Skip to main content
Erschienen in: Current Diabetes Reports 11/2019

01.11.2019 | Obesity (KM Gadde, Section Editor)

Management of Diabetes in Patients Undergoing Bariatric Surgery

verfasst von: Christopher M. Mulla, Harris M. Baloch, Samar Hafida

Erschienen in: Current Diabetes Reports | Ausgabe 11/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

The number of bariatric surgeries for patients with type 1 or type 2 diabetes continues to grow. Clinicians are challenged to choose therapies that reach glycemic targets without inducing adverse effects in post-bariatric patients without published guidelines. This review evaluates data supporting the best strategies for diabetes management in patients undergoing bariatric surgery.

Recent Findings

Though few clinical trials have evaluated the safety and effectiveness of different glucose-lowering therapies following bariatric surgery, remission of diabetes or reduced medications is an established benefit of bariatric surgery. Adverse events including diabetic ketoacidosis in post-bariatric patients on sodium-glucose co-transporter 2 (SGLT2) inhibitors or inadequate insulin have been reported in patient's with both type 1 and type 2 diabetes. Metformin, glucagon-like peptide-1 (GLP-1) agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, SGLT2 inhibitors, insulin, and sulfonylureas have been used successfully in the perioperative period for other surgeries and guidelines recommend adjusting the doses of these medications especially in the perioperative period.

