Lipton RB, Stewart WF, Stone AM, et al., Disability in Strategies of Care Study group. Stratified care vs step care strategies for migraine: the Disability in Strategies of Care (DISC) Study: a randomized trial. JAMA 2000 Nov 22–29; 284(20): 2599–605PubMedCrossRef Lipton RB, Stewart WF, Stone AM, et al., Disability in Strategies of Care Study group. Stratified care vs step care strategies for migraine: the Disability in Strategies of Care (DISC) Study: a randomized trial. JAMA 2000 Nov 22–29; 284(20): 2599–605PubMedCrossRef
13.
Zurück zum Zitat Tepper SJ. Acute treatment of migraine. Continuum 2006; 12(6): 87–105 Tepper SJ. Acute treatment of migraine. Continuum 2006; 12(6): 87–105
14.
Zurück zum Zitat Edmeads J, Lainez JM, Brandes JL, et al. Potential of the Migraine Disability Assessment (MIDAS) Questionnaire as a public health initiative and in clinical practice. Neurology 2001; 56 (6 Suppl. 1): S29–34PubMedCrossRef Edmeads J, Lainez JM, Brandes JL, et al. Potential of the Migraine Disability Assessment (MIDAS) Questionnaire as a public health initiative and in clinical practice. Neurology 2001; 56 (6 Suppl. 1): S29–34PubMedCrossRef
15.
Zurück zum Zitat Stewart WF, Lipton RB, Dowson AJ, et al. Development and testing of the Migraine Disability Assessment (MIDAS) Questionnaire to assess headache-related disability. Neurology 2001; 56 (6 Suppl. 1): S20–8PubMedCrossRef Stewart WF, Lipton RB, Dowson AJ, et al. Development and testing of the Migraine Disability Assessment (MIDAS) Questionnaire to assess headache-related disability. Neurology 2001; 56 (6 Suppl. 1): S20–8PubMedCrossRef
16.
Zurück zum Zitat Stewart WF, Lipton RB, Kolodner KB, et al. Validity of the Migraine Disability Assessment (MIDAS) score in comparison to a diary-based measure in a population sample of migraine sufferers. Pain 2000 Oct; 88(1): 41–52PubMedCrossRef Stewart WF, Lipton RB, Kolodner KB, et al. Validity of the Migraine Disability Assessment (MIDAS) score in comparison to a diary-based measure in a population sample of migraine sufferers. Pain 2000 Oct; 88(1): 41–52PubMedCrossRef
17.
Zurück zum Zitat Stewart WF, Lipton RB, Whyte J, et al. An international study to assess reliability of the Migraine Disability Assessment (MIDAS) score. Neurology 1999 Sep 22; 53(5): 988–94PubMedCrossRef Stewart WF, Lipton RB, Whyte J, et al. An international study to assess reliability of the Migraine Disability Assessment (MIDAS) score. Neurology 1999 Sep 22; 53(5): 988–94PubMedCrossRef
18.
Zurück zum Zitat Kosinski M, Bayliss MS, Bjorner JB, et al. A six-item short-form survey for measuring headache impact: the HIT-6. Qual Life Res 2003 Dec; 12(8): 963–74PubMedCrossRef Kosinski M, Bayliss MS, Bjorner JB, et al. A six-item short-form survey for measuring headache impact: the HIT-6. Qual Life Res 2003 Dec; 12(8): 963–74PubMedCrossRef
19.
Zurück zum Zitat Sculpher M, Millson D, Meddis D, et al. Cost-effectiveness analysis of stratified versus stepped care strategies for acute treatment of migraine: the Disability in Strategies for Care (DISC) Study. Pharmacoeconomics 2002; 20(2): 91–100PubMedCrossRef Sculpher M, Millson D, Meddis D, et al. Cost-effectiveness analysis of stratified versus stepped care strategies for acute treatment of migraine: the Disability in Strategies for Care (DISC) Study. Pharmacoeconomics 2002; 20(2): 91–100PubMedCrossRef
20.
Zurück zum Zitat Berde B, Sturmer E. Introduction to the pharmacology of ergot alkaloids and related compounds as a basis of their therapeutic application. In: Berde B, Shild HO, editors. Ergot alkaloids and related compounds. New York (NY): Springer-Verlag, 1978CrossRef Berde B, Sturmer E. Introduction to the pharmacology of ergot alkaloids and related compounds as a basis of their therapeutic application. In: Berde B, Shild HO, editors. Ergot alkaloids and related compounds. New York (NY): Springer-Verlag, 1978CrossRef
21.
Zurück zum Zitat Saper JR, Silberstein S. Pharmacology of dihydroergotamine and evidence for efficacy and safety in migraine. Headache 2006 Nov; 46 Suppl. 4: S171–81PubMedCrossRef Saper JR, Silberstein S. Pharmacology of dihydroergotamine and evidence for efficacy and safety in migraine. Headache 2006 Nov; 46 Suppl. 4: S171–81PubMedCrossRef
22.
Zurück zum Zitat Goadsby PJ, Edvinsson L. The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol 1993 Jan; 33(1): 48–56PubMedCrossRef Goadsby PJ, Edvinsson L. The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol 1993 Jan; 33(1): 48–56PubMedCrossRef
23.
