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Immunologic Research
Erschienen in: Immunologic Research 2/2015

01.06.2015 | Interpretive synthesis review article

Mcl-1 is vital for neutrophil survival

verfasst von: Mark P. Murphy, Emma Caraher

Erschienen in: Immunologic Research | Ausgabe 2/2015

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Abstract

Upon entry to the systemic circulation, neutrophils exhibit a short mean time to cell death. The viability of most cell types in a steady state is preserved by the interplay of the Bcl-2 family of proteins, wherein the anti-apoptotic members inhibit the action of their pro-apoptotic counterparts. Neutrophils, however, display absent or severely reduced expression of several anti-apoptotic Bcl-2 family proteins. Hence, they rely on the expression of Mcl-1, an anti-apoptotic member of the Bcl-2 family, for survival. This protein is uniquely short-lived relative to related proteins and its loss likely precipitates the induction of apoptosis in neutrophils. This review describes the role of Mcl-1 in the neutrophil in the context of apoptosis and highlights the proteins’ importance to the cell. We also address neutrophil apoptosis in the broader context of the cells’ response to pathogens, focussing particularly on the strategies used by pathogens to manipulate the apoptotic pathway to their own ends.
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Metadaten
Titel
Mcl-1 is vital for neutrophil survival
verfasst von
Mark P. Murphy
Emma Caraher
Publikationsdatum
01.06.2015
Verlag
Springer US
Erschienen in
Immunologic Research / Ausgabe 2/2015
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-015-8655-z

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