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31.07.2021 | Sleep Breathing Physiology and Disorders • Original Article

Lower 24-h urinary potassium excretion is negatively associated with excessive daytime sleepiness in the general population

verfasst von: Reyila Abudoureyimu, Mulalibieke Heizhati, Lin Wang, Mei Li, Delian Zhang, Zhongrong Wang, Zhikang Yang, Jing Hong, Nanfang Li

Erschienen in: Sleep and Breathing | Ausgabe 2/2022

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Abstract

Objectives

Uncertainty remains about the association of potassium (K) intake and sleepiness. Therefore, we aimed to explore the relationship between K excretion using 24-h urine samples and excessive daytime sleepiness (EDS) in the general population.

Methods

In a cross-sectional study, we used multi-stage proportional random sampling to obtain a study sample aged ≥ 18 years from Emin, China between March and June 2019. We collected timed 24-h urine specimens and conducted EDS assessments using the Epworth Sleepiness Scale (ESS) questionnaire. Subjects were divided into two groups by the median of 24-h urinary potassium (24-h UK). EDS was defined as ESS score ≥ 10. Multi-variable linear regression was used to examine the association between the 24-h UK and the odds of prevalent EDS. We performed a sensitivity analysis by excluding subjects under anti-hypertensive treatment and those with sleep disordered breathing by the NoSAS scale.

Results

A total of 470 participants with complete 24-h urine samples and ESS data (62% women, mean age 49.6 years, mean ESS score of 9.0 ± 5.2) were enrolled. The mean ESS score was significantly lower in the upper half of 24-h UK group than in the lower half (9.5 ± 5.3 vs 8.5 ± 5.1, P = 0.044), and accordingly, prevalent EDS was significantly greater in the lower half than in the higher half (49% vs 40%, P = 0.039). In further improving the propensity matching score, the results remained consistent with the overall results. In multiple linear regression, 24-h UK was negatively correlated with ESS score (β = − 0.180 (− 0.276, − 0.085), < 0.001). Sensitivity analysis demonstrated augmented results in those without anti-hypertensive treatment.

Conclusion

Lower potassium intake, as suggested by lower UK excretion, may be implicated in the presence of EDS in the general population.

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Titel: Lower 24-h urinary potassium excretion is negatively associated with excessive daytime sleepiness in the general population
verfasst von: Reyila Abudoureyimu
Mulalibieke Heizhati
Lin Wang
Mei Li
Delian Zhang
Zhongrong Wang
Zhikang Yang
Jing Hong
Nanfang Li
Publikationsdatum: 31.07.2021
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 2/2022
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-021-02444-7

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Lower 24-h urinary potassium excretion is negatively associated with excessive daytime sleepiness in the general population