Background
Methods
Study aims and design
Parental socio-economic, lifestyle, and anthropometric data
GDM diagnosis and treatment
Clinical pregnancy-related characteristics
Birth outcomes
Statistical analyses
Results
General parental characteristics
Characteristics | Total GDM cohort | Maternal prepregnancy BMI category | ||||
---|---|---|---|---|---|---|
Normal weight | Overweight | Obese | P-valuea | |||
N
| ||||||
n | 205 | 89b | 51b | 65b | ||
Paternal | ||||||
Age (years) | 204 | 35.7 ± 7.7 | 35.9 ± 7.2 | 36.2 ± 7.6 | 34.9 ± 8.4 | ns |
Socio-economic status – %c | ||||||
Lower SES category | 143 | 69.8 | 54.5 | 68.0 | 93.8d | < 0.001 |
Higher SES category | 60 | 29.3 | 45.5 | 32.0 | 6.2d | < 0.001 |
BMI (kg/m2) | 202 | 26.9 ± 5.0 | 25.5 ± 3.2 | 27.0 ± 4.7d | 28.7 ± 6.4d | 0.002 |
Maternal | ||||||
Age (years) | 205 | 31.8 ± 5.4 | 32.2 ± 5.5 | 31.2 ± 4.9 | 31.7 ± 5.8 | ns |
Ethnic origin – % | ||||||
European | 129 | 62.9 | 73.0 | 52.9d | 56.9d | < 0.001 |
Non-European (e.g. Turkish, Arabic) | 76 | 37.1 | 27.0 | 47.1d | 43.1d | < 0.001 |
Socio-economic status – %c | ||||||
Lower SES category | 161 | 78.5 | 62.9 | 86.3d | 93.8d | < 0.001 |
Higher SES category | 44 | 21.1 | 37.1 | 13.7d | 6.2d | < 0.001 |
Smoking in pregnancy (any) – % | 30 | 14.6 | 10.1 | 7.8 | 26.2d | 0.009 |
Nulliparous – % | 61 | 29.8 | 37.1 | 37.3 | 13.9d | 0.002 |
History of GDM (multiparous only) – % | 52 | 40.6 | 29.2 | 48.4 | 46.9 | ns |
Height (cm) | 205 | 165.8 ± 6.6 | 166.9 ± 6.6 | 164.9 ± 7.0 | 165.1 ± 6.2 | ns |
Prepregnancy weight (kg) | 205 | 76.8 ± 20.9 | 60.6 ± 6.7 | 73.8 ± 6.6d | 101.4 ± 17.6d | < 0.001 |
Prepregnancy BMI (kg/m2) | 205 | 28.0 ± 7.4 | 21.7 ± 1.7 | 27.1 ± 1.4d | 37.1 ± 5.5d | < 0.001 |
Total GWG (kg) | 205 | 13.4 ± 6.4 | 14.8 ± 5.3 | 14.0 ± 7.1 | 10.8 ± 6.4d | < 0.001 |
GWG category (IOM) – % | ||||||
Inadequate | 43 | 21.0 | 28.1 | 19.6 | 12.3d | ns |
Adequate | 67 | 32.7 | 37.1 | 23.5 | 33.9 | ns |
Excessive | 95 | 46.3 | 34.8 | 56.9d | 53.8d | 0.014 |
Net GWG (kg) | 205 | 9.3 ± 6.3 | 11.0 ± 5.2 | 9.7 ± 7.0 | 6.6 ± 6.3d | < 0.001 |
BMI at delivery (kg/m2) | 205 | 32.8 ± 7.1 | 27.1 ± 2.5 | 32.3 ± 2.7d | 41.1 ± 5.5d | < 0.001 |
Blood glucose at oGTT (mg/dL)e | ||||||
Fasting | 205 | 94.2 ± 19.0 | 88.6 ± 13.3 | 91.8 ± 14.3 | 103.7 ± 24.7d | < 0.001 |