Zurück zum Zitat Markowitz S, Saito K, Moskowitz MA. Neurogenically mediated plasma extravasation in dura mater: effect of ergot alkaloids. A possible mechanism of action in vascular headache. Cephalalgia 1988 Jun; 8(2): 83–91PubMedCrossRef Markowitz S, Saito K, Moskowitz MA. Neurogenically mediated plasma extravasation in dura mater: effect of ergot alkaloids. A possible mechanism of action in vascular headache. Cephalalgia 1988 Jun; 8(2): 83–91PubMedCrossRef
24.
Zurück zum Zitat Muller-Schweinitzer E. Venoconstrictor responses to dihydroergocristine and dihydroergotamine: evidence for the involvement of 5-HT1 like receptors. Cardiovasc Drugs Ther 1990 Dec; 4(6): 1455–60PubMedCrossRef Muller-Schweinitzer E. Venoconstrictor responses to dihydroergocristine and dihydroergotamine: evidence for the involvement of 5-HT1 like receptors. Cardiovasc Drugs Ther 1990 Dec; 4(6): 1455–60PubMedCrossRef
25.
Zurück zum Zitat Muller-Schweinitzer E, Rosenthaler J. Dihydroergotamine: pharmacokinetics, pharmacodynamics, and mechanism of venoconstrictor action in beagle dogs. J Cardiovasc Pharmacol 1987 Jun; 9(6): 686–93PubMedCrossRef Muller-Schweinitzer E, Rosenthaler J. Dihydroergotamine: pharmacokinetics, pharmacodynamics, and mechanism of venoconstrictor action in beagle dogs. J Cardiovasc Pharmacol 1987 Jun; 9(6): 686–93PubMedCrossRef
26.
Zurück zum Zitat Kelley NE, Tepper DE. Rescue therapy for acute migraine, part 1: triptans, dihydroergotamine, and magnesium. Headache 2012 Jan; 52(1): 114–28PubMedCrossRef Kelley NE, Tepper DE. Rescue therapy for acute migraine, part 1: triptans, dihydroergotamine, and magnesium. Headache 2012 Jan; 52(1): 114–28PubMedCrossRef
27.
Zurück zum Zitat Moskowitz MA. Basic mechanisms in vascular headache. Neurol Clin 1990 Nov; 8(4): 801–15PubMed Moskowitz MA. Basic mechanisms in vascular headache. Neurol Clin 1990 Nov; 8(4): 801–15PubMed
28.
Zurück zum Zitat Masterson CG, Durham PL. DHE repression of ATP-mediated sensitization of trigeminal ganglion neurons. Headache 2010 Oct; 50(9): 1424–39PubMedCrossRef Masterson CG, Durham PL. DHE repression of ATP-mediated sensitization of trigeminal ganglion neurons. Headache 2010 Oct; 50(9): 1424–39PubMedCrossRef
29.
Zurück zum Zitat Nagy AJ, Gandhi S, Bhola R, et al. Intravenous dihydroergotamine for inpatient management of refractory primary headaches. Neurology 2011 Nov 15; 77(20): 1827–32PubMedCrossRef Nagy AJ, Gandhi S, Bhola R, et al. Intravenous dihydroergotamine for inpatient management of refractory primary headaches. Neurology 2011 Nov 15; 77(20): 1827–32PubMedCrossRef
30.
Zurück zum Zitat Horton BT, Peters GA, Blumenthal LS. A new product in the treatment of migraine: a preliminary report. Mayo Clin Proc 1945; 20: 241–8 Horton BT, Peters GA, Blumenthal LS. A new product in the treatment of migraine: a preliminary report. Mayo Clin Proc 1945; 20: 241–8
31.
Zurück zum Zitat Callaham M, Raskin N. A controlled study of dihydroergotamine in the treatment of acute migraine headache. Headache 1986 Apr; 26(4): 168–71PubMedCrossRef Callaham M, Raskin N. A controlled study of dihydroergotamine in the treatment of acute migraine headache. Headache 1986 Apr; 26(4): 168–71PubMedCrossRef
32.
Zurück zum Zitat Raskin NH. Repetitive intravenous dihydroergotamine as therapy for intractable migraine. Neurology 1986 Jul; 36(7): 995–7PubMedCrossRef Raskin NH. Repetitive intravenous dihydroergotamine as therapy for intractable migraine. Neurology 1986 Jul; 36(7): 995–7PubMedCrossRef
33.
Zurück zum Zitat Belgrade MJ, Ling LJ, Schleevogt MB, et al. Comparison of single-dose meperidine, butorphanol, and dihydroergotamine in the treatment of vascular headache. Neurology 1989 Apr; 39(4): 590–2PubMedCrossRef Belgrade MJ, Ling LJ, Schleevogt MB, et al. Comparison of single-dose meperidine, butorphanol, and dihydroergotamine in the treatment of vascular headache. Neurology 1989 Apr; 39(4): 590–2PubMedCrossRef
34.
