Skip to main content
Erschienen in: Critical Care 5/2012

01.10.2012 | Commentary

Measuring glomerular filtration rate in acute kidney injury: Yes, but not yet

verfasst von: Bruce A Molitoris

Erschienen in: Critical Care | Ausgabe 5/2012

Einloggen, um Zugang zu erhalten

Abstract

Acute kidney injury has become a major focus for nephrologists and critical care physicians. The development of structural biomarkers is proceeding, but the results to date have been disappointing. The use of a shortened creatinine clearance as a functional acute kidney injury biomarker is not new but has not been compared with that of other diagnostic approaches. A rapid, repeatable, and accurate measured glomerular filtration rate would be the gold standard for a functional biomarker and is not far off.
Literatur
1.
Zurück zum Zitat Pickering JW, Frampton CM, Walker RJ, Shaw GM, Endre ZH: Four hour creatinine clearance is better than plasma creatinine for monitoring renal function in critically ill patients. Crit Care. 2012, 16: R107-10.1186/cc11391.PubMedCentralCrossRefPubMed Pickering JW, Frampton CM, Walker RJ, Shaw GM, Endre ZH: Four hour creatinine clearance is better than plasma creatinine for monitoring renal function in critically ill patients. Crit Care. 2012, 16: R107-10.1186/cc11391.PubMedCentralCrossRefPubMed
2.
Zurück zum Zitat Hewitt SM, Dear J, Star RA: Discovery of protein biomarkers for renal diseases. J Am Soc Nephrol. 2004, 15: 1677-1689. 10.1097/01.ASN.0000129114.92265.32.CrossRefPubMed Hewitt SM, Dear J, Star RA: Discovery of protein biomarkers for renal diseases. J Am Soc Nephrol. 2004, 15: 1677-1689. 10.1097/01.ASN.0000129114.92265.32.CrossRefPubMed
3.
Zurück zum Zitat Pisitkun T, Shen RF, Knepper MA: Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci USA. 2004, 101: 13368-13373. 10.1073/pnas.0403453101.PubMedCentralCrossRefPubMed Pisitkun T, Shen RF, Knepper MA: Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci USA. 2004, 101: 13368-13373. 10.1073/pnas.0403453101.PubMedCentralCrossRefPubMed
4.
Zurück zum Zitat Herget-Rosenthal S, Kribben A, Pietruck F, Ross B, Philipp T: Two by two hour creatinine clearance--repeatable and valid. Clin Nephrol. 1999, 51: 348-354.PubMed Herget-Rosenthal S, Kribben A, Pietruck F, Ross B, Philipp T: Two by two hour creatinine clearance--repeatable and valid. Clin Nephrol. 1999, 51: 348-354.PubMed
5.
Zurück zum Zitat Cherry RA, Eachempati SR, Hydo L, Barie PS: Accuracy of short-duration creatinine clearance determinations in predicting 24-hour creatinine clearance in critically ill and injured patients. J Trauma. 2002, 53: 267-271. 10.1097/00005373-200208000-00013.CrossRefPubMed Cherry RA, Eachempati SR, Hydo L, Barie PS: Accuracy of short-duration creatinine clearance determinations in predicting 24-hour creatinine clearance in critically ill and injured patients. J Trauma. 2002, 53: 267-271. 10.1097/00005373-200208000-00013.CrossRefPubMed
6.
