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01.12.2012 | Research | Ausgabe 1/2012 Open Access

Malaria Journal 1/2012

Malaria resistance genes are associated with the levels of IgG subclasses directed against Plasmodium falciparum blood-stage antigens in Burkina Faso

Zeitschrift:
Malaria Journal > Ausgabe 1/2012
Autoren:
Sarwat Afridi, Alexandre Atkinson, Séverine Garnier, Francis Fumoux, Pascal Rihet
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2875-11-308) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no conflicting interests.

Authors’ contributions

SA calculated the IgG subclass phenotypes, evaluated the correlation between IgG subclass phenotypes, and carried out most of the FBAT analyses. AA and SG participated in the FBAT analyses, and the multiple test correction. FF participated in the design of the study, and revised the results and the manuscript. PR performed the design of the study, supervised the IgG phenotype determination and the statistical analyses, and wrote the manuscript. All authors read and approved the final manuscript.

Abstract

Background

HBB, IL4, IL12, TNF, LTA, NCR3 and FCGR2A polymorphisms have been associated with malaria resistance in humans, whereas cytophilic immunoglobulin G (IgG) antibodies are thought to play a critical role in immune protection against asexual blood stages of the parasite. Furthermore, HBB, IL4, TNF, and FCGR2A have been associated with both malaria resistance and IgG levels. This suggests that some malaria resistance genes influence the levels of IgG subclass antibodies.

Methods

In this study, the effect of HBB, IL4, IL12, TNF, LTA, NCR3 and FCGR2A polymorphisms on the levels of IgG responses against Plasmodium falciparum blood-stage extract was investigated in 220 individuals living in Burkina Faso. The Pearson’s correlation coefficient among IgG subclasses was determined. A family-based approach was used to assess the association of polymorphisms with anti-P. falciparum IgG, IgG1, IgG2, IgG3 and IgG4 levels.

Results

After applying a multiple test correction, several polymorphisms were associated with IgG subclass or IgG levels. There was an association of i) haemoglobin C with IgG levels; ii) the FcγRIIa H/R131 with IgG2 and IgG3 levels; iii) TNF-863 with IgG3 levels; iv) TNF-857 with IgG levels; and, v) TNF 1304 with IgG3, IgG4, and IgG levels.

Conclusion

Taken together, the results support the hypothesis that some polymorphisms affect malaria resistance through their effect on the acquired immune response, and pave the way towards further comprehension of genetic control of an individual’s humoral response against malaria.
Zusatzmaterial
Additional file 1: Family-based association of polymorphisms with parasitological and clinical phenotypes. (XLS 40 KB)
12936_2012_2619_MOESM1_ESM.xls
Literatur
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