Zurück zum Zitat Bell R, Montoya D, Shuaib A, et al. A comparative trial of three agents in the treatment of acute migraine headache. Ann Emerg Med 1990 Oct; 19(10): 1079–82PubMedCrossRef Bell R, Montoya D, Shuaib A, et al. A comparative trial of three agents in the treatment of acute migraine headache. Ann Emerg Med 1990 Oct; 19(10): 1079–82PubMedCrossRef
35.
Zurück zum Zitat Klapper JA, Stanton JS. Ketorolac versus DHE and metoclopramide in the treatment of migraine headaches. Headache 1991 Sep; 31(8): 523–4PubMedCrossRef Klapper JA, Stanton JS. Ketorolac versus DHE and metoclopramide in the treatment of migraine headaches. Headache 1991 Sep; 31(8): 523–4PubMedCrossRef
36.
Zurück zum Zitat Klapper JA, Stanton JS. The emergency treatment of acute migraine headache; a comparison of intravenous dihydroergotamine, dexamethasone, and placebo. Cephalalgia 1991; 11 Suppl. 11: 159–60 Klapper JA, Stanton JS. The emergency treatment of acute migraine headache; a comparison of intravenous dihydroergotamine, dexamethasone, and placebo. Cephalalgia 1991; 11 Suppl. 11: 159–60
37.
Zurück zum Zitat Haugh MJ, Lavender L, Jensen A, et al. An office-based double-blind comparison of dihydroergotamine vs dihydroergotamine/metoclopramide in the treatment of acute migraine [abstract]. Headache 1992; 32: 251CrossRef Haugh MJ, Lavender L, Jensen A, et al. An office-based double-blind comparison of dihydroergotamine vs dihydroergotamine/metoclopramide in the treatment of acute migraine [abstract]. Headache 1992; 32: 251CrossRef
38.
Zurück zum Zitat Saadah HA. Abortive headache therapy in the office with intravenous dihydroergotamine plus prochlorperazine. Headache 1992 Mar; 32(3): 143–6PubMedCrossRef Saadah HA. Abortive headache therapy in the office with intravenous dihydroergotamine plus prochlorperazine. Headache 1992 Mar; 32(3): 143–6PubMedCrossRef
39.
Zurück zum Zitat Klapper JA, Stanton J. Current emergency treatment of severe migraine headaches. Headache 1993 Nov–Dec; 33(10): 560–2PubMedCrossRef Klapper JA, Stanton J. Current emergency treatment of severe migraine headaches. Headache 1993 Nov–Dec; 33(10): 560–2PubMedCrossRef
40.
Zurück zum Zitat Scherl ER, Wilson JF. Comparison of dihydroergotamine with metoclopramide versus meperidine with promethazine in the treatment of acute migraine. Headache 1995 May; 35(5): 256–9PubMedCrossRef Scherl ER, Wilson JF. Comparison of dihydroergotamine with metoclopramide versus meperidine with promethazine in the treatment of acute migraine. Headache 1995 May; 35(5): 256–9PubMedCrossRef
41.
Zurück zum Zitat Winner P, Ricalde O, Le Force B, et al. A double-blind study of subcutaneous dihydroergotamine vs subcutaneous sumatriptan in the treatment of acute migraine. Arch Neurol 1996 Feb; 53(2): 180–4PubMedCrossRef Winner P, Ricalde O, Le Force B, et al. A double-blind study of subcutaneous dihydroergotamine vs subcutaneous sumatriptan in the treatment of acute migraine. Arch Neurol 1996 Feb; 53(2): 180–4PubMedCrossRef
42.
Zurück zum Zitat Carleton SC, Shesser RF, Pietrzak MP, et al. Double-blind, multicenter trial to compare the efficacy of intramuscular dihydroergotamine plus hydroxyzine versus intramuscular meperidine plus hydroxyzine for the emergency department treatment of acute migraine headache. Ann Emerg Med 1998 Aug; 32(2): 129–38PubMedCrossRef Carleton SC, Shesser RF, Pietrzak MP, et al. Double-blind, multicenter trial to compare the efficacy of intramuscular dihydroergotamine plus hydroxyzine versus intramuscular meperidine plus hydroxyzine for the emergency department treatment of acute migraine headache. Ann Emerg Med 1998 Aug; 32(2): 129–38PubMedCrossRef
43.
Zurück zum Zitat Edwards KR, Norton J, Behnke M. Comparison of intravenous valproate versus intramuscular dihydroergotamine and metoclopramide for acute treatment of migraine headache. Headache 2001 Nov–Dec; 41(10): 976–80PubMedCrossRef Edwards KR, Norton J, Behnke M. Comparison of intravenous valproate versus intramuscular dihydroergotamine and metoclopramide for acute treatment of migraine headache. Headache 2001 Nov–Dec; 41(10): 976–80PubMedCrossRef
44.
Zurück zum Zitat Swidan SZ, Lake AE, Saper JR. Efficacy of intravenous diphenhydramine versus intravenous DHE-45 in the treatment of severe migraine headache. Curr Pain Headache Rep 2005 Feb; 9(1): 65–70PubMedCrossRef Swidan SZ, Lake AE, Saper JR. Efficacy of intravenous diphenhydramine versus intravenous DHE-45 in the treatment of severe migraine headache. Curr Pain Headache Rep 2005 Feb; 9(1): 65–70PubMedCrossRef
45.