Fasting > 90 mg/dL – %f | 118 | 57.6 | 42.7 | 54.9 | 80.0d | < 0.001 |
1 h | 203 | 197.0 ± 28.2 | 196.0 ± 26.0 | 192.8 ± 24.0 | 201.8 ± 33.4 | ns |
1 h > 180 mg/dL – %f | 169 | 83.7 | 86.5 | 80.0 | 82.5 | ns |
2 h | 193 | 144.5 ± 37.6 | 140.0 ± 27.3 | 143.3 ± 32.4 | 151.4 ± 50.6 | ns |
2 h > 155 mg/dL – %f | 63 | 32.8 | 28.6 | 34.0 | 37.7 | ns |
Area under the curve (mg/dL*h) | 193 | 315.6 ± 44.3 | 310.2 ± 32.9 | 306.9 ± 31.0 | 329.6 ± 60.6 | ns |
Mean glucose at 32nd weeks’ gestation (mg/dL)g | ||||||
Fasting | 195 | 88.0 ± 11.3 | 83.8 ± 7.0 | 87.8 ± 9.0d | 93.8 ± 14.5d | < 0.001 |
Fasting > 90 mg/dL – %f | 70 | 35.9 | 16.9 | 34.7d | 61.9d | < 0.001 |
Postprandial | 183 | 121.7 ± 14.3 | 117.6 ± 11.5 | 122.8 ± 13.3d | 126.4 ± 16.8d | < 0.001 |
Postprandial > 140 mg/dL – %f | 14 | 7.7 | 2.5 | 6.8 | 15.0d | 0.020 |
Mean glucose at 36th weeks’ gestation (mg/dL)g | ||||||
Fasting | 188 | 84.2 ± 8.0 | 80.8 ± 6.0 | 85.2 ± 8.0d | 87.7 ± 8.4d | < 0.001 |
Fasting > 90 mg/dL – %f | 38 | 20.2 | 6.3 | 20.0d | 37.5d | < 0.001 |
Postprandial | 169 | 118.6 ± 12.1 | 114.0 ± 8.9 | 121.5 ± 14.0d | 122.3 ± 12.2d | ns |
Postprandial > 140 mg/dL – %f | 6 | 3.6 | 0.0 | 4.8 | 7.1d | ns |
HbA1c in 3rd trimester (%) | 196 | 5.4 ± 0.6 | 5.1 ± 0.4 | 5.5 ± 0.6d | 5.7 ± 0.6d | < 0.001 |
HbA1c in 3rd trimester > 6% – % | 24 | 12.2 | 2.4 | 18.8d | 20.3d | < 0.001 |
HbA1c partum (%) | 197 | 5.5 ± 0.6 | 5.3 ± 0.5 | 5.6 ± 0.5d | 5.8 ± 0.6d | < 0.001 |
HbA1c partum > 6% – % | 42 | 21.3 | 6.9 | 23.9d | 39.1d | < 0.001 |
Insulin therapy – % | 75 | 36.6 | 16.9 | 41.2d | 60.0d | < 0.001 |
Prepregnancy hypertension – % | 10 | 4.9 | 2.2 | 2.0 | 10.8d | 0.035 |
Gestational hypertension – % | 12 | 5.9 | 2.2 | 5.9 | 10.8d | ns |
Preeclampsia – % | 9 | 4.4 | 2.2 | 2.0 | 9.2 | ns |
Mode of delivery – % | ||||||
Spontaneous | 115 | 56.1 | 66.3 | 45.1d | 50.8 | 0.028 |
Vaginal-operative | 20 | 9.8 | 7.9 | 17.7 | 6.2 | ns |
Primary Cesarean section | 31 | 15.1 | 15.7 | 11.8 | 16.9 | ns |
Repeat Cesarean section | 39 | 19.0 | 10.1 | 25.5d | 26.2d | 0.015 |
Gestational age at delivery (weeks) | 205 | 38.6 ± 1.5 | 38.7 ± 1.6 | 38.9 ± 1.3 | 38.3 ± 1.5d | ns |
Newborn | ||||||
Female sex – % | 88 | 42.9 | 43.8 | 43.1 | 41.5 | ns |
Preterm birth (< 37 weeks’ gestation) – % | 15 | 7.3 | 6.7 | 3.9 | 10.8 | ns |
