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01.07.2012 | Original paper

Medical conditions and risk of adult myeloid leukemia

verfasst von: Kimberly J. Johnson, Cindy M. Blair, James M. Fink, James R. Cerhan, Michelle A. Roesler, Betsy A. Hirsch, Phuong L. Nguyen, Julie A. Ross

Erschienen in: Cancer Causes & Control | Ausgabe 7/2012

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Abstract

Purpose

Although a few previous studies have reported positive associations between adult myeloid leukemia and a history of certain medical conditions, the etiology of most cases remains largely unknown. Our purpose was to examine associations between certain medical conditions and adult myeloid leukemia.

Methods

Using logistic regression, we evaluated associations between 16 self-reported medical conditions and myeloid leukemia in a case–control study of 670 cases [including 420 acute myeloid leukemia (AML) and 186 chronic myelogenous leukemia (CML)] and 701 population-based controls.

Results

We observed significant positive associations between AML and ulcerative colitis (odds ratio (OR) = 3.8; 95 % confidence interval (CI), 1.1–13) and between CML and peptic ulcer (OR = 2.0; 95% CI, 1.1–3.8). A personal cancer history increased both AML (OR = 2.6; 95% CI, 1.7–3.9) and CML (OR = 3.5; 95% CI, 2.0–5.8) risk even after excluding individuals who reported prior radiation and/or chemotherapy treatment.

Conclusion

Certain inflammatory medical conditions and a personal history of cancer, independent from therapy, are associated with an increased risk of myeloid leukemia.

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Titel: Medical conditions and risk of adult myeloid leukemia
verfasst von: Kimberly J. Johnson
Cindy M. Blair
James M. Fink
James R. Cerhan
Michelle A. Roesler
Betsy A. Hirsch
Phuong L. Nguyen
Julie A. Ross
Publikationsdatum: 01.07.2012
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 7/2012
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-012-9977-y

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Medical conditions and risk of adult myeloid leukemia