Zurück zum Zitat Silberstein SD, Young WB. Safety and efficacy of ergotamine tartrate and dihydroergotamine in the treatment of migraine and status migrainosus: Working Panel of the Headache and Facial Pain Section of the American Academy of Neurology. Neurology 1995 Mar; 45(3 Pt 1): 577–84PubMedCrossRef Silberstein SD, Young WB. Safety and efficacy of ergotamine tartrate and dihydroergotamine in the treatment of migraine and status migrainosus: Working Panel of the Headache and Facial Pain Section of the American Academy of Neurology. Neurology 1995 Mar; 45(3 Pt 1): 577–84PubMedCrossRef
46.
Zurück zum Zitat Shrewsbury SB, Cook RO, Taylor G, et al. Safety and pharmacokinetics of dihydroergotamine mesylate administered via a Novel (Tempo) inhaler. Headache 2008 Mar; 48(3): 355–67PubMedCrossRef Shrewsbury SB, Cook RO, Taylor G, et al. Safety and pharmacokinetics of dihydroergotamine mesylate administered via a Novel (Tempo) inhaler. Headache 2008 Mar; 48(3): 355–67PubMedCrossRef
47.
Zurück zum Zitat Aurora SK, Silberstein SD, Kori SH, et al. MAP0004, orally inhaled DHE: a randomized, controlled study in the acute treatment of migraine. Headache 2011 Apr; 51(4): 507–17PubMedCrossRef Aurora SK, Silberstein SD, Kori SH, et al. MAP0004, orally inhaled DHE: a randomized, controlled study in the acute treatment of migraine. Headache 2011 Apr; 51(4): 507–17PubMedCrossRef
48.
Zurück zum Zitat Tepper SJ, Kori SH, Goadsby PJ, et al. MAP0004, orally inhaled dihydroergotamine for acute treatment of migraine: efficacy of early and late treatments. Mayo Clin Proc 2011 Oct; 86(10): 948–55PubMedCrossRef Tepper SJ, Kori SH, Goadsby PJ, et al. MAP0004, orally inhaled dihydroergotamine for acute treatment of migraine: efficacy of early and late treatments. Mayo Clin Proc 2011 Oct; 86(10): 948–55PubMedCrossRef
49.
Zurück zum Zitat Saxena PR, Ferrari MD. 5-HT(1)-like receptor agonists and the pathophysiology of migraine. Trends Pharmacol Sci 1989 May; 10(5): 200–4PubMedCrossRef Saxena PR, Ferrari MD. 5-HT(1)-like receptor agonists and the pathophysiology of migraine. Trends Pharmacol Sci 1989 May; 10(5): 200–4PubMedCrossRef
50.
Zurück zum Zitat Hargreaves RJ, Shepheard SL. Pathophysiology of migraine: new insights. Can J Neurol Sci 1999 Nov; 26 Suppl. 3: S12–9PubMed Hargreaves RJ, Shepheard SL. Pathophysiology of migraine: new insights. Can J Neurol Sci 1999 Nov; 26 Suppl. 3: S12–9PubMed
51.
Zurück zum Zitat Humphrey PP, Apperly E, Feniuk W, et al. A rational approach to identifying a fundamentally new drug for the treatment of migraine. In: Saxena PR, Wallis DI, Wouters W, et al., editors. Cardiovascular pharmacology of 5-hydroxytryptamine. Dordrecht: Kluwer Academic Publishers, 1990:417–31 Humphrey PP, Apperly E, Feniuk W, et al. A rational approach to identifying a fundamentally new drug for the treatment of migraine. In: Saxena PR, Wallis DI, Wouters W, et al., editors. Cardiovascular pharmacology of 5-hydroxytryptamine. Dordrecht: Kluwer Academic Publishers, 1990:417–31
52.
Zurück zum Zitat Humphrey PP, Feniuk W, Perren MJ, et al. The pharmacology of the novel 5-HT1-like receptor agonist, GR43175. Cephalalgia 1989; 9 Suppl. 9: 23–33PubMed Humphrey PP, Feniuk W, Perren MJ, et al. The pharmacology of the novel 5-HT1-like receptor agonist, GR43175. Cephalalgia 1989; 9 Suppl. 9: 23–33PubMed
53.
Zurück zum Zitat Humphrey PP, Feniuk W, Perren MJ, et al. GR43175, a selective agonist for the 5-HT1-like receptor in dog isolated saphenous vein. Br J Pharmacol 1988 Aug; 94(4): 1123–32PubMedCrossRef Humphrey PP, Feniuk W, Perren MJ, et al. GR43175, a selective agonist for the 5-HT1-like receptor in dog isolated saphenous vein. Br J Pharmacol 1988 Aug; 94(4): 1123–32PubMedCrossRef
54.
