Skip to main content
Erschienen in: Strahlentherapie und Onkologie 8/2015

01.08.2015 | Case Study

Lipiodol injections for optimization of target volume delineation in a patient with a second tumor of the oropharynx

A case report

verfasst von: Dr. med. Marlen Haderlein, Ricarda Merten, Andrea Stojanovic, Stefan Speer, Claudia Scherl, Rainer Fietkau, Oliver J. Ott

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 8/2015

Einloggen, um Zugang zu erhalten

Abstract

Background

Lipiodol injections were administered in the head and neck area to improve gross tumor volume (GTV) definition for small-volume re-irradiation of a 63-year-old previously irradiated patient with a second tumor of the oropharynx in the posterior wall with longitudinal ligament infiltration (cT4cN0cM0).

Methods

The patient had dialysis-depending renal failure. On diagnostic computed tomography (CT), which was performed with intravenous contrast agent, the tumor in the oropharynx was not detectable. Because of dialysis-depending renal failure comorbidity, no contrast agent was applied in the planning CT and in the diagnostic magnetic resonance imaging (MRI) study. In each cross-sectional imaging study performed, the GTV, especially in craniocaudal extensions, was not safely delineable. Therefore, craniocaudal tumor margins were pharyngoscopically marked with Lipiodol injections, an iodine-containing contrast agent.

Results

In a second planning CT, the GTV could be defined with the help of the Lipiodol marks and small-volume re-irradiation was performed. No Lipiodol-associated side effects occurred in the patient.

