Introduction
Methods
Study Cohort
Data Collection
Statistical Analysis
Results
Study Population
Baseline Characteristics
All (N = 519) | Unsuccessful reperfusion (N = 84) | Successful reperfusion (N = 435) | P-value | |
---|---|---|---|---|
Baseline | ||||
Age at admission (median, IQR) | 75.6 (62.8–82.9) | 72.2 (61.0–81.0) | 75.9 (63.6–83.6) | 0.33 |
Sex (female) (No./total No. (%)) | 271/519 (52.2) | 45/84 (53.6) | 226/435 (52.0) | 0.81 |
Independence before stroke (mRS ≤ 2) (No./total No. (%)) | 452/515 (87.8) | 69/82 (84.1) | 383/433 (87.6) | 0.27 |
Risk factors (No/total No. (%)) | ||||
Diabetes | 89/518 (17.2) | 16/84 (19.0) | 73/434 (17.0) | 0.64 |
Hypertension | 368/518 (71.0) | 57/84 (68.0) | 311/434 (71.7) | 0.51 |
Dyslipidemia | 287/515 (55.7) | 43/83 (51.8) | 244/432 (56.5) | 0.47 |
Smoking | 120/514 (23.3) | 19/82 (23.2) | 101/432 (23.4) | 1.00 |
Previous stroke | 66/519 (12.7) | 10/84 (11.9) | 56/435 (12.4) | 1.00 |
CAD | 109/516 (21.1) | 18/83 (21.7) | 9/433 (21.0) | 0.88 |
Stroke characteristics | ||||
Time from last known well to admission in min (median, IQR) | 120 (71–239) | 150 (94–283) | 109.5 (69–231) | 0.02 |
NIHSS on admission (median, IQR) | 16 (10–20) | 15 (9–21) | 16 (10–20) | 0.44 |
Time from last known well to groin puncture in min (median, IQR) | 218 (161–345) | 252.5 (192.5–391.5) | 208 (156–335) | 0.002 |
Mechanical thrombectomy beyond 6 h No./total No. (%) | 121/511 (23.7) | 27/84 (29.8) | 94/427 (22) | 0.050 |
MRI as baseline imaging (No./total No. (%)) | 246/517 (47.6) | 37/83 (44.6) | 209/434 (48.2) | 0.63 |
Initial ischemic core volume ≥ 50 ml (No./total No. (%)) | 136/519 (26.2) | 25/84 (29.8) | 111/435 (25.5) | 0.42 |
Initial ischemic core volume ≥ 70 ml (No./total No. (%)) | 101/519 (19.5) | 19/84 (22.6) | 82/435 (18.9) | 0.45 |
Initial ischemic core volume ≥ 100 ml (No./total No. (%)) | 60/519 (11.56) | 14/84 (16.7) | 46/435 (10.6) | 0.13 |
HIR (median, IQR) | 0.43 (0.26–0.58) | 0.40 (0.26–0.59) | 0.44 (0.26–0.57) | 0.99 |
Low HIR (≤ 0.43) (No./total No. (%)) | 259/519 (49.9) | 46/84 (54.8) | 213/435 (49) | 0.34 |
Relevant mismatch (≥ 50 ml) (No./total No. (%)) | 82/136 (60.29) | 12/25 (48.0) | 70/111 (63.1) | 0.18 |
Site of occlusion (No./total No. (%)) | ||||
ICA | 132/519 (25.4) | 25/84 (29.8) | 107/435 (24.6) | < 0.001 |
M1 | 263/519 (50.7) | 28/84 (33.3) | 235/435 (54.0) | |
M2 | 83/519 (16.0) | 23/84 (27.4) | 60/435 (13.8) | |
Other anterior occlusion | 7/519 (1.3) | 3/84 (3.6) | 4/435 (0.9) | |
Vertebrobasilar occlusion | 23/519 (4.4) | 1/84 (1.2) | 22/435 (5.1) | |
Other posterior occlusion | 11/519 (2.1) | 4/84 (4.8) | 7/435 (1.6) | |
Stroke treatment | ||||
IVT-bridging (No./total No. (%)) | 206 (39.7) | 25/84 (29.8) | 181/435 (41.6) | 0.051 |
Number of maneuvers (median, IQR) | 1 (1–2) | 2 (1–4) | 1 (1–2) | < 0.001 |
Long-term mortality | ||||
3‑months mortality (No./total No. (%)) | 143/518 (27.6) | 45/84 (53.6) | 98/434 (22.6) | < 0.001 |
Long-term follow-up time in months (median, IQR) | 28 (1–55) | 1 (0.1–25) | 30 (6–58) | < 0.001 |
Long-term mortality (No./total No. (%)) | 231/519 (44.5) | 56/84 (66.7) | 175/435 (40.2) | < 0.001 |