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Magnetic Resonance Materials in Physics, Biology and Medicine

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01.02.2015 | Research Article

Measuring short-term liver metabolism non-invasively: postprandial and post-exercise ¹H and ³¹P MR spectroscopy

verfasst von: Antti Hakkarainen, Jesper Lundbom, Esa K. Tuominen, Marja-Riitta Taskinen, Kirsi H. Pietiläinen, Nina Lundbom

Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine | Ausgabe 1/2015

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Abstract

Object

The objective of this study was to determine the effects of a standardized fat rich meal and subsequent exercise on liver fat content by ¹H MRS and on liver adenosine triphosphate (ATP) content by ³¹P MRS in healthy subjects.

Materials and methods

Hepatic ¹H and proton decoupled ³¹P MRS were performed on nine healthy subjects on a clinical 3.0 T MR imager three times during a day: after (1) an overnight fast, (2) a following standardized fat rich meal and (3) a subsequent exercise session. Blood parameters were followed during the day to serve as a reference to MRS.

Results

Liver fat content increased gradually over the day (p = 0.0001) with an overall increase of 30 %. Also γ-NTP changed significantly over the day (p = 0.005). γ-NTP/tP decreased by 9 % (p = 0.019, post hoc) from the postprandial to the post-exercise state.

Conclusion

Our study shows that in vivo MRS can depict short lived physiological changes; entering of fat into liver cells and consumption of ATP during exercise can be measured non-invasively in healthy subjects. The physiological state may have an impact on fat and energy metabolite levels. Hepatic ¹H and ³¹P MRS studies should be performed under standardized conditions.

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Titel: Measuring short-term liver metabolism non-invasively: postprandial and post-exercise 1H and 31P MR spectroscopy
verfasst von: Antti Hakkarainen
Jesper Lundbom
Esa K. Tuominen
Marja-Riitta Taskinen
Kirsi H. Pietiläinen
Nina Lundbom
Publikationsdatum: 01.02.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine / Ausgabe 1/2015
Print ISSN: 0968-5243
Elektronische ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-014-0450-7

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Measuring short-term liver metabolism non-invasively: postprandial and post-exercise ¹H and ³¹P MR spectroscopy