Placental weight (g) | 201 | 607.0 ± 159.9 | 559.4 ± 124.6 | 666.1 ± 172.3d | 624.9 ± 175.1d | < 0.001 |
Birth weight (g) | 205 | 3450 ± 506 | 3345 ± 496 | 3591 ± 481d | 3483 ± 514 | 0.006 |
Birth length (cm) | 205 | 51.3 ± 2.5 | 51.2 ± 2.5 | 51.7 ± 2.4 | 50.9 ± 2.5 | ns |
Relative birth weight (g/cm) | 205 | 67.1 ± 8.1 | 65.1 ± 7.8 | 69.3 ± 7.7d | 68.2 ± 8.4d | 0.001 |
Ponderal index (g/cm3 × 100) | 205 | 2.6 ± 0.3 | 2.5 ± 0.2 | 2.6 ± 0.3 | 2.6 ± 0.3d | 0.009 |
Birth weight category – % | ||||||
SGA | 9 | 4.4 | 4.5 | 2.0 | 6.2 | ns |
AGA | 155 | 75.6 | 84.3 | 70.6 | 67.7d | 0.036 |
LGA | 41 | 20.0 | 11.2 | 27.5d | 26.2d | 0.018 |
Macrosomia (≥4000 g) – % | 27 | 13.2 | 7.9 | 21.6d | 13.8 | ns |
Head circumference (cm) | 205 | 34.8 ± 2.9 | 34.7 ± 1.8 | 35.3 ± 1.4 | 35.0 ± 1.5 | ns |
Hypoglycemia – % | 20 | 9.8 | 5.6 | 7.8 | 16.9d | ns |
Shoulder dystocia – % | 1 | 0.5 | 0.0 | 0.0 | 1.5 | ns |
Cord-blood plasma levels | ||||||
C-peptide (ng/mL) | 162 | 1.4 ± 0.7 | 1.3 ± 0.6 | 1.4 ± 0.7 | 1.6 ± 0.7d | 0.016 |
C-peptide > 90th percentile – %h | 17 | 10.5 | 5.4 | 7.7 | 20.4d | 0.034 |
Insulin (μU/mL) | 164 | 17.3 ± 13.7 | 14.3 ± 10.6 | 18.5 ± 17.6 | 20.7 ± 13.6d | 0.022 |
Insulin > 90th percentile – %h | 15 | 9.2 | 5.4 | 7.9 | 15.7 | ns |
Leptin (ng/mL) | 164 | 13.3 ± 10.7 | 10.6 ± 8.6 | 15.2 ± 11.1d | 15.9 ± 12.3d | 0.013 |
Leptin > 90th percentile – %h | 16 | 9.8 | 6.8 | 10.3 | 13.7 | ns |
Maternal anthropometrics
Maternal metabolism
Birth outcomes
Associations between parental anthropometric and maternal metabolic variables and birth outcomes
Maternal characteristics | Neonatal outcomes | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Placental weight | Birth weight | Relative birth weight | Cord-blood insulin | Cord-blood leptin | ||||||
r | P-value | r | P-value | r | P-value | r | P-value | r | P-value | |
Prepregnancy BMI | 0.24 | 0.001 | 0.14 | ns | 0.18 | 0.009 | 0.19 | 0.015 | 0.20 | 0.009 |
Net GWG | 0.06 | ns | 0.09 | ns | 0.09 | ns | 0.04 | ns | − 0.06 | ns |
FG at oGTT | 0.18 | 0.010 | 0.12 | ns | 0.13 | ns | 0.10 | ns | 0.15 | ns |
AUC glucose at oGTT | −0.02 | ns | − 0.09 | ns | − 0.07 | ns | 0.02 | ns | 0.15 | ns |
Mean FG at 32nd GW | 0.24 | < 0.001 | 0.16 | 0.029 | 0.19 | 0.007 | 0.23 | 0.003 | 0.23 | 0.004 |
Mean FG at 36th GW | 0.12 | ns | 0.10 | ns | 0.15 | 0.041 | 0.21 | 0.010 | 0.21 | 0.011 |