Zurück zum Zitat Rapoport AM, Tepper SJ, Bigal ME, et al. The triptan formulations: how to match patients and products. CNS Drugs 2003; 17(6): 431–47PubMedCrossRef Rapoport AM, Tepper SJ, Bigal ME, et al. The triptan formulations: how to match patients and products. CNS Drugs 2003; 17(6): 431–47PubMedCrossRef
55.
Zurück zum Zitat Gillman PK. Triptans, serotonin agonists, and serotonin syndrome (serotonin toxicity): a review. Headache 2010 Feb; 50(2): 264–72PubMedCrossRef Gillman PK. Triptans, serotonin agonists, and serotonin syndrome (serotonin toxicity): a review. Headache 2010 Feb; 50(2): 264–72PubMedCrossRef
56.
Zurück zum Zitat McCrory DC, Gray RN. Oral sumatriptan for acute migraine. Cochrane Database Syst Rev 2003; 3(3): CD002915PubMed McCrory DC, Gray RN. Oral sumatriptan for acute migraine. Cochrane Database Syst Rev 2003; 3(3): CD002915PubMed
57.
Zurück zum Zitat Mathew NT, Landy S, Stark S, et al. Fixed-dose sumatriptan and naproxen in poor responders to triptans with a short half-life. Headache 2009 Jul; 49(7): 971–82PubMedCrossRef Mathew NT, Landy S, Stark S, et al. Fixed-dose sumatriptan and naproxen in poor responders to triptans with a short half-life. Headache 2009 Jul; 49(7): 971–82PubMedCrossRef
58.
Zurück zum Zitat Smith TR, Sunshine A, Stark SR, et al. Sumatriptan and naproxen sodium for the acute treatment of migraine. Headache 2005 Sep; 45(8): 983–91PubMedCrossRef Smith TR, Sunshine A, Stark SR, et al. Sumatriptan and naproxen sodium for the acute treatment of migraine. Headache 2005 Sep; 45(8): 983–91PubMedCrossRef
59.
Zurück zum Zitat Akpunonu BE, Mutgi AB, Federman DJ, et al. Subcutaneous sumatriptan for treatment of acute migraine in patients admitted to the emergency department: a multicenter study. Ann Emerg Med 1995 Apr; 25(4): 464–9PubMedCrossRef Akpunonu BE, Mutgi AB, Federman DJ, et al. Subcutaneous sumatriptan for treatment of acute migraine in patients admitted to the emergency department: a multicenter study. Ann Emerg Med 1995 Apr; 25(4): 464–9PubMedCrossRef
60.
Zurück zum Zitat Kelly AM, Ardagh M, Curry C, et al. Intravenous chlorpromazine versus intramuscular sumatriptan for acute migraine. J Accid Emerg Med 1997 Jul; 14(4): 209–11PubMedCrossRef Kelly AM, Ardagh M, Curry C, et al. Intravenous chlorpromazine versus intramuscular sumatriptan for acute migraine. J Accid Emerg Med 1997 Jul; 14(4): 209–11PubMedCrossRef
61.
Zurück zum Zitat Hay E, Rodrig J, Hussain A, et al. Rizatriptan RPD for severe migraine in the emergency department: a multicenter study. J Emerg Med 2003 Oct; 25(3): 245–9PubMedCrossRef Hay E, Rodrig J, Hussain A, et al. Rizatriptan RPD for severe migraine in the emergency department: a multicenter study. J Emerg Med 2003 Oct; 25(3): 245–9PubMedCrossRef
62.
Zurück zum Zitat Meredith JT, Wait S, Brewer KL. A prospective double-blind study of nasal sumatriptan versus IV ketorolac in migraine. Am J Emerg Med 2003 May; 21(3): 173–5PubMedCrossRef Meredith JT, Wait S, Brewer KL. A prospective double-blind study of nasal sumatriptan versus IV ketorolac in migraine. Am J Emerg Med 2003 May; 21(3): 173–5PubMedCrossRef
63.
Zurück zum Zitat Friedman BW, Corbo J, Lipton RB, et al. A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines. Neurology 2005 Feb 8; 64(3): 463–8PubMedCrossRef Friedman BW, Corbo J, Lipton RB, et al. A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines. Neurology 2005 Feb 8; 64(3): 463–8PubMedCrossRef
64.
Zurück zum Zitat Friedman BW, Hochberg M, Esses D, et al. A clinical trial of trimethobenzamide/diphenhydramine versus sumatriptan for acute migraines. Headache 2006 Jun; 46(6): 934–41PubMedCrossRef Friedman BW, Hochberg M, Esses D, et al. A clinical trial of trimethobenzamide/diphenhydramine versus sumatriptan for acute migraines. Headache 2006 Jun; 46(6): 934–41PubMedCrossRef
65.
Zurück zum Zitat Miner JR, Smith SW, Moore J, et al. Sumatriptan for the treatment of undifferentiated primary headaches in the ED. Am J Emerg Med 2007 Jan; 25(1): 60–4PubMedCrossRef Miner JR, Smith SW, Moore J, et al. Sumatriptan for the treatment of undifferentiated primary headaches in the ED. Am J Emerg Med 2007 Jan; 25(1): 60–4PubMedCrossRef
66.