Summary

Clinicians should favor weight-neutral or weight-loss promoting therapies in post-bariatric surgery patients such as medical nutrition therapy, metformin, GLP-1 agonists, SGLT2 inhibitors, and DPP-4 inhibitors.
Literatur
22.
27.
Zurück zum Zitat Parikh M, Chung M, Sheth S, McMacken M, Zahra T, Saunders JK, et al. Randomized pilot trial of bariatric surgery versus intensive medical weight management on diabetes remission in type 2 diabetic patients who do NOT meet NIH criteria for surgery and the role of soluble RAGE as a novel biomarker of success. Ann Surg. 2014;260(4):617–24. https://doi.org/10.1097/sla.0000000000000919.CrossRefPubMed Parikh M, Chung M, Sheth S, McMacken M, Zahra T, Saunders JK, et al. Randomized pilot trial of bariatric surgery versus intensive medical weight management on diabetes remission in type 2 diabetic patients who do NOT meet NIH criteria for surgery and the role of soluble RAGE as a novel biomarker of success. Ann Surg. 2014;260(4):617–24. https://​doi.​org/​10.​1097/​sla.​0000000000000919​.CrossRefPubMed
29.
37.
Zurück zum Zitat Eliasson B, Liakopoulos V, Franzén S, Näslund I, Svensson A-M, Ottosson J, et al. Cardiovascular disease and mortality in patients with type 2 diabetes after bariatric surgery in Sweden: a nationwide, matched, observational cohort study. The Lancet Diabetes & Endocrinology. 2015;3(11):847–54. https://doi.org/10.1016/s2213-8587(15)00334-4.CrossRef Eliasson B, Liakopoulos V, Franzén S, Näslund I, Svensson A-M, Ottosson J, et al. Cardiovascular disease and mortality in patients with type 2 diabetes after bariatric surgery in Sweden: a nationwide, matched, observational cohort study. The Lancet Diabetes & Endocrinology. 2015;3(11):847–54. https://​doi.​org/​10.​1016/​s2213-8587(15)00334-4.CrossRef
38.
Zurück zum Zitat Ortega CB, Lee H-J, Portenier D, Guerron AD, Tong J. Preoperative hemoglobin A1c predicts postoperative weight loss following bariatric surgery in patients with diabetes. 2018;67(Supplement 1):2045–P. https://doi.org/10.2337/db18-2045-P%JDiabetes. Ortega CB, Lee H-J, Portenier D, Guerron AD, Tong J. Preoperative hemoglobin A1c predicts postoperative weight loss following bariatric surgery in patients with diabetes. 2018;67(Supplement 1):2045–P. https://​doi.​org/​10.​2337/​db18-2045-P%JDiabetes.
41.
Zurück zum Zitat Underwood P, Askari R, Hurwitz S, Chamarthi B, Garg R. Response to comment on underwood et al. preoperative a1c and clinical outcomes in patients with diabetes undergoing major noncardiac surgical procedures. Diabetes Care. 2014;37:611–6. Diabetes Care. 2014;37(8):e191-e. https://doi.org/10.2337/dc14-0738.CrossRefPubMed Underwood P, Askari R, Hurwitz S, Chamarthi B, Garg R. Response to comment on underwood et al. preoperative a1c and clinical outcomes in patients with diabetes undergoing major noncardiac surgical procedures. Diabetes Care. 2014;37:611–6. Diabetes Care. 2014;37(8):e191-e. https://​doi.​org/​10.​2337/​dc14-0738.CrossRefPubMed
42.
Zurück zum Zitat •• Yong PH, Weinberg L, Torkamani N, Churilov L, Robbins RJ, Ma R, et al. The presence of diabetes and higher Hba1care independently associated with adverse outcomes after surgery. Diabetes Care. 2018;41(6):1172–9. https://doi.org/10.2337/dc17-2304 This prospective observational study of over 7500 patients undergoing bariatric surgery found an increased risk of major complications, ICU admission, and longer length of hospital stay with each point rise in hemoglobin A1c. This suggests that pre-operative and post-operative glucose management may lead to less post-operative complications. CrossRefPubMed •• Yong PH, Weinberg L, Torkamani N, Churilov L, Robbins RJ, Ma R, et al. The presence of diabetes and higher Hba1care independently associated with adverse outcomes after surgery. Diabetes Care. 2018;41(6):1172–9. https://​doi.​org/​10.​2337/​dc17-2304 This prospective observational study of over 7500 patients undergoing bariatric surgery found an increased risk of major complications, ICU admission, and longer length of hospital stay with each point rise in hemoglobin A1c. This suggests that pre-operative and post-operative glucose management may lead to less post-operative complications. CrossRefPubMed
44.
Zurück zum Zitat Mechanick J, Youdim A, Jones D, Garvey W, Hurley D, McMahon M, et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient—2013 update: cosponsored by American Association of Clinical Endocrinologists, the Obesity Society, and American Society for Metabolic & Bariatric Surgery. Endocr Pract. 2013;19(2):337–72. https://doi.org/10.4158/ep12437.Gl.CrossRefPubMedPubMedCentral Mechanick J, Youdim A, Jones D, Garvey W, Hurley D, McMahon M, et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient—2013 update: cosponsored by American Association of Clinical Endocrinologists, the Obesity Society, and American Society for Metabolic & Bariatric Surgery. Endocr Pract. 2013;19(2):337–72. https://​doi.​org/​10.​4158/​ep12437.​Gl.CrossRefPubMedPubMedCentral
51.
69.
84.
Zurück zum Zitat • Kaneko S, Ueda Y, Tahara Y. GLP1 receptor agonist liraglutide is an effective therapeutic option for perioperative glycemic control in type 2 diabetes within enhanced recovery after surgery (ERAS) protocols. Eur Surg Res. 2018;59(5–6):349–60. https://doi.org/10.1159/000494768 This study demonstrated the safety and efficacy of a GLP-1 agonist in the perioperative setting and supports utilization of this class of medications due to their weight loss and cardiovascular and renoprotactive benefits.CrossRefPubMed • Kaneko S, Ueda Y, Tahara Y. GLP1 receptor agonist liraglutide is an effective therapeutic option for perioperative glycemic control in type 2 diabetes within enhanced recovery after surgery (ERAS) protocols. Eur Surg Res. 2018;59(5–6):349–60. https://​doi.​org/​10.​1159/​000494768 This study demonstrated the safety and efficacy of a GLP-1 agonist in the perioperative setting and supports utilization of this class of medications due to their weight loss and cardiovascular and renoprotactive benefits.CrossRefPubMed
93.
Zurück zum Zitat Garber AJ, Abrahamson MJ, Barzilay JI, Blonde L, Bloomgarden ZT, Bush MA, et al. Consensus statement by the American Association of Clinical Endocrinologists and American College of endocrinology on the comprehensive type 2 diabetes management algorithm – 2019 executive summary. Endocr Pract. 2019;25(1):69–100. https://doi.org/10.4158/cs-2018-0535.CrossRefPubMed Garber AJ, Abrahamson MJ, Barzilay JI, Blonde L, Bloomgarden ZT, Bush MA, et al. Consensus statement by the American Association of Clinical Endocrinologists and American College of endocrinology on the comprehensive type 2 diabetes management algorithm – 2019 executive summary. Endocr Pract. 2019;25(1):69–100. https://​doi.​org/​10.​4158/​cs-2018-0535.CrossRefPubMed
95.
99.
Zurück zum Zitat Elasha HEA, Wafa W, Meeran K. SGLT2 inhibition may precipitate euglycemic DKA after bariatric surgery. Clinical Diabetes and Research. 2018;2(1):40–2. Elasha HEA, Wafa W, Meeran K. SGLT2 inhibition may precipitate euglycemic DKA after bariatric surgery. Clinical Diabetes and Research. 2018;2(1):40–2.
103.
Zurück zum Zitat Handelsman Y, Henry RR, Bloomgarden ZT, Dagogo-Jack S, DeFronzo RA, Einhorn D, et al. American Association of Clinical Endocrinologists and American College of endocrinology position statement on the association of Sglt-2 inhibitors and diabetic ketoacidosis. Endocr Pract. 2016;22(6):753–62. https://doi.org/10.4158/ep161292.Ps.CrossRefPubMed Handelsman Y, Henry RR, Bloomgarden ZT, Dagogo-Jack S, DeFronzo RA, Einhorn D, et al. American Association of Clinical Endocrinologists and American College of endocrinology position statement on the association of Sglt-2 inhibitors and diabetic ketoacidosis. Endocr Pract. 2016;22(6):753–62. https://​doi.​org/​10.​4158/​ep161292.​Ps.CrossRefPubMed
106.
Zurück zum Zitat Alvarenga ES, Lo Menzo E, Szomstein S, Rosenthal RJ. Safety and efficacy of 1020 consecutive laparoscopic sleeve gastrectomies performed as a primary treatment modality for morbid obesity. A single-center experience from the metabolic and bariatric surgical accreditation quality and improvement program. Surg Endosc. 2015;30(7):2673–8. https://doi.org/10.1007/s00464-015-4548-4.CrossRefPubMed Alvarenga ES, Lo Menzo E, Szomstein S, Rosenthal RJ. Safety and efficacy of 1020 consecutive laparoscopic sleeve gastrectomies performed as a primary treatment modality for morbid obesity. A single-center experience from the metabolic and bariatric surgical accreditation quality and improvement program. Surg Endosc. 2015;30(7):2673–8. https://​doi.​org/​10.​1007/​s00464-015-4548-4.CrossRefPubMed
111.
Zurück zum Zitat Bilezikian JP, Watts NB, Usiskin K, Polidori D, Fung A, Sullivan D, et al. Evaluation of bone mineral density and bone biomarkers in patients with type 2 diabetes treated with canagliflozin. The Journal of Clinical Endocrinology & Metabolism. 2016;101(1):44–51. https://doi.org/10.1210/jc.2015-1860.CrossRef Bilezikian JP, Watts NB, Usiskin K, Polidori D, Fung A, Sullivan D, et al. Evaluation of bone mineral density and bone biomarkers in patients with type 2 diabetes treated with canagliflozin. The Journal of Clinical Endocrinology & Metabolism. 2016;101(1):44–51. https://​doi.​org/​10.​1210/​jc.​2015-1860.CrossRef
114.
Zurück zum Zitat Catalan VS, Couture JA, LeLorier J. Predictors of persistence of use of the novel antidiabetic agent acarbose. Arch Intern Med. 2001;161(8):1106–12.CrossRefPubMed Catalan VS, Couture JA, LeLorier J. Predictors of persistence of use of the novel antidiabetic agent acarbose. Arch Intern Med. 2001;161(8):1106–12.CrossRefPubMed
Metadaten
Titel
Management of Diabetes in Patients Undergoing Bariatric Surgery
verfasst von
Christopher M. Mulla
Harris M. Baloch
Samar Hafida
Publikationsdatum
01.11.2019
Verlag
Springer US
Erschienen in
Current Diabetes Reports / Ausgabe 11/2019
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-019-1242-2