HbA1c in 3rd trimester | 0.21 | 0.004 | 0.17 | 0.017 | 0.22 | 0.002 | 0.31 | < 0.001 | 0.32 | < 0.001 |
HbA1c partum | 0.24 | < 0.001 | 0.25 | < 0.001 | 0.29 | < 0.001 | 0.39 | < 0.001 | 0.38 | < 0.001 |
Outcome variable | Independent variable | Crude | Adjusteda | ||||
---|---|---|---|---|---|---|---|
Model I | Model II | ||||||
B (95% CI) | P-value | B (95% CI) | P-value | B (95% CI) | P-value | ||
Placental weight | |||||||
Prepregnancy body weight | 0.195 (0.06; 0.34) | 0.006 | 0.171 (0.02; 0.33) | 0.032 | 0.118 (− 0.09; 0.32) | ns | |
Prepregnancy BMI | 0.201 (0.06; 0.34) | 0.005 | 0.164 (0.01; 0.32) | 0.036 | 0.097 (− 0.10; 0.30) | ns | |
GWG in 1. trimester | 0.066 (− 0.08; 0.21) | ns | 0.077 (−0.06; 0.21) | ns | 0.052 (− 0.10; 0.20) | ns | |
GWG in 2. trimester | 0.082 (− 0.06; 0.22) | ns | 0.058 (− 0.09; 0.20) | ns | 0.029 (− 0.14; 0.19) | ns | |
GWG in 3. trimester | 0.184 (0.04; 0.32) | 0.010 | 0.131 (−0.01; 0.27) | ns | 0.057 (− 0.10; 0.22) | ns | |
Total GWG | 0.120 (−0.02; 0.26) | ns | 0.099 (−0.04; 0.24) | ns | 0.018 (− 0.14; 0.18) | ns | |
Net GWG | 0.054 (−0.09; 0.20) | ns | 0.045 (−0.09; 0.18) | ns | −0.034 (− 0.19; 0.12) | ns | |
Birth weight | |||||||
Prepregnancy body weight | 0.142 (0.00; 0.28) | 0.044 | 0.113 (− 0.03; 0.25) | ns | 0.085 (−0.10; 0.27) | ns | |
Prepregnancy BMI | 0.103 (− 0.04; 0.24) | ns | 0.102 (−0.04; 0.24) | ns | 0.081 (−0.11; 0.27) | ns | |
GWG in 1. trimester | 0.043 (−0.10; 0.18) | ns | 0.058 (−0.06; 0.18) | ns | 0.025 (−0.11; 0.17) | ns | |
GWG in 2. trimester | 0.139 (− 0.00; 0.28) | ns | 0.084 (−0.04; 0.21) | ns | 0.091 (−0.06; 0.24) | ns | |
GWG in 3. trimester | 0.190 (0.05; 0.33) | 0.007 | 0.146 (0.02; 0.27) | 0.021 | 0.113 (− 0.03; 0.26) | ns | |
Total GWG | 0.172 (0.03; 0.31) | 0.016 | 0.139 (0.02; 0.26) | 0.028 | 0.108 (−0.04; 0.25) | ns | |
Net GWG | 0.086 (− 0.05; 0.23) | ns | 0.077 (−0.05; 0.20) | ns | 0.048 (−0.10; 0.19) | ns | |
Relative birth weight | |||||||
Prepregnancy body weight | 0.188 (0.05; 0.33) | 0.007 | 0.133 (− 0.01; 0.28) | ns | 0.069 (− 0.12; 0.26) | ns | |
Prepregnancy BMI | 0.150 (0.01; 0.29) | 0.033 | 0.121 (−0.02; 0.26) | ns | 0.069 (− 0.12; 0.26) | ns | |
GWG in 1. trimester | 0.026 (−0.12; 0.17) | ns | 0.038 (− 0.09; 0.16) | ns | 0.043 (− 0.10; 0.19) | ns | |
