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Journal of Cancer Research and Clinical Oncology

Erschienen in:

01.01.2005 | Original Paper

Listeria monocytogenes produces a pro-invasive factor that signals via ErbB2/ErbB3 heterodimers

verfasst von: Maria José Oliveira, Tineke Lauwaet, Georges De Bruyne, Marc Mareel, Ancy Leroy

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 1/2005

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Abstract

Purpose

We have previously demonstrated that conditioned medium from bacteria, some of which were isolated from the colon of cancer patients, stimulate cancer cell invasion in vitro through a 13-mer β-casein-derived peptide. Since invasion signalling pathways are coordinated by the balance between protein kinases and phosphatases, we investigated the effect of conditioned medium from bacteria on the overall cellular tyrosine phosphorylation.

Methods

The tyrosine phosphorylation level of HCT-8/E11 human colon cancer cells treated with the pro-invasive conditioned medium of Listeria, prepared on top of collagen type I gels (CM^CollListeria/TSB), were analysed by means of immunoprecipitation and Western blot, with specific anti-phosphotyrosine antibodies.

Results

We demonstrated that CM^CollListeria/TSB increases the tyrosine phosphorylation level of ErbB2 and ErbB3, members of the epidermal growth factor receptor (EGFR) family, and the association between ErbB3 and the phosphatidylinositol 3-kinase (PI3K) regulatory subunit (p85α). CM^CollListeria/TSB-stimulated ErbB3 tyrosine phosphorylation and cancer cell invasion were independent from EGFR expression and activity but dependent on ErbB2 activity.

Conclusions

The interaction between Listeria and collagen type I produces, next to the 13-mer peptide, at least another pro-invasive factor that signals via ErbB2/ErbB3 heterodimers.

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Titel: Listeria monocytogenes produces a pro-invasive factor that signals via ErbB2/ErbB3 heterodimers
verfasst von: Maria José Oliveira
Tineke Lauwaet
Georges De Bruyne
Marc Mareel
Ancy Leroy
Publikationsdatum: 01.01.2005
Verlag: Springer-Verlag
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 1/2005
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-004-0601-8

Springer Medizin

Listeria monocytogenes produces a pro-invasive factor that signals via ErbB2/ErbB3 heterodimers

Abstract

Purpose

Methods

Results

Conclusions

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Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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