Weitere Artikel der Ausgabe 11/2019

Current Diabetes Reports 11/2019 Zur Ausgabe

Lifestyle Management to Reduce Diabetes/Cardiovascular Risk (B Conway and H Keenan, Section Editors)

Exercise and Cardiovascular Risk among Masters Athletes with Type 2 Diabetes

Health Care Delivery Systems and Implementation in Diabetes (ME McDonnell and AR Sadhu, Section Editors)

USA Vs Europe: Who Is Leading the Diabetes Tech Race?

Microvascular Complications—Retinopathy (DL Chao and G Yiu, Section Editors)

Emerging Concepts in the Treatment of Diabetic Retinopathy

Immunology, Transplantation, and Regenerative Medicine (L Piemonti and V Sordi, Section Editors)

Pancreas Transplantation from Donors after Circulatory Death: an Irrational Reluctance?

Genetics (AP Morris, Section Editor)

The Genetic Contribution to Type 1 Diabetes

Hospital Management of Diabetes (A Wallia and JJ Seley, Section Editors)

Glycemic Management in the Operating Room: Screening, Monitoring, Oral Hypoglycemics, and Insulin Therapy

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Echinokokkose medikamentös behandeln oder operieren?

06.05.2024 DCK 2024 Kongressbericht

Die Therapie von Echinokokkosen sollte immer in spezialisierten Zentren erfolgen. Eine symptomlose Echinokokkose kann – egal ob von Hunde- oder Fuchsbandwurm ausgelöst – konservativ erfolgen. Wenn eine Op. nötig ist, kann es sinnvoll sein, vorher Zysten zu leeren und zu desinfizieren. 

Umsetzung der POMGAT-Leitlinie läuft

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Die „Zehn Gebote“ des Endokarditis-Managements

30.04.2024 Endokarditis Leitlinie kompakt

Worauf kommt es beim Management von Personen mit infektiöser Endokarditis an? Eine Kardiologin und ein Kardiologe fassen die zehn wichtigsten Punkte der neuen ESC-Leitlinie zusammen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.