GWG in 2. trimester | 0.136 (−0.01; 0.28) | ns | 0.105 (−0.03; 0.24) | ns | 0.107 (−0.05; 0.26) | ns | |
GWG in 3. trimester | 0.216 (0.08; 0.35) | 0.002 | 0.171 (0.05; 0.30) | 0.008 | 0.105 (−0.04; 0.25) | ns | |
Total GWG | 0.197 (0.06; 0.33) | 0.005 | 0.168 (0.04; 0.29) | 0.009 | 0.131 (−0.02; 0.28) | ns | |
Net GWG | 0.106 (− 0.03; 0.25) | ns | 0.098 (−0.03; 0.23) | ns | 0.064 (−0.08; 0.21) | ns | |
Cord-blood insulin | |||||||
Prepregnancy body weight | 0.109 (−0.04; 0.26) | ns | 0.078 (−0.09; 0.24) | ns | −0.046 (− 0.25; 0.16) | ns | |
Prepregnancy BMI | 0.177 (0.03; 0.33) | 0.023 | 0.090 (−0.07; 0.25) | ns | −0.021 (− 0.23; 0.18) | ns | |
GWG in 1. trimester | −0.067 (− 0.22; 0.09) | ns | − 0.059 (− 0.20; 0.08) | ns | − 0.109 (− 0.26; 0.05) | ns | |
GWG in 2. trimester | 0.050 (− 0.11; 0.21) | ns | 0.083 (− 0.07; 0.24) | ns | 0.157 (− 0.01; 0.32) | ns | |
GWG in 3. trimester | 0.142 (− 0.01; 0.30) | ns | 0.111 (− 0.03; 0.26) | ns | 0.146 (−0.02; 0.31) | ns | |
Total GWG | 0.107 (−0.05; 0.26) | ns | 0.129 (−0.01; 0.27) | ns | 0.147 (−0.01; 0.31) | ns | |
Net GWG | 0.069 (−0.09; 0.23) | ns | 0.102 (−0.04; 0.25) | ns | 0.124 (−0.04; 0.28) | ns | |
Cord-blood leptin | |||||||
Prepregnancy body weight | 0.159 (0.01; 0.31) | 0.042 | 0.116 (− 0.05; 0.28) | ns | 0.102 (−0.11; 0.31) | ns | |
Prepregnancy BMI | 0.177 (0.02; 0.33) | 0.024 | 0.098 (− 0.06; 0.26) | ns | 0.088 (− 0.12; 0.29) | ns | |
GWG in 1. trimester | −0.032 (− 0.19; 0.13) | ns | − 0.018 (− 0.16; 0.12) | ns | − 0.061 (− 0.22; 0.10) | ns | |
GWG in 2. trimester | −0.102 (− 0.26; 0.06) | ns | − 0.049 (− 0.20; 0.10) | ns | 0.031 (− 0.14; 0.20) | ns | |
GWG in 3. trimester | 0.117 (− 0.04; 0.27) | ns | 0.069 (−0.08; 0.22) | ns | 0.103 (− 0.06; 0.27) | ns | |
Total GWG | 0.006 (−0.15; 0.16) | ns | 0.032 (−0.11; 0.18) | ns | 0.022 (− 0.14; 0.18) | ns | |
Net GWG | −0.019 (− 0.18; 0.14) | ns | 0.020 (− 0.12; 0.16) | ns | 0.015 (− 0.15; 0.18) | ns |
Outcome variable | Independent variable | Crude | Adjusteda | ||||
---|---|---|---|---|---|---|---|
Model I | Model II | ||||||
B (95% CI) | P-value | B (95% CI) | P-value | B (95% CI) | P-value | ||
Placental weight | |||||||
FG at oGTT | 0.170 (0.03; 0.31) | 0.017 | 0.106 (−0.04; 0.25) | ns | 0.072 (− 0.08; 0.22) | ns | |
1-h glucose at oGTT | −0.084 (− 0.23; 0.06) | ns | − 0.088 (− 0.23; 0.05) | ns | −0.051 (− 0.19; 0.09) | ns | |
