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28.06.2017 | Clinical trial

Mammographic breast density decreases after bariatric surgery

verfasst von: Austin D. Williams, Alycia So, Marie Synnestvedt, Colleen M. Tewksbury, Despina Kontos, Meng-Kang Hsiehm, Lauren Pantalone, Emily F. Conant, Mitchell Schnall, Kristoffel Dumon, Noel Williams, Julia Tchou

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 3/2017

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Abstract

Purpose

Breast density (BD), an important risk factor for breast cancer, can change over time in some women, but the underlying mechanism is unclear. Very little is known about the impact of surgical weight loss on BD. Our hypothesis is that weight loss after bariatric surgery is associated with a significant and favorable change in mammographic BD.

Methods

We identified 1097 women 40 years of age or older who underwent gastric bypass or sleeve gastrectomy at our institution from 2010 to 2014. Women who did not have either pre- and post-bariatric surgery mammograms performed at our institution were excluded; 110 had both mammograms and comprised the cohort. Breast density was determined both qualitatively, using reported BI-RADS density, and quantitatively, using the Laboratory for Individualized Breast Radiodensity Assessment.

Results

Qualitative BI-RADS density, quantitative breast area, and percent BD significantly decreased in post-bariatric surgery mammograms (p = 0.009, <0.001, and <0.001, respectively).

Conclusions

Our retrospective study demonstrated that surgical weight loss was associated with a significant decrease in breast density. Additional studies are warranted to validate our findings and elucidate the molecular mechanisms underlying breast density change after weight loss surgery.

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Titel: Mammographic breast density decreases after bariatric surgery
verfasst von: Austin D. Williams
Alycia So
Marie Synnestvedt
Colleen M. Tewksbury
Despina Kontos
Meng-Kang Hsiehm
Lauren Pantalone
Emily F. Conant
Mitchell Schnall
Kristoffel Dumon
Noel Williams
Julia Tchou
Publikationsdatum: 28.06.2017
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 3/2017
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-017-4361-y

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Mammographic breast density decreases after bariatric surgery