Conclusion

In the present case, the use of Lipiodol injections at the tumor margins facilitated the definition of the GTV.
Literatur
1.
Zurück zum Zitat Basile A, Carrafiello G, Ierardi AM, Tsetis D, Brountzos E (2012) Quality-improvement guidelines for hepatic transarterial chemoembolization. Cardiovasc Intervent Radiol 35:765–774. doi:10.1007/s00270-012-0423-zPubMedCrossRef Basile A, Carrafiello G, Ierardi AM, Tsetis D, Brountzos E (2012) Quality-improvement guidelines for hepatic transarterial chemoembolization. Cardiovasc Intervent Radiol 35:765–774. doi:10.1007/s00270-012-0423-zPubMedCrossRef
2.
Zurück zum Zitat Bhide SA, Newbold KL, Harrington KJ, Nutting CM (2012) Clinical evaluation of intensity-modulated radiotherapy for head and neck cancers. Br J Radiol 85:487–494. doi:10.1259/bjr/85942136PubMedCentralPubMedCrossRef Bhide SA, Newbold KL, Harrington KJ, Nutting CM (2012) Clinical evaluation of intensity-modulated radiotherapy for head and neck cancers. Br J Radiol 85:487–494. doi:10.1259/bjr/85942136PubMedCentralPubMedCrossRef
3.
Zurück zum Zitat Chen AM, Yu Y, Daly ME, Farwell DG, S HB, Purdy JA (2013) Long-term experience with reduced planning target volume margins and intensity-modulated radiotherapy with daily image-guidance for head and neck cancer. Head Neck. doi:10.1002/hed.23532 Chen AM, Yu Y, Daly ME, Farwell DG, S HB, Purdy JA (2013) Long-term experience with reduced planning target volume margins and intensity-modulated radiotherapy with daily image-guidance for head and neck cancer. Head Neck. doi:10.1002/hed.23532
4.
Zurück zum Zitat Lambrecht M, Nevens D, Nuyts S (2013) Intensity-modulated radiotherapy vs. parotid-sparing 3D conformal radiotherapy. Effect on outcome and toxicity in locally advanced head and neck cancer. Strahlenther Onkol 189:223–229. doi:10.1007/s00066-012-0289-7PubMedCrossRef Lambrecht M, Nevens D, Nuyts S (2013) Intensity-modulated radiotherapy vs. parotid-sparing 3D conformal radiotherapy. Effect on outcome and toxicity in locally advanced head and neck cancer. Strahlenther Onkol 189:223–229. doi:10.1007/s00066-012-0289-7PubMedCrossRef
5.
Zurück zum Zitat Modesto A, Laprie A, Vieillevigne L, Graff P, Sarini J, Vergez S, Delord JP, Farenc JC, Vigarios E, Filleron T, Rives M (2014) Intensity-modulated radiotherapy for laryngeal and hypopharyngeal cancer: minimization of late dysphagia without jeopardizing tumor control. Strahlenther Onkol. doi:10.1007/s00066-014-0767-1 Modesto A, Laprie A, Vieillevigne L, Graff P, Sarini J, Vergez S, Delord JP, Farenc JC, Vigarios E, Filleron T, Rives M (2014) Intensity-modulated radiotherapy for laryngeal and hypopharyngeal cancer: minimization of late dysphagia without jeopardizing tumor control. Strahlenther Onkol. doi:10.1007/s00066-014-0767-1
6.
Zurück zum Zitat Patel A, Khalsa B, Lord B, Sandrasegaran K, Lall C (2013) Planting the seeds of success: CT-guided gold seed fiducial marker placement to guide robotic radiosurgery. J Med Imaging Radiat Oncol 57:207–211. doi:10.1111/j.1754-9485.2012.02445.xPubMedCrossRef Patel A, Khalsa B, Lord B, Sandrasegaran K, Lall C (2013) Planting the seeds of success: CT-guided gold seed fiducial marker placement to guide robotic radiosurgery. J Med Imaging Radiat Oncol 57:207–211. doi:10.1111/j.1754-9485.2012.02445.xPubMedCrossRef
7.
Zurück zum Zitat Pos F, Bex A, Dees-Ribbers HM, Betgen A, van Herk M, Remeijer P (2009) Lipiodol injection for target volume delineation and image guidance during radiotherapy for bladder cancer. Radiother Oncol 93:364–367. doi:10.1016/j.radonc.2009.09.003PubMedCrossRef Pos F, Bex A, Dees-Ribbers HM, Betgen A, van Herk M, Remeijer P (2009) Lipiodol injection for target volume delineation and image guidance during radiotherapy for bladder cancer. Radiother Oncol 93:364–367. doi:10.1016/j.radonc.2009.09.003PubMedCrossRef
8.