Zurück zum Zitat Herrera-Gutiérrez ME, Seller-Pérez G, Banderas-Bravo E, Muñoz-Bono J, Lebrón-Gallardo M, Fernandez-Ortega JF: Replacement of 24-h creatinine clearance by 2-h creatinine clearance in intensive care unit patients: a single-center study. Intensive Care Med. 2007, 33: 1900-1906. 10.1007/s00134-007-0745-5.CrossRefPubMed Herrera-Gutiérrez ME, Seller-Pérez G, Banderas-Bravo E, Muñoz-Bono J, Lebrón-Gallardo M, Fernandez-Ortega JF: Replacement of 24-h creatinine clearance by 2-h creatinine clearance in intensive care unit patients: a single-center study. Intensive Care Med. 2007, 33: 1900-1906. 10.1007/s00134-007-0745-5.CrossRefPubMed
7.
Zurück zum Zitat Doi K, Yuen PS, Eisner C, Hu X, Leelahavanichkul A, Schnermann J, Star RA: Reduced production of creatinine limits its use as marker of kidney injury in sepsis. J Am Soc Nephrol. 2009, 20: 1217-1221. 10.1681/ASN.2008060617.PubMedCentralCrossRefPubMed Doi K, Yuen PS, Eisner C, Hu X, Leelahavanichkul A, Schnermann J, Star RA: Reduced production of creatinine limits its use as marker of kidney injury in sepsis. J Am Soc Nephrol. 2009, 20: 1217-1221. 10.1681/ASN.2008060617.PubMedCentralCrossRefPubMed
8.
Zurück zum Zitat Dagher PC, Herget-Rosenthal S, Ruehm SG, Jo SK, Star RA, Agarwal R, Molitoris BA: Newly developed techniques to study and diagnose acute renal failure. J Am Soc Nephrol. 2003, 14: 2188-2198. 10.1097/01.ASN.0000079790.91292.4A.CrossRefPubMed Dagher PC, Herget-Rosenthal S, Ruehm SG, Jo SK, Star RA, Agarwal R, Molitoris BA: Newly developed techniques to study and diagnose acute renal failure. J Am Soc Nephrol. 2003, 14: 2188-2198. 10.1097/01.ASN.0000079790.91292.4A.CrossRefPubMed
9.
Zurück zum Zitat Poreddy AR, Neumann WL, Freskos JN, Rajagopalan R, Asmelash B, Gaston KR, Fitch RM, Galen KP, Shieh JJ, Dorshow RB: Exogenous fluorescent tracer agents based on pegylated pyrazine dyes for real-time point-of-care measurement of glomerular filtration rate. Bioorg Med Chem. 2012, 20: 2490-2497. 10.1016/j.bmc.2012.03.015.CrossRefPubMed Poreddy AR, Neumann WL, Freskos JN, Rajagopalan R, Asmelash B, Gaston KR, Fitch RM, Galen KP, Shieh JJ, Dorshow RB: Exogenous fluorescent tracer agents based on pegylated pyrazine dyes for real-time point-of-care measurement of glomerular filtration rate. Bioorg Med Chem. 2012, 20: 2490-2497. 10.1016/j.bmc.2012.03.015.CrossRefPubMed
10.
Zurück zum Zitat Wang E, Meier DJ, Sandoval RM, Von Hendy-Willson VE, Pressler BM, Bunch RM, Alloosh M, Sturek MS, Schwartz GJ, Molitoris BA: A portable fiberoptic ratiometric fluorescence analyzer provides rapid point-of-care determination of glomerular filtration rate in large animals. Kidney Int. 2012, 81: 112-117. 10.1038/ki.2011.294.CrossRefPubMed Wang E, Meier DJ, Sandoval RM, Von Hendy-Willson VE, Pressler BM, Bunch RM, Alloosh M, Sturek MS, Schwartz GJ, Molitoris BA: A portable fiberoptic ratiometric fluorescence analyzer provides rapid point-of-care determination of glomerular filtration rate in large animals. Kidney Int. 2012, 81: 112-117. 10.1038/ki.2011.294.CrossRefPubMed
Metadaten
Titel
Measuring glomerular filtration rate in acute kidney injury: Yes, but not yet
verfasst von
Bruce A Molitoris
Publikationsdatum
01.10.2012
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 5/2012
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc11482

Weitere Artikel der Ausgabe 5/2012

Critical Care 5/2012 Zur Ausgabe

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.