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Journal of Cancer Research and Clinical Oncology

Erschienen in:

01.11.2013 | Original Paper

Loss of chromosome 4 correlates with better long-term survival and lower relapse rate after R0-resection of colorectal liver metastases

verfasst von: Nadine Aust, Silke Schüle, Annelore K. Altendorf-Hofmann, Yuan Chen, Thomas Knösel, Olaf Dirsch, Utz Settmacher, Anja Weise, Kristin Mrasek, Thomas Liehr

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 11/2013

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Abstract

Purpose

Liver metastases are the major cause of cancer-related death in colorectal cancer patients with a tendency to recur in over 50 % of the cases even after curatively intended surgery. Prognosis after liver resection, however, can neither be based on macroscopic or light microscopic evaluation of the metastases nor on clinical data alone. This is a pilot study in order to determine a potential influence of chromosomal aberrations on overall survival and relapse rate after curative liver resection.

Methods

Twenty randomly selected cases (10 patients with a survival of more and 10 patients with a survival of less than 5 years after resection) were studied by array comparative genomic hybridization.

Results

The distributions concerning age, gender, stage and grading of primary tumor, percentage of patients with chemotherapy, number and distribution of the liver metastases, Nordlinger and Fong scores showed no differences between long- and short-term survivors and no correlation to any chromosomal aberration. However, the relapse rate of patients with (partial) monosomy 4 was lower and the long-time survival better than in the other patients.

Conclusions

Loss of chromosome 4 in colorectal liver metastases seems not only to be associated with the progression of the primary tumor as reported in the literature, but also with the long-term survival and the cumulative relapse rate after complete resection of colorectal liver metastases.

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Titel: Loss of chromosome 4 correlates with better long-term survival and lower relapse rate after R0-resection of colorectal liver metastases
verfasst von: Nadine Aust
Silke Schüle
Annelore K. Altendorf-Hofmann
Yuan Chen
Thomas Knösel
Olaf Dirsch
Utz Settmacher
Anja Weise
Kristin Mrasek
Thomas Liehr
Publikationsdatum: 01.11.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 11/2013
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-013-1505-2

Springer Medizin

Loss of chromosome 4 correlates with better long-term survival and lower relapse rate after R0-resection of colorectal liver metastases