Background
Methods
Study areas
Human samples
DNA preparation
CRP genotyping
Statistical analysis
Results
CRP genotype and allele frequencies
Mali
|
Sudan
| |||
---|---|---|---|---|
Fulani (n = 166)
|
Non-Fulani (n = 608)
|
Fulani (n = 225)
|
Non-Fulani (n = 100)
| |
Genotype frequency
| ||||
AA
| 6 (4%) | 107 (18%) | 11 (5%) | 17 (17%) |
AC
| 37 (22%) | 170 (28%) | 42 (19%) | 39 (39%) |
AT
| 12 (7%) | 113 (19%) | 29 (13%) | 6 (6%) |
CC
| 62 (29%) | 80 (13%) | 65 (29%) | 25 (25%) |
CT
| 41 (25%) | 98 (16%) | 56 (25%) | 12 (12%) |
TT
| 8 (5%) | 40 (7%) | 22 (10%) | 1 (1%) |
P-value
| < 0.0001 | < 0.0001 | ||
Allele frequency
| ||||
A
| 0.18 | 0.39 | 0.21 | 0.39 |
C
| 0.61 | 0.36 | 0.51 | 0.51 |
T
| 0.21 | 0.25 | 0.28 | 0.10 |
P-value
| < 0.0001 | < 0.0001 | ||
Frequency of A-allele carriers
a
| ||||
A
| 55 (33%) | 390 (64%) | 82 (36%) | 62 (62%) |
Non-A
| 111 (67%) | 218 (35%) | 143 (64%) | 38 (38%) |
P-value
| < 0.0001 | < 0.0001 |
All | Fulani | Non-Fulani | |||||||
---|---|---|---|---|---|---|---|---|---|
Parasitesa: | n | Positive | Nagative | n | Positive | Nagative | n | Positive | Nagative |
CRP genotype
| |||||||||
AA | 113 | 0.16 | 0.14 | 6 | 0.06 | 0.03 | 107 | 0.18 | 0.17 |
AC | 207 | 0.31 | 0.25 | 37 | 0.22 | 0.22 | 170 | 0.32 | 0.26 |
AT | 125 | 0.17 | 0.16 | 12 | 0.13 | 0.06 | 113 | 0.18 | 0.19 |
CC | 142 | 0.12 | 0.21 | 62 | 0.31 | 0.39 | 80 | 0.09 | 0.15 |
CT | 139 | 0.18 | 0.18 | 41 | 0.25 | 0.25 | 98 | 0.16 | 0.16 |
TT | 48 | 0.06 | 0.06 | 8 | 0.03 | 0.05 | 40 | 0.07 | 0.07 |
P-value | 0.2 | 0.7 | 0.4 | ||||||
A-allele carrier
| |||||||||
A-allele | 445 | 0.64 | 0.55 | 55 | 0.41 | 0.31 | 390 | 0.68 | 0.62 |
Non-A | 329 | 0.36 | 0.45 | 111 | 0.59 | 0.69 | 218 | 0.32 | 0.38 |
P-value | 0.04 | 0.3 | 0.18 |
Mali
|
Sudan
| |||
---|---|---|---|---|
Fulani (n = 166)
|
Non-Fulani (n=165)
|
Fulani (n = 211)
|
Non-Fulani (n = 45)
| |
Genotype frequency
| ||||
CC
| 8 (5%) | 2 (1%) | 12 (6%) | 3 (7%) |
CT
| 48 (29%) | 21 (13%) | 59 (28%) | 9 (20%) |
TT
| 110 (66%) | 142 (86%) | 140 (66%) | 33 (73%) |
P-value
| < 0.0001 | 0.5 | ||
Allele frequency
| ||||
C
| 0.19 | 0.08 | 0.20 | 0.17 |
T
| 0.81 | 0.92 | 0.80 | 0.83 |
