Background
Methods
Study population and phenotypes
SNP selection and genotyping
Statistical methods
Results
Study population characteristics
Non-hispanic whites | Non-hispanic blacks | Mexican Americans | |||||||
---|---|---|---|---|---|---|---|---|---|
n = 2,408 | n = 1,719 | n = 1,708 | |||||||
Cases | Controls | P-value | Cases | Controls | P-value | Cases | Controls | P-value | |
n
| 446 | 1,962 | - | 179 | 1,540 | - | 227 | 1,478 | - |
% Female
| 71.13% | 58.10% | 5.24E-07 | 76.54% | 56.17% | 3.66E-07 | 73.29% | 45.81% | 5.55E-16 |
Age in years
| 61.74 | 51.91 | 6.49E-23 | 49.67 | 40.02 | 1.11E-16 | 53.80 | 39.27 | 2.59E-33 |
(16.45) | (20.61) | (16.71) | (16.48) | (15.16) | (16.95) | ||||
BMI
| 28.51 | 26.24 | 5.13E-14 | 30.77 | 27.96 | 2..32E-07 | 30.27 | 27.22 | 3.33E-16 |
(kg/m
2
)
| (6.1) | (5.35) | 6.67) | (6.61) | (5.86) | (5.2) |
SNPs | Gene | OAT | Non-Hispanic Whites | Non-Hispanic Blacks | Mexican Americans | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Case/ Control CAF | OR (95% C.I.) | P | Case/ Control CAF | OR (95% C.I.) | P | Case/ Control CAF | OR (95% C.I.) | P | |||
rs10401969 |
SUGP1
| TG | § | 1.37 (1.05, 1.78) |
1.89E-02
| § | 1.01 (0.74, 1.38) | 9.61E-01 | § | 0.69 (0.41, 1.15) | 1.52E-01 |
rs10889353 |
DOCK7
| TG | 0.64/ 0.67 | 0.90 (0.76, 1.05) | 1.83E-01 | 0.61/ 0.62 | 0.84 (0.67, 1.06) | 1.50E-01 | 0.66/ 0.62 | 1.32 (1.05, 1.67) |
1.73E-02
|
rs17216525 |
CILP2
| TG | § | 0.76 (0.58, 0.99) |
4.45E-02
| § | 1.26 (0.64, 2.46) | 5.02E-01 | § | 0.88 (0.53, 1.45) | 6.15E-01 |
rs1883025 |
ABCA1
| HDL | 0.27/ 0.26 | 1.09 (0.92, 1.30) | 3.36E-01 | 0.30/ 0.33 | 0.84 (0.66, 1.09) | 1.86E-01 | 0.26/ 0.28 | 0.78 (0.62, 0.98) |
3.30E-02
|
rs2650000 |
HNF1A LEF1
| LDL | 0.66/ 0.65 | 1.146 (0.97, 1.35) | 1.02E-01 | § | 1.50 (1.02, 2.21) |
3.73E-02
| 0.63/ 0.63 | 0.976 (0.79, 1.20) | 8.21E-01 |
rs28927680 |
BUD13
| HDL TG | 0.09/ 0.07 | 1.23 (0.93, 1.62) | 1.53E-01 | 0.22/ 0.17 | 1.40 (1.06, 1.86) |
1.92E-02
| 0.16/ 0.14 | 1.07 (0.81, 1.42) | 6.27E-01 |
rs3764261 |
CETP
| HDL | 0.68/ 0.68 | 0.95 (0.80, 1.12) | 5.15E-01 | 0.63/ 0.69 | 0.71 (0.56, 0.90) |
4.70E-03
| 0.66/ 0.66 | 1.06 (0.85, 1.33) | 5.89E-01 |
rs4149268 |
ABCA1
| HDL | 0.38/ 0.38 | 1.10 (0.94, 1.30) | 2.34E-01 | 0.69/ 0.65 | 1.03 (0.81, 1.31) | 8.21E-01 | 0.30/ 0.33 | 0.75 (0.60, 0.95) |
1.53E-02
|
rs4939883 |
LIPG
| HDL | 0.83/ 0.83 | 1.28 (1.03, 1.59) |
2.71E-02
| 0.56/ 0.54 | 0.94 (0.75, 1.19) | 6.17E-01 | § | 0.88 (0.65, 1.19) | 4.14E-01 |
rs6544713 |
ABCG8
| LDL | 0.71/ 0.68 | 1.35 (1.14, 1.61) |
7.00E-04
| § | 1.19 (0.88, 1.62) | 2.65E-01 | 0.85/ 0.82 | 1.22 (0.92, 1.60) | 1.66E-01 |
rs6756629 |
ABCG5
| LDL | 0.09/ 0.06 | 1.89 (1.44, 2.49) |
1.00E-04
| 0.13/ 0.08 | 1.24 (0.82, 1.87) | 3.03E-01 | 0.12/ 0.09 | 1.19 (0.85, 1.67) | 3.04E-01 |
rs754523 |
APOB
| LDL | 0.33/ 0.32 | 1.02 (0.86, 1.20) | 8.34E-01 | 0.27/ 0.22 | 1.36 (1.04, 1.78) |
2.41E-02
| 0.24/ 0.29 | 0.86 (0.68, 1.08) | 1.82E-01 |
rs7679 |
PCIF1
| HDL | 0.19/ 0.16 | 0.97 (0.79, 1.19) | 7.45E-01 | § | 1.18 (0.75, 1.84) | 4.73E-01 | 0.14/ 0.11 | 1.51 (1.13, 2.01) |
4.80E-03
|