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Journal of Cancer Research and Clinical Oncology

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01.01.2007 | Original Paper

Microsatellite instability analysis of bilateral breast tumors suggests treatment-related origin of some contralateral malignancies

verfasst von: Ekatherina Sh. Kuligina, Maxim Yu. Grigoriev, Evgeny N. Suspitsin, Konstantin G. Buslov, Olga A. Zaitseva, Olga S. Yatsuk, Yulia R. Lazareva, Alexandr V. Togo, Evgeny N. Imyanitov

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 1/2007

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Abstract

Purpose

High-frequency microsatellite instability (MSI-H) occurs frequently in colorectal cancers and some other tumor types, but is very uncommon in breast cancer. In the earlier study devoted to microsatellite analysis of allelic imbalances, the authors accidentally detected several MSI-H tumors in patients with the bilateral form of breast cancer (biBC). The present study was designed to examine this unexpected phenomenon in more detail.

Methods

All DNA samples were tested by the standard panel of MSI-specific markers BAT25, BAT26, BAT40, D5S346, and D17S250. If the tumor was unstable for at least one marker, or PCR amplification was not successful for any of the listed above loci, the analysis of additional five dinucleotide markers (D1S225, D11S4167, D22S272, D22S1166, and D3S3527) was performed. Tumors showing instability in ≥30% loci were classified as MSI-H.

Results

In biBC group, MSI-H status was detected in 6/60 (10%) contralateral tumors, but in 0/50 (0%) first malignancies (P = 0.021) and only in 1/22 (5%) synchronous biBC (P = 0.434). None of 52 unilateral breast cancers showed MSI-H status. Shifts of mononucleotide markers were revealed in four second carcinomas from biBC patients but in none of the breast tumors from other categories.

Conclusions

MSI-H is detected with a noticeable frequency in bilateral but not in unilateral breast cancers. Preferable occurrence of MSI-H in second metachronous tumors from biBC patients allows to hypothesize that the development of some contralateral breast neoplasms is casually related to the adjuvant treatment of the initial malignancy.

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Titel: Microsatellite instability analysis of bilateral breast tumors suggests treatment-related origin of some contralateral malignancies
verfasst von: Ekatherina Sh. Kuligina
Maxim Yu. Grigoriev
Evgeny N. Suspitsin
Konstantin G. Buslov
Olga A. Zaitseva
Olga S. Yatsuk
Yulia R. Lazareva
Alexandr V. Togo
Evgeny N. Imyanitov
Publikationsdatum: 01.01.2007
Verlag: Springer-Verlag
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 1/2007
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-006-0146-0

Springer Medizin

Microsatellite instability analysis of bilateral breast tumors suggests treatment-related origin of some contralateral malignancies