P-value
| < 0.0001 | 0.5 | ||
Frequency of T-allele carriers
a
| ||||
T
| 158 (95%) | 163 (99%) | 12 (6%) | 199 (94%) |
Non-T
| 8 (5%) | 2 (1%) | 3 (7%) | 42 (93%) |
P-value
| 0.06 | 0.8 |
Mali
|
Sudan
| |||
---|---|---|---|---|
Fulani (n = 166)
|
Non-Fulani (n = 165)
|
Fulani (n = 213)
|
Non-Fulani (n = 46)
| |
Genotype frequency
| ||||
CC
| 123 (74%) | 130 (79%) | 160 (75%) | 32 (70%) |
CT
| 41 (25%) | 34 (20%) | 47 (22%) | 14 (30%) |
TT
| 2 (1%) | 1 (1%) | 6 (3%) | 0 (0%) |
P-value
| 0.5 | 0.3 | ||
Allele frequency
| ||||
C
| 0.86 | 0.89 | 0.86 | 0.85 |
T
| 0.14 | 0.11 | 0.14 | 0.15 |
P-value
| 0.3 | 0.7 | ||
Frequency of T-allele carriers
a
| ||||
T
| 43 (26%) | 35 (21%) | 53 (25%) | 14 (30%) |
Non-T
| 123 (74%) | 130 (79%) | 160 (75%) | 32 (70%) |
P-value
| 0.3 | 0.4 |
Haplotype associations between CRP -717 T/C, -286 C/T/A, +1444C/T and FcγRIIa 131 R/H
Mali | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
FcγRIIa131R/H CRP-286C/T/A | CRP-286C/T/A CRP-717C/T | CRP-286C/T/A CRP+1444T/C | FcγRIIa131R/H CRP-286C/T/A CRP-717C/T | CRP-286C/T/A CRP-717C/T CRP+1444T/C | FcγRIIa131R/H CRP-286C/T/A CRP+1444T/C | FcγRIIa131R/H CRP-286C/T/A CRP-717C/T CRP+1444T/C | ||||||
Reference haplotype
|
HA
|
AC
|
AC
| HAC |
ACC
|
HAC
|
HACC
| |||||
N | HA | RA | AT | AC | HAT | RAT | ATC | HAC | HATC | RATC | ||
Non-Fulani
| 159 | 0.20 | 0.19 | 0.39 | 0.39 | 0.20 | 0.19 | 0.39 | 0.21 | 0.20 | 0.19 | |
Fulani
| 164 | 0.09 | 0.09 | 0.18 | 0.18 | 0.09 | 0.09 | 0.18 | 0.7 | 0.09 | 0.09 | |
OR
| 2.57 | 2.26 | 2.79 | 2.79 | 2.58 | 2.29 | 2.79 | 3.6 | 2.6 | 2.28 | ||
P-value
| 0.0001 | 0.0006 | 1 × 10-8 | 1 × 10-8 | 0.0001 | 0.0005 | 1 × 10-8 | 1 × 10-8 | 0.0001 | 0.0004 | ||
Sudan
| ||||||||||||
N | HA | RA | AT | AC | HAT | RAT | ATC | HAT | RAC | HATC | RATC | |
Non-Fulani
| 100 | 0.21 | 0.18 | 0.41 | 0.41 | 0.22 | 0.18 | 0.41 | 0.25 | 0.17 | 0.24 | 0.17 |
Fulani
| 225 | 0.13 | 0.08 | 0.21 | 0.21 | 0.13 | 0.08 | 0.21 | 0.12 | 0.08 | 0.13 | 0.09 |
OR
| 1.88 | 2.52 | 2.65 | 2.66 | 2.05 | 2.6 | 2.65 | 2.33 | 2.24 | 2.19 | 2.42 | |
P-value
| 0.007 | 0.0003 | 0.0001 | 0.0001 | 0.03 | 0.006 | 0.0001 | 0.005 | 0.03 | 0.01 | 0.02 |