Zurück zum Zitat Chai X, van Herk M, van de Kamer JB, Remeijer P, Bex A, Betgen A, De Reijke TM, Hulshof MC, Pos FJ, Bel A (2010) Behavior of lipiodol markers during image guided radiotherapy of bladder cancer. Int J Radiat Oncol Biol Phys 77:309–314. doi:10.1016/j.ijrobp.2009.08.019PubMedCrossRef Chai X, van Herk M, van de Kamer JB, Remeijer P, Bex A, Betgen A, De Reijke TM, Hulshof MC, Pos FJ, Bel A (2010) Behavior of lipiodol markers during image guided radiotherapy of bladder cancer. Int J Radiat Oncol Biol Phys 77:309–314. doi:10.1016/j.ijrobp.2009.08.019PubMedCrossRef
9.
Zurück zum Zitat Sondergaard J, Olsen KO, Muren LP, Elstrom UV, Grau C, Hoyer M (2010) A study of image-guided radiotherapy of bladder cancer based on lipiodol injection in the bladder wall. Acta Oncologica 49:1109–1115. doi:10.3109/02841861003789491PubMedCrossRef Sondergaard J, Olsen KO, Muren LP, Elstrom UV, Grau C, Hoyer M (2010) A study of image-guided radiotherapy of bladder cancer based on lipiodol injection in the bladder wall. Acta Oncologica 49:1109–1115. doi:10.3109/02841861003789491PubMedCrossRef
10.
Zurück zum Zitat Meijer GJ, van der Toorn PP, Bal M, Schuring D, Weterings J, de Wildt M (2012) High precision bladder cancer irradiation by integrating a library planning procedure of 6 prospectively generated SIB IMRT plans with image guidance using lipiodol markers. Radiother Oncol 105:174–179. doi:10.1016/j.radonc.2012.08.011PubMedCrossRef Meijer GJ, van der Toorn PP, Bal M, Schuring D, Weterings J, de Wildt M (2012) High precision bladder cancer irradiation by integrating a library planning procedure of 6 prospectively generated SIB IMRT plans with image guidance using lipiodol markers. Radiother Oncol 105:174–179. doi:10.1016/j.radonc.2012.08.011PubMedCrossRef
11.
Zurück zum Zitat Baumgarten AS, Emtage JB, Wilder RB, Biagioli MC, Gupta S, Spiess PE (2014) Intravesical lipiodol injection technique for image-guided radiation therapy for bladder cancer. Urology. doi:10.1016/j.urology.2013.09.058 Baumgarten AS, Emtage JB, Wilder RB, Biagioli MC, Gupta S, Spiess PE (2014) Intravesical lipiodol injection technique for image-guided radiation therapy for bladder cancer. Urology. doi:10.1016/j.urology.2013.09.058
12.
Zurück zum Zitat Wolff HA, Wolff CR, Hess CF, Jung K, Sennhenn-Kirchner S, Hinterthaner M, Muller-Dornieden A, Korber W, Marten-Engelke K, Roedel R, Christiansen H, Engelke C (2013) Second primary malignancies in head and neck cancer patients: high prevalence of curable-stage disease. Strahlenther Onkol 189:874–880. doi:10.1007/s00066-013-0404-4PubMedCrossRef Wolff HA, Wolff CR, Hess CF, Jung K, Sennhenn-Kirchner S, Hinterthaner M, Muller-Dornieden A, Korber W, Marten-Engelke K, Roedel R, Christiansen H, Engelke C (2013) Second primary malignancies in head and neck cancer patients: high prevalence of curable-stage disease. Strahlenther Onkol 189:874–880. doi:10.1007/s00066-013-0404-4PubMedCrossRef
13.
Zurück zum Zitat Milanovic D, Jeremic B, Grosu AL, Rucker G, Henke M (2013) Reirradiation plus EGFR inhibition in locally recurrent and unresectable head and neck cancer: final results from a single institution. Strahlenther Onkol 189:842–848. doi:10.1007/s00066-013-0402-6PubMedCrossRef Milanovic D, Jeremic B, Grosu AL, Rucker G, Henke M (2013) Reirradiation plus EGFR inhibition in locally recurrent and unresectable head and neck cancer: final results from a single institution. Strahlenther Onkol 189:842–848. doi:10.1007/s00066-013-0402-6PubMedCrossRef
14.
Zurück zum Zitat Cacicedo J, Navarro A, Alongi F, Gomez de Iturriaga A, Del Hoyo O, Boveda E, Casquero F, Perez JF, Bilbao P (2014) The role of re-irradiation of secondary and recurrent head and neck carcinomas. Is it a potentially curative treatment? A practical approach. Cancer Treat Rev 40:178–189. doi:10.1016/j.ctrv.2013.08.002PubMedCrossRef Cacicedo J, Navarro A, Alongi F, Gomez de Iturriaga A, Del Hoyo O, Boveda E, Casquero F, Perez JF, Bilbao P (2014) The role of re-irradiation of secondary and recurrent head and neck carcinomas. Is it a potentially curative treatment? A practical approach. Cancer Treat Rev 40:178–189. doi:10.1016/j.ctrv.2013.08.002PubMedCrossRef
15.