Zurück zum Zitat Kostic MA, Gutierrez FJ, Rieg TS, et al. A prospective, randomized trial of intravenous prochlorperazine versus subcutaneous sumatriptan in acute migraine therapy in the emergency department. Ann Emerg Med 2010 Jul; 56(1): 1–6PubMedCrossRef Kostic MA, Gutierrez FJ, Rieg TS, et al. A prospective, randomized trial of intravenous prochlorperazine versus subcutaneous sumatriptan in acute migraine therapy in the emergency department. Ann Emerg Med 2010 Jul; 56(1): 1–6PubMedCrossRef
67.
Zurück zum Zitat Suthisisang CC, Poolsup N, Suksomboon N, et al. Meta-analysis of the efficacy and safety of naproxen sodium in the acute treatment of migraine. Headache 2010 May; 50(5): 808–18PubMedCrossRef Suthisisang CC, Poolsup N, Suksomboon N, et al. Meta-analysis of the efficacy and safety of naproxen sodium in the acute treatment of migraine. Headache 2010 May; 50(5): 808–18PubMedCrossRef
68.
Zurück zum Zitat Suthisisang C, Poolsup N, Kittikulsuth W, et al. Efficacy of low-dose ibuprofen in acute migraine treatment: systematic review and meta-analysis. Ann Pharmacother 2007 Nov; 41(11): 1782–91PubMedCrossRef Suthisisang C, Poolsup N, Kittikulsuth W, et al. Efficacy of low-dose ibuprofen in acute migraine treatment: systematic review and meta-analysis. Ann Pharmacother 2007 Nov; 41(11): 1782–91PubMedCrossRef
69.
Zurück zum Zitat Jakubowski M, Levy D, Goor-Aryeh I, et al. Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors. Headache 2005 Jul–Aug; 45(7): 850–61PubMedCrossRef Jakubowski M, Levy D, Goor-Aryeh I, et al. Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors. Headache 2005 Jul–Aug; 45(7): 850–61PubMedCrossRef
70.
Zurück zum Zitat Diener HC, Montagna P, Gacs G, et al. Efficacy and tolerability of diclofenac potassium sachets in migraine: a randomized, double-blind, cross-over study in comparison with diclofenac potassium tablets and placebo. Cephalalgia 2006 May; 26(5): 537–47PubMedCrossRef Diener HC, Montagna P, Gacs G, et al. Efficacy and tolerability of diclofenac potassium sachets in migraine: a randomized, double-blind, cross-over study in comparison with diclofenac potassium tablets and placebo. Cephalalgia 2006 May; 26(5): 537–47PubMedCrossRef
71.
Zurück zum Zitat Lipton RB, Grosberg B, Singer RP, et al. Efficacy and tolerability of a new powdered formulation of diclofenac potassium for oral solution for the acute treatment of migraine: results from the International Migraine Pain Assessment Clinical Trial (IMPACT). Cephalalgia 2010 Nov; 30(11): 1336–45PubMedCrossRef Lipton RB, Grosberg B, Singer RP, et al. Efficacy and tolerability of a new powdered formulation of diclofenac potassium for oral solution for the acute treatment of migraine: results from the International Migraine Pain Assessment Clinical Trial (IMPACT). Cephalalgia 2010 Nov; 30(11): 1336–45PubMedCrossRef
72.
Zurück zum Zitat Marmura MJ. Use of dopamine antagonists in treatment of migraine. Curr Treat Options Neurol 2012 Feb; 14(1): 27–35PubMedCrossRef Marmura MJ. Use of dopamine antagonists in treatment of migraine. Curr Treat Options Neurol 2012 Feb; 14(1): 27–35PubMedCrossRef
73.
Zurück zum Zitat Peroutka SJ, Wilhoit T, Jones K. Clinical susceptibility to migraine with aura is modified by dopamine D2 receptor (DRD2) NcoI alleles. Neurology 1997 Jul; 49(1): 201–6PubMedCrossRef Peroutka SJ, Wilhoit T, Jones K. Clinical susceptibility to migraine with aura is modified by dopamine D2 receptor (DRD2) NcoI alleles. Neurology 1997 Jul; 49(1): 201–6PubMedCrossRef
74.
Zurück zum Zitat Fernandez F, Lea RA, Colson NJ, et al. Association between a 19 bp deletion polymorphism at the dopamine beta-hydroxylase (DBH) locus and migraine with aura. J Neurol Sci 2006 Dec 21; 251(1–2): 118–23PubMedCrossRef Fernandez F, Lea RA, Colson NJ, et al. Association between a 19 bp deletion polymorphism at the dopamine beta-hydroxylase (DBH) locus and migraine with aura. J Neurol Sci 2006 Dec 21; 251(1–2): 118–23PubMedCrossRef
76.
Zurück zum Zitat Colman I, Brown MD, Innes GD, et al. Parenteral metoclopramide for acute migraine: meta-analysis of randomised controlled trials. BMJ 2004 Dec 11; 329(7479): 1369–73PubMedCrossRef Colman I, Brown MD, Innes GD, et al. Parenteral metoclopramide for acute migraine: meta-analysis of randomised controlled trials. BMJ 2004 Dec 11; 329(7479): 1369–73PubMedCrossRef
77.
