Erschienen in:
01.03.2000 | Meeting abstract
Loss of heterozygosity on chromosome arm 16q in breast cancer: clinical, molecular and statistical approaches
verfasst von:
A-M Cleton-Jansen, HM van Beerendonk, NT ter Haar, PHC Eilers, HC van Houwelingen, BA Bonsing, VTHBM Smit, G-JB van Ommen, CJ Cornelisse
Erschienen in:
Breast Cancer Research
|
Sonderheft 1/2000
Einloggen, um Zugang zu erhalten
Excerpt
Loss of heterozygosity (LOH) on the long arm of chromosome 16 is one of the most frequent genetic events in breast cancer, occurring in at least 50% of the breast cancer cases. It is one of the earliest genetic events, occurring already in the pre-invasive stage, in ductal carcinoma in situ. Our study on flow-sorted tumour populations shows that chromosome 16q loss occurs in the DNA diploid sub-population of tumour cells, before aneuploidization, which is also indicative of a role in early tumorigenesis. …