Zurück zum Zitat Becker S, Walter S, Witzke O, Wilde B, Hillen U, Napieralski D, Kreuter A, Altmeyer P, Schieren G, Daul A, Rump LC, Kribben A (2010) The German registry for nephrogenic systemic fibrosis: findings from 23 patients. Clinical Nephrol 73:426–430CrossRef Becker S, Walter S, Witzke O, Wilde B, Hillen U, Napieralski D, Kreuter A, Altmeyer P, Schieren G, Daul A, Rump LC, Kribben A (2010) The German registry for nephrogenic systemic fibrosis: findings from 23 patients. Clinical Nephrol 73:426–430CrossRef
16.
Zurück zum Zitat Elmholdt TR, Pedersen M, Jorgensen B, Sondergaard K, Jensen JD, Ramsing M, Olesen AB (2011) Nephrogenic systemic fibrosis is found only among gadolinium-exposed patients with renal insufficiency: a case-control study from Denmark. Br J Dermatol 165:828–836. doi:10.1111/j.1365–2133.2011.10465.xPubMedCrossRef Elmholdt TR, Pedersen M, Jorgensen B, Sondergaard K, Jensen JD, Ramsing M, Olesen AB (2011) Nephrogenic systemic fibrosis is found only among gadolinium-exposed patients with renal insufficiency: a case-control study from Denmark. Br J Dermatol 165:828–836. doi:10.1111/j.1365–2133.2011.10465.xPubMedCrossRef
17.
Zurück zum Zitat Amet S, Launay-Vacher V, Clement O, Frances C, Tricotel A, Stengel B, Gauvrit JY, Grenier N, Reinhardt G, Janus N, Choukroun G, Laville M, Deray G (2014) Incidence of nephrogenic systemic fibrosis in patients undergoing dialysis after contrast-enhanced magnetic resonance imaging with gadolinium-based contrast agents: the prospective fibrose nephrogenique systemique study. Invest Radiol 49:109–115. doi:10.1097/RLI.0000000000000000PubMedCrossRef Amet S, Launay-Vacher V, Clement O, Frances C, Tricotel A, Stengel B, Gauvrit JY, Grenier N, Reinhardt G, Janus N, Choukroun G, Laville M, Deray G (2014) Incidence of nephrogenic systemic fibrosis in patients undergoing dialysis after contrast-enhanced magnetic resonance imaging with gadolinium-based contrast agents: the prospective fibrose nephrogenique systemique study. Invest Radiol 49:109–115. doi:10.1097/RLI.0000000000000000PubMedCrossRef
18.
Zurück zum Zitat Hamming-Vrieze O, van Kranen SR, van Beek S, Heemsbergen W, van Herk M, van den Brekel MW, Sonke JJ, Rasch CR (2012) Evaluation of tumor shape variability in head-and-neck cancer patients over the course of radiation therapy using implanted gold markers. Int J Radiat Oncol Biol Phys 84:e201–e207. doi:10.1016/j.ijrobp.2012.03.014CrossRef Hamming-Vrieze O, van Kranen SR, van Beek S, Heemsbergen W, van Herk M, van den Brekel MW, Sonke JJ, Rasch CR (2012) Evaluation of tumor shape variability in head-and-neck cancer patients over the course of radiation therapy using implanted gold markers. Int J Radiat Oncol Biol Phys 84:e201–e207. doi:10.1016/j.ijrobp.2012.03.014CrossRef
Metadaten
Titel
Lipiodol injections for optimization of target volume delineation in a patient with a second tumor of the oropharynx
A case report
verfasst von
Dr. med. Marlen Haderlein
Ricarda Merten
Andrea Stojanovic
Stefan Speer
Claudia Scherl
Rainer Fietkau
Oliver J. Ott
Publikationsdatum
01.08.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Strahlentherapie und Onkologie / Ausgabe 8/2015
Print ISSN: 0179-7158
Elektronische ISSN: 1439-099X
DOI
https://doi.org/10.1007/s00066-015-0856-9

Weitere Artikel der Ausgabe 8/2015

Strahlentherapie und Onkologie 8/2015 Zur Ausgabe

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

25.04.2024 NSCLC Nachrichten

Das Risiko für Rezidiv oder Tod von Patienten und Patientinnen mit reseziertem ALK-positivem NSCLC ist unter einer adjuvanten Therapie mit dem Tyrosinkinase-Inhibitor Alectinib signifikant geringer als unter platinbasierter Chemotherapie.

Bei Senioren mit Prostatakarzinom auf Anämie achten!

24.04.2024 DGIM 2024 Nachrichten

Patienten, die zur Behandlung ihres Prostatakarzinoms eine Androgendeprivationstherapie erhalten, entwickeln nicht selten eine Anämie. Wer ältere Patienten internistisch mitbetreut, sollte auf diese Nebenwirkung achten.

ICI-Therapie in der Schwangerschaft wird gut toleriert

Müssen sich Schwangere einer Krebstherapie unterziehen, rufen Immuncheckpointinhibitoren offenbar nicht mehr unerwünschte Wirkungen hervor als andere Mittel gegen Krebs.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.