Zurück zum Zitat Bigal ME, Bordini CA, Speciali JG. Intravenous chlorpromazine in the emergency department treatment of migraines: a randomized controlled trial. J Emerg Med 2002 Aug; 23(2): 141–8PubMedCrossRef Bigal ME, Bordini CA, Speciali JG. Intravenous chlorpromazine in the emergency department treatment of migraines: a randomized controlled trial. J Emerg Med 2002 Aug; 23(2): 141–8PubMedCrossRef
78.
Zurück zum Zitat Shrestha M, Singh R, Moreden J, et al. Ketorolac vs chlorpromazine in the treatment of acute migraine without aura: a prospective, randomized, double-blind trial. Arch Intern Med 1996 Aug 12–26; 156(15): 1725–8PubMedCrossRef Shrestha M, Singh R, Moreden J, et al. Ketorolac vs chlorpromazine in the treatment of acute migraine without aura: a prospective, randomized, double-blind trial. Arch Intern Med 1996 Aug 12–26; 156(15): 1725–8PubMedCrossRef
79.
Zurück zum Zitat Jones J, Sklar D, Dougherty J, et al. Randomized double-blind trial of intravenous prochlorperazine for the treatment of acute headache. JAMA 1989 Feb 24; 261(8): 1174–6PubMedCrossRef Jones J, Sklar D, Dougherty J, et al. Randomized double-blind trial of intravenous prochlorperazine for the treatment of acute headache. JAMA 1989 Feb 24; 261(8): 1174–6PubMedCrossRef
80.
Zurück zum Zitat Seim MB, March JA, Dunn KA. Intravenous ketorolac vs intravenous prochlorperazine for the treatment of migraine headaches. Acad Emerg Med 1998 Jun; 5(6): 573–6PubMedCrossRef Seim MB, March JA, Dunn KA. Intravenous ketorolac vs intravenous prochlorperazine for the treatment of migraine headaches. Acad Emerg Med 1998 Jun; 5(6): 573–6PubMedCrossRef
81.
Zurück zum Zitat Ginder S, Oatman B, Pollack M. A prospective study of i.v. magnesium and i.v. prochlorperazine in the treatment of headaches. J Emerg Med 2000 Apr; 18(3): 311–5PubMedCrossRef Ginder S, Oatman B, Pollack M. A prospective study of i.v. magnesium and i.v. prochlorperazine in the treatment of headaches. J Emerg Med 2000 Apr; 18(3): 311–5PubMedCrossRef
82.
Zurück zum Zitat Derry S, Moore RA, McQuay HJ. Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev 2010 Nov 10; 11(11): CD008040PubMed Derry S, Moore RA, McQuay HJ. Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev 2010 Nov 10; 11(11): CD008040PubMed
83.
Zurück zum Zitat Tfelt-Hansen P, Olesen J. Paracetamol (acetaminophen) versus acetylsalicylic acid in migraine. Eur Neurol 1980; 19(3): 163–5PubMedCrossRef Tfelt-Hansen P, Olesen J. Paracetamol (acetaminophen) versus acetylsalicylic acid in migraine. Eur Neurol 1980; 19(3): 163–5PubMedCrossRef
84.
Zurück zum Zitat Lipton RB, Stewart WF, Ryan Jr RE, et al. Efficacy and safety of acetaminophen, aspirin, and caffeine in alleviating migraine headache pain: three double-blind, randomized, placebo-controlled trials. Arch Neurol 1998 Feb; 55(2): 210–7PubMedCrossRef Lipton RB, Stewart WF, Ryan Jr RE, et al. Efficacy and safety of acetaminophen, aspirin, and caffeine in alleviating migraine headache pain: three double-blind, randomized, placebo-controlled trials. Arch Neurol 1998 Feb; 55(2): 210–7PubMedCrossRef
85.
Zurück zum Zitat Goldstein J, Hoffman HD, Armellino JJ, et al. Treatment of severe, disabling migraine attacks in an over-the-counter population of migraine sufferers: results from three randomized, placebo-controlled studies of the combination of acetaminophen, aspirin, and caffeine. Cephalalgia 1999 Sep; 19(7): 684–91PubMedCrossRef Goldstein J, Hoffman HD, Armellino JJ, et al. Treatment of severe, disabling migraine attacks in an over-the-counter population of migraine sufferers: results from three randomized, placebo-controlled studies of the combination of acetaminophen, aspirin, and caffeine. Cephalalgia 1999 Sep; 19(7): 684–91PubMedCrossRef
86.
Zurück zum Zitat Diener HC, Pfaffenrath V, Pageler L, et al. The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel group study. Cephalalgia 2005 Oct; 25(10): 776–87PubMedCrossRef Diener HC, Pfaffenrath V, Pageler L, et al. The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel group study. Cephalalgia 2005 Oct; 25(10): 776–87PubMedCrossRef
87.