2-h glucose at oGTT | 0.046 (−0.10; 0.19) | ns | 0.065 (−0.08; 0.21) | ns | 0.080 (−0.07; 0.23) | ns | |
AUC glucose at oGTT | −0.034 (− 0.18; 0.11) | ns | − 0.037 (− 0.19; 0.11) | ns | −0.008 (− 0.16; 0.14) | ns | |
Mean FG at 32nd GW | 0.250 (0.11; 0.39) | 0.001 | 0.231 (0.07; 0.39) | 0.006 | 0.197 (0.03; 0.36) | 0.021 | |
Mean PPG at 32nd GW | 0.300 (0.16; 0.44) | < 0.001 | 0.265 (0.11; 0.42) | 0.001 | 0.234 (0.08; 0.39) | 0.003 | |
Mean FG at 36th GW | 0.145 (−0.00; 0.29) | ns | 0.125 (− 0.03; 0.28) | ns | 0.071 (− 0.09; 0.23) | ns | |
Mean PPG at 36th GW | 0.218 (0.07; 0.37) | 0.005 | 0.215 (0.06; 0.37) | 0.008 | 0.179 (0.02; 0.34) | 0.040 | |
HbA1c in 3.trimester | 0.220 (0.08; 0.36) | 0.003 | 0.192 (0.04; 0.35) | 0.015 | 0.141 (−0.02; 0.31) | ns | |
HbA1c partum | 0.222 (0.08; 0.37) | 0.003 | 0.151 (−0.00; 0.30) | ns | 0.106 (−0.05; 0.27) | ns | |
Birth weight | |||||||
FG at oGTT | 0.094 (−0.05; 0.23) | ns | 0.052 (−0.08; 0.19) | ns | 0.062 (− 0.08; 0.20) | ns | |
1-h glucose at oGTT | −0.142 (− 0.28; − 0.00) | 0.044 | −0.091 (− 0.22; 0.04) | ns | −0.059 (− 0.19; 0.07) | ns | |
2-h glucose at oGTT | −0.049 (− 0.19; 0.09) | ns | 0.016 (− 0.12; 0.15) | ns | 0.045 (− 0.09; 0.18) | ns | |
AUC glucose at oGTT | −0.126 (− 0.27; 0.02) | ns | − 0.057 (− 0.19; 0.08) | ns | − 0.014 (− 0.15; 0.12) | ns | |
Mean FG at 32nd GW | 0.157 (0.01; 0.30) | 0.032 | 0.147 (− 0.00; 0.30) | ns | 0.120 (−0.03; 0.27) | ns | |
Mean PPG at 32nd GW | 0.295 (0.15; 0.44) | < 0.001 | 0.259 (0.12; 0.40) | < 0.001 | 0.233 (0.09; 0.38) | 0.002 | |
Mean FG at 36th GW | 0.125 (−0.02; 0.27) | ns | 0.118 (−0.02; 0.26) | ns | 0.080 (−0.06; 0.22) | ns | |
Mean PPG at 36th GW | 0.161 (0.01; 0.31) | 0.033 | 0.171 (0.03; 0.32) | 0.020 | 0.111 (−0.04; 0.26) | ns | |
HbA1c in 3.trimester | 0.141 (0.00; 0.28) | 0.048 | 0.146 (0.01; 0.29) | 0.040 | 0.112 (−0.04; 0.26) | ns | |
HbA1c partum | 0.218 (0.08; 0.36) | 0.003 | 0.186 (0.05; 0.32) | 0.008 | 0.176 (0.03; 0.32) | 0.016 | |
Relative birth weight | |||||||
FG at oGTT | 0.108 (−0.03; 0.25) | ns | 0.031 (− 0.11; 0.17) | ns | 0.034 (− 0.11; 0.17) | ns | |
1-h glucose at oGTT | −0.108 (− 0.25; 0.03) | ns | − 0.074 (− 0.20; 0.06) | ns | −0.046 (− 0.18; 0.09) | ns | |
2-h glucose at oGTT | 0.005 (−0.14; 0.15) | ns | 0.050 (−0.09; 0.18) | ns | 0.088 (−0.05; 0.22) | ns | |