Zurück zum Zitat Freitag FG, Cady R, DiSerio F, et al. Comparative study of a combination of isometheptene mucate, dichloralphenazone with acetaminophen and sumatriptan succinate in the treatment of migraine. Headache 2001 Apr; 41(4): 391–8PubMedCrossRef Freitag FG, Cady R, DiSerio F, et al. Comparative study of a combination of isometheptene mucate, dichloralphenazone with acetaminophen and sumatriptan succinate in the treatment of migraine. Headache 2001 Apr; 41(4): 391–8PubMedCrossRef
88.
Zurück zum Zitat Moskowitz MA, Cutrer FM. Sumatriptan: a receptortargeted treatment for migraine. Annu Rev Med 1993; 44: 145–54PubMedCrossRef Moskowitz MA, Cutrer FM. Sumatriptan: a receptortargeted treatment for migraine. Annu Rev Med 1993; 44: 145–54PubMedCrossRef
89.
Zurück zum Zitat May A, Shepheard SL, Knorr M, et al. Retinal plasma extravasation in animals but not in humans: implications for the pathophysiology of migraine. Brain 1998 Jul; 121(Pt 7): 1231–7PubMedCrossRef May A, Shepheard SL, Knorr M, et al. Retinal plasma extravasation in animals but not in humans: implications for the pathophysiology of migraine. Brain 1998 Jul; 121(Pt 7): 1231–7PubMedCrossRef
90.
Zurück zum Zitat Friedman BW, Greenwald P, Bania TC, et al. Randomized trial of IV dexamethasone for acute migraine in the emergency department. Neurology 2007 Nov 27; 69(22): 2038–44PubMedCrossRef Friedman BW, Greenwald P, Bania TC, et al. Randomized trial of IV dexamethasone for acute migraine in the emergency department. Neurology 2007 Nov 27; 69(22): 2038–44PubMedCrossRef
91.
Zurück zum Zitat Donaldson D, Sundermann R, Jackson R, et al. Intravenous dexamethasone vs placebo as adjunctive therapy to reduce the recurrence rate of acute migraine headaches: a multicenter, double-blinded, placebo-controlled randomized clinical trial. Am J Emerg Med 2008 Feb; 26(2): 124–30PubMedCrossRef Donaldson D, Sundermann R, Jackson R, et al. Intravenous dexamethasone vs placebo as adjunctive therapy to reduce the recurrence rate of acute migraine headaches: a multicenter, double-blinded, placebo-controlled randomized clinical trial. Am J Emerg Med 2008 Feb; 26(2): 124–30PubMedCrossRef
92.
Zurück zum Zitat Rowe BH, Colman I, Edmonds ML, et al. Randomized controlled trial of intravenous dexamethasone to prevent relapse in acute migraine headache. Headache 2008 Mar; 48(3): 333–40PubMedCrossRef Rowe BH, Colman I, Edmonds ML, et al. Randomized controlled trial of intravenous dexamethasone to prevent relapse in acute migraine headache. Headache 2008 Mar; 48(3): 333–40PubMedCrossRef
93.
Zurück zum Zitat Fiesseler FW, Shih R, Szucs P, et al. Steroids for migraine headaches: a randomized double-blind, two-armed, placebo-controlled trial. J Emerg Med 2011 Apr; 40(4): 463–8PubMedCrossRef Fiesseler FW, Shih R, Szucs P, et al. Steroids for migraine headaches: a randomized double-blind, two-armed, placebo-controlled trial. J Emerg Med 2011 Apr; 40(4): 463–8PubMedCrossRef
94.
Zurück zum Zitat Kelley NE, Tepper DE. Rescue therapy for acute migraine, part 3: opioids, NSAIDs, steroids, and post-discharge medications. Headache 2012 Mar; 52(3): 467–82PubMedCrossRef Kelley NE, Tepper DE. Rescue therapy for acute migraine, part 3: opioids, NSAIDs, steroids, and post-discharge medications. Headache 2012 Mar; 52(3): 467–82PubMedCrossRef
95.
Zurück zum Zitat Bigal ME, Lipton RB. Excessive acute migraine medication use and migraine progression. Neurology 2008 Nov 25; 71(22): 1821–8PubMedCrossRef Bigal ME, Lipton RB. Excessive acute migraine medication use and migraine progression. Neurology 2008 Nov 25; 71(22): 1821–8PubMedCrossRef
96.
Zurück zum Zitat Members of the task force:, Evers S, Afra J, Frese A, et al. EFNS guideline on the drug treatment of migraine-report of an EFNS task force. Eur J Neurol 2006 Jun; 13(6): 560–72PubMedCrossRef Members of the task force:, Evers S, Afra J, Frese A, et al. EFNS guideline on the drug treatment of migraine-report of an EFNS task force. Eur J Neurol 2006 Jun; 13(6): 560–72PubMedCrossRef
Metadaten
Titel
Acute Treatment of Migraines
verfasst von
Dr Arnaldo N. Da Silva
Dr Stewart J. Tepper
Publikationsdatum
01.10.2012
Verlag
Springer International Publishing
Erschienen in
CNS Drugs / Ausgabe 10/2012
Print ISSN: 1172-7047
Elektronische ISSN: 1179-1934
DOI
https://doi.org/10.2165/11635440-000000000-00000

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