AUC glucose at oGTT | −0.080 (− 0.22; 0.06) | ns | − 0.039 (− 0.18; 0.10) | ns | 0.003 (− 0.14; 0.14) | ns | |
Mean FG at 32nd GW | 0.193 (0.05; 0.34) | 0.008 | 0.142 (−0.01; 0.29) | ns | 0.105 (−0.05; 0.26) | ns | |
Mean PPG at 32nd GW | 0.319 (0.18; 0.46) | < 0.001 | 0.285 (0.14; 0.43) | < 0.001 | 0.241 (0.09; 0.39) | 0.002 | |
Mean FG at 36th GW | 0.174 (0.03; 0.32) | 0.017 | 0.139 (−0.00; 0.28) | ns | 0.098 (−0.05; 0.24) | ns | |
Mean PPG at 36th GW | 0.175 (0.03; 0.32) | 0.019 | 0.164 (0.02; 0.31) | 0.030 | 0.097 (−0.06; 0.25) | ns | |
HbA1c in 3.trimester | 0.214 (0.08; 0.35) | 0.002 | 0.202 (0.06; 0.34) | 0.006 | 0.162 (0.01; 0.31) | 0.037 | |
HbA1c partum | 0.269 (0.13; 0.41) | < 0.001 | 0.217 (0.08; 0.35) | 0.002 | 0.196 (0.05; 0.34) | 0.008 | |
Cord-blood insulin | |||||||
FG at oGTT | 0.114 (−0.04; 0.27) | ns | 0.018 (−0.14; 0.18) | ns | 0.012 (−0.15; 0.18) | ns | |
1-h glucose at oGTT | 0.039 (−0.12; 0.20) | ns | −0.027 (− 0.18; 0.13) | ns | 0.003 (− 0.15; 0.16) | ns | |
2-h glucose at oGTT | 0.047 (−0.11; 0.20) | ns | 0.037 (−0.11; 0.19) | ns | 0.065 (−0.09; 0.22) | ns | |
AUC glucose at oGTT | 0.041 (−0.12; 0.20) | ns | −0.012 (− 0.17; 0.14) | ns | 0.026 (− 0.14; 0.19) | ns | |
Mean FG at 32nd GW | 0.241 (0.08; 0.40) | 0.004 | 0.243 (0.07; 0.41) | 0.005 | 0.231 (0.06; 0.41) | 0.010 | |
Mean PPG at 32nd GW | 0.225 (0.07; 0.38) | 0.005 | 0.116 (−0.04; 0.28) | ns | 0.085 (−0.08; 0.25) | ns | |
Mean FG at 36th GW | 0.224 (0.07; 0.38) | 0.006 | 0.194 (0.04; 0.35) | 0.012 | 0.172 (0.01; 0.33) | 0.035 | |
Mean PPG at 36th GW | 0.143 (−0.02; 0.31) | ns | 0.080 (−0.07; 0.24) | ns | 0.037 (−0.12; 0.20) | ns | |
HbA1c in 3.trimester | 0.315 (0.16; 0.48) | < 0.001 | 0.209 (0.04; 0.37) | 0.014 | 0.180 (−0.01; 0.37) | ns | |
HbA1c partum | 0.386 (0.24; 0.54) | < 0.001 | 0.300 (0.15; 0.45) | < 0.001 | 0.282 (0.11; 0.45) | 0.001 | |
Cord-blood leptin | |||||||
FG at oGTT | 0.157 (0.01; 0.31) | 0.042 | 0.065 (−0.09; 0.22) | ns | 0.034 (− 0.13; 0.20) | ns | |
1-h glucose at oGTT | 0.084 (−0.07; 0.24) | ns | 0.054 (−0.10; 0.21) | ns | 0.072 (−0.09; 0.23) | ns | |
2-h glucose at oGTT | 0.134 (−0.02; 0.29) | ns | 0.154 (0.01; 0.30) | ns | 0.169 (0.02; 0.32) | 0.028 | |
AUC glucose at oGTT | 0.124 (−0.03; 0.28) | ns | 0.107 (−0.05; 0.26) | ns | 0.122 (−0.04; 0.28) | ns | |
Mean FG at 32nd GW | 0.204 (0.05; 0.36) | 0.012 | 0.172 (0.01; 0.34) | 0.043 | 0.149 (−0.02; 0.32) | ns | |
Mean PPG at 32nd GW | 0.194 (0.04; 0.35) | 0.015 | 0.131 (−0.03; 0.29) | ns | 0.122 (−0.04; 0.28) | ns | |
Mean FG at 36th GW | 0.188 (0.03; 0.35) | 0.020 | 0.122 (−0.04; 0.28) | ns | 0.073 (−0.10; 0.24) | ns | |
Mean PPG at 36th GW | 0.104 (−0.06; 0.27) | ns | 0.030 (−0.13; 0.19) | ns | 0.004 (−0.16; 0.17) | ns | |
HbA1c in 3.trimester | 0.290 (0.14; 0.44) | < 0.001 | 0.190 (0.03; 0.35) | 0.021 | 0.188 (0.01; 0.37) | 0.041 | |
HbA1c partum | 0.350 (0.20; 0.50) | < 0.001 | 0.261 (0.11; 0.42) | 0.001 | 0.259 (0.09; 0.43) | 0.003 |
Identification of major categorical parental determinants of anthropometric birth and cord-blood hormone outcomes
Outcome variable | Predictor variablea | B (95% CI) | P-value | Adj. Sr2 |
---|---|---|---|---|
Placental weight | Mean FG at 32nd GW > 90 mg/dL | 0.487 (0.18; 0.80) | 0.002 | 0.057 |
Term delivery | 0.934 (0.30; 1.57) | 0.004 | 0.040 | |
Cesarean section | 0.424 (0.11; 0.74) | 0.008 | 0.036 | |
Birth weight | Term delivery | 1.400 (0.80; 2.00) | < 0.001 | 0.118 |
1-h glucose at oGTT > 180 mg/dL | −0.501 (−0.86; −0.15) | 0.006 | 0.035 | |
Smoking in pregnancy | −0.561 (− 0.96; − 0.17) | 0.006 | 0.029 | |
Male sex | 0.333 (0.05; 0.62) | 0.022 | 0.023 | |
Mean FG at 32nd GW >90 mg/dL | 0.297 (0.01; 0.59) | 0.044 | 0.017 | |
Relative birth weight | Term delivery | 1.457 (0.86; 2.06) | < 0.001 | 0.121 |
Excessive GWG | 0.332 (0.04; 0.62) | 0.026 | 0.029 | |
Smoking in pregnancy | −0.565 (−0.97; −0.16) | 0.007 | 0.025 | |
Prepregnancy BMI > 25 kg/m2 | 0.319 (0.02; 0.61) | 0.034 | 0.024 | |
1-h glucose at oGTT > 180 mg/dL | −0.375 (− 0.74; − 0.01) | 0.042 | 0.016 | |
Male sex | 0.295 (0.01; 0.58) | 0.044 | 0.016 | |
Cord-blood insulin | Cesarean section | 0.679 (0.38; 0.97) | < 0.001 | 0.170 |
HbA1c partum > 6% | 0.460 (0.09; 0.83) | 0.016 | 0.066 | |
Non-European ethnicity | 0.438 (0.13; 0.75) | 0.006 | 0.043 | |
Mean FG at 32nd GW >90 mg/dL | 0.321 (0.02; 0.63) | 0.038 | 0.020 | |
Cord-blood leptin | HbA1c partum > 6% | 0.470 (0.08; 0.86) | 0.017 | 0.070 |
Non-European ethnicity | 0.519 (0.19; 0.85) | 0.002 | 0.048 | |
Male sex | −0.395 (−0.71; −0.08) | 0.013 | 0.042 | |
FG at oGTT >90 mg/dL | 0.339 (0.03; 0.65) | 